B. Cragg, Overcoming the failure of electronmicroscopy to preserve the brain's extracellular space, Trends in Neurosciences, vol.2, pp.159-61, 1979.
DOI : 10.1016/0166-2236(79)90062-6

A. Vernadakis and D. Woodbury, Cellular and Extracellular Spaces in Developing Rat Brain, Archives of Neurology, vol.12, issue.3, pp.284-93, 1965.
DOI : 10.1001/archneur.1965.00460270060008

D. Rall, W. Oppelt, and C. Patlak, Extracellular space of brain as determined by diffusion of inulin from the ventricular system, Life Sciences, vol.1, issue.2, pp.43-51, 1962.
DOI : 10.1016/0024-3205(62)90104-2

W. Oppelt and D. Rall, Brain Extracellular Space as Measured by Diffusion of Various Molecules into Brain, pp.333-379, 1967.
DOI : 10.1007/978-3-7091-7545-3_23

J. Fenstermacher and M. Bartlett, Sucrose space measurements in the rabbit central nervous system, Am J Physiol, vol.212, pp.1268-72, 1967.

J. Fenstermacher, D. Rall, C. Patlak, and V. Levin, Ventriculocisternal perfusion as a technique for analysis of brain capillary permeability and extracellular transport Capillary permeability Alfred Benzoin symposium II, pp.483-90, 1970.

V. Levin, J. Fenstermacher, and C. Patlak, Sucrose and inulin space measurements of cerebral cortex in four mammalian species, Am J Physiol, vol.219, pp.1528-1561, 1970.

J. Fenstermacher, Ventriculocisternal Perfusion as a Technique for Studying Transport and Metabolism Within the Brain, Research methods in neurochemistry. US, pp.165-78, 1972.
DOI : 10.1007/978-1-4615-7748-5_7

J. Fenstermacher, C. Patlak, and R. Blasberg, Transport of material between brain extracellular fluid, brain cells and blood, Fed Proc, vol.33, pp.2070-2074, 1974.

C. Patlak and J. Fenstermacher, Measurements of dog blood?brain transfer constants by ventriculocisternal perfusion, Am J Physiol, vol.229, pp.877-84, 1975.

J. Fenstermacher and C. Patlak, The Movements of Water and Solutes in the Brains of Mammals, Dynamics of Brain Edema, pp.87-94, 1976.
DOI : 10.1007/978-3-642-66524-0_16

N. Abbott, Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology, Neurochemistry International, vol.45, issue.4, pp.545-52, 2004.
DOI : 10.1016/j.neuint.2003.11.006

J. Iliff, M. Wang, Y. Liao, B. Plogg, W. Peng et al., A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta, Sci Transl Med, vol.4, pp.147-111, 2012.

L. Xie, H. Kang, Q. Xu, M. Chen, Y. Liao et al., Sleep Drives Metabolite Clearance from the Adult Brain, Science, vol.342, issue.6156, pp.373-380, 2013.
DOI : 10.1126/science.1241224

R. Blasberg, C. Patlak, and J. Fenstermacher, Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion, J Pharm Exp Ther, vol.195, pp.73-83, 1975.

J. Kessler, J. Fenstermacher, and E. Owens, Spinal subarachnoid perfusion of rhesus monkeys, Am J Physiol, vol.230, pp.614-622, 1976.

J. Fenstermacher and T. Kaye, Drug "Diffusion" within the Brain, Annals of the New York Academy of Sciences, vol.61, issue.1 Neurological, pp.29-39, 1988.
DOI : 10.1016/0006-8993(85)91383-6

C. Nicholson and J. Phillips, Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum., The Journal of Physiology, vol.321, issue.1, pp.225-57, 1981.
DOI : 10.1113/jphysiol.1981.sp013981

C. Nicholson, Ion-selective microelectrodes and diffusion measurements as tools to explore the brain cell microenvironment, Journal of Neuroscience Methods, vol.48, issue.3, pp.199-213, 1993.
DOI : 10.1016/0165-0270(93)90092-6

E. Syková and C. Nicholson, Diffusion in Brain Extracellular Space, Physiological Reviews, vol.88, issue.4, pp.1277-340, 2008.
DOI : 10.1152/physrev.00027.2007

C. Nicholson, Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity, Brain Research, vol.333, issue.2, pp.325-334, 1985.
DOI : 10.1016/0006-8993(85)91586-0

M. Rice, Y. Okada, and C. Nicholson, Anisotropic and heterogeneous diffusion in the turtle cerebellum: implications for volume transmission, J Neurophysiol, vol.70, pp.2035-2079, 1993.

