A. Albini and M. Sporn, The tumour microenvironment as a target for chemoprevention, Nature Reviews Cancer, vol.10, issue.2, pp.139-147, 2007.
DOI : 10.1038/nrc2067

M. Allen, L. Jones, and J. , Jekyll and Hyde: the role of the microenvironment on the progression of cancer, The Journal of Pathology, vol.175, issue.2, pp.162-176, 2011.
DOI : 10.1002/path.2803

G. Andrews, Latent Carcinoma of the Prostate, Journal of Clinical Pathology, vol.2, issue.3, pp.197-208, 1949.
DOI : 10.1136/jcp.2.3.197

D. Angelis, R. Sant, M. Coleman, M. Francisci, S. Baili et al., Cancer survival in Europe 1999???2007 by country and age: results of EUROCARE-5???a population-based study, The Lancet Oncology, vol.15, issue.1, pp.23-34
DOI : 10.1016/S1470-2045(13)70546-1

S. Ansell, A. Lesokhin, I. Borrello, A. Halwani, E. Scott et al., PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma, New England Journal of Medicine, vol.372, issue.4, 2014.
DOI : 10.1056/NEJMoa1411087

L. Arendt, J. Rudnick, P. Keller, and C. Kuperwasser, Stroma in breast development and disease, Seminars in Cell & Developmental Biology, vol.21, issue.1, pp.11-18, 2010.
DOI : 10.1016/j.semcdb.2009.10.003

P. Autier, M. Boniol, C. Héry, E. Masuyer, and J. Ferlay, Cancer survival statistics should be viewed with caution, The Lancet Oncology, vol.8, issue.12, pp.1050-1052, 2007.
DOI : 10.1016/S1470-2045(07)70354-6

T. Batchelor, E. Gerstner, K. Emblem, D. Duda, J. Kalpathy-cramer et al., Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation, Proceedings of the National Academy of Sciences, vol.110, issue.47, pp.19059-19064, 2013.
DOI : 10.1073/pnas.1318022110

F. Berrino, D. Angelis, R. Sant, M. Rosso, S. Bielska-lasota et al., Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995???99: results of the EUROCARE-4 study, The Lancet Oncology, vol.8, issue.9, pp.773-783, 2007.
DOI : 10.1016/S1470-2045(07)70245-0
URL : https://hal.archives-ouvertes.fr/hal-00492650

J. Bishop, Cellular Oncogenes and Retroviruses, Annual Review of Biochemistry, vol.52, issue.1, pp.301-354, 1983.
DOI : 10.1146/annurev.bi.52.070183.001505

M. Bissell, H. Hall, and G. Parry, How does the extracellular matrix direct gene expression?, Journal of Theoretical Biology, vol.99, issue.1, pp.31-68, 1982.
DOI : 10.1016/0022-5193(82)90388-5

M. Bissell and W. Hines, Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression, Nature Medicine, vol.23, issue.3, pp.320-329, 2011.
DOI : 10.1038/nm.2328

M. Bissell and D. Radisky, Putting tumours in context, Nature Reviews Cancer, vol.1, issue.1, pp.46-54, 2001.
DOI : 10.1038/35094059

H. Blau and A. Banfi, The well-tempered vessel, Nature Medicine, vol.7, issue.5, pp.532-534, 2001.
DOI : 10.1038/87850

A. Bleyer and H. Welch, Effect of Three Decades of Screening Mammography on Breast-Cancer Incidence, New England Journal of Medicine, vol.367, issue.21, pp.1998-2005, 2012.
DOI : 10.1056/NEJMoa1206809

B. Booth, C. Boulanger, L. Anderson, and G. Smith, The normal mammary microenvironment suppresses the tumorigenic phenotype of mouse mammary tumor virus-neu-transformed mammary tumor cells, Oncogene, vol.129, issue.6, pp.679-689, 2011.
DOI : 10.1093/nar/25.21.4323

