R. Anty, S. Bekri, N. Luciani, M. Saint-paul, M. Dahman et al., The Inflammatory C-Reactive Protein Is Increased in Both Liver and Adipose Tissue in Severely Obese Patients Independently from Metabolic Syndrome, Type 2 Diabetes, and NASH, The American Journal of Gastroenterology, vol.33, issue.8, pp.1824-1833, 2006.
DOI : 10.1111/j.1572-0241.2006.00724.x

B. Gaillard, C. Pallesi-pocachard, E. Massey-harroche, D. Richard, F. Arsanto et al., Hook2 is involved in the morphogenesis of the primary cilium, Molecular Biology of the Cell, vol.22, issue.23, pp.4549-4562, 2011.
DOI : 10.1091/mbc.E11-05-0405

URL : https://hal.archives-ouvertes.fr/hal-00848911

S. Bekri, P. Gual, R. Anty, N. Luciani, M. Dahman et al., Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH, Gastroenterology, vol.131, issue.3, pp.788-796, 2006.
DOI : 10.1053/j.gastro.2006.07.007

A. Bertola, V. Deveaux, S. Bonnafous, D. Rousseau, R. Anty et al., Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity, Diabetes, vol.58, issue.1, pp.125-133, 2009.
DOI : 10.2337/db08-0400

URL : https://hal.archives-ouvertes.fr/hal-00419058

I. Bondia-pons, L. Ryan, and J. Martinez, Oxidative stress and inflammation interactions in human obesity, Journal of Physiology and Biochemistry, vol.59, issue.Pt 1, pp.701-711, 2012.
DOI : 10.1007/s13105-012-0154-2

C. Broca, J. Quoyer, S. Costes, N. Linck, A. Varrault et al., ??-Arrestin 1 Is Required for PAC1 Receptor-mediated Potentiation of Long-lasting ERK1/2 Activation by Glucose in Pancreatic ??-Cells, Journal of Biological Chemistry, vol.284, issue.7, pp.4332-4342, 2009.
DOI : 10.1074/jbc.M807595200

P. Calder, N. Ahluwalia, F. Brouns, T. Buetler, K. Clement et al., Dietary factors and low-grade inflammation in relation to overweight and obesity, British Journal of Nutrition, vol.106, issue.S3, pp.5-78, 2011.
DOI : 10.1017/S0007114511005460

C. Cano, J. Gommeaux, S. Pietri, M. Culcasi, S. Garcia et al., Tumor Protein 53-Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function, Cancer Research, vol.69, issue.1, pp.219-226, 2009.
DOI : 10.1158/0008-5472.CAN-08-2320

URL : https://hal.archives-ouvertes.fr/inserm-01270304

S. Cauchi, I. Ezzidi, E. Achhab, Y. Mtiraoui, N. Chaieb et al., European genetic variants associated with type 2 diabetes in North African Arabs, Diabetes & Metabolism, vol.38, issue.4, pp.316-323, 2012.
DOI : 10.1016/j.diabet.2012.02.003

A. Chawla, K. Nguyen, and Y. Goh, Macrophage-mediated inflammation in metabolic disease, Nature Reviews Immunology, vol.17, issue.11, pp.738-749, 2011.
DOI : 10.1038/nri3071

A. Crujeiras, A. Diaz-lagares, M. Carreira, M. Amil, and F. Casanueva, Oxidative stress associated to dysfunctional adipose tissue: a potential link between obesity, type 2 diabetes mellitus and breast cancer, Free Radical Research, vol.16, issue.4, pp.243-256, 2013.
DOI : 10.1016/S1470-2045(11)70030-4

T. Deng, C. Lyon, L. Minze, J. Lin, J. Zou et al., Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation, Cell Metabolism, vol.17, issue.3, pp.411-422, 2013.
DOI : 10.1016/j.cmet.2013.02.009