A. Saghyan, D. Lewis, J. Hrabe, and S. Hrab?tová, Extracellular diffusion in laminar brain structures exemplified by hippocampus, Journal of Neuroscience Methods, vol.205, issue.1, pp.110-118, 2012.
DOI : 10.1016/j.jneumeth.2011.12.008

S. Hrab?tová and C. Nicholson, Dextran Decreases Extracellular Tortuosity in Thick-Slice Ischemia Model, Journal of Cerebral Blood Flow & Metabolism, vol.14, issue.9, pp.1306-1316, 2000.
DOI : 10.1016/0306-4522(96)00303-X

I. Vo?í?ek and E. Syková, Ischemia-induced changes in the extracellular space diffusion parameters, K + , and pH in the developing rat cortex and corpus callosum, J Cereb Blood Flow Metab, vol.17, pp.191-203, 1997.

S. Hrab?tová, D. Masri, L. Tao, F. Xiao, and C. Nicholson, Calcium diffusion enhanced after cleavage of negatively charged components of brain extracellular matrix by chondroitinase ABC, The Journal of Physiology, vol.95, issue.16, pp.4029-4078, 2009.
DOI : 10.1113/jphysiol.2009.170092

C. Nicholson and L. Tao, Hindered diffusion of high molecular weight compounds in brain extracellular microenvironment measured with integrative optical imaging, Biophysical Journal, vol.65, issue.6, pp.2277-90, 1993.
DOI : 10.1016/S0006-3495(93)81324-9

R. Thorne and C. Nicholson, In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space, Proceedings of the National Academy of Sciences, vol.103, issue.14, pp.5567-72, 2006.
DOI : 10.1073/pnas.0509425103

R. Thorne, A. Lakkaraju, E. Rodriguez-boulan, and C. Nicholson, In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate, Proceedings of the National Academy of Sciences, vol.105, issue.24, pp.8416-8437, 2008.
DOI : 10.1073/pnas.0711345105

A. Arranz, K. Perkins, F. Irie, D. Lewis, J. Hrabe et al., Hyaluronan Deficiency Due to Has3 Knock-Out Causes Altered Neuronal Activity and Seizures via Reduction in Brain Extracellular Space, Journal of Neuroscience, vol.34, issue.18, pp.6164-76, 2014.
DOI : 10.1523/JNEUROSCI.3458-13.2014

C. Patlak, F. Hospod, S. Trowbridge, and G. Newman, Diffusion of Radiotracers in Normal and Ischemic Brain Slices, Journal of Cerebral Blood Flow & Metabolism, vol.30, pp.776-802, 1998.
DOI : 10.1097/00004647-199807000-00009

L. Tao and C. Nicholson, Maximum geometrical hindrance to diffusion in brain extracellular space surrounding uniformly spaced convex cells, Journal of Theoretical Biology, vol.229, issue.1, pp.59-68, 2004.
DOI : 10.1016/j.jtbi.2004.03.003

J. Hrabe, S. Hrab?tová, and K. Segeth, A Model of Effective Diffusion and Tortuosity in the Extracellular Space of the Brain, Biophysical Journal, vol.87, issue.3, pp.1606-1623, 2004.
DOI : 10.1529/biophysj.103.039495

A. Tao, L. Tao, and C. Nicholson, Cell cavities increase tortuosity in brain extracellular space, Journal of Theoretical Biology, vol.234, issue.4, pp.525-561, 2005.
DOI : 10.1016/j.jtbi.2004.12.009

C. Nicholson, P. Kamali-zare, and L. Tao, Brain extracellular space as a diffusion barrier, Computing and Visualization in Science, vol.57, issue.3, pp.309-334, 2011.
DOI : 10.1007/s00791-012-0185-9

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500962

T. Milhorat, M. Hammock, D. Davis, and J. Fenstermacher, Choroid plexus papilloma. I. Proof of cerebrospinal fluid overproduction, Childs Brain, vol.2, pp.273-89, 1976.

R. Curran, M. Mosher, E. Owens, and J. Fenstermacher, Cerebrospinal fluid production rates determined by simultaneous albumin and inulin perfusion, Experimental Neurology, vol.29, issue.3, pp.546-53, 1970.
DOI : 10.1016/0014-4886(70)90079-8

L. Jr, W. Fenstermacher, and J. , Cerebrospinal fluid formation in ventricles and spinal subarachnoid space of the rhesus monkey, J Neurosurg, vol.42, pp.674-682, 1975.

T. Milhorat, M. Hammock, J. Fenstermacher, and V. Levin, Cerebrospinal Fluid Production by the Choroid Plexus and Brain, Science, vol.173, issue.3994, pp.330-332, 1971.
DOI : 10.1126/science.173.3994.330

V. Levin, T. Milhorat, J. Fenstermacher, M. Hammock, and D. Rall, The pathophysiology of obstructive hydrocephalus in the monkey, Trans Am Neurol Assoc, vol.95, pp.274-280, 1970.