A. Carrel and M. Burrows, CULTIVATION OF ADULT TISSUES AND ORGANS OUTSIDE OF THE BODY, JAMA: The Journal of the American Medical Association, vol.55, issue.16, pp.1379-1381, 1910.
DOI : 10.1001/jama.1910.04330160047018

O. Chinot, W. Wick, W. Mason, R. Henriksson, F. Saran et al., Bevacizumab plus Radiotherapy???Temozolomide for Newly Diagnosed Glioblastoma, New England Journal of Medicine, vol.370, issue.8, pp.709-722, 2014.
DOI : 10.1056/NEJMoa1308345

W. Coleman, A. Wennerberg, G. Smith, and J. Grisham, Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment, Am J Pathol, vol.142, pp.1373-1382, 1993.

M. Collado and M. Serrano, Senescence in tumours: evidence from mice and humans, Nature Reviews Cancer, vol.15, issue.1, pp.51-57, 2010.
DOI : 10.1038/nrc2772

S. Conley, E. Gheordunescu, P. Kakarala, B. Newman, H. Korkaya et al., Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia, Proceedings of the National Academy of Sciences, vol.109, issue.8, pp.2784-2789, 2012.
DOI : 10.1073/pnas.1018866109

R. Demicheli, M. Retsky, W. Hrushesky, M. Baum, and I. Gukas, The effects of surgery on tumor growth: a century of investigations, Annals of Oncology, vol.19, issue.11, pp.1821-1828, 2008.
DOI : 10.1093/annonc/mdn386

B. Druker, Perspectives on the development of imatinib and the future of cancer research, Nature Medicine, vol.330, issue.10, pp.1149-1152, 2009.
DOI : 10.1038/nm1009-1149

C. Dufort, M. Paszek, and V. Weaver, Balancing forces: architectural control of mechanotransduction, Nature Reviews Molecular Cell Biology, vol.13, issue.5, pp.308-319, 2011.
DOI : 10.1038/nrm3112

A. Dufour and C. Overall, Missing the target: matrix metalloproteinase antitargets in inflammation and cancer, Trends in Pharmacological Sciences, vol.34, issue.4, pp.233-242, 2013.
DOI : 10.1016/j.tips.2013.02.004

H. Dvorak, Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing, N Engl J Med, vol.315, pp.1650-1659, 1986.

H. Eagle, Animal cells and microbiology, Bacteriol Rev, vol.22, pp.217-222, 1958.

K. Emblem, K. Mouridsen, A. Bjornerud, C. Farrar, D. Jennings et al., Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy, Nature Medicine, vol.8, issue.9, pp.1178-1183, 2013.
DOI : 10.1038/jcbfm.2010.4

L. Esserman, I. Thompson, R. B. Nelson, P. Ransohoff, D. Welch et al., Addressing overdiagnosis and overtreatment in cancer: a prescription for change, The Lancet Oncology, vol.15, issue.6, pp.234-242, 2014.
DOI : 10.1016/S1470-2045(13)70598-9

J. Folkman and R. Kalluri, Cancer without disease, Nature, vol.427, issue.6977, p.787, 2004.
DOI : 10.1038/427787a

O. Franco and S. Hayward, Targeting the Tumor Stroma as a Novel Therapeutic Approach for Prostate Cancer, Adv Pharmacol, vol.65, pp.267-313, 2012.
DOI : 10.1016/B978-0-12-397927-8.00009-9

L. Franks, Latent carcinoma, Ann R Coll Surg Engl, vol.15, pp.236-249, 1954.

K. Frese and D. Tuveson, Maximizing mouse cancer models, Nature Reviews Cancer, vol.303, issue.9, pp.645-658, 2007.
DOI : 10.1038/nrc2192

H. Fukuda, S. Mochizuki, H. Abe, H. Okano, C. Hara-miyauchi et al., Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production, British Journal of Cancer, vol.129, issue.10, 2011.
DOI : 10.1038/bjc.2011.431

E. Garcion, P. Naveilhan, F. Berger, and D. Wion, Cancer stem cells: Beyond Koch???s postulates, Cancer Letters, vol.278, issue.1, pp.3-8, 2009.
DOI : 10.1016/j.canlet.2008.09.006
URL : https://hal.archives-ouvertes.fr/inserm-01194481

S. Gately, P. Twardowski, M. Stack, M. Patrick, L. Boggio et al., Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin, Cancer Res, vol.56, pp.4887-4890, 1996.

