Effects of physical activity on cognitive functioning in middle age: evidence from the Whitehall II prospective cohort study.

Abstract : We examined the association between physical activity and cognitive functioning in middle age. Data were derived from a prospective occupational cohort study of 10308 civil servants aged 35-55 years at baseline (phase 1; 1985-1988). Physical activity level, categorized as low, medium, or high, was assessed at phases 1, 3 (1991-1994), and 5 (1997-1999). Cognitive functioning was tested at phase 5, when respondents were 46-68 years old. In both prospective (odds ratio [OR] = 1.65; 95% confidence interval [CI]=1.30, 2.10) and cross-sectional (OR=1.79; 95% CI=1.38, 2.32) analyses, low levels of physical activity were a risk factor for poor performance on a measure of fluid intelligence. Analyses aimed at assessing cumulative effects (summary of physical activity levels at the 3 time points) showed a graded linear relationship with fluid intelligence, with persistently low levels of physical activity being particularly harmful (OR=2.21; 95% CI=1.37, 3.57). Low levels of physical activity are a risk factor for cognitive functioning in middle age, fluid intelligence in particular.
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American Journal of Public Health, American Public Health Association, 2005, 95 (12), pp.2252-8. 〈10.2105/AJPH.2004.055574)〉
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Archana Singh-Manoux, Melvyn Hillsdon, Eric Brunner, Michael Marmot. Effects of physical activity on cognitive functioning in middle age: evidence from the Whitehall II prospective cohort study.. American Journal of Public Health, American Public Health Association, 2005, 95 (12), pp.2252-8. 〈10.2105/AJPH.2004.055574)〉. 〈inserm-01155214〉

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