Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits, Journal of Neuroscience, vol.26, issue.41, pp.10380-10386, 2006. ,
DOI : 10.1523/JNEUROSCI.3863-06.2006
New optical tools for controlling neuronal activity, Current Opinion in Neurobiology, vol.17, issue.1, pp.87-94, 2007. ,
DOI : 10.1016/j.conb.2006.12.002
Optogenetics: the age of light, Nature Methods, vol.7, issue.10, pp.1012-1016, 2014. ,
DOI : 10.1038/nprot.2009.56
Rhodopsin-like Protein from the Purple Membrane of Halobacterium halobium, Nature New Biology, vol.233, issue.39, pp.149-52, 1971. ,
DOI : 10.1038/newbio233149a0
Isolation and Characterization of Halorhodopsm from Halobacterium halobium1, The Journal of Biochemistry, vol.96, issue.2, pp.413-433, 1984. ,
DOI : 10.1093/oxfordjournals.jbchem.a134852
Channelrhodopsin-1: A Light-Gated Proton Channel in Green Algae, Science, vol.296, issue.5577, pp.2395-2403, 2002. ,
DOI : 10.1126/science.1072068
Selective Photostimulation of Genetically ChARGed Neurons, Neuron, vol.33, issue.1, pp.15-22, 2002. ,
DOI : 10.1016/S0896-6273(01)00574-8
Light-activated ion channels for remote control of neuronal firing, Nature Neuroscience, vol.417, issue.12, pp.1381-1387, 2004. ,
DOI : 10.1038/nn1356
Millisecond-timescale, genetically targeted optical control of neural activity, Nature Neuroscience, vol.72, issue.9, pp.1263-1271, 2005. ,
DOI : 10.1016/S0896-6273(04)00266-1
The Microbial Opsin Family of Optogenetic Tools, Cell, vol.147, issue.7, pp.1446-57, 2011. ,
DOI : 10.1016/j.cell.2011.12.004
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel, Proceedings of the National Academy of Sciences, vol.100, issue.24, pp.13940-13945, 2003. ,
DOI : 10.1073/pnas.1936192100
Optogenetic tools for analyzing the neural circuits of behavior, Trends in Cognitive Sciences, vol.15, issue.12, pp.592-600, 2011. ,
DOI : 10.1016/j.tics.2011.10.003
Circuit-breakers: optical technologies for probing neural signals and systems, Nature Reviews Neuroscience, vol.446, issue.8, pp.577-81, 2007. ,
DOI : 10.1038/nrn2192
In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2, Neuron, vol.54, issue.2, pp.205-223, 2007. ,
DOI : 10.1016/j.neuron.2007.03.005
A high-light sensitivity optical neural silencer: development and application to optogenetic control of non-human primate cortex High-performance genetically targetable optical neural silencing by light-driven proton pumps, Front Syst Neurosci Boyden ES. Nature, vol.5, issue.463, pp.98-102, 2010. ,
Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin, Proceedings of the National Academy of Sciences, vol.102, issue.49, pp.17816-17837, 2005. ,
DOI : 10.1073/pnas.0509030102
Substitution of 5-HT1A Receptor Signaling by a Light-activated G Protein-coupled Receptor, Journal of Biological Chemistry, vol.285, issue.40, pp.30825-30861, 2010. ,
DOI : 10.1074/jbc.M110.147298
Vertebrate Cone Opsins Enable Sustained and Highly Sensitive Rapid Control of Gi/o Signaling in Anxiety Circuitry, Neuron, vol.81, issue.6, pp.1263-73, 2014. ,
DOI : 10.1016/j.neuron.2014.01.041
Histopathology of the human retina in retinitis pigmentosa, Prog Retin Eye Res, vol.17, pp.175-205, 1998. ,
Rod photoreceptor neurite sprouting in retinitis pigmentosa, J Neurosci, vol.15, pp.5429-5467, 1995. ,
Remodeling of cone photoreceptor cells after rod degeneration in rd mice, Experimental Eye Research, vol.88, issue.3, pp.589-99, 2009. ,
DOI : 10.1016/j.exer.2008.11.022
Gene Therapy for Blindness, Annual Review of Neuroscience, vol.36, issue.1, pp.467-88, 2013. ,
DOI : 10.1146/annurev-neuro-062012-170304
URL : https://hal.archives-ouvertes.fr/inserm-01258538
Ectopic Expression of a Microbial-Type Rhodopsin Restores Visual Responses in Mice with Photoreceptor Degeneration, Neuron, vol.50, issue.1, pp.23-33, 2006. ,
DOI : 10.1016/j.neuron.2006.02.026
Ectopic Expression of Multiple Microbial Rhodopsins Restores ON and OFF Light Responses in Retinas with Photoreceptor Degeneration, Journal of Neuroscience, vol.29, issue.29, pp.9186-96, 2009. ,
DOI : 10.1523/JNEUROSCI.0184-09.2009
Restoration of Visual Response in Aged Dystrophic RCS Rats Using AAV-Mediated Channelopsin-2 Gene Transfer, Investigative Opthalmology & Visual Science, vol.48, issue.8, pp.3821-3827, 2007. ,
DOI : 10.1167/iovs.06-1501
Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats, Experimental Eye Research, vol.90, issue.3, pp.429-465, 2010. ,
DOI : 10.1016/j.exer.2009.12.006
Differential Targeting of Optical Neuromodulators to Ganglion Cell Soma and Dendrites Allows Dynamic Control of Center-Surround Antagonism, Neuron, vol.69, issue.4, pp.713-733, 2011. ,
