Why vitamin Din Alzheimer's disease? The hypothesis, J Alzheimers Dis, vol.40, pp.257-269, 2014. ,
Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases, Psychoneuroendocrinology, vol.34, pp.265-277, 2009. ,
DOI : 10.1016/j.psyneuen.2009.05.023
URL : https://hal.archives-ouvertes.fr/hal-00417412
Review: The role of vitamin D in nervoussystem health and disease, pp.458-484, 2013. ,
Vitamin D in the healthy and inflamed central nervoussystem: Access and function, J NeurolSci311, pp.37-43, 2011. ,
Vitamin D, cognition, and dementia: A systematic review and meta-analysis, Neurology, vol.79, issue.13, 2012. ,
DOI : 10.1212/WNL.0b013e31826c197f
Theeffects of vitamin D on brain development and adult brainfunction, Mol Cell, vol.347, pp.121-127, 2011. ,
Meta-analysis ofmemory and executive dysfunctions in relation to vitamin D, J Alzheimers Dis, vol.37, pp.147-171, 2013. ,
Neurosteroidvitamin D system as a nontraditional drug target inneuropsychopharmacology, pp.420-426, 2010. ,
Vitamin D deficiency and depression in adults: systematic review and meta-analysis, The British Journal of Psychiatry, vol.202, issue.2, pp.100-107, 2013. ,
DOI : 10.1192/bjp.bp.111.106666
Vitamin D Deficiency, New England Journal of Medicine, vol.357, issue.3, pp.266-281, 2007. ,
DOI : 10.1056/NEJMra070553
From vitamin D to hormone D: Fundamentalsof the vitamin D endocrine system essential for goodhealth, Am J ClinNutr88, pp.491-499, 2008. ,
The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain, Neuroscience, vol.236, pp.77-87, 2013. ,
DOI : 10.1016/j.neuroscience.2013.01.035
Distribution of the vitamin D receptor and 1alpha-hydroxylase in human brain, J ChemNeuroanat29, pp.21-30, 2005. ,
Distributionof 1,25-dihydroxyvitamin D3 receptor immunoreactivityin the rat brain and spinal cord, J ChemNeuroanat16, pp.135-145, 1999. ,
(OH)2 vitamin D3 sitesof action in the brain. An autoradiographic study, pp.25-393, 1987. ,
New clues about vitamin D functions in thenervous system. Trends EndocrinolMetab13, pp.100-105, 2002. ,
The anti-cancer and anti-inflammatory actions of 1, OH)2D3. Best Pract Res ClinEndocrinolMetab25, pp.593-604, 2011. ,
Low serumvitamin D concentrations in Alzheimer's disease: A systematicreview and meta-analysis, J Alzheimers Dis, vol.33, pp.659-674, 2013. ,
Developmental Vitamin D Deficiency and Risk of Schizophrenia: A 10-Year Update, Schizophrenia Bulletin, vol.36, issue.6, pp.1073-1078, 2010. ,
DOI : 10.1093/schbul/sbq101
Parkinson disease: Low vitamin D and Parkinson disease???a causal conundrum, Nature Reviews Neurology, vol.10, issue.1, pp.8-9, 2014. ,
DOI : 10.1111/j.1469-1809.2010.00631.x
Vitamin D, effectson brain development, adult brain function and the linksbetween lowlevels of vitaminDand neuropsychiatric disease.Front Neuroendocrinol34, pp.47-64, 2013. ,
Role of vitamin D in the onset, progression, and severity ofmultiple sclerosis, pp.129-136, 2013. ,
Progesterone and Vitamin D Hormone as a Biologic Treatment of Traumatic Brain Injury in the Aged, PM&R, vol.3, issue.6, pp.100-110, 2011. ,
DOI : 10.1016/j.pmrj.2011.03.010
The transcriptomicresponse ofmixed neuron-glial cell cultures to1,25-dihydroxyvitamin D3 includes genes limiting the progression of neurodegenerative diseases, J Alzheimers Dis, vol.35, pp.553-564, 2013. ,
Anewmechanismfor amyloid-? induction of iNOS: Vitamin D-VDR pathwaydisruption, J Alzheimers Dis, vol.36, pp.459-474, 2013. ,
25- dihydroxyvitamin D3 regulates thesynthesis of nerve growth factor in primary cultures of glialcells, Brain Res Mol Brain Res, vol.1, issue.24, pp.70-76, 1994. ,
