??-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains, Endocrine Reviews, vol.28, issue.1, pp.84-116, 2007. ,
DOI : 10.1210/er.2006-0007
The pathophysiology of hypoglycaemia in diabetes, Diabetes Nutrition & Metabolism, vol.15, pp.330-333, 2002. ,
Effects of Vagal Stimulation on Glucagon and Insulin Secretion, Endocrinology, vol.95, issue.4, 1974. ,
DOI : 10.1210/endo-95-4-1005
Sympathetic Nerve Stimulation Versus Pancreatic Norepinephrine Infusion in the Dog: 1) Effects on Basal Release of Insulin and Glucagon*, Endocrinology, vol.121, issue.1, pp.323-331, 1987. ,
DOI : 10.1210/endo-121-1-323
Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes, Diabetes, vol.47, pp.995-1005, 1998. ,
Regulating Glucagon Secretion: Somatostatin in the Spotlight, Diabetes, vol.58, issue.2, pp.299-301, 2009. ,
DOI : 10.2337/db08-1534
Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic ??-Cells, Diabetes, vol.54, issue.6, pp.1789-1797, 2005. ,
DOI : 10.2337/diabetes.54.6.1789
Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells, Diabetologia, vol.146, issue.Suppl 3, pp.370-379, 2007. ,
DOI : 10.1007/s00125-006-0511-1
The Influence of ??-Aminobutyric Acid on Hormone Release by the Mouse and Rat Endocrine Pancreas*, Endocrinology, vol.129, issue.5, pp.2521-2529, 1991. ,
DOI : 10.1210/endo-129-5-2521
Glucose-Dependent Regulation of ??-Aminobutyric Acid (GABAA) Receptor Expression in Mouse Pancreatic Islet ??-Cells, Diabetes, vol.56, issue.2, pp.320-327, 2007. ,
DOI : 10.2337/db06-0712
Insulin Signaling in ?? Cells Modulates Glucagon Secretion In Vivo, Cell Metabolism, vol.9, issue.4, pp.350-361, 2009. ,
DOI : 10.1016/j.cmet.2009.02.007
URL : http://doi.org/10.1016/j.cmet.2009.02.007
Islet ??-cell secretion determines glucagon release from neighbouring ??-cells, Nature Cell Biology, vol.5, issue.4, pp.330-335, 2003. ,
DOI : 10.1038/ncb951
??-Cell Secretory Products Activate ??-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release, Diabetes, vol.54, issue.6, pp.1808-1815, 2005. ,
DOI : 10.2337/diabetes.54.6.1808
Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in ??-Cells Inhibits Glucagon Secretion From Human Islets, Diabetes, vol.59, issue.9, pp.2198-2208, 2010. ,
DOI : 10.2337/db09-1505
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy, Nature Reviews Molecular Cell Biology, vol.367, issue.10, pp.774-785, 2007. ,
DOI : 10.1038/nrm2249
Structure of mammalian AMPK and its regulation by ADP, Nature, vol.50, issue.7342, pp.230-233, 2011. ,
DOI : 10.1038/nature09932
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome, Nature, vol.391, pp.184-187, 1998. ,
Calmodulin-dependent protein kinase kinase-?? is an alternative upstream kinase for AMP-activated protein kinase, Cell Metabolism, vol.2, issue.1, pp.9-19, 2005. ,
DOI : 10.1016/j.cmet.2005.05.009
Ca2+/calmodulin-dependent protein kinase kinase-?? acts upstream of AMP-activated protein kinase in mammalian cells, Cell Metabolism, vol.2, issue.1, pp.21-33, 2005. ,
DOI : 10.1016/j.cmet.2005.06.005
Mammalian TAK1 Activates Snf1 Protein Kinase in Yeast and Phosphorylates AMP-activated Protein Kinase in Vitro, Journal of Biological Chemistry, vol.281, issue.35, pp.25336-25343, 2006. ,
DOI : 10.1074/jbc.M604399200
The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 ?? cells, MIN6 beta cells, pp.5080-5091, 2010. ,
DOI : 10.1096/fj.10-166306
AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells, Diabetologia, vol.38, issue.Pt 3, pp.125-134, 2011. ,
DOI : 10.1007/s00125-010-1929-z
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression, The Proceedings of the National Academy of Sciences 97, pp.4023-4028, 2000. ,
DOI : 10.1073/pnas.97.8.4023
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression, Biochemical Journal, vol.371, issue.3, pp.761-774, 2003. ,
DOI : 10.1042/bj20021812
Metformin-induced stimulation of AMP-activated protein kinase in ??-cells impairs their glucose responsiveness and can lead to apoptosis, Biochemical Pharmacology, vol.68, issue.3, pp.409-416, 2004. ,
DOI : 10.1016/j.bcp.2004.04.003
Loss of Lkb1 in Adult ?? Cells Increases ?? Cell Mass and Enhances Glucose Tolerance in Mice, Cell Metabolism, vol.10, issue.4, pp.285-295, 2009. ,
DOI : 10.1016/j.cmet.2009.08.008
LKB1 Regulates Pancreatic ?? Cell Size, Polarity, and Function, Cell Metabolism, vol.10, issue.4, pp.296-308, 2009. ,
DOI : 10.1016/j.cmet.2009.08.010
URL : http://doi.org/10.1016/j.cmet.2009.08.010
