A. Key-4-i, H. C. Heim, N. H. Kalin, M. E. Thurow, M. A. Rosenkranz et al., 4-I; CAR, cortisol awakening response; CI, confidence interval; M, mean; REF, reference; SD, standard deviation. a Cognitive data have been converted to z-scores for the analysis Cortisol variation in humans affects memory for emotionally laden and neutral information, References Abercrombie, Behav. Neurosci, vol.117, pp.505-516, 2003.

E. K. Adam and M. Kumari, Assessing salivary cortisol in large-scale, epidemiological research, Psychoneuroendocrinology, vol.34, issue.10, 2009.
DOI : 10.1016/j.psyneuen.2009.06.011

I. Beluche, I. Carriere, K. Ritchie, and M. L. Ancelin, A prospective study of diurnal cortisol and cognitive function in community-dwelling elderly people, Psychological Medicine, vol.48, issue.06, 2010.
DOI : 10.1192/bjp.123.4.467

URL : https://hal.archives-ouvertes.fr/inserm-00489050

H. Braak and T. K. Del, The pathological process underlying Alzheimer???s disease in individuals under thirty, Acta Neuropathologica, vol.24, issue.Suppl. 1, pp.171-181, 2011.
DOI : 10.1007/s00401-010-0789-4

T. W. Buchanan and W. R. Lovallo, Enhanced memory for emotional material following stress-level cortisol treatment in humans, Psychoneuroendocrinology, vol.26, issue.3, pp.307-317, 2001.
DOI : 10.1016/S0306-4530(00)00058-5

R. J. Caselli, A. C. Dueck, D. Osborne, M. N. Sabbagh, D. J. Connor et al., ??4 Effect, New England Journal of Medicine, vol.361, issue.3, pp.255-263, 2009.
DOI : 10.1056/NEJMoa0809437

E. H. Corder, A. M. Saunders, W. J. Strittmatter, D. E. Schmechel, P. C. Gaskell et al., Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, Science, vol.261, issue.5123, pp.921-923, 1993.
DOI : 10.1126/science.8346443

J. G. Csernansky, H. Dong, A. M. Fagan, L. Wang, C. Xiong et al., Plasma Cortisol and Progression of Dementia in Subjects With Alzheimer-Type Dementia, American Journal of Psychiatry, vol.163, issue.12, 2006.
DOI : 10.1176/ajp.2006.163.12.2164

A. Sr, R. B. Vasan, R. S. Pencina, M. J. Wolf, P. A. Cobain et al., General cardiovascular risk profile for use in primary care: the Framingham Heart Study, Circulation, vol.117, pp.743-753, 2008.

E. Elgh, A. A. Lindqvist, M. Fagerlund, S. Eriksson, T. Olsson et al., Cognitive Dysfunction, Hippocampal Atrophy and Glucocorticoid Feedback in Alzheimer???s Disease, Biological Psychiatry, vol.59, issue.2, pp.155-161, 2006.
DOI : 10.1016/j.biopsych.2005.06.017

A. J. Fiocco, N. Wan, N. Weekes, H. Pim, and S. J. Lupien, Diurnal cycle of salivary cortisol in older adult men and women with subjective complaints of memory deficits and/or depressive symptoms: Relation to cognitive functioning, Stress, vol.17, issue.1, pp.143-152, 2006.
DOI : 10.1001/archneur.1997.00550180064014

C. E. Franz, R. C. O-'brien, R. L. Hauger, S. P. Mendoza, M. S. Panizzon et al., Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging, Psychoneuroendocrinology, vol.36, issue.7, 2011.
DOI : 10.1016/j.psyneuen.2011.01.002

L. Gerritsen, H. C. Comijs, D. J. Deeg, B. W. Penninx, and M. I. Geerlings, Salivary cortisol, APOE-epsilon4 allele and cognitive decline in a prospective study of older persons, Neurobiol. Aging, vol.32, 2011.