F. Gattazzo, A. Urciuolo, and P. Bonaldo, Extracellular matrix: A dynamic microenvironment for stem cell niche, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1840, issue.8, pp.2506-2519, 2014.
DOI : 10.1016/j.bbagen.2014.01.010

M. Gilbert, J. Dignam, T. Armstrong, J. Wefel, D. Blumenthal et al., A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma, New England Journal of Medicine, vol.370, issue.8, pp.699-708, 2014.
DOI : 10.1056/NEJMoa1308573

D. Good, P. Polverini, F. Rastinejad, L. Beau, M. Lemons et al., A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin., Proceedings of the National Academy of Sciences, vol.87, issue.17, pp.6624-6628, 1990.
DOI : 10.1073/pnas.87.17.6624

F. Greco, Cancer of unknown primary site: still an entity, a biological mystery and a metastatic model, Nature Reviews Cancer, vol.6, issue.1, pp.3-4, 2014.
DOI : 10.1038/nrc3646

M. Guba, G. Cernaianu, G. Koehl, E. Geissler, K. Jauch et al., A primary tumor promotes dormancy of solitary tumor cells before inhibiting angiogenesis, Cancer Res, vol.61, pp.5575-5579, 2001.

G. Hadfield, The Dormant Cancer Cell, BMJ, vol.2, issue.4888, pp.607-610, 1954.
DOI : 10.1136/bmj.2.4888.607

Y. Hamano and R. Kalluri, Tumstatin, the NC1 domain of alpha3 chain of type IV collagen, is an endogenous inhibitor of pathological angiogenesis and suppresses tumor growth, 2005.

Y. Hamano, M. Zeisberg, H. Sugimoto, J. Lively, Y. Maeshima et al., Physiological levels of tumstatin, a fragment of collagen IV ??3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via ??V??3 integrin, Cancer Cell, vol.3, issue.6, pp.589-601, 2003.
DOI : 10.1016/S1535-6108(03)00133-8

D. Hanahan, Rethinking the war on cancer, The Lancet, vol.383, issue.9916, pp.558-563, 2014.
DOI : 10.1016/S0140-6736(13)62226-6

R. Heljasvaara, P. Nyberg, J. Luostarinen, M. Parikka, P. Heikkilä et al., Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases, Experimental Cell Research, vol.307, issue.2, pp.292-304, 2005.
DOI : 10.1016/j.yexcr.2005.03.021

S. Hiscox, P. Barrett-lee, and R. Nicholson, Therapeutic targeting of tumor???stroma interactions, Expert Opinion on Therapeutic Targets, vol.65, issue.5, pp.609-621, 2011.
DOI : 10.1158/0008-5472.CAN-04-4037

B. Hoffman, C. Grashoff, and M. Schwartz, Dynamic molecular processes mediate cellular mechanotransduction, Nature, vol.40, issue.7356, pp.316-323, 2011.
DOI : 10.1038/nature10316

L. Holmgren, O. Reilly, M. Folkman, and J. , Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression, Nature Medicine, vol.218, issue.2, pp.149-153, 1995.
DOI : 10.1016/0022-3468(93)90246-H

G. Holton, On the Role of Themata in Scientific Thought, Science, vol.188, issue.4186, pp.328-334, 1975.
DOI : 10.1126/science.188.4186.328