V. Levin, T. Milhorat, J. Fenstermacher, M. Hammock, and D. Rall, Physiological studies on the development of obstructive hydrocephalus in the monkey, Neurology, vol.21, issue.3, pp.238-284, 1971.
DOI : 10.1212/WNL.21.3.238

D. Gomez, J. Fenstermacher, R. Manzo, D. Johnson, and D. Potts, Cerebrospinal Fluid Absorption in the Rabbit: Olfactory Pathways, Acta Oto-Laryngologica, vol.14, issue.5-6, pp.429-465, 1985.
DOI : 10.1083/jcb.36.1.129

D. Gomez, R. Manzo, J. Fenstermacher, and D. Potts, Cerebrospinal fluid absorption in the rabbit, Graefe's Archive for Clinical and Experimental Ophthalmology, vol.27, issue.1, pp.1-7, 1988.
DOI : 10.1007/BF02172707

J. Ghersi-egea, W. Finnegan, J. Chen, and J. Fenstermacher, Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat, Neuroscience, vol.75, issue.4, pp.1271-88, 1996.
DOI : 10.1016/0306-4522(96)00281-3

H. Cserr, D. Cooper, P. Suri, and C. Patlak, Efflux of radiolabeled polyethylene glycols and albumin from rat brain, Am J Physiol, vol.240, pp.319-347, 1981.

S. Yamada, M. Depasquale, C. Patlak, and H. Cserr, Albumin outflow into deep cervical lymph from different regions of rabbit brain, Am J Physiol, vol.261, pp.1197-204, 1991.

S. Kida and R. Weller, Morphological basis for fluid transport through and arround ependymal, arachnoidal, and glial cells, Principles of pediatric neurosurgery intracranial cyst lesions, pp.37-52, 1993.

J. Ghersi-egea, P. Gorevic, J. Ghiso, B. Frangione, C. Patlak et al., Fate of Cerebrospinal Fluid-Borne Amyloid ??-Peptide: Rapid Clearance into Blood and Appreciable Accumulation by Cerebral Arteries, Journal of Neurochemistry, vol.67, issue.2, pp.880-883, 1996.
DOI : 10.1046/j.1471-4159.1996.67020880.x

N. Strazielle, J. Ghersi-egea, J. Ghiso, M. Dehouck, B. Frangione et al., In Vitro Evidence That ??-Amyloid Peptide 1???40 Diffuses Across the Blood???Brain Barrier and Affects Its Permeability, Journal of Neuropathology & Experimental Neurology, vol.59, issue.1, pp.29-38, 2000.
DOI : 10.1093/jnen/59.1.29

X. Alvira-botero and E. Carro, Clearance of Amyloid-?? Peptide Across the Choroid Plexus in Alzheimers Disease, Current Aging Sciencee, vol.3, issue.3, pp.219-248, 2010.
DOI : 10.2174/1874609811003030219

P. Kivisakk, D. Mahad, M. Callahan, C. Trebst, T. B. Wei et al., Human cerebrospinal fluid central memory CD4+ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin, Proceedings of the National Academy of Sciences, vol.100, issue.14, pp.8389-94, 2003.
DOI : 10.1073/pnas.1433000100

B. Engelhardt and C. Coisne, Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle, Fluids and Barriers of the CNS, vol.8, issue.1, p.4, 2011.
DOI : 10.1186/2045-8118-8-4

I. Bartholomaus, N. Kawakami, F. Odoardi, C. Schlager, D. Miljkovic et al., Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions, Nature, vol.95, issue.7269, pp.94-102, 2009.
DOI : 10.1038/nature08478

C. Schmitt, N. Strazielle, and J. Ghersi-egea, Brain leukocyte infiltration initiated by peripheral inflammation or experimental autoimmune encephalomyelitis occurs through pathways connected to the CSF-filled compartments of the forebrain and midbrain, Journal of Neuroinflammation, vol.63, issue.1, p.187, 2012.
DOI : 10.1186/1742-2094-9-187

URL : https://hal.archives-ouvertes.fr/inserm-00735829

J. Szmydynger-chodobska, J. Gandy, A. Varone, R. Shan, and A. Chodobski, Synergistic Interactions between Cytokines and AVP at the Blood-CSF Barrier Result in Increased Chemokine Production and Augmented Influx of Leukocytes after Brain Injury, PLoS ONE, vol.32, issue.11, p.79328, 2013.
DOI : 10.1371/journal.pone.0079328.g007

J. Szmydynger-chodobska, N. Strazielle, J. Gandy, T. Keefe, B. Zink et al., Posttraumatic Invasion of Monocytes across the Blood???Cerebrospinal Fluid Barrier, Journal of Cerebral Blood Flow & Metabolism, vol.759, issue.1, pp.93-104, 2012.
DOI : 10.1038/sj.jcbfm.9600055