Differential regulation of GDNF, neurturin, and their receptors in primary cultures of rat glial cells, Journal of Neuroscience Research, vol.122, issue.3, pp.242-251, 2001. ,
DOI : 10.1002/jnr.1072
25- Dihydroxyvitamin D3 regulatesthe expression of the low-affinity neurotrophin receptor, Brain Res Mol Brain Res, vol.1, issue.41, pp.259-268, 1996. ,
25-Dihydroxyvitamin D3 inhibits the expression of induciblenitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis, Brain Res Mol BrainRes, vol.1, issue.45, pp.255-267, 1997. ,
Vitamin Dmediatedimmune regulation in multiple sclerosis, J NeurolSci311, pp.23-31, 2011. ,
Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line, Journal of Neuroscience Research, vol.86, issue.4, pp.575-582, 2003. ,
DOI : 10.1002/jnr.10491
The blood???brain barrier: an overview, Neurobiology of Disease, vol.16, issue.1, pp.1-13, 2004. ,
DOI : 10.1016/j.nbd.2003.12.016
Morphology and propertiesof pericytes, Methods, vol.686, pp.49-68, 2011. ,
Pericytes.Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche, pp.909-969, 2009. ,
Central nervoussystem pericytes in health and disease, pp.1398-1405, 2011. ,
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders, Neuron, vol.57, issue.2, pp.178-201, 2008. ,
DOI : 10.1016/j.neuron.2008.01.003
Microvessel Organization and Structure in Experimental Brain Tumors: Microvessel Populations with Distinctive Structural and Functional Properties, Microvascular Research, vol.58, issue.3, pp.312-328, 1999. ,
DOI : 10.1006/mvre.1999.2188
URL : http://hdl.handle.net/2437/121657
Pathophysiology of theneurovascular unit: Disease cause or consequence? J CerebBlood Flow Metab32, pp.1207-1221, 2012. ,
Neurovascular unit:A focus on pericytes, pp.327-347, 2012. ,
Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging, Neuron, vol.68, issue.3, pp.409-427, 2010. ,
DOI : 10.1016/j.neuron.2010.09.043
Infection and upregulation of proinflammatorycytokines in human brain vascular pericytes by humancytomegalovirus, J Neuroinflammation9, p.95, 2012. ,
Participation of blood vessel cellsin human adaptive immune responses. Trends Immunol33, pp.49-57, 2012. ,
Retinal Pericytes Inhibit Activated T Cell Proliferation, Investigative Opthalmology & Visual Science, vol.52, issue.12, pp.9005-9010, 2011. ,
DOI : 10.1167/iovs.11-8008
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231798
Pericyte loss influences Alzheimerlikeneurodegeneration in mice, 2013. ,
Neurovascular pathways to neurodegenerationin Alzheimer's disease and other disorders, Nat RevNeurosci12, pp.723-738, 2011. ,
DOI : 10.1038/nrn3114
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036520
Expression of 25(OH) vitamin D3 24-hydroxylasegene in glial cells, pp.255-257, 1993. ,
Transcriptional effects of 1,25 dihydroxyvitamin D(3) physiologicaland supra-physiological concentrations in breastcancer organotypic culture, BMC Cancer, vol.13, issue.119, 2013. ,
Primary vitamin D target genes allow a categorizationof possible benefits of vitamin D3 supplementation, 2013. ,
The odd-skipped related genes Osr1 and Osr2 are induced by 1,25-dihydroxyvitamin D3, The Journal of Steroid Biochemistry and Molecular Biology, vol.136, pp.94-97, 2013. ,
DOI : 10.1016/j.jsbmb.2012.12.001
Transcriptional profiling of keratinocytes revealsa vitamin D-regulated epidermal differentiation network, NagpalS, pp.778-785, 2005. ,
alpha,25- dihydroxyvitamin D3 increasesIGF binding protein-5 expression in cultured osteoblasts, FEBS Lett, vol.1, issue.392, pp.21-24, 1996. ,