D. Eizirik, M. Sammeth, T. Bouckenooghe, G. Bottu, G. Sisino et al., The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines, PLoS Genetics, vol.6, issue.3, p.1002552, 2012.
DOI : 10.1371/journal.pgen.1002552.s011

V. Forte, A. Pandey, R. Abdelmessih, G. Forte, A. Whaley-connell et al., Obesity, Diabetes, the Cardiorenal Syndrome, and Risk for Cancer, Cardiorenal Medicine, vol.2, issue.2, pp.143-162, 2012.
DOI : 10.1159/000337314

M. Gironella, M. Seux, M. Xie, C. Cano, R. Tomasini et al., Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development, Proceedings of the National Academy of Sciences, vol.104, issue.41, pp.16170-16175, 2007.
DOI : 10.1073/pnas.0703942104

J. Gommeaux, C. Cano, S. Garcia, M. Gironella, S. Pietri et al., Colitis and Colitis-Associated Cancer Are Exacerbated in Mice Deficient for Tumor Protein 53-Induced Nuclear Protein 1, Molecular and Cellular Biology, vol.27, issue.6, pp.2215-2228, 2007.
DOI : 10.1128/MCB.01454-06

URL : https://hal.archives-ouvertes.fr/hal-00145430

M. Gregor and G. Hotamisligil, Inflammatory Mechanisms in Obesity, Annual Review of Immunology, vol.29, issue.1, pp.415-445, 2011.
DOI : 10.1146/annurev-immunol-031210-101322

T. Greiner and F. Backhed, Effects of the gut microbiota on obesity and glucose homeostasis, Trends in Endocrinology & Metabolism, vol.22, issue.4, pp.117-123, 2011.
DOI : 10.1016/j.tem.2011.01.002

S. Gupta, D. Hevia, S. Patchva, B. Park, W. Koh et al., Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy, Antioxidants & Redox Signaling, vol.16, issue.11, pp.1295-1322, 2012.
DOI : 10.1089/ars.2011.4414

D. Hodson, R. Mitchell, E. Bellomo, G. Sun, L. Vinet et al., Lipotoxicity disrupts incretin-regulated human ?? cell connectivity, Journal of Clinical Investigation, vol.123, issue.10, pp.4182-4194, 2013.
DOI : 10.1172/JCI68459DS1

L. Hwang, C. Wang, T. Li, S. Chang, L. Lin et al., Sex Differences in High-fat Diet-induced Obesity, Metabolic Alterations and Learning, and Synaptic Plasticity Deficits in Mice, Obesity, vol.271, issue.1, pp.463-469, 2010.
DOI : 10.1095/biolreprod38.5.1035

P. Jiang, Y. Motoo, J. Iovanna, M. Pebusque, M. Xie et al., Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas, J Pancreas, vol.5, pp.205-216, 2004.

V. Kameswaran, N. Bramswig, L. Mckenna, M. Penn, J. Schug et al., Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets, Cell Metabolism, vol.19, issue.1, pp.135-145, 2014.
DOI : 10.1016/j.cmet.2013.11.016

N. Khoo, N. Cantu-medellin, J. Devlin, S. Croix, C. Watkins et al., Obesity-induced tissue free radical generation: An in vivo immuno-spin trapping study, Free Radical Biology and Medicine, vol.52, issue.11-12, 2012.
DOI : 10.1016/j.freeradbiomed.2012.04.011

R. Van-kruijsdijk, E. Van-der-wall, and F. Visseren, Obesity and Cancer: The Role of Dysfunctional Adipose Tissue, Cancer Epidemiology Biomarkers & Prevention, vol.18, issue.10, pp.2569-2578, 2009.
DOI : 10.1158/1055-9965.EPI-09-0372

V. Lavallard, A. Meijer, P. Codogno, and P. Gual, Autophagy, signaling and obesity, Pharmacological Research, vol.66, issue.6, pp.513-525, 2012.
DOI : 10.1016/j.phrs.2012.09.003