S. Horne, J. Stevens, B. Abdallah, G. Liu, S. Bremer et al., Why imatinib remains an exception of cancer research, Journal of Cellular Physiology, vol.31, issue.103, pp.665-670, 2013.
DOI : 10.1002/jcp.24233

H. Ikushima and K. Miyazono, TGF?? signalling: a complex web in cancer progression, Nature Reviews Cancer, vol.124, issue.6, pp.415-424, 2010.
DOI : 10.1038/nrc2853

D. Ingber, Can cancer be reversed by engineering the tumor microenvironment?, Seminars in Cancer Biology, vol.18, issue.5, pp.356-364, 2008.
DOI : 10.1016/j.semcancer.2008.03.016

A. Jain, M. Betancur, G. Patel, C. Valmikinathan, V. Mukhatyar et al., Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres, Nature Materials, vol.33, issue.3, pp.308-316, 2014.
DOI : 10.1038/nmat3878

R. Jain, Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy, Nature Medicine, vol.7, issue.9, pp.987-989, 2001.
DOI : 10.1038/nm0901-987

J. Joyce, Therapeutic targeting of the tumor microenvironment, Cancer Cell, vol.7, issue.6, pp.513-520, 2005.
DOI : 10.1016/j.ccr.2005.05.024

R. Kalluri and M. Zeisberg, Fibroblasts in cancer, Nature Reviews Cancer, vol.59, issue.5, pp.392-401, 2006.
DOI : 10.1038/nrc1877

P. Kenny, G. Lee, and M. Bissell, Targeting the tumor microenvironment, Frontiers in Bioscience, vol.12, issue.8-12, pp.3468-3474, 2007.
DOI : 10.2741/2327

P. Kotsakis and M. Griffin, Tissue transglutaminase in tumour progression: friend or foe?, Amino Acids, vol.13, issue.2, pp.373-384, 2007.
DOI : 10.1007/s00726-007-0516-1

T. Kuhn, Historical Structure of Scientific Discovery: To the historian discovery is seldom a unit event attributable to some particular man, time, and place, Science, vol.136, issue.3518, pp.760-764, 1962.
DOI : 10.1126/science.136.3518.760

T. Kuhn, The structure of scientific revolutions Chicago, 1962.

J. Li, L. Chen, and Z. Qin, Multifaceted Tumor Stromal Fibroblasts, Cancer Microenvironment, vol.14, issue.3, pp.187-193, 2012.
DOI : 10.1007/s12307-012-0109-8

S. Loges, M. Mazzone, P. Hohensinner, and P. Carmeliet, Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited, Cancer Cell, vol.15, issue.3, pp.167-170, 2009.
DOI : 10.1016/j.ccr.2009.02.007

S. Lowe, E. Cepero, and G. Evan, Intrinsic tumour suppression, Nature, vol.35, issue.7015, pp.307-315, 2004.
DOI : 10.1038/nature03098

M. Martin and L. Matrisian, The other side of MMPs: Protective roles in tumor progression, Cancer and Metastasis Reviews, vol.295, issue.3-4, pp.717-724, 2007.
DOI : 10.1007/s10555-007-9089-4

A. Mayorca-guiliani and J. Erler, The potential for targeting extracellular LOX proteins in human malignancy, OncoTargets Ther, vol.6, pp.1729-1735, 2013.

B. Mintz and K. Illmensee, Normal genetically mosaic mice produced from malignant teratocarcinoma cells., Proceedings of the National Academy of Sciences, vol.72, issue.9, pp.3585-3589, 1975.
DOI : 10.1073/pnas.72.9.3585

G. Morris, F. Greco, J. Hainsworth, P. Engstrom, S. Scialla et al., Cancer of Unknown Primary Site, Seminars in Oncology, vol.37, issue.2, pp.71-79, 2010.
DOI : 10.1053/j.seminoncol.2010.03.009