LKB1 deletion with the RIP2.Cre transgene modifies pancreatic ??-cell morphology and enhances insulin secretion in vivo, AJP: Endocrinology and Metabolism, vol.298, issue.6, pp.1261-1273, 2010. ,
DOI : 10.1152/ajpendo.00100.2010
Loss of AMP-activated protein kinase ??2 subunit in mouse ??-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia, Biochemical Journal, vol.112, issue.2, pp.323-333, 2010. ,
DOI : 10.1210/10.1210/er.2006-0038
URL : https://hal.archives-ouvertes.fr/hal-00495491
Ablation of AMP-activated protein kinase ??1 and ??2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo, Diabetologia, vol.24, issue.5, pp.924-936, 2010. ,
DOI : 10.1007/s00125-010-1692-1
Conditional Gene Targeting in Mouse Pancreatic ??-Cells: Analysis of Ectopic Cre Transgene Expression in the Brain, Diabetes, vol.59, issue.12, pp.3090-3098, 2010. ,
DOI : 10.2337/db10-0624
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation, Nature, vol.99, issue.6903, pp.162-167, 2002. ,
DOI : 10.1038/35092592
Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages, Development, vol.127, pp.2317-2322, 2000. ,
The GluCre-ROSA26EYFP mouse: A new model for easy identification of living pancreatic ??-cells, FEBS Letters, vol.278, issue.22, pp.4235-4240, 2007. ,
DOI : 10.1016/j.febslet.2007.07.068
Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion, Diabetologia, vol.123, issue.9, pp.2445-2455, 2012. ,
DOI : 10.1007/s00125-012-2585-2
The AMP-activated protein kinase ??2 catalytic subunit controls whole-body insulin sensitivity, Journal of Clinical Investigation, vol.111, issue.1, pp.91-98, 2003. ,
DOI : 10.1172/JCI16567
Myosin Va Transports Dense Core Secretory Vesicles in Pancreatic MIN6 ??-Cells, Molecular Biology of the Cell, vol.16, issue.6, pp.2670-2680, 2005. ,
DOI : 10.1091/mbc.E04-11-1001
Normal Glucagon Signaling and ??-Cell Function After Near-Total ??-Cell Ablation in Adult Mice, Diabetes, vol.60, issue.11, pp.2872-2882, 2011. ,
DOI : 10.2337/db11-0876
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1, The EMBO Journal, vol.23, issue.4, pp.833-843, 2004. ,
DOI : 10.1038/sj.emboj.7600110
Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver, Diabetes, vol.54, issue.5, pp.1331-1339, 2005. ,
DOI : 10.2337/diabetes.54.5.1331
Glucagon and regulation of glucose metabolism, American Journal of Physiology - Endocrinology And Metabolism, vol.284, issue.4, pp.671-678, 2003. ,
DOI : 10.1152/ajpendo.00492.2002
Studies of pancreatic alpha cell function in normal and diabetic subjects, Journal of Clinical Investigation, vol.49, issue.4, pp.837-848, 1970. ,
DOI : 10.1172/JCI106297
mTOR Complex1???S6K1 signaling: at the crossroads of obesity, diabetes and cancer, Trends in Molecular Medicine, vol.13, issue.6, pp.252-259, 2007. ,
DOI : 10.1016/j.molmed.2007.04.002
Impact of lack of suppression of glucagon on glucose tolerance in humans, American Journal of Physiology, vol.277, pp.283-290, 1999. ,
Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia, Diabetologia, vol.52, issue.1, pp.142-150, 2007. ,
DOI : 10.1007/s00125-006-0481-3
Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice, Diabetes, vol.60, issue.2, pp.391-397, 2011. ,
DOI : 10.2337/db10-0426
Beta cell connectivity in pancreatic islets: a type 2 diabetes target? Cellular and Molecular Life Sciences, 2014. ,
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice, Disease Models & Mechanisms, vol.7, issue.11, pp.1275-1286, 2014. ,
DOI : 10.1242/dmm.014720
The Nutrition Transition: New Trends in the Global Diet, Nutrition Reviews, vol.55, issue.2, pp.31-43, 1997. ,
DOI : 10.1111/j.1753-4887.1997.tb01593.x
channels, The Journal of Physiology, vol.444, issue.3, pp.509-520, 2000. ,
DOI : 10.1111/j.1469-7793.2000.00509.x
A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic ??-cell, Cell Calcium, vol.35, issue.4, pp.357-365, 2004. ,
DOI : 10.1016/j.ceca.2003.10.002
Regulation of Net Hepatic Glucose Uptake in VIVO, Annual Review of Physiology, vol.54, issue.1, pp.847-860, 1992. ,
DOI : 10.1146/annurev.ph.54.030192.004215
Considerations in the Design of Hyperinsulinemic-Euglycemic Clamps in the Conscious Mouse, Diabetes, vol.55, issue.2, pp.390-397, 2006. ,
DOI : 10.2337/diabetes.55.02.06.db05-0686
AMP-activated protein kinase signaling in metabolic regulation, Journal of Clinical Investigation, vol.116, issue.7, pp.1776-1783, 2006. ,
DOI : 10.1172/JCI29044
Role of the Sik2-p35-Pja2 Complex in Pancreatic Beta Cell Functional Compensation, Canadian Journal of Diabetes, vol.37, pp.234-244, 2014. ,
DOI : 10.1016/j.jcjd.2013.08.020