A. Leboucher, C. Laurent, F. Fernandez-gomez, S. Burnouf, L. Troquier et al., Detrimental Effects of Diet-Induced Obesity on ?? Pathology Are Independent of Insulin Resistance in ?? Transgenic Mice, Diabetes, vol.62, issue.5, pp.1681-1688, 2013.
DOI : 10.2337/db12-0866

Y. Liang, J. Liu, and Z. Feng, The regulation of cellular metabolism by tumor suppressor p53, Cell & Bioscience, vol.3, issue.1, p.9, 2013.
DOI : 10.1016/j.molmed.2006.11.002

O. Maddocks and K. Vousden, Metabolic regulation by p53, Journal of Molecular Medicine, vol.54, issue.3, pp.237-245, 2011.
DOI : 10.1007/s00109-011-0735-5

C. Mauvezin, M. Orpinell, V. Francis, F. Mansilla, J. Duran et al., The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells, EMBO reports, vol.4, issue.1, pp.37-44, 2010.
DOI : 10.1016/0014-5793(93)80398-E

M. Moldes, Y. Zuo, R. Morrison, D. Silva, B. Park et al., Peroxisome-proliferator-activated receptor ?? suppresses Wnt/??-catenin signalling during adipogenesis, Biochemical Journal, vol.376, issue.3, pp.607-613, 2003.
DOI : 10.1042/bj20030426

M. Murphy, How mitochondria produce reactive oxygen species, Biochemical Journal, vol.417, issue.1, pp.1-13, 2009.
DOI : 10.1042/BJ20081386

G. Musso, R. Gambino, and M. Cassader, Obesity, Diabetes, and Gut Microbiota: The hygiene hypothesis expanded?, Diabetes Care, vol.33, issue.10, pp.2277-2284, 2010.
DOI : 10.2337/dc10-0556

P. Guessan, L. Pouyet, G. Gosset, S. Hamlaoui, M. Seillier et al., Absence of Tumor Suppressor Tumor Protein 53-Induced Nuclear Protein 1 (TP53INP1) Sensitizes Mouse Thymocytes and Embryonic Fibroblasts to Redox-Driven Apoptosis, Antioxidants & Redox Signaling, vol.15, issue.6, pp.1639-1653, 2011.
DOI : 10.1089/ars.2010.3553

URL : https://hal.archives-ouvertes.fr/inserm-01270303

I. Novak, Mitophagy: A Complex Mechanism of Mitochondrial Removal, Antioxidants & Redox Signaling, vol.17, issue.5, pp.794-802, 2012.
DOI : 10.1089/ars.2011.4407

J. Nowak, C. Archange, J. Tardivel-lacombe, P. Pontarotti, M. Pebusque et al., The TP53INP2 Protein Is Required for Autophagy in Mammalian Cells, Molecular Biology of the Cell, vol.20, issue.3, pp.870-881, 2009.
DOI : 10.1091/mbc.E08-07-0671

URL : https://hal.archives-ouvertes.fr/hal-00831186

P. Pothiwala, S. Jain, and S. Yaturu, Metabolic Syndrome and Cancer, Metabolic Syndrome and Related Disorders, vol.7, issue.4, pp.279-288, 2009.
DOI : 10.1089/met.2008.0065

L. Pouyet and A. Carrier, Mutant mouse models of oxidative stress, Transgenic Research, vol.34, issue.2, pp.155-164, 2010.
DOI : 10.1007/s11248-009-9308-6

J. Quoyer, C. Longuet, C. Broca, N. Linck, S. Costes et al., GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a ??-Arrestin 1-mediated ERK1/2 Activation in Pancreatic ??-Cells, Journal of Biological Chemistry, vol.285, issue.3, pp.1989-2002, 2010.
DOI : 10.1074/jbc.M109.067207

