Cervical human papillomavirus prevalence and genotype distribution among hybrid capture 2 positive women 15 to 64 years of age in the Gurage zone, rural Ethiopia

Abstract : Background: Human papillomavirus (HPV) infection is a prerequisite of cervical cancer, the leading cause of cancer mortality in Ethiopian women today. Data on Ethiopian cervical HPV prevalence and genotype distribution are rare, but essential as pre-vaccine baseline data to monitor changes after initiating HPV vaccination. The objectives of this study were to assess the cervical HPV prevalence, genotype distribution and associated correlates among female hospital outpatients in rural Ethiopia. Methods: We examined a consecutive sample of 537 women 15–64 years of age in rural Ethiopia between November and December 2006. Screening for low risk (LR) and high-risk (HR) cervical HPV infection was performed and HR positive samples were genotyped with a GP5+/6 + − and SPF10-primer based system. Results: The age-standardized prevalence of HPV, HPV HR and HPV LR infection was 17.3% (95% CI 14.1-20.5), 15.8% (95% CI 12.7-18.9) and 3.9% (95% CI 2.3-5.6), respectively. Among HC2 HPV HR positive infections (n = 86), the most common genotype was HPV 16 (24.4%), followed by 52 (11.6%), 56 (10.5%) and 31 (10.5%). Non-married relationship and widowhood, increasing number of lifetime sexual partners, human immunodeficiency virus infection and non-traditional housing type, but not age, were significantly associated with HR HPV infection. Conclusions: These results on cervical HPV prevalence and genotype distribution may serve as baseline data in evaluating the impact of future HPV vaccination programmes in rural Ethiopia.
Type de document :
Article dans une revue
Infectious Agents and Cancer, BioMed Central, 2014, 9 (1), pp.33. 〈10.1128/JCM.02078-05〉
Liste complète des métadonnées

Littérature citée [34 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01196791
Contributeur : Christine Dupuis <>
Soumis le : jeudi 10 septembre 2015 - 14:01:31
Dernière modification le : lundi 18 décembre 2017 - 10:16:35
Document(s) archivé(s) le : lundi 28 décembre 2015 - 23:54:50

Fichier

1750-9378-9-33.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Sami-Ramzi Leyh-Bannurah, Christof Prugger, Maurits De Koning, Hartmut Goette, Ralph Lellé. Cervical human papillomavirus prevalence and genotype distribution among hybrid capture 2 positive women 15 to 64 years of age in the Gurage zone, rural Ethiopia. Infectious Agents and Cancer, BioMed Central, 2014, 9 (1), pp.33. 〈10.1128/JCM.02078-05〉. 〈inserm-01196791〉

Partager

Métriques

Consultations de la notice

186

Téléchargements de fichiers

101