Plasmodium vivax, Adv. Parasitol, vol.81, pp.1-26, 2013. ,
DOI : 10.1016/B978-0-12-407826-0.00001-1
Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures, Nature Medicine, vol.13, issue.3, pp.307-312, 2014. ,
DOI : 10.1007/s00125-005-1694-6
A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax, Cell Host & Microbe, vol.14, issue.1, pp.104-115, 2013. ,
DOI : 10.1016/j.chom.2013.06.005
Complete development of hepatic stages of Plasmodium falciparum in vitro, Science, vol.227, issue.4685, pp.440-442, 1985. ,
DOI : 10.1126/science.3880923
Establishment of a human hepatocyte line that supports in vitro development of the exo-erythrocytic stages of the malaria parasites Plasmodium falciparum and P. vivax. Am, J. Trop. Med. Hyg, vol.74, pp.708-715, 2006. ,
Towards an optimized inhibition of liver stage development assay (ILSDA) for Plasmodium falciparum, Malaria Journal, vol.12, issue.1, p.394, 2013. ,
DOI : 10.1016/0035-9203(90)90303-V
In vitro culture of two populations (dividing and nondividing) of exoerythrocytic parasites of Plasmodium vivax, Am. J. Trop. Med. Hyg, vol.34, pp.216-222, 1985. ,
Cultivation of the liver forms of Plasmodium vivax in human hepatocytes, Nature, vol.193, issue.5949, pp.367-369, 1984. ,
DOI : 10.1038/307367a0
A pre-emptive strike against malaria's stealthy hepatic forms, Nature Reviews Drug Discovery, vol.313, issue.11, pp.854-864, 2009. ,
DOI : 10.1038/nrd2960
Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook, Cell Host & Microbe, vol.6, issue.1, pp.5-9, 2009. ,
DOI : 10.1016/j.chom.2009.06.006
Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes, Journal of Experimental Medicine, vol.181, issue.6, pp.2265-2270, 1995. ,
DOI : 10.1084/jem.181.6.2265
in a Humanized Mouse Model, The Journal of Infectious Diseases, vol.193, issue.7, pp.996-1004, 2006. ,
DOI : 10.1086/500840
Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers, International Journal for Parasitology, vol.36, issue.3, pp.353-360, 2006. ,
DOI : 10.1016/j.ijpara.2005.10.014
A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes, PLoS ONE, vol.13, issue.3, p.2252, 2008. ,
DOI : 10.1371/journal.pone.0002252.t003
Further Improvements of the P. falciparum Humanized Mouse Model, PLoS ONE, vol.7, issue.3, p.18045, 2011. ,
DOI : 10.1371/journal.pone.0018045.s003
The course of infections and pathology in immunomodulated NOD/LtSz-SCID mice inoculated with Plasmodium falciparum laboratory lines and clinical isolates, International Journal for Parasitology, vol.36, issue.3, pp.361-369, 2006. ,
DOI : 10.1016/j.ijpara.2005.10.012
Robust expansion of human hepatocytes in Fah???/???/Rag2???/???/Il2rg???/??? mice, Nature Biotechnology, vol.43, issue.8, pp.903-910, 2007. ,
DOI : 10.1038/nbt1326
Complete Plasmodium falciparum liver-stage development in liver-chimeric mice, Journal of Clinical Investigation, vol.122, issue.10, pp.3618-3628, 2012. ,
DOI : 10.1172/JCI62684DS1
The reconstituted ???humanized liver??? in TK-NOG mice is mature and functional, Biochemical and Biophysical Research Communications, vol.405, issue.3, pp.405-410, 2011. ,
DOI : 10.1016/j.bbrc.2011.01.042
Macrophages prevent human red blood cell reconstitution in immunodeficient mice, Blood, vol.118, issue.22, pp.5938-5946, 2011. ,
DOI : 10.1182/blood-2010-11-321414
Exo-erythrocytic stages of Plasmodium falciparum, Am. J. Trop. Med. Hyg, vol.1, pp.917-925, 1952. ,
Towards an In Vitro Model of Plasmodium Hypnozoites Suitable for Drug Discovery, PLoS ONE, vol.65, issue.3, p.18162, 2011. ,