T. Nagaraja, P. Patel, M. Gorski, P. Gorevic, C. Patlak et al., In normal rat, intraventricularly administered insulin-like growth factor-1 is rapidly cleared from CSF with limited distribution into brain, Cerebrospinal Fluid Research, vol.2, issue.1, p.5, 2005.
DOI : 10.1186/1743-8454-2-5

D. Smith, Y. Hu, H. Shen, T. Nagaraja, J. Fenstermacher et al., Null Mice, Journal of Cerebral Blood Flow & Metabolism, vol.272, issue.2, pp.250-61, 2011.
DOI : 10.1016/0092-8674(94)90212-7

URL : https://hal.archives-ouvertes.fr/inserm-00349467

J. Fenstermacher and J. Johnson, Filtration and reflection coefficients of the rabbit blood?brain barrier, Am J Physiol, vol.211, pp.341-347, 1966.

R. Blasberg, C. Patlak, and J. Fenstermacher, Selection of Experimental Conditions for the Accurate Determination of Blood ??? Brain Transfer Constants from Single-Time Experiments: A Theoretical Analysis, Journal of Cerebral Blood Flow & Metabolism, vol.23, issue.2, pp.215-240, 1983.
DOI : 10.1038/jcbfm.1983.29

H. Cserr, J. Fenstermacher, and D. Rall, Brain-barrier systems in sharks, Comparative Biochemistry and Physiology Part A: Physiology, vol.42, issue.1, pp.73-81, 1972.
DOI : 10.1016/0300-9629(72)90368-4

H. Cserr, J. Fenstermacher, and D. Rall, Comparative aspects of brain barrier systems for nonelectrolytes, Am J Physiol, vol.234, pp.52-60, 1978.

A. Roomet and J. Fenstermacher, Ventricular fluid production and absorption in Squalus acanthias, Comparative Biochemistry and Physiology Part A: Physiology, vol.51, issue.4, pp.897-901, 1975.
DOI : 10.1016/0300-9629(75)90072-9

Y. Ziylan, P. Robinson, and S. Rapoport, Differential blood-brain barrier permeabilities to [14C]sucrose and [3H]inulin after osmotic opening in the rat, Experimental Neurology, vol.79, issue.3, pp.845-57, 1983.
DOI : 10.1016/0014-4886(83)90047-X

E. Preston and D. Foster, Evidence for pore-like opening of the blood-brain barrier following forebrain ischemia in rats, Brain Research, vol.761, issue.1, pp.4-10, 1997.
DOI : 10.1016/S0006-8993(97)00323-5

R. Knight, P. Barker, S. Fagan, Y. Li, M. Jacobs et al., Prediction of Impending Hemorrhagic Transformation in Ischemic Stroke Using Magnetic Resonance Imaging in Rats ?? Editorial Comment, Stroke, vol.29, issue.1, pp.144-51, 1998.
DOI : 10.1161/01.STR.29.1.144

L. Wei, T. Otsuka, V. Acuff, D. Bereczki, K. Pettigrew et al., The Velocities of Red Cell and Plasma Flows through Parenchymal Microvessels of Rat Brain are Decreased by Pentobarbital, Journal of Cerebral Blood Flow & Metabolism, vol.12, issue.3, pp.487-97, 1993.
DOI : 10.1161/01.RES.66.2.271

S. Brown, J. Ewing, T. Nagaraja, P. Swerdlow, Y. Cao et al., Sickle red blood cells accumulate in tumor, Magnetic Resonance in Medicine, vol.43, issue.6, pp.1209-1223, 2003.
DOI : 10.1002/mrm.10646

T. Nagaraja, K. Keenan, S. Brown, J. Fenstermacher, and R. Knight, Relative distribution of plasma flow markers and red blood cells across BBB openings in acute cerebral ischemia, Neurological Research, vol.248, issue.1, pp.78-80, 2007.
DOI : 10.1016/0014-4886(83)90047-X

T. Nagaraja, K. Keenan, J. Fenstermacher, and R. Knight, Acute Leakage Patterns of Fluorescent Plasma Flow Markers after Transient Focal Cerebral Ischemia Suggest Large Openings in Blood-Brain Barrier, Microcirculation, vol.15, issue.1, pp.1-14, 2008.
DOI : 10.1080/10739680701409811

T. Nagaraja, K. Karki, J. Ewing, R. Croxen, and R. Knight, Identification of Variations in Blood-Brain Barrier Opening After Cerebral Ischemia by Dual Contrast-Enhanced Magnetic Resonance Imaging and T1sat Measurements, Stroke, vol.39, issue.2, pp.427-459, 2008.
DOI : 10.1161/STROKEAHA.107.496059

