Use of neuraminidase inhibitors in primary health care during pandemic and seasonal influenza between 2009 and 2013: Outpatient influenza antiviral treatment

Abstract : BACKGROUND: In a context of controversy about influenza antiviral treatments, this study assessed primary health-care physicians' prescription of neuraminidase inhibitors (NIs) in France during pandemic and seasonal influenza between 2009 and 2013. METHODS: This observational study, using data recorded in three national databases, estimated the rate of NI prescription among influenza-like illness (ILI) patients seen in GP and paediatrician consultations, and determined factors associated with this prescription according to a multivariate analysis. NI delivery by pharmacists was also evaluated. RESULTS: Rates of NI prescription were estimated to be 61.1% among ILI patients with a severe influenza risk factor seen in GP consultation during the A(H1N1)pdm2009 pandemic versus an average rate of 25.9% during the three following seasonal influenza epidemics. Factors associated with NI prescription were a chronic disease in patients under 65 years (OR 14.85; 95% CI 13.00, 16.97) and in those aged 65 and older (OR 7.54; 5.86, 9.70), an age ≥65 years in patients without chronic disease (OR 1.35; 1.04, 1.74), a pregnancy (OR 10.63; 7.67, 15.76), obesity (OR 4.67; 3.50, 6.22) and a consultation during the pandemic A(H1N1)pdm2009 (OR 3.19; 2.93, 3.48). The number of antiviral treatments delivered by pharmacists during the A(H1N1)pdm2009 pandemic was 835 per 100,000 inhabitants, and an average of 275 per 100,000 inhabitants during the three following seasonal influenza epidemics. CONCLUSIONS: Although physicians seem to follow the recommended indications for NIs in primary health-care practice, this study confirms the low rate of NI prescription to ILI patients with a severe influenza risk factor, especially during seasonal epidemics.
Type de document :
Article dans une revue
Antiviral Therapy, International Medical Press, 2015, 20 (7), pp.753-61. 〈10.3851/IMP2945〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-01242944
Contributeur : Thierry Blanchon <>
Soumis le : lundi 14 décembre 2015 - 12:46:23
Dernière modification le : mercredi 21 mars 2018 - 18:57:57
Document(s) archivé(s) le : samedi 29 avril 2017 - 12:51:53

Fichiers

HAL-Inserm_retroDINA_Antivir-T...
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Thierry Blanchon, Félicité Geffrier, Clément Turbelin, Isabelle Daviaud, Cédric Laouénan, et al.. Use of neuraminidase inhibitors in primary health care during pandemic and seasonal influenza between 2009 and 2013: Outpatient influenza antiviral treatment. Antiviral Therapy, International Medical Press, 2015, 20 (7), pp.753-61. 〈10.3851/IMP2945〉. 〈inserm-01242944〉

Partager

Métriques

Consultations de la notice

344

Téléchargements de fichiers

72