Co-activation of AMPK and mTORC1 Induce Cytotoxicity in Acute Myeloid Leukemia
Résumé
Graphical Abstract Highlights d AMPK activation blocks AML propagation without toxicity to normal hematopoiesis d Cytotoxicity induced by an AMPK activator (GSK621) involves autophagy in AML d Co-activation of AMPK and mTORC1 is synthetically lethal in AML d AMPK and mTORC1 crosstalk requires eIF2a/ATF4 signaling
Domaines
Biochimie, Biologie Moléculaire
Origine : Fichiers éditeurs autorisés sur une archive ouverte
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