DOI : 10.1371/journal.pone.0018162.t001
An exported protein of Plasmodium falciparum is synthesized as an integral membrane protein, Molecular and Biochemical Parasitology, vol.46, issue.1, pp.149-157, 1991. ,
DOI : 10.1016/0166-6851(91)90208-N
In vitro biosynthesis and membrane translocation of the serine rich protein of Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.42, issue.1, pp.93-100, 1990. ,
DOI : 10.1016/0166-6851(90)90116-4
A 50 kilodalton exoantigen specific to the merozoite release-reinvasion stage of Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.17, issue.2, pp.239-251, 1985. ,
DOI : 10.1016/0166-6851(85)90021-0
Precise Timing of Expression of a Plasmodium falciparum-derived Transgene in Plasmodium berghei Is a Critical Determinant of Subsequent Subcellular Localization, Journal of Biological Chemistry, vol.273, issue.24, pp.15119-15124, 1998. ,
DOI : 10.1074/jbc.273.24.15119
Characterization of a 225 kilodalton rhoptry protein of Plasmodium falciparum, Molecular and Biochemical Parasitology, vol.27, issue.2-3, pp.135-141, 1988. ,
DOI : 10.1016/0166-6851(88)90033-3
Release of Hepatic Plasmodium yoelii Merozoites into the Pulmonary Microvasculature, PLoS Pathogens, vol.153, issue.11, p.171, 2007. ,
DOI : 10.1371/journal.ppat.0030171.sv010
Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids, Science, vol.313, issue.5791, pp.1287-1290, 2006. ,
DOI : 10.1126/science.1129720
Passive immunoprotection of Plasmodium falciparuminfected mice designates the CyRPA as candidate malaria vaccine antigen ,
The pre-erythrocytic stage of Plasmodium ovals, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.49, issue.2, pp.158-167, 1955. ,
DOI : 10.1016/0035-9203(55)90042-0
Plasmodium ovale: Observations on the Parasite Development in Saimiri Monkey Hepatocytes in Vivo and in Vitro in Contrast with Its Inability to Induce Parasitemia, Experimental Parasitology, vol.78, issue.4, pp.394-399, 1994. ,
DOI : 10.1006/expr.1994.1043
Studies on malaria in chimpanzees. XI. The early forms of the pre-erythrocytic phase of Laverania falcipara, Am. J. Trop. Med. Hyg, vol.12, pp.13-18, 1963. ,
Infection of chimpanzees with Nigerian I/CDC strain of Plasmodium ovale, Am. J. Trop. Med. Hyg, vol.37, pp.455-459, 1987. ,
Plasmodium ovale: In vitro development of hepatic stages, Experimental Parasitology, vol.64, issue.3, pp.393-400, 1987. ,
DOI : 10.1016/0014-4894(87)90052-X
The transmission of a West African strain of Plasmodium ovale by Anopheles freeborni and Anopheles maculatus, Am. J. Trop. Med. Hyg, vol.15, pp.690-693, 1966. ,
Relapse activity in sporozoite-induced infections with a West African strain of Plasmodium ovale, Am. J. Trop. Med. Hyg, vol.20, pp.825-827, 1971. ,
Plasmodium falciparum: Studies on mature exoerythrocytic forms in the liver of the chimpanzee, Pan troglodytes, Experimental Parasitology, vol.70, issue.1, pp.1-11, 1990. ,
DOI : 10.1016/0014-4894(90)90080-V
The pre-erythrocytic stage of plasmodium falciparum, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.44, issue.4, pp.405-419, 1951. ,
DOI : 10.1016/S0035-9203(51)80019-1
Studies on malaria in chimpanzees. IX. The distribution of the pre-erythrocytic forms of Laverania falcipara, Am. J. Trop. Med. Hyg, vol.11, pp.437-439, 1962. ,
Human Malaria in Immunocompromised Mice, The Journal of Experimental Medicine, vol.57, issue.11, pp.1653-1660, 2000. ,
DOI : 10.1084/jem.186.10.1689
Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2R??null Mice Engrafted with Human Erythrocytes, Antimicrobial Agents and Chemotherapy, vol.53, issue.10, pp.4533-4536, 2009. ,
