Apolipoprotein E Suppresses the Type I Inflammatory Response In Vivo, Circulation Research, vol.97, issue.9, pp.922-927, 2005. ,
DOI : 10.1161/01.RES.0000187467.67684.43
Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation, American Journal of Ophthalmology, vol.131, issue.6, pp.767-781, 2001. ,
DOI : 10.1016/S0002-9394(00)00961-2
Interleukin-6 (IL-6) prevents activation-induced cell death, 1998. ,
Crosstalk between reverse cholesterol transport and innate immunity, Trends in Endocrinology & Metabolism, vol.23, issue.4, pp.169-178, 2012. ,
DOI : 10.1016/j.tem.2012.02.001
Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes, J Biol Chem, vol.257, pp.9788-9795, 1982. ,
Apolipoproteins modulate the inflammatory response to lipopolysaccharide, Journal of Endotoxin Research, vol.11, issue.2, pp.97-103, 2005. ,
DOI : 10.1179/096805105X35215
Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages, Angiogenesis, vol.484, issue.5415, pp.609-622, 2012. ,
DOI : 10.1007/s10456-012-9290-0
URL : https://hal.archives-ouvertes.fr/inserm-00853034
Survey of Common Eye Diseases in Laboratory Mouse Strains, Investigative Opthalmology & Visual Science, vol.54, issue.7, pp.4974-4981, 2013. ,
DOI : 10.1167/iovs.13-12289
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration, Proceedings of the National Academy of Sciences, vol.107, issue.16, pp.7401-7406, 2010. ,
DOI : 10.1073/pnas.0912702107
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867722
Paraquat-Induced Retinal Degeneration Is Exaggerated in CX3CR1-Deficient Mice and Is Associated with Increased Retinal Inflammation, Investigative Opthalmology & Visual Science, vol.54, issue.1, pp.682-690, 2013. ,
DOI : 10.1167/iovs.12-10888
Studying the mononuclear phagocyte system in the molecular age, Nature Reviews Immunology, vol.83, issue.11, pp.788-798, 2011. ,
DOI : 10.1038/nri3087
CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration, Journal of Clinical Investigation, vol.117, issue.10, pp.2920-2928, 2007. ,
DOI : 10.1172/JCI31692DS1
URL : https://hal.archives-ouvertes.fr/inserm-00176389
Infiltration of Proinflammatory M1 Macrophages into the Outer Retina Precedes Damage in a Mouse Model of Age-Related Macular Degeneration, International Journal of Inflammation, vol.53, issue.6, p.503725, 2013. ,
DOI : 10.1016/j.bmc.2009.09.009
Human Apolipoprotein E4 Domain Interaction: ARGININE 61 AND GLUTAMIC ACID 255 INTERACT TO DIRECT THE PREFERENCE FOR VERY LOW DENSITY LIPOPROTEINS, Journal of Biological Chemistry, vol.271, issue.32, pp.19053-19057, 1996. ,
DOI : 10.1074/jbc.271.32.19053
What is immune privilege (not)?, Trends in Immunology, vol.28, issue.1, pp.12-18, 2007. ,
DOI : 10.1016/j.it.2006.11.004
Local apoptosis mediates clearance of macrophages from resolving inflammation in mice, Blood, vol.122, issue.15, pp.2714-2722, 2013. ,
DOI : 10.1182/blood-2013-01-478206
A Fas agonist induces high levels of apoptosis in haematological malignancies, Leukemia Research, vol.30, issue.4, pp.415-426, 2006. ,
DOI : 10.1016/j.leukres.2005.08.006
Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege, Science, vol.270, issue.5239, pp.1189-1192, 1995. ,
DOI : 10.1126/science.270.5239.1189
A Dual Role for Apolipoprotein E in Neuroinflammation: Anti- and Pro-Inflammatory Activity, Journal of Molecular Neuroscience, vol.23, issue.3, pp.205-212, 2004. ,
DOI : 10.1385/JMN:23:3:205
Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration, Experimental Eye Research, vol.76, issue.4, pp.463-471, 2003. ,
DOI : 10.1016/S0014-4835(02)00332-9
An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration, Progress in Retinal and Eye Research, vol.20, issue.6, pp.705-732, 2001. ,
DOI : 10.1016/S1350-9462(01)00010-6
Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation, Journal of Biological Chemistry, vol.279, issue.53, pp.55483-55492, 2004. ,
DOI : 10.1074/jbc.M409324200