P. Molnar, R. Blasberg, D. Groothuis, D. Bigner, and J. Fenstermacher, Regional blood-to-tissue transport in avian sarcoma virus (ASV)-induced brain tumors, Neurology, vol.33, issue.6, pp.702-713, 1983.
DOI : 10.1212/WNL.33.6.702

R. Blasberg, T. Kobayashi, M. Horowitz, J. Rice, D. Groothuis et al., Regional blood-to-tissue transport in ethylnitrosourea-induced brain tumors, Annals of Neurology, vol.23, issue.2
DOI : 10.1002/ana.410140207

P. Molnar, R. Blasberg, M. Horowitz, B. Smith, and J. Fenstermacher, Regional blood-to-tissue transport in RT-9 brain tumors, Journal of Neurosurgery, vol.58, issue.6, pp.874-84, 1983.
DOI : 10.3171/jns.1983.58.6.0874

R. Blasberg, W. Shapiro, P. Molnar, C. Patlak, and J. Fenstermacher, Local blood-to-tissue transport in Walker 256 metastatic brain tumors, Journal of Neuro-Oncology, vol.2, issue.3, pp.205-223, 1984.
DOI : 10.1007/BF00253272

J. Chen, L. Wei, V. Acuff, D. Bereczki, F. Hans et al., Slightly Altered Permeability???Surface Area Products Imply Some Cerebral Capillary Recruitment during Hypercapnia, Microvascular Research, vol.48, issue.2, pp.190-211, 1994.
DOI : 10.1006/mvre.1994.1049

J. Chen, L. Wei, D. Bereczki, F. Hans, T. Otsuka et al., Virtually Unaltered Permeability-Surface Area Products Imply Little Capillary Recruitment in Brain with Hypoxia, Microcirculation, vol.1, issue.1, pp.35-47, 1994.
DOI : 10.3109/10739689409148260

D. Bereczki, L. Wei, T. Otsuka, F. Hans, V. Acuff et al., Hypercapnia slightly raises blood volume and sizably elevates flow velocity in brain microvessels, Am J Physiol, vol.264, pp.1360-1369, 1993.

D. Bereczki, L. Wei, T. Otsuka, V. Acuff, K. Pettigrew et al., Hypoxia Increases Velocity of Blood Flow through Parenchymal Microvascular Systems in Rat Brain, Journal of Cerebral Blood Flow & Metabolism, vol.12, issue.3, pp.475-86, 1993.
DOI : 10.1161/01.RES.66.2.271

L. Wei, S. Lin, A. Tajima, H. Nakata, V. Acuff et al., Cerebral glucose utilization and blood flow in adult spontaneously hypertensive rats, Hypertension, vol.20, issue.4, pp.501-511, 1992.
DOI : 10.1161/01.HYP.20.4.501

J. Chen, L. Wei, D. Bereczki, F. Hans, T. Otsuka et al., Nicotine Raises the Influx of Permeable Solutes across the Rat Blood???Brain Barrier with Little or No Capillary Recruitment, Journal of Cerebral Blood Flow & Metabolism, vol.51, issue.4, pp.687-98, 1995.
DOI : 10.1161/01.RES.66.2.271

F. Hans, L. Wei, D. Bereczki, V. Acuff, J. Demaro et al., Nicotine increases microvascular blood flow and flow velocity in three groups of brain areas, Am J Physiol, vol.265, pp.2142-50, 1993.

T. Otsuka, L. Wei, D. Bereczki, V. Acuff, C. Patlak et al., Pentobarbital produces dissimilar changes in glucose influx and utilization in brain

W. Eckman, R. Phair, J. Fenstermacher, C. Patlak, C. Kennedy et al., Permeability limitation in estimation of local brain blood flow with [ 14 C] antipyrine, Am J Physiol, vol.229, pp.215-236, 1975.

C. Patlak, R. Blasberg, and J. Fenstermacher, An Evaluation of Errors in the Determination of Blood Flow by the Indicator Fractionation and Tissue Equilibration (Kety) Methods, Journal of Cerebral Blood Flow & Metabolism, vol.9, issue.1, pp.47-60, 1984.
DOI : 10.1038/jcbfm.1984.7

D. Groothuis, R. Blasberg, P. Molnar, D. Bigner, and J. Fenstermacher, Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors, Neurology, vol.33, issue.6, pp.686-96, 1983.
DOI : 10.1212/WNL.33.6.686

R. Blasberg, T. Kobayashi, M. Horowitz, J. Rice, D. Groothuis et al., Regional blood flow in ethylnitrosourea-induced brain tumors, Annals of Neurology, vol.55, issue.2, pp.189-201, 1983.
DOI : 10.1002/ana.410140206