A. Hartmann, J. D. Veldhuis, M. Deuschle, H. Standhardt, and I. Heuser, Twenty-Four Hour Cortisol Release Profiles in Patients With Alzheimer's and Parkinson's Disease Compared to Normal Controls: Ultradian Secretory Pulsatility and Diurnal Variation, Neurobiology of Aging, vol.18, issue.3, pp.285-289, 1997.
DOI : 10.1016/S0197-4580(97)80309-0

A. W. Heim, AH 4 Group Test of General Intelligence, 1970.

C. Hoschl and T. Hajek, Hippocampal damage mediated by corticosteroids ??? a neuropsychiatric research challenge, European Archives of Psychiatry and Clinical Neuroscience, vol.34, issue.Suppl 1, pp.81-88, 2001.
DOI : 10.1007/BF03035134

A. M. Issa, W. Rowe, S. Gauthier, and M. J. Meaney, Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats, 1990.

J. Jr, C. R. Knopman, D. S. Jagust, W. J. Shaw, L. M. Aisen et al., Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade, Lancet Neurol, vol.9, pp.119-128, 2010.

L. Jacobson and R. Sapolsky, The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*, Endocrine Reviews, vol.12, issue.2, pp.118-134, 1991.
DOI : 10.1210/edrv-12-2-118

S. Kalmijn, L. J. Launer, R. P. Stolk, F. H. De-jong, H. A. Pols et al., A Prospective Study on Cortisol, Dehydroepiandrosterone Sulfate, and Cognitive Function in the Elderly, The Journal of Clinical Endocrinology & Metabolism, vol.83, issue.10, pp.3487-3492, 1998.
DOI : 10.1210/jcem.83.10.5164

A. S. Karlamangla, B. H. Singer, J. Chodosh, B. S. Mcewen, and T. E. Seeman, Urinary cortisol excretion as a predictor of incident cognitive impairment, Neurobiology of Aging, vol.26, issue.1, pp.80-84, 2005.
DOI : 10.1016/j.neurobiolaging.2005.09.037

C. Kirschbaum and D. H. Hellhammer, Salivary Cortisol in Psychobiological Research: An Overview, Neuropsychobiology, vol.22, issue.3, pp.150-169, 1989.
DOI : 10.1159/000118611

C. Kirschbaum and D. H. Hellhammer, Salivary cortisol in psychoneuroendocrine research: Recent developments and applications, Psychoneuroendocrinology, vol.19, issue.4, pp.313-333, 1994.
DOI : 10.1016/0306-4530(94)90013-2

S. Kuhlmann and O. T. Wolf, Arousal and Cortisol Interact in Modulating Memory Consolidation in Healthy Young Men., Behavioral Neuroscience, vol.120, issue.1, pp.217-223, 2006.
DOI : 10.1037/0735-7044.120.1.217

N. M. Laird and J. H. Ware, Random-Effects Models for Longitudinal Data, Biometrics, vol.38, issue.4, pp.963-974, 1982.
DOI : 10.2307/2529876

B. K. Lee, T. A. Glass, G. S. Wand, M. J. Mcatee, K. Bandeen-roche et al., Apolipoprotein E Genotype, Cortisol, and Cognitive Function in Community-Dwelling Older Adults, American Journal of Psychiatry, vol.165, issue.11, 2008.
DOI : 10.1176/appi.ajp.2008.07091532

S. Lupien, A. R. Lecours, I. Lussier, G. Schwartz, N. P. Nair et al., Basal cortisol levels and cognitive deficits in human aging, J. Neurosci, vol.14, 1994.

S. J. Lupien, L. M. De, S. S. De, A. Convit, C. Tarshish et al., Cortisol levels during human aging predict hippocampal atrophy and memory deficits, Nature Neuroscience, vol.1, issue.1, pp.69-73, 1998.
DOI : 10.1038/271

A. M. Maclullich, I. J. Deary, J. M. Starr, K. J. Ferguson, J. M. Wardlaw et al., Plasma cortisol levels, brain volumes and cognition in healthy elderly men, Psychoneuroendocrinology, vol.30, issue.5, pp.505-515, 2005.
DOI : 10.1016/j.psyneuen.2004.12.005

M. Marmot and E. Brunner, Cohort Profile: The Whitehall II study, International Journal of Epidemiology, vol.34, issue.2, pp.251-256, 2005.
DOI : 10.1093/ije/dyh372

B. S. Mcewen, E. R. De-kloet, and W. Rostene, Adrenal steroid receptors and actions in the nervous system, Physiol. Rev, vol.66, 1986.