DOI : 10.1016/j.neuron.2011.01.024
Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration, Nature Neuroscience, vol.446, issue.6, pp.667-75, 2008. ,
DOI : 10.1038/nn.2117
Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adenoassociated virus capsid and promoter, Mol Ther Sci Transl Med EMBO Mol Med, vol.19, issue.6, pp.1220-1229, 2011. ,
Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice, Molecular Therapy, vol.23, issue.1, pp.7-16, 2015. ,
DOI : 10.1038/mt.2014.154
Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa, Science, vol.329, issue.5990, pp.413-420, 2010. ,
DOI : 10.1126/science.1190897
URL : https://hal.archives-ouvertes.fr/inserm-00496717
Adaptive Optics Imaging of Geographic Atrophy, Investigative Ophthalmology & Visual Science, vol.54, issue.5, pp.3673-80, 2013. ,
DOI : 10.1167/iovs.12-10672
Gene Therapy in Ophthalmology: Validation on Cultured Retinal Cells and Explants from Postmortem Human Eyes, Human Gene Therapy, vol.22, issue.5, pp.587-93, 2011. ,
DOI : 10.1089/hum.2010.157
Novel adeno-associated viral vectors for retinal gene therapy, Gene Therapy, vol.72, issue.2, pp.162-170, 2012. ,
DOI : 10.1038/nrg2628
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis, New England Journal of Medicine, vol.358, issue.21, pp.2240-2248, 2008. ,
DOI : 10.1056/NEJMoa0802315
Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis, New England Journal of Medicine, vol.358, issue.21, pp.2231-2240, 2008. ,
DOI : 10.1056/NEJMoa0802268
Human RPE65 gene therapy for Leber congenital amaurosis: persistence of early visual improvements and safety at 1 year. Hum Gene Ther, pp.999-1004, 2009. ,
Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial, The Lancet, vol.383, issue.9923, pp.1129-1166, 2014. ,
DOI : 10.1016/S0140-6736(13)62117-0
Designer Gene Delivery Vectors: Molecular Engineering and Evolution of Adeno-Associated Viral Vectors for Enhanced Gene Transfer, Pharmaceutical Research, vol.23, issue.3, pp.489-99, 2008. ,
DOI : 10.1007/s11095-007-9431-0
Adeno-associated Virus Serotypes: Vector Toolkit for Human Gene Therapy, Molecular Therapy, vol.14, issue.3, pp.316-343, 2006. ,
DOI : 10.1016/j.ymthe.2006.05.009
URL : http://dx.doi.org/10.1016/j.ymthe.2006.05.009
Novel Adeno-Associated Virus Serotypes Efficiently Transduce Murine Photoreceptors, Journal of Virology, vol.81, issue.20, pp.11372-80, 2007. ,
DOI : 10.1128/JVI.01327-07
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045569
Adeno-associated virus-mediated gene transfer, Journal of Cellular Biochemistry, vol.179, issue.Suppl 1, pp.17-24, 2008. ,
DOI : 10.1002/jcb.21819
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983091
A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Muller cells Molecular evolution of adeno-associated virus for enhanced glial gene delivery, PLoS One Mol Ther, vol.4, issue.17, pp.2088-95, 2009. ,
The Development and Application of Optogenetics, Annual Review of Neuroscience, vol.34, issue.1, pp.389-412, 2011. ,
DOI : 10.1146/annurev-neuro-061010-113817
Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh, Nature Neuroscience, vol.137, issue.4, pp.513-521, 2011. ,
DOI : 10.1016/j.tibtech.2005.12.006
ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration, PLoS ONE, vol.16, issue.6, p.98924, 2014. ,
DOI : 10.1371/journal.pone.0098924.t001
Conversion of channelrhodopsin into a light-gated chloride channel Structure-guided transformation of channelrhodopsin into a light-activated chloride channel, Science Science, vol.344, issue.344, pp.409-421, 2014. ,
Bi-stable neural state switches, Nature Neuroscience, vol.21, issue.2, pp.229-263, 2009. ,
DOI : 10.1016/S0006-3495(01)75976-0
Optogenetic Long-Term Manipulation of Behavior and Animal Development, PLoS ONE, vol.326, issue.4, pp.18766-55, 2008. ,
DOI : 10.1371/journal.pone.0018766.s009
Neocortical excitation/inhibition balance in information processing and social dysfunction, Nature, vol.31, issue.7363, pp.171-179, 2011. ,
DOI : 10.1038/nature10360
ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation, Nature Neuroscience, vol.207, issue.10, pp.1499-508, 2013. ,
DOI : 10.1152/jn.00718.2004
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation, Nature Methods, vol.5, issue.12, pp.1171-1180, 2012. ,
DOI : 10.1073/pnas.0506029102
Independent optical excitation of distinct neural populations Noninvasive optical inhibition with a red-shifted microbial rhodopsin, Nat Methods Nat Neurosci, vol.11, issue.17, pp.338-384, 2014. ,