CD36 Deficiency Leads to Choroidal Involution via COX2 Down-Regulation in Rodents, PLoS Medicine, vol.278, issue.2, pp.39-263, 2004. ,
DOI : 10.1371/journal.pmed.0050039.g004
URL : https://hal.archives-ouvertes.fr/inserm-00258554
Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration, Proceedings of the National Academy of Sciences, vol.108, issue.45, pp.18277-18282, 2011. ,
DOI : 10.1073/pnas.1109703108
Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction, Nature Medicine, vol.26, issue.7, pp.738-743, 1997. ,
DOI : 10.1074/jbc.271.47.29969
Diabetic Mouse, Investigative Opthalmology & Visual Science, vol.54, issue.1, pp.854-863, 2013. ,
DOI : 10.1167/iovs.12-10876
Differential Induction of Apoptosis by Fas???Fas Ligand Interactions in Human Monocytes and Macrophages, The Journal of Experimental Medicine, vol.86, issue.8, pp.1511-1516, 1997. ,
DOI : 10.1002/eji.1830241111
Genetic Association of Apolipoprotein E with Age-Related Macular Degeneration, The American Journal of Human Genetics, vol.63, issue.1, pp.200-206, 1998. ,
DOI : 10.1086/301901
The epidemiology of age-related macular degeneration, American Journal of Ophthalmology, vol.137, issue.3, pp.486-495, 2004. ,
DOI : 10.1016/j.ajo.2003.11.069
Inflammation, Complement Factor H, and Age-Related Macular Degeneration, Ophthalmology, vol.115, issue.10, pp.1742-1749, 2008. ,
DOI : 10.1016/j.ophtha.2008.03.021
URL : http://doi.org/10.1016/j.ophtha.2008.03.021
Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction and the 20-Year Cumulative Incidence of Early Age-Related Macular Degeneration, JAMA Ophthalmology, vol.132, issue.4, pp.446-455, 2014. ,
DOI : 10.1001/jamaophthalmol.2013.7671
Photoreceptor Proteins Initiate Microglial Activation via Toll-like Receptor 4 in Retinal Degeneration Mediated by All-trans-retinal, Journal of Biological Chemistry, vol.288, issue.21, 2013. ,
DOI : 10.1074/jbc.M112.448712
Proteomics of Vitreous Humor of Patients with Exudative Age-Related Macular Degeneration, PLoS ONE, vol.2012, issue.5, p.96895, 2014. ,
DOI : 10.1371/journal.pone.0096895.t004
Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation, Science, vol.267, issue.5200, pp.1034-1037, 1995. ,
DOI : 10.1126/science.7863332
Differential Modulation of Retinal Degeneration by Ccl2 and Cx3cr1 Chemokine Signalling, PLoS ONE, vol.152, issue.4, p.35551, 2012. ,
DOI : 10.1371/journal.pone.0035551.s002
Microglia in the Mouse Retina Alter the Structure and Function of Retinal Pigmented Epithelial Cells: A Potential Cellular Interaction Relevant to AMD, PLoS ONE, vol.4, issue.11, p.7945, 2009. ,
DOI : 10.1371/journal.pone.0007945.t001
E: Far More Than a Lipid Transport Protein, Annual Review of Genomics and Human Genetics, vol.1, issue.1, pp.507-537, 2000. ,
DOI : 10.1146/annurev.genom.1.1.507
Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration, Proceedings of the National Academy of Sciences, vol.102, issue.33, pp.11900-11905, 2005. ,
DOI : 10.1073/pnas.0503015102
HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway, Journal of Clinical Investigation, vol.116, issue.5, 2006. ,
DOI : 10.1172/JCI27602DS1
with age-related macular degeneration - a pooled analysis of 15 studies, Human Mutation, vol.45, issue.12, pp.1407-1416, 2011. ,
DOI : 10.1002/humu.21577
Peripherin. A rim-specific membrane protein of rod outer segment discs, Invest Ophthalmol Vis Sci, vol.28, pp.50-61, 1987. ,
ApoE Plasma Levels and Risk of Cardiovascular Mortality in Old Age, PLoS Medicine, vol.16, issue.6, p.176, 2006. ,
DOI : 10.1371/journal.pmed.0030176.t006
Expression of apolipoprotein E mRNA in rat microglia, Neuroscience Letters, vol.211, issue.1, pp.41-44, 1996. ,
DOI : 10.1016/0304-3940(96)12716-6
The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes, Invest Ophthalmol Vis Sci, vol.40, pp.1891-1898, 1999. ,
Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice, Invest Ophthalmol Vis Sci, vol.42, pp.1891-1900, 2001. ,