R. Blasberg, P. Molnar, M. Horowitz, P. Kornblith, R. Pleasants et al., Regional blood flow in RT-9 brain tumors, Journal of Neurosurgery, vol.58, issue.6, pp.863-73, 1983.
DOI : 10.3171/jns.1983.58.6.0863

R. Blasberg, W. Shapiro, P. Molnar, C. Patlak, and J. Fenstermacher, Local blood flow in Walker 256 metastatic brain tumors, Journal of Neuro-Oncology, vol.2, issue.3, pp.195-204, 1984.
DOI : 10.1007/BF00253271

R. Blasberg, P. Molnar, D. Groothius, C. Patlak, E. Owens et al., Concurrent measurements of blood flow and transcapillary transport in avian sarcoma virus-induced experimental brain tumors: implications for chemotherapy, J Pharmacol Exp Ther, vol.231, pp.724-759, 1984.

P. Gross, R. Blasberg, J. Fenstermacher, and C. Patlak, The microcirculation of rat circumventricular organs and pituitary gland, Brain Research Bulletin, vol.18, issue.1, pp.73-85, 1987.
DOI : 10.1016/0361-9230(87)90035-9

T. Otsuka, L. Wei, V. Acuff, A. Shimizu, K. Pettigrew et al., Variation in local cerebral blood flow response to high-dose pentobarbitol sodium in the rat, Am J Physiol, vol.261, pp.110-130, 1991.

J. Ewing, L. Wei, R. Knight, S. Pawa, T. Nagaraja et al., Direct Comparison of Local Cerebral Blood Flow Rates Measured by MRI Arterial Spin-Tagging and Quantitative Autoradiography in a Rat Model of Experimental Cerebral Ischemia, Journal of Cerebral Blood Flow & Metabolism, vol.23, issue.2, pp.198-209, 2003.
DOI : 10.1097/01.WCB.0000046147.31247.E8

T. Nagaraja, K. Karki, J. Ewing, G. Divine, J. Fenstermacher et al., The MRI-measured arterial input function resulting from a bolus injection of Gd-DTPA in a rat model of stroke slightly underestimates that of Gd-[14C]DTPA and marginally overestimates the blood-to-brain influx rate constant determined by Patlak plots, Magnetic Resonance in Medicine, vol.45, issue.6, pp.1502-1511, 2010.
DOI : 10.1002/mrm.22339

C. Patlak, R. Blasberg, and J. Fenstermacher, Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data, Journal of Cerebral Blood Flow & Metabolism, vol.84, issue.1, pp.1-7, 1983.
DOI : 10.1111/j.1471-4159.1977.tb10649.x

J. Ewing, R. Knight, T. Nagaraja, J. Yee, V. Nagesh et al., Patlak plots of Gd-DTPA MRI data yield blood-brain transfer constants concordant with those of14C-sucrose in areas of blood-brain opening, Magnetic Resonance in Medicine, vol.19, issue.2, pp.283-92, 2003.
DOI : 10.1002/mrm.10524

J. Fenstermacher, R. Knight, J. Ewing, T. Nagaraja, V. Nagesh et al., Estimating blood-brain barrier opening in a rat model of hemorrhagic transformation with Patlak plots of Gd-DTPA contrast-enhanced MRI, Acta Neurochir, vol.86, pp.35-42, 2003.
DOI : 10.1007/978-3-7091-0651-8_7

R. Blasberg, J. Fenstermacher, and C. Patlak, Transport of ??-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes, Journal of Cerebral Blood Flow & Metabolism, vol.76, issue.1, pp.8-32, 1983.
DOI : 10.1126/science.211586

R. Knight, T. Nagaraja, J. Ewing, V. Nagesh, P. Whitton et al., Quantitation and localization of blood-to-brain influx by magnetic resonance imaging and quantitative autoradiography in a model of transient focal ischemia, Magnetic Resonance in Medicine, vol.64, issue.4, pp.813-834, 2005.
DOI : 10.1002/mrm.20629

R. Knight, V. Nagesh, T. Nagaraja, J. Ewing, P. Whitton et al., Acute blood-brain barrier opening in experimentally induced focal cerebral ischemia is preferentially identified by quantitative magnetization transfer imaging, Magnetic Resonance in Medicine, vol.29, issue.4, pp.822-854, 2005.
DOI : 10.1002/mrm.20630

T. Nagaraja, J. Ewing, K. Karki, P. Jacobs, G. Divine et al., MRI and quantitative autoradiographic studies following bolus injections of unlabeled and 14C-labeled gadolinium-diethylenetriaminepentaacetic acid in a rat model of stroke yield similar distribution volumes and blood-to-brain influx rate constants, NMR in Biomedicine, vol.37, issue.(Suppl 1), pp.547-58, 2011.
DOI : 10.1002/nbm.1625