M. Ravier, M. Leduc, J. Richard, N. Linck, A. Varrault et al., ??-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice, Diabetologia, vol.20, issue.Suppl 3, pp.532-541, 2014.
DOI : 10.1007/s00125-013-3130-7

A. Rolo, J. Teodoro, and C. Palmeira, Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis, Free Radical Biology and Medicine, vol.52, issue.1, pp.59-69, 2012.
DOI : 10.1016/j.freeradbiomed.2011.10.003

A. Rufini, M. Niklison-chirou, S. Inoue, R. Tomasini, I. Harris et al., TAp73 depletion accelerates aging through metabolic dysregulation, Genes & Development, vol.26, issue.18, pp.2009-2014, 2012.
DOI : 10.1101/gad.197640.112

H. Saadi, M. Seillier, M. Sandi, S. Peuget, C. Kellenberger et al., Development of an ELISA detecting Tumor Protein 53-Induced Nuclear Protein 1 in serum of prostate cancer patients, Results in Immunology, vol.3, pp.51-56, 2013.
DOI : 10.1016/j.rinim.2013.05.002

N. Sahini and J. Borlak, Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes, Progress in Lipid Research, vol.54, pp.86-112, 2014.
DOI : 10.1016/j.plipres.2014.02.002

D. Sala, S. Ivanova, N. Plana, V. Ribas, J. Duran et al., Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes, Journal of Clinical Investigation, vol.124, issue.5, pp.1914-1927, 2014.
DOI : 10.1172/JCI72327DS1

M. Seillier, S. Peuget, O. Gayet, C. Gauthier, N. Guessan et al., TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death, Cell Death and Differentiation, vol.8, issue.9, pp.1525-1535, 2012.
DOI : 10.1101/gad.2016111

M. Seux, S. Peuget, M. Montero, C. Siret, V. Rigot et al., TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression, Oncogene, vol.281, issue.27, pp.3049-3061, 2011.
DOI : 10.1038/onc.2011.25

A. Siegel and A. Zhu, Metabolic syndrome and hepatocellular carcinoma, Cancer, vol.37, issue.May 20 suppl, pp.5651-5661, 2009.
DOI : 10.1002/cncr.24687

R. Singh and A. Cuervo, Autophagy in the Cellular Energetic Balance, Cell Metabolism, vol.13, issue.5, pp.495-504, 2011.
DOI : 10.1016/j.cmet.2011.04.004

X. Su, Y. Gi, D. Chakravarti, I. Chan, A. Zhang et al., TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism, Cell Metabolism, vol.16, issue.4, pp.511-525, 2012.
DOI : 10.1016/j.cmet.2012.09.006

R. Tomasini, A. Samir, M. Vaccaro, M. Pebusque, J. Dagorn et al., Molecular and Functional Characterization of the Stress-induced Protein (SIP) Gene and Its Two Transcripts Generated by Alternative Splicing: SIP INDUCED BY STRESS AND PROMOTES CELL DEATH, Journal of Biological Chemistry, vol.276, issue.47, pp.44185-44192, 2001.
DOI : 10.1074/jbc.M105647200

R. Tomasini, M. Seux, J. Nowak, C. Bontemps, A. Carrier et al., TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity, Oncogene, vol.404, pp.8093-8104, 2005.
DOI : 10.1038/sj.onc.1208951

B. Voight, L. Scott, V. Steinthorsdottir, A. Morris, C. Dina et al., Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis, Nature Genetics, vol.37, issue.7, pp.579-589, 2010.
DOI : 10.1038/ng.609

T. Wallace, J. Levy, and D. Matthews, Use and Abuse of HOMA Modeling, Diabetes Care, vol.27, issue.6, pp.1487-1495, 2004.
DOI : 10.2337/diacare.27.6.1487

J. Zhang and P. Ney, Role of BNIP3 and NIX in cell death, autophagy, and mitophagy, Cell Death and Differentiation, vol.72, issue.7, pp.939-946, 2009.
DOI : 10.1038/cdd.2008.131