Additional Clues for a Protective Role ofVitamin D in Neurodegenerative Diseases: 1,25-Dihydroxyvitamin D3 Triggers an Anti-Inflammatory Response in BrainPericytes

Marie-France Nissou 1, 2 Audrey Guttin 2, 1 Cyril Zenga 3 François Berger 1, 2 Jean-Paul Issartel 1, 2 Didier Wion 1, 2
2 Equipe 7 : Nanomédecine et Cerveau
UJF - Université Joseph Fourier - Grenoble 1, CEA - Commissariat à l'énergie atomique et aux énergies alternatives, INSERM - Institut National de la Santé et de la Recherche Médicale : U836, [GIN] Grenoble Institut des Neurosciences
Abstract : Epidemiological and experimental studies suggest that 1,25-dihydroxyvitamin D3 (1,25D) plays a neuroprotectiverole in neurodegenerative diseases including Alzheimer's disease. Most of the experimental data regarding the genes regulatedby this hormone in brain cells have been obtained with neuron and glial cells. Pericytes play a critical role in brain function thatencompasses their classical function in blood-brain barrier control and maintenance. However, the gene response of brain pericyteto 1,25D remains to be investigated. Analyses of the transcriptomic response of human brain pericytes to 1,25D demonstrate thathuman brain pericytes in culture respond to 1,25D by regulating genes involved in the control of neuroinflammation. In addition,ericytes respond to the pro-inflammatory cytokines tumor necrosis factor and Interferon  by inducing the expression of theCYP27B1 gene which is involved in 1,25D synthesis. Taken together, these results suggest that neuroinflammation could triggerthe synthesis of 1,25D by brain pericytes, which in turn respond to the hormone by a global anti-inflammatory response. Thesefindings identify brain pericytes as a novel 1,25D-responsive cell type and provide additional evidence for the potential value ofvitamin D in the prevention or therapy of Alzheimer's disease and other neurodegenerative/neuropsychiatric diseases associatedwith an inflammatory component.
Type de document :
Article dans une revue
Journal of Alzheimer's Disease, IOS Press, 2014, pp.789-99. 〈10.3233/JAD-140411〉
Liste complète des métadonnées

Littérature citée [96 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01199883
Contributeur : Didier Wion <>
Soumis le : mercredi 16 septembre 2015 - 13:19:48
Dernière modification le : dimanche 4 février 2018 - 19:02:05
Document(s) archivé(s) le : mardi 29 décembre 2015 - 07:31:07

Fichiers

HALJAD2014.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

CEA | UGA

Citation

Marie-France Nissou, Audrey Guttin, Cyril Zenga, François Berger, Jean-Paul Issartel, et al.. Additional Clues for a Protective Role ofVitamin D in Neurodegenerative Diseases: 1,25-Dihydroxyvitamin D3 Triggers an Anti-Inflammatory Response in BrainPericytes. Journal of Alzheimer's Disease, IOS Press, 2014, pp.789-99. 〈10.3233/JAD-140411〉. 〈inserm-01199883〉

Partager

Métriques

Consultations de la notice

123

Téléchargements de fichiers

150