Job strain as a risk factor for type 2 diabetes: a pooled analysis of 124,808 men and women.
Solja T Nyberg
(1)
,
Eleonor I Fransson
(2, 3)
,
Katriina Heikkilä
(1)
,
Kirsi Ahola
(1)
,
Lars Alfredsson
(4, 5)
,
Jakob B Bjorner
(6)
,
Marianne Borritz
(7)
,
Hermann Burr
(8)
,
Nico Dragano
(9)
,
Marcel Goldberg
(10)
,
Mark Hamer
(11)
,
Markus Jokela
(12, 13)
,
Anders Knutsson
(14)
,
Markku Koskenvuo
(15)
,
Aki Koskinen
(1)
,
Anne Kouvonen
(16, 17)
,
Constanze Leineweber
(18)
,
Ida E H Madsen
(6)
,
Linda L Magnusson Hanson
(18)
,
Michael G Marmot
(19)
,
Martin L Nielsen
(7)
,
Maria Nordin
(15)
,
Tuula Oksanen
(1)
,
Jan H Pejtersen
(20)
,
Jaana Pentti
(1)
,
Reiner Rugulies
(21, 6)
,
Paula Salo
(1, 22)
,
Johannes Siegrist
(9)
,
Andrew Steptoe
(19)
,
Sakari Suominen
(23, 24, 25)
,
Töres Theorell
(18)
,
Ari Väänänen
(1)
,
Jussi Vahtera
(1, 26, 27, 28)
,
Marianna Virtanen
(1)
,
Peter J M Westerholm
(29)
,
Hugo Westerlund
(18)
,
Marie Zins
(10)
,
G David Batty
(11, 30)
,
Eric J Brunner
(19)
,
Jane E Ferrie
(31, 32)
,
Archana Singh-Manoux
(10, 11)
,
Mika Kivimäki
(1, 19, 33)
1
Finnish Institute of Occupational Health
2 Institute of Environmental Medicine
3 School of Health Sciences
4 Institute of Environmental Medicine
5 Centre for Occupational and Environmental Medicine
6 National Research Centre for the Working Environment
7 Department of Occupational and Environmental Medicine
8 BAuA - Federal Institute for Occupational Safety and Health
9 Department of Medical Sociology
10 CESP - Centre de recherche en épidémiologie et santé des populations
11 Department of Epidemiology and Public Health
12 Finnish Institute of Occupational Health and Institute of Behavioral Sciences
13 IBS - Institute of Behavioural Sciences [Helsinki]
14 Department of Health Sciences
15 Department of Public Health
16 School of Sociology, Social Policy, & Social Work
17 UKCRC Centre of Excellence for Public Health (NI)
18 Stress Research Institute
19 Department of Epidemiology and Public Health
20 The Danish National Centre for Social Research
21 Department of Public Health [Copenhagen]
22 Department of Psychology
23 Folkhälsan Research Center
24 Department of Public Health
25 Nordic School of Public Health
26 Department of Public Health
27 Finnisth Institute of Occupational Health
28 TYKS - Turku University Hospital
29 Occupational and Environmental Medicine
30 Centre for Cognitive Ageing and Cognitive Epidemiology
31 Department of Epidemiology and Public Health
32 School of Community and Social Medicine
33 Department of Public Health [Helsinki]
2 Institute of Environmental Medicine
3 School of Health Sciences
4 Institute of Environmental Medicine
5 Centre for Occupational and Environmental Medicine
6 National Research Centre for the Working Environment
7 Department of Occupational and Environmental Medicine
8 BAuA - Federal Institute for Occupational Safety and Health
9 Department of Medical Sociology
10 CESP - Centre de recherche en épidémiologie et santé des populations
11 Department of Epidemiology and Public Health
12 Finnish Institute of Occupational Health and Institute of Behavioral Sciences
13 IBS - Institute of Behavioural Sciences [Helsinki]
14 Department of Health Sciences
15 Department of Public Health
16 School of Sociology, Social Policy, & Social Work
17 UKCRC Centre of Excellence for Public Health (NI)
18 Stress Research Institute
19 Department of Epidemiology and Public Health
20 The Danish National Centre for Social Research
21 Department of Public Health [Copenhagen]
22 Department of Psychology
23 Folkhälsan Research Center
24 Department of Public Health
25 Nordic School of Public Health
26 Department of Public Health
27 Finnisth Institute of Occupational Health
28 TYKS - Turku University Hospital
29 Occupational and Environmental Medicine
30 Centre for Cognitive Ageing and Cognitive Epidemiology
31 Department of Epidemiology and Public Health
32 School of Community and Social Medicine
33 Department of Public Health [Helsinki]
Solja T Nyberg
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Marcel Goldberg
- Fonction : Auteur
- PersonId : 756730
- ORCID : 0000-0002-6161-5880
- IdRef : 028740637
Mark Hamer
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- PersonId : 765702
- ORCID : 0000-0002-8726-7992
Marie Zins
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- PersonId : 756219
- ORCID : 0000-0002-4540-4282
- IdRef : 074613324
Archana Singh-Manoux
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- PersonId : 756221
- ORCID : 0000-0002-1244-5037
- IdRef : 136768229
Mika Kivimäki
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Résumé
The status of psychosocial stress at work as a risk factor for type 2 diabetes is unclear because existing evidence is based on small studies and is subject to confounding by lifestyle factors, such as obesity and physical inactivity. This collaborative study examined whether stress at work, defined as "job strain," is associated with incident type 2 diabetes independent of lifestyle factors. We extracted individual-level data for 124,808 diabetes-free adults from 13 European cohort studies participating in the IPD-Work Consortium. We measured job strain with baseline questionnaires. Incident type 2 diabetes at follow-up was ascertained using national health registers, clinical screening, and self-reports. We analyzed data for each study using Cox regression and pooled the study-specific estimates in fixed-effect meta-analyses. There were 3,703 cases of incident diabetes during a mean follow-up of 10.3 years. After adjustment for age, sex, and socioeconomic status (SES), the hazard ratio (HR) for job strain compared with no job strain was 1.15 (95% CI 1.06-1.25) with no difference between men and women (1.19 [1.06-1.34] and 1.13 [1.00-1.28], respectively). In stratified analyses, job strain was associated with an increased risk of diabetes among those with healthy and unhealthy lifestyle habits. In a multivariable model adjusted for age, sex, SES, and lifestyle habits, the HR was 1.11 (1.00-1.23). Findings from a large pan-European dataset suggest that job strain is a risk factor for type 2 diabetes in men and women independent of lifestyle factors.
Domaines
Santé publique et épidémiologie
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Nyberg et al. Job_strain_diabetes Diabetes Care.pdf (853.66 Ko)
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