M. Mueller and N. Fusenig, Friends or foes ??? bipolar effects of the tumour stroma in cancer, Nature Reviews Cancer, vol.22, issue.11, pp.839-849, 2004.
DOI : 10.1038/nrc1477

G. Naumov, E. Bender, D. Zurakowski, S. Kang, D. Sampson et al., A Model of Human Tumor Dormancy: An Angiogenic Switch From the Nonangiogenic Phenotype, JNCI Journal of the National Cancer Institute, vol.98, issue.5, pp.316-325, 2006.
DOI : 10.1093/jnci/djj068

P. Nowell and D. Hungerford, Chromosome studies in human leukemia. II. Chronic granulocytic leukemia, J Natl Cancer Inst, vol.27, pp.1013-1035, 1961.

G. Nugue and D. Wion, Angiogenesis and the tumor space-time continuum, Proceedings of the National Academy of Sciences, vol.109, issue.16, pp.914-914, 2012.
DOI : 10.1073/pnas.1203154109
URL : https://hal.archives-ouvertes.fr/inserm-00734054

P. Nyberg, L. Xie, and R. Kalluri, Endogenous Inhibitors of Angiogenesis, Cancer Research, vol.65, issue.10, pp.3967-3979, 2005.
DOI : 10.1158/0008-5472.CAN-04-2427

O. Reilly, M. Holmgren, L. Shing, Y. Chen, C. Rosenthal et al., Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma, Cell, vol.79, issue.2, pp.315-328, 1994.
DOI : 10.1016/0092-8674(94)90200-3

B. Ozdemir, T. Pentcheva-hoang, J. Carstens, X. Zheng, C. Wu et al., Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival, Cancer Cell, vol.25, issue.6, pp.719-734, 2014.
DOI : 10.1016/j.ccr.2014.04.005

N. Pavlidis and G. Pentheroudakis, Cancer of unknown primary site, The Lancet, vol.379, issue.9824, pp.1428-1435, 2012.
DOI : 10.1016/S0140-6736(11)61178-1

M. Pickup, S. Novitskiy, and H. Moses, The roles of TGF?? in the tumour microenvironment, Nature Reviews Cancer, vol.191, issue.11, pp.788-799, 2013.
DOI : 10.1038/nrc3603

K. Pietras and A. Ostman, Hallmarks of cancer: Interactions with the tumor stroma, Experimental Cell Research, vol.316, issue.8, pp.1324-1331, 2010.
DOI : 10.1016/j.yexcr.2010.02.045

T. Powles, J. Eder, G. Fine, F. Braiteh, Y. Loriot et al., MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer, Nature, vol.45, issue.7528, pp.558-562, 2014.
DOI : 10.1038/nature13904

D. Principe, J. Doll, J. Bauer, B. Jung, H. Munshi et al., TGF-??: Duality of Function Between Tumor Prevention and Carcinogenesis, JNCI Journal of the National Cancer Institute, vol.106, issue.2, p.369, 2014.
DOI : 10.1093/jnci/djt369

D. Quail and J. Joyce, Microenvironmental regulation of tumor progression and metastasis, Nature Medicine, vol.87, issue.11, pp.1423-1437, 2013.
DOI : 10.1016/j.ccr.2013.02.013

A. Rhim, P. Oberstein, D. Thomas, E. Mirek, C. Palermo et al., Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma, Cancer Cell, vol.25, issue.6, pp.735-747, 2014.
DOI : 10.1016/j.ccr.2014.04.021

P. Rous and F. Jones, A METHOD FOR OBTAINING SUSPENSIONS OF LIVING CELLS FROM THE FIXED TISSUES, AND FOR THE PLATING OUT OF INDIVIDUAL CELLS, Journal of Experimental Medicine, vol.23, issue.4, pp.549-555, 1916.
DOI : 10.1084/jem.23.4.549

