Impact of sleep disturbances on kidney function decline in the elderly

Abstract : While sleep disturbances are frequent in renal disease patients, no studies have examined prospectively the associations between sleep disturbances and kidney function decline in community-dwelling elderly subjects.Glomerular filtration rates (eGFRs) were estimated at baseline and at 11-year follow-up. A glomerular filtration decline over the follow-up period was defined as a percentage decline greater than or equal to the cut-off value of the highest tertile of kidney function decline (22%) in 1105 subjects. Excessive daytime sleepiness (EDS) and insomnia complaints were self-rated at baseline. Restless legs syndrome (RLS) and its age at onset were assessed at study end-point. An ambulatory polysomnography recording was performed during the follow-up in 277 subjects. Apnoea-hypopnoea index (AHI), periodic limb movements during sleep (PLMS) and total sleep time were analysed.An increased risk of eGFR decline was associated with EDS (OR 1.67, 95% CI 1.18-2.34) and RLS (OR 1.98, 95% CI 1.18-3.30) independently of potential confounders including cardiovascular risk factors. Among insomnia complaints, a borderline association with eGFR decline was found for early morning awakening only. High AHI (≥30 events·h-1) and short total sleep time (<6 h), but not PLMS were linked to eGFR decline in crude associations, but only AHI remained significantly associated after multi-adjustments.EDS, RLS and AHI constitute independent risk factors for kidney glomerular function decline.
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Article dans une revue
European Respiratory Journal, European Respiratory Society, 2015, 〈10.1183/13993003.01147-2015〉
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Soumis le : vendredi 11 décembre 2015 - 15:56:15
Dernière modification le : jeudi 11 janvier 2018 - 06:27:49
Document(s) archivé(s) le : samedi 29 avril 2017 - 11:50:13


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Isabelle Jaussent, Jean-Paul Cristol, Benedicte Stengel, Marie-Laure Ancelin, Anne-Marie Dupuy, et al.. Impact of sleep disturbances on kidney function decline in the elderly. European Respiratory Journal, European Respiratory Society, 2015, 〈10.1183/13993003.01147-2015〉. 〈inserm-01241687〉



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