T. Nagaraja, V. Nagesh, J. Ewing, P. Whitton, J. Fenstermacher et al., Step-down infusions of Gd???DTPA yield greater contrast-enhanced magnetic resonance images of BBB damage in acute stroke than bolus injections, Magnetic Resonance Imaging, vol.25, issue.3, pp.311-319, 2007.
DOI : 10.1016/j.mri.2006.09.003

R. Knight, K. Karki, J. Ewing, G. Divine, J. Fenstermacher et al., C]DTPA, Journal of Cerebral Blood Flow & Metabolism, vol.142, issue.5, pp.1048-58, 2009.
DOI : 10.1038/jcbfm.1983.1

T. Nagaraja, K. Keenan, M. Aryal, J. Ewing, S. Gopinath et al., Extravasation into brain and subsequent spread beyond the ischemic core of a magnetic resonance contrast agent following a step-down infusion protocol in acute cerebral ischemia. Fluids Barriers CNS, p.21, 2014.

T. Nagaraja, R. Croxen, S. Panda, R. Knight, K. Keenan et al., Application of arsenazo III in the preparation and characterization of an albumin-linked, gadolinium-based macromolecular magnetic resonance contrast agent, Journal of Neuroscience Methods, vol.157, issue.2, pp.238-283, 2006.
DOI : 10.1016/j.jneumeth.2006.05.013

R. Paudyal, J. Ewing, T. Nagaraja, H. Bagher-ebadian, R. Knight et al., The concordance of MRI and quantitative autoradiography estimates of the transvascular transfer rate constant of albumin in a rat brain tumor model, Magnetic Resonance in Medicine, vol.18, issue.5, pp.1422-1453, 2011.
DOI : 10.1002/mrm.22914

J. Ewing, S. Brown, M. Lu, S. Panda, G. Ding et al., Model Selection in Magnetic Resonance Imaging Measurements of Vascular Permeability: Gadomer in a 9L Model of Rat Cerebral Tumor, Journal of Cerebral Blood Flow & Metabolism, vol.41, issue.3, pp.310-330, 2006.
DOI : 10.1038/sj.jcbfm.9600189

H. Nakagawa, D. Groothuis, E. Owens, J. Fenstermacher, C. Patlak et al., I]Albumin Distribution in Experimental RG-2 Gliomas and Adjacent Brain, Journal of Cerebral Blood Flow & Metabolism, vol.59, issue.6, pp.687-701, 1987.
DOI : 10.1038/jcbfm.1987.123

J. Ewing, S. Brown, T. Nagaraja, H. Bagher-ebadian, R. Paudyal et al., MRI measurement of change in vascular parameters in the 9L rat cerebral tumor after dexamethasone administration, Journal of Magnetic Resonance Imaging, vol.53, issue.Suppl, pp.1430-1438, 2008.
DOI : 10.1002/jmri.21356

P. Tofts and A. Kermode, Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts, Magnetic Resonance in Medicine, vol.113, issue.2, pp.357-67, 1991.
DOI : 10.1002/mrm.1910170208

J. Logan, Graphical analysis of PET data applied to reversible and irreversible tracers, Nuclear Medicine and Biology, vol.27, issue.7, pp.661-70, 2000.
DOI : 10.1016/S0969-8051(00)00137-2

M. Aryal, T. Nagaraja, K. Keenan, H. Bagher-ebadian, S. Panda et al., Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T, Magnetic Resonance in Medicine, vol.37, issue.6, pp.2206-2220, 2014.
DOI : 10.1002/mrm.24873

T. Nagaraja, M. Aryal, S. Brown, H. Bagher-ebadian, T. Mikkelsen et al., Cilengitide-Induced Temporal Variations in Transvascular Transfer Parameters of Tumor Vasculature in a Rat Glioma Model: Identifying Potential MRI Biomarkers of Acute Effects, PLoS ONE, vol.29, issue.12, p.84493, 2013.
DOI : 10.1371/journal.pone.0084493.t001

K. Barton, D. Tyson, H. Stricker, Y. Lew, G. Heisey et al., GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo, Molecular Therapy, vol.8, issue.3, pp.508-526, 2003.
DOI : 10.1016/S1525-0016(03)00153-9

K. Barton, X. Xia, H. Yan, H. Stricker, G. Heisey et al., A Quantitative Method for Measuring Gene Expression Magnitude and Volume Delivered by Gene Therapy Vectors, Molecular Therapy, vol.9, issue.4, pp.625-656, 2004.
DOI : 10.1016/j.ymthe.2004.01.011