B. Van-der-sanden, F. Appaix, F. Berger, L. Selek, J. Issartel et al., Translation of the ecological trap concept to glioma therapy: the cancer cell trap concept, Future Oncology, vol.9, issue.6, pp.817-824, 2013.
DOI : 10.2217/fon.13.30
URL : https://hal.archives-ouvertes.fr/inserm-00851156

H. Schiller and R. Fässler, Mechanosensitivity and compositional dynamics of cell???matrix adhesions, EMBO reports, vol.14, issue.6, pp.509-519, 2013.
DOI : 10.1038/nature01805

M. Serrano, A. Lin, M. Mccurrach, D. Beach, and S. Lowe, Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a, Cell, vol.88, issue.5, pp.593-602, 1997.
DOI : 10.1016/S0092-8674(00)81902-9

D. Smithers, AN ATTACK ON CYTOLOGISM, The Lancet, vol.279, issue.7235, pp.493-499, 1962.
DOI : 10.1016/S0140-6736(62)91937-2

D. Smithers, MATURATION IN HUMAN TUMOURS, The Lancet, vol.294, issue.7627, pp.949-952, 1969.
DOI : 10.1016/S0140-6736(69)90603-5

C. Sonnenschein and A. Soto, Somatic mutation theory of carcinogenesis: Why it should be dropped and replaced, Molecular Carcinogenesis, vol.183, issue.4, pp.205-211, 2000.
DOI : 10.1002/1098-2744(200012)29:4<205::AID-MC1002>3.0.CO;2-W

C. Sonnenschein and A. Soto, The Death of the Cancer Cell, Cancer Research, vol.71, issue.13, pp.4334-4337, 2011.
DOI : 10.1158/0008-5472.CAN-11-0639

A. Sorensen, K. Emblem, P. Polaskova, D. Jennings, H. Kim et al., Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion, Cancer Research, vol.72, issue.2, pp.402-407, 2012.
DOI : 10.1158/0008-5472.CAN-11-2464

A. Soto and C. Sonnenschein, One hundred years of somatic mutation theory of carcinogenesis: Is it time to switch?, BioEssays, vol.499, issue.1, pp.118-120, 2014.
DOI : 10.1002/bies.201300160

D. Stehelin, H. Varmus, J. Bishop, and P. Vogt, DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA, Nature, vol.3, issue.5547, pp.170-173, 1976.
DOI : 10.1038/260170a0

D. Strauss and J. Thomas, Transmission of donor melanoma by organ transplantation, The Lancet Oncology, vol.11, issue.8, pp.790-796, 2010.
DOI : 10.1016/S1470-2045(10)70024-3

J. Tchou and J. Conejo-garcia, Targeting the Tumor Stroma as a Novel Treatment Strategy for Breast Cancer, 2012.
DOI : 10.1016/B978-0-12-397927-8.00003-8

T. Tlsty and L. Coussens, TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT, Annual Review of Pathology: Mechanisms of Disease, vol.1, issue.1, pp.119-150, 2006.
DOI : 10.1146/annurev.pathol.1.110304.100224

F. Watt and W. Huck, Role of the extracellular matrix in regulating stem cell fate, Nature Reviews Molecular Cell Biology, vol.18, issue.8, pp.467-473, 2013.
DOI : 10.1038/nmeth.1487

R. Weinberg, Coming Full Circle???From Endless Complexity to Simplicity and Back Again, Cell, vol.157, issue.1, pp.267-271, 2014.
DOI : 10.1016/j.cell.2014.03.004

H. Welch and H. Passow, Quantifying the Benefits and Harms of Screening Mammography, JAMA Internal Medicine, vol.174, issue.3, pp.448-454, 2014.
DOI : 10.1001/jamainternmed.2013.13635

J. Westin and R. Kurzrock, It's About Time: Lessons for Solid Tumors from Chronic Myelogenous Leukemia Therapy, Molecular Cancer Therapeutics, vol.11, issue.12, pp.2549-2555, 2012.
DOI : 10.1158/1535-7163.MCT-12-0473