No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.

Abstract : A hybrid allele between the carboxyl ester lipase gene (CEL) and its pseudogene, CELP (called CEL–HYB), generated by non-allelic homologous recombination between CEL intron 10 and CELP intron 10′, was found to increase susceptibility to chronic pancreatitis in a case–control study of patients of European ancestry. We attempted to replicate this finding in 3 independent cohorts from China, Japan, and India, but failed to detect the CEL–HYB allele in any of these populations. The CEL–HYB allele might therefore be an ethnic-specific risk factor for chronic pancreatitis. An alternative hybrid allele (CEL–HYB2) was identified in all 3 Asian populations (1.7% combined carrier frequency), but was not associated with chronic pancreatitis.
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http://www.hal.inserm.fr/inserm-01293422
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Dernière modification le : mardi 30 janvier 2018 - 10:42:01
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Wen-Bin Zou, Arnaud Boulling, Atsushi Masamune, Prachand Issarapu, Emmanuelle Masson, et al.. No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.. Gastroenterology, WB Saunders, 2016, 〈10.1053/j.gastro.2016.02.071〉. 〈inserm-01293422〉

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