A. Majid, Y. He, J. Gidday, S. Kaplan, E. Gonzales et al., Differences in Vulnerability to Permanent Focal Cerebral Ischemia Among 3 Common Mouse Strains Editorial Comment, Stroke, vol.31, issue.11, pp.2707-2721, 2000.
DOI : 10.1161/01.STR.31.11.2707

L. Wei, K. Craven, J. Erinjeri, G. Liang, D. Bereczki et al., Local Cerebral Blood Flow during the First Hour Following Acute Ligation of Multiple Arterioles in Rat Whisker Barrel Cortex, Neurobiology of Disease, vol.5, issue.3, pp.142-50, 1998.
DOI : 10.1006/nbdi.1998.0199

T. Kuroiwa, G. Xi, Y. Hua, T. Nagaraja, J. Fenstermacher et al., Development of a Rat Model of Photothrombotic Ischemia and Infarction Within the Caudoputamen, Stroke, vol.40, issue.1, pp.248-53, 2009.
DOI : 10.1161/STROKEAHA.108.527853

T. Kuroiwa, G. Xi, Y. Hua, T. Nagaraja, J. Fenstermacher et al., Brain Edema and Blood???Brain Barrier Opening After Photothrombotic Ischemia in Rat, Acta Neurochir, vol.118, pp.11-16, 2013.
DOI : 10.1007/978-3-7091-1434-6_2

Y. Cao, S. Brown, R. Knight, J. Fenstermacher, and J. Ewing, Effect of intravascular-to-extravascular water exchange on the determination of blood-to-tissue transfer constant by magnetic resonance imaging, Magnetic Resonance in Medicine, vol.12, issue.2, pp.282-93, 2005.
DOI : 10.1002/mrm.20340

J. Ewing, Y. Cao, and J. Fenstermacher, Single-coil arterial spin-tagging for estimating cerebral blood flow as viewed from the capillary: Relative contributions of intra- and extravascular signal, Magnetic Resonance in Medicine, vol.32, issue.3, pp.465-75, 2001.
DOI : 10.1002/mrm.1215

J. Ewing, Y. Cao, R. Knight, and J. Fenstermacher, Arterial spin labeling: Validity testing and comparison studies, Journal of Magnetic Resonance Imaging, vol.36, issue.6, pp.737-777, 2005.
DOI : 10.1002/jmri.20451

H. Bagher-ebadian, T. Nagaraja, R. Paudyal, P. Whitton, S. Panda et al., MRI estimation of contrast agent concentration in tissue using a neural network approach, Magnetic Resonance in Medicine, vol.15, issue.2, pp.290-297, 2007.
DOI : 10.1002/mrm.21332

H. Bagher-ebadian, R. Paudyal, T. Nagaraja, R. Croxen, J. Fenstermacher et al., MRI estimation of gadolinium and albumin effects on water proton, NeuroImage, vol.54, issue.1, pp.176-185, 2011.
DOI : 10.1016/j.neuroimage.2010.05.032

R. Paudyal, H. Bagher-ebadian, T. Nagaraja, J. Fenstermacher, and J. Ewing, Modeling of Look-Locker estimates of the magnetic resonance imaging estimate of longitudinal relaxation rate in tissue after contrast administration, Magnetic Resonance in Medicine, vol.206, issue.4, pp.1432-1476, 2011.
DOI : 10.1002/mrm.22852

F. Li, K. Liu, M. Silva, X. Meng, T. Gerriets et al., Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats, AJNR Am J Neuroradiol, vol.23, pp.180-188, 2002.

F. Li, K. Liu, M. Silva, T. Omae, C. Sotak et al., Transient and Permanent Resolution of Ischemic Lesions on Diffusion-Weighted Imaging After Brief Periods of Focal Ischemia in Rats : Correlation With Histopathology ?? Editorial Comment: Correlation With Histopathology, Stroke, vol.31, issue.4, pp.946-54, 2000.
DOI : 10.1161/01.STR.31.4.946

F. Li, M. Silva, K. Liu, K. Helmer, T. Omae et al., Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats, Annals of Neurology, vol.30, issue.2, pp.236-280, 2000.
DOI : 10.1002/1531-8249(200008)48:2<236::AID-ANA14>3.0.CO;2-7

K. Liu, F. Li, T. Tatlisumak, J. Garcia, C. Sotak et al., Regional Variations in the Apparent Diffusion Coefficient and the Intracellular Distribution of Water in Rat Brain During Acute Focal Ischemia, Stroke, vol.32, issue.8, pp.1897-905, 2001.
DOI : 10.1161/01.STR.32.8.1897

. Chodobski, The quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher. Fluids and Barriers of the CNS, 2015.
URL : https://hal.archives-ouvertes.fr/inserm-01264512