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Article Dans Une Revue Journal of Cerebral Blood Flow and Metabolism Année : 2016

Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease.

1 U1161 / UMR_S 1161 - Génétique et Physiopathologie des Maladies Cérébro-Vasculaires
2 DHU NeuroVasc Sorbonne Paris-Cité
3 Service de Neurologie [Lariboisière]
4 Department of Neurology
5 Department of Medicine (Neurology)
6 Department of Public Health and Primary Care
7 Department of Pharmacology [Singapour]
8 TCDV - Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046
9 Department of Neurology [Nijmegen]
10 ISD - Institute for Stroke and Dementia Research
11 SyNergy - Munich Center for Systems Neurology
12 Edin. - University of Edinburgh
13 Epidémiologie et Biostatistique [Bordeaux]
14 Department of Cognitive Neurology and Dementia Research [Magdeburg, Germany]
15 Department of Neurology [Austria]
16 Department of Clinical Neurological Sciences [London, Canada]
17 Departments of Radiology and of Epidemiology [Rotterdam]
18 Department of Neurology [Rotterdam]
19 Department of Neuroradiology [Munich]
20 Division of Brain Sciences [London]
21 GIN - UMR 5296 - Groupe d'Imagerie Neurofonctionnelle
22 Department of Medicine and Therapeutics [Hong Kong]
23 Skane University Hospital [Lund]
24 Department of Psychiatry [Cambridge, UK]
25 NEUROFARBA Department [Firenze, Italy]
26 Centre for Healthy Brain Ageing [Sydney]
27 School of Computer Science [Manchester]
28 Department of Neurology [Boston, USA]
29 Department of Clinical Neurosciences and Hotchkiss Brain Institute [Calgary, Canada]
30 Institute of Health and Society [Newcastle, UK]
31 Department of Radiology [Leiden, The Netherlands]
32 Department of Neurology [Maastricht, The Netherlands]
33 Glaucoma Research Unit [London]
34 Department of Brain Repair and Rehabilitation - Stroke Research Group [London, UK]
35 CCACE - Centre for Cognitive Ageing and Cognitive Epidemiology
Bernard Mazoyer
Perminder Sachdev

Résumé

Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.
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Dates et versions

inserm-01317759 , version 1 (18-05-2016)

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François de Guio, Eric Jouvent, Geert Jan Biessels, Sandra E Black, Carol Brayne, et al.. Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease.. Journal of Cerebral Blood Flow and Metabolism, 2016, 36 (8), pp.1319-37. ⟨10.1177/0271678X16647396⟩. ⟨inserm-01317759⟩
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