Anti-adipogenic effects of 1,25-dihydroxyvitamin D3 are mediated by the maintenance of thewingless-type MMTV integration site/_-catenin pathway, Int J Mol Med, vol.30, pp.1219-1224, 2012. ,
VitaminDregulation ofOX40ligand in immune responses to Aspergillusfumigatus, pp.1510-1519, 2013. ,
Expression of vitamin D receptor and metabolizing enzymesin multiple sclerosisaffected brain tissue, J, vol.72, pp.91-105, 2013. ,
Reduced 25-hydroxyvitamin D and risk of Alzheimer???s disease and vascular dementia, Alzheimer's & Dementia, vol.10, issue.3, pp.296-302, 2014. ,
DOI : 10.1016/j.jalz.2013.05.1765
Vitamin D, Cognitive Dysfunction and Dementia in Older Adults, CNS Drugs, vol.16, issue.6, pp.629-639, 2011. ,
DOI : 10.2165/11593080-000000000-00000
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097668
Cerebrospinal fluid(CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesteraseactivity are reduced in patients withAlzheimer's disease, PloS One, vol.8, 2013. ,
DOI : 10.1371/journal.pone.0081989
URL : http://doi.org/10.1371/journal.pone.0081989
25-Dihydroxyvitamin D3 is a potent inducerof nerve growth factor synthesis, J Neurosci Res, vol.1, issue.28, pp.110-114, 1991. ,
DOI : 10.1002/jnr.490280111
1,25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons, Neuroscience Letters, vol.343, issue.2, pp.139-143, 2003. ,
DOI : 10.1016/S0304-3940(03)00303-3
URL : https://hal.archives-ouvertes.fr/hal-00094024
25-Dihydroxyvitamin D3, an inducer of glial cell line-derivedneurotrophic factor, pp.2171-2175, 1996. ,
Vitamin D and itsanalogs as regulators of immune activation and antigen presentation, pp.117-145, 2003. ,
Vitamin D and 1,25-dihydroxyvitamin D3 as modulators in the immune system, The Journal of Steroid Biochemistry and Molecular Biology, vol.89, issue.90, pp.449-452, 2004. ,
DOI : 10.1016/j.jsbmb.2004.03.014
25-dihydroxyvitamin D3 regulates the synthesis of gammaglutamyltranspeptidase and glutathione levels in rat primaryastrocytes, J Neurochem73, vol.1, pp.859-866, 1999. ,
Differential expression of M-CSF, LIF, and TNF-? genes in normal and malignant rat glial cells: Regulation by lipopolysaccharide and vitamin D, Journal of Neuroscience Research, vol.13, issue.3, pp.360-366, 1996. ,
DOI : 10.1002/(SICI)1097-4547(19961101)46:3<360::AID-JNR9>3.0.CO;2-I
Inflammatory factors are elevatedin brain microvessels in Alzheimer's disease, Neurobiol, vol.22, pp.837-842, 2001. ,
Serum MCP-1 levels are increased in mildcognitive impairment and mild Alzheimer's disease, NeurobiolAging, vol.27, pp.1763-1768, 2006. ,
CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease, PLoS ONE, vol.30, issue.1, p.30525, 2012. ,
DOI : 10.1371/journal.pone.0030525.t003
Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2), The Journal of Experimental Medicine, vol.59, issue.7, pp.1075-1080, 2000. ,
DOI : 10.1038/29788
OX40-OX40 ligand interaction in T-cellmediated immunity andimmunopathology, pp.63-98, 2010. ,
OX40-OX40L interactions: a promising therapeutic target for allergic diseases?, Journal of Clinical Investigation, vol.117, issue.12, pp.3655-3657, 2007. ,
DOI : 10.1172/JCI34182
CD134 plays a crucial role inthe pathogenesis of EAE and is upregulated in the CNS ofpatients with multiple sclerosis, J Neuroimmunol145, pp.1-11, 2003. ,
OX40/OX40 Ligand Interactions in T-Cell Regulation and Asthma, Chest, vol.141, issue.2, pp.494-499, 2012. ,
DOI : 10.1378/chest.11-1730
OX40ligand regulates inflammation and mortality in the innateimmune response to sepsis, J Immunol185, pp.4856-4862, 2010. ,
Targeting OX40 andOX40L for the treatment of autoimmunity and cancer, CritRev, vol.27, pp.415-436, 2007. ,
Lipid chaperonesand metabolic inflammation, IntJ, 2011. ,
