Development of Targeted Microbubbles for Ultrasound Molecular Imaging of Breast Cancer

Abstract : A subtype of metastatic breast cancer has recently been identified, in which netrin-1 is over-expressed. Netrin-1 binds to dependence receptors inducing survival, while its absence actively triggers apoptosis. An anti-netrin-1 therapy is under development , which disrupts ligand-receptor interaction and induces apoptosis. To identify potential responders for such a targeted therapy, netrin-1 expression has to be analyzed. Molecular imaging with ultrasound (US) is able to detect the expression of a specific protein when using targeted contrast agents. Thus, we aim to develop an US molecular imaging approach using microbubbles (MB) functionalized with an anti-netrin-1 antibody. Binding was tested on purified netrin-1 protein in static and dynamic conditions. Anti-netrin-1 MB were validated in in-vitro assays and will be further tested in pre-clinical studies using metastatic breast cancer animal models.
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Communication dans un congrès
Journées RITS 2015, Mar 2015, Dourdan, France. Actes des Journées RITS 2015, pp 150-151, 2015
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Jennifer Wischhusen, Jean-Guy Delcros, Patrick Mehlen, Frédéric Padilla. Development of Targeted Microbubbles for Ultrasound Molecular Imaging of Breast Cancer. Journées RITS 2015, Mar 2015, Dourdan, France. Actes des Journées RITS 2015, pp 150-151, 2015. 〈inserm-01155018〉

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