DOI : 10.1128/AAC.00519-09
Gametocytogenesis: the puberty of Plasmodium falciparum, Malaria Journal, vol.3, issue.1, p.24, 2004. ,
DOI : 10.1186/1475-2875-3-24
Humanized HLA-DR4.RagKO.IL2R??cKO.NOD (DRAG) mice sustain the complex vertebrate life cycle of Plasmodium falciparum malaria, Malaria Journal, vol.13, issue.1, p.386, 2014. ,
DOI : 10.1182/blood-2001-12-0207
Plasmodium vivax Liver Stage Development and Hypnozoite Persistence in Human Liver-Chimeric Mice, Cell Host & Microbe, vol.17, issue.4, pp.526-535, 2015. ,
DOI : 10.1016/j.chom.2015.02.011
Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing, PLoS Medicine, vol.69, issue.4, p.1001628, 2014. ,
DOI : 10.1371/journal.pmed.1001628.s006
Human pharmacogenetic analysis in chimeric mice with ???humanized livers???, Pharmacogenetics and Genomics, vol.23, issue.2, pp.78-83, 2013. ,
DOI : 10.1097/FPC.0b013e32835cb2c7
Detection of Four Plasmodium Species in Blood from Humans by 18S rRNA Gene Subunit-Based and Species-Specific Real-Time PCR Assays, Journal of Clinical Microbiology, vol.42, issue.12, pp.5636-5643, 2004. ,
DOI : 10.1128/JCM.42.12.5636-5643.2004
A malaria heat-shock-like determinant expressed on the infected hepatocyte surface is the target of antibody-dependent cell-mediated cytotoxic mechanisms by nonparenchymal liver cells, European Journal of Immunology, vol.19, issue.7, pp.1445-1449, 1990. ,
DOI : 10.1002/eji.1830200706
Diversity Covering AMA1-MSP119 Fusion Proteins as Malaria Vaccines, Infection and Immunity, vol.81, issue.5, pp.1479-1490, 2013. ,
DOI : 10.1128/IAI.01267-12
) for the antibodies to Pf-RON4, to C. Enond (Centre d'Expérimentation Fonctionnelle, UMS28, La Pitié-Salpêtrière, Paris) for her help with TK-NOG housing and breeding The Netherlands ) for the provision of P. falciparum-infected mosquitoes, to Pr, Pr. R. Sauerwein and G.J. Van Gemert C. Hennequin, vol.19 ,
) for providing us with hepatic resections, to A. Lesot (Service d'Anatomie et Cytologie Pathologiques AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Paris) for her precious help with the processing of paraffin-embedded liver samples, to Terres for their help with mosquito breeding, infection and processing of liver sections, to L. Ciceron and N. Chartrel for their invaluable help with Plasmodium species diagnosis, to M. Bauzou and G. Pieumi for their support with quantification of P. falciparum blood stage parasites, to A. Dauphin and C. Lovo for their help with confocal microscopy (Plateforme d'Imagerie Cellulaire de la Pitié-Salpêtrière PICPS), to C. Blanc and B. Hoareau-Coudert for their help with flow cytometry analyses (Cytometry Platform of the Pitié-Salpêtière CYPS), to S. Fouquet and D. Godefroy for their help with the digital scanning of liver sections (Imaging Plateform This work was supported by the MaTuRe Project funded by the French National Agency for research (ANR), the Fondation pour la Recherche Médicale (grant DPM20121125558), the MultiMalVax project (Grant Agreement number: 305282) and the PathCo project (Grant Agreement n°HEALTH-F3-2012-305578) both funded by the European Community's Seventh Framework Programme, the PARAFRAP LabEx of the French Parasitology Alliance For Health Care, and a DIM Malinf grant from the Ile-de-France region. V.S. was a recipient of a postdoctoral fellowship from the MaTuRe and the MultiMalVax projects; C.R. was a recipient from a DIM Malinf postdoctoral fellowship from the Ile-de-France region, 2007. ,