FABP 4 is associated with inflammatory markersand metabolic syndrome in morbidly obese women, Eur, vol.164, pp.539-547, 2011. ,
DOI : 10.1530/eje-10-1195
The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation, Journal of Clinical Investigation, vol.116, issue.8, pp.2183-2192, 2006. ,
DOI : 10.1172/JCI24767DS1
The level of fatty acid-binding protein 4, a novel adipokine, is increased in rheumatoid arthritis and correlates with serum cholesterol levels, Cytokine, vol.64, issue.1, pp.441-447, 2013. ,
DOI : 10.1016/j.cyto.2013.05.001
Thrombomodulin Links Coagulation to Inflammation and Immunity, Current Drug Targets, vol.13, issue.3, pp.421-431, 2012. ,
DOI : 10.2174/138945012799424606
URL : http://doi.org/10.2174/138945012799424606
Thrombomodulin and its role in inflammation, Seminars in Immunopathology, vol.125, issue.5, pp.107-125, 2012. ,
DOI : 10.1007/s00281-011-0282-8
Selective inhibitory effects of the anticoagulantactivated protein C on the responses of humanmononuclear phagocytes to LPS, IFN-gamma, or phorbolester, J, vol.153, pp.3664-3672, 1994. ,
TSG-6: A multifunctional proteinassociated with inflammation, J Cell, vol.116, pp.1863-1873, 2003. ,
Kruppel-like factor 4 is a novel mediator of Kallistatin ininhibiting endothelial inflammation via increased endothelialnitric-oxide synthase expression, J BiolChem284, pp.35471-35478, 2009. ,
Kruppel-like factor4 (KLF4) represses histidine decarboxylase gene expressionthrough an upstream Sp1 site and downstream gastrin responsiveelements, J BiolChem279, pp.8684-8693, 2004. ,
Kr??ppel-like factor 4 regulates macrophage polarization, Journal of Clinical Investigation, vol.121, issue.7, pp.2736-2749, 2011. ,
DOI : 10.1172/JCI45444DS1
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223832
Brain macrophages: on the role of pericytes and perivascular cells, Brain Research Reviews, vol.31, issue.1, pp.42-57, 1999. ,
DOI : 10.1016/S0165-0173(99)00024-7
Therapeutic targeting of Kruppel-like factor 4abrogates microglial activation, J Neuroinflammation9, vol.57, 2012. ,
Ventroptin: A BMP-4 Antagonist Expressed in a Double-Gradient Pattern in the Retina, Science, vol.293, issue.5527, pp.111-115, 2001. ,
DOI : 10.1126/science.1058379
Chordin-like 1, abone morphogenetic protein-4 antagonist, is upregulated byhypoxia in human retinal pericytes and plays a role in regulatingangiogenesis, Mol Vis, vol.14, pp.1138-1148, 2008. ,
Decreased hippocampal cell proliferation correlates with increased expression of BMP4 in the APPswe/PS1??E9 mouse model of Alzheimer's disease, Hippocampus, vol.355, issue.7, pp.692-698, 2008. ,
DOI : 10.1002/hipo.20428
Bone morphogenetic proteins 4, 6, and7 are up-regulated in mouse spinal cord during experimental autoimmuneencephalomyelitis, J, vol.86, pp.125-135, 2008. ,
Role of NADPH Oxidases in Disturbed Flow- and BMP4- Induced Inflammation and Atherosclerosis, Antioxidants & Redox Signaling, vol.8, issue.9-10, pp.1609-1619, 2006. ,
DOI : 10.1089/ars.2006.8.1609
Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes, Cell, vol.59, issue.6, pp.1203-1211, 1989. ,
DOI : 10.1016/0092-8674(89)90775-7
VCAM1 is essential to maintainthe structure of the SVZ niche and acts as an environmentalsensor to regulate SVZ lineage progression, Cell Stem Cell11, pp.220-230, 2012. ,
Deficiency in mural vascular cellscoincides with blood-brain barrier disruption in Alzheimer'sdisease, Brain, vol.23, pp.303-310, 2013. ,
) the early contributionof cerebrovascular factors to the pathogenesis of Alzheimer'sdisease, Eur J Neurosci35, pp.1917-1937, 2012. ,