Fas (CD95) Induces Proinflammatory Cytokine Responses by Human Monocytes and Monocyte-Derived Macrophages, The Journal of Immunology, vol.170, issue.12, pp.6209-6216, 2003. ,
DOI : 10.4049/jimmunol.170.12.6209
Senile macular degeneration: The involvement of immunocompetent cells, Graefe's Archive for Clinical and Experimental Ophthalmology, vol.121, issue.2, pp.69-76, 1985. ,
DOI : 10.1007/BF02150948
Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo, Cell, vol.133, issue.5, pp.916-927, 2008. ,
DOI : 10.1016/j.cell.2008.04.037
Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology, Immunity, vol.31, issue.5, pp.711-721, 2009. ,
DOI : 10.1016/j.immuni.2009.09.010
Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells, Journal of Neuroimmunology, vol.198, issue.1-2, pp.56-61, 2008. ,
DOI : 10.1016/j.jneuroim.2008.04.014
URL : https://hal.archives-ouvertes.fr/inserm-00311574
Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels, Journal of Neuroscience, vol.28, issue.45, pp.11445-11453, 2008. ,
DOI : 10.1523/JNEUROSCI.1972-08.2008
Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.13, issue.9, pp.1382-1389, 1993. ,
DOI : 10.1161/01.ATV.13.9.1382
Small interfering RNA-mediated suppression of Ccl2 in M??ller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration, Journal of Neuroinflammation, vol.452, issue.5, p.221, 2012. ,
DOI : 10.1186/1742-2094-9-221
Macrophage Depletion Inhibits Experimental Choroidal Neovascularization, Investigative Opthalmology & Visual Science, vol.44, issue.8, pp.3578-3585, 2003. ,
DOI : 10.1167/iovs.03-0097
Ageing and degeneration in the macular region: a clinico-pathological study., British Journal of Ophthalmology, vol.60, issue.5, pp.324-341, 1976. ,
DOI : 10.1136/bjo.60.5.324
A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation, Blood, vol.109, issue.3, pp.1026-1033, 2007. ,
DOI : 10.1182/blood-2006-05-021634
CD14 signalling in lipid rafts: new ligands and co-receptors, Current Opinion in Lipidology, vol.13, issue.5, pp.513-521, 2002. ,
DOI : 10.1097/00041433-200210000-00007
Progression of Age-Related Macular Degeneration, Archives of Ophthalmology, vol.123, issue.6, pp.774-782, 2005. ,
DOI : 10.1001/archopht.123.6.774
deficient mice, EMBO Molecular Medicine, vol.48, issue.11, pp.1775-1793, 2013. ,
DOI : 10.1002/emmm.201302692
URL : https://hal.archives-ouvertes.fr/inserm-00315944
Constitutive and Inflammatory Mediator-Regulated Fractalkine Expression in Human Ocular Tissues and Cultured Cells, Investigative Opthalmology & Visual Science, vol.44, issue.4, pp.1608-1615, 2003. ,
DOI : 10.1167/iovs.02-0233
Myeloid Differentiation Primary Response Protein 88 Couples Reverse Cholesterol Transport to Inflammation, Cell Metabolism, vol.11, issue.6, pp.493-502, 2010. ,
DOI : 10.1016/j.cmet.2010.04.006
Immunobiology and privilege of neuronal retina and pigment epithelium transplants, Vision Research, vol.42, issue.4, pp.487-495, 2002. ,
DOI : 10.1016/S0042-6989(01)00185-7
Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration, Journal of Cell Science, vol.125, issue.10, pp.2407-2415, 2012. ,
DOI : 10.1242/jcs.097683
The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization, Journal of Leukocyte Biology, vol.74, issue.1, pp.25-32, 2003. ,
DOI : 10.1189/jlb.0902436
Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway, 1996. ,
Evidence that retinal pigment epithelium functions as an immune-privileged tissue, Invest Ophthalmol Vis Sci, vol.41, pp.3467-3473, 2000. ,
Macrophage-Mediated Degradation of ??-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism, Journal of Neuroscience, vol.29, issue.11, pp.3603-3612, 2009. ,
DOI : 10.1523/JNEUROSCI.5302-08.2009
CX3CL1 (Fractalkine) Protein Expression in Normal and Degenerating Mouse Retina: In Vivo Studies, PLoS ONE, vol.32, issue.9, p.106562, 2014. ,
DOI : 10.1371/journal.pone.0106562.s003