M. F. Montaron, E. Drapeau, D. Dupret, P. Kitchener, C. Aurousseau et al., Lifelong corticosterone level determines age-related decline in neurogenesis and memory, Neurobiology of Aging, vol.27, issue.4, pp.645-654, 2006.
DOI : 10.1016/j.neurobiolaging.2005.02.014

J. C. Pruessner, C. Kirschbaum, G. Meinlschmid, and D. H. Hellhammer, Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change, Psychoneuroendocrinology, vol.28, issue.7, pp.916-931, 2003.
DOI : 10.1016/S0306-4530(02)00108-7

L. Radloff, The CES-D Scale: A Self-Report Depression Scale for Research in the General Population, Applied Psychological Measurement, vol.1, issue.3, pp.385-401, 1997.
DOI : 10.1177/014662167700100306

M. M. Sanchez, L. J. Young, P. M. Plotsky, and T. R. Insel, Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation, J. Neurosci, vol.20, pp.4657-4668, 2000.

R. M. Sapolsky, L. C. Krey, and B. S. Mcewen, The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*, Endocrine Reviews, vol.7, issue.3, pp.284-301, 1986.
DOI : 10.1210/edrv-7-3-284

R. M. Sapolsky, L. M. Romero, and A. U. Munck, How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions, Endocrine Reviews, vol.21, issue.1, pp.55-89, 2000.
DOI : 10.1210/er.21.1.55

E. M. Schrijvers, N. Direk, P. J. Koudstaal, C. Kirschbaum, A. Hofman et al., Associations of serum cortisol with cognitive function and dementia: the Rotterdam Study, J. Alzheimers Dis, vol.25, pp.671-677, 2011.

T. E. Seeman, B. S. Mcewen, B. H. Singer, M. S. Albert, and J. W. Rowe, Increase in Urinary Cortisol Excretion and Memory Declines: MacArthur Studies of Successful Aging, Journal of Clinical Endocrinology & Metabolism, vol.82, issue.8, 1997.
DOI : 10.1210/jc.82.8.2458

M. N. Starkman, S. S. Gebarski, S. Berent, and D. E. Schteingart, Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome, Biological Psychiatry, vol.32, issue.9, pp.756-765, 1992.
DOI : 10.1016/0006-3223(92)90079-F

R. S. Stawski, D. M. Almeida, M. E. Lachman, P. A. Tun, C. B. Rosnick et al., Associations Between Cognitive Function and Naturally Occurring Daily Cortisol During Middle Adulthood: Timing Is Everything, The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, vol.66, issue.Supplement 1, 2011.
DOI : 10.1093/geronb/gbq094

J. B. Toledo, E. Toledo, M. W. Weiner, J. Jr, C. R. Jagust et al., Cardiovascular risk factors, cortisol, and amyloid-?? deposition in Alzheimer's Disease Neuroimaging Initiative, Alzheimer's & Dementia, vol.8, issue.6, pp.483-489, 2012.
DOI : 10.1016/j.jalz.2011.08.008

R. F. Vining, R. A. Mcginley, J. J. Maksvytis, and K. Y. Ho, Salivary Cortisol: A Better Measure of Adrenal Cortical Function than Serum Cortisol, Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine, vol.20, issue.6, pp.329-335, 1983.
DOI : 10.1177/000456328302000601

M. F. Weiner, S. Vobach, K. Olsson, D. Svetlik, and R. C. Risser, Cortisol Secretion and Alzheimer???s Disease Progression, Biological Psychiatry, vol.42, issue.11, 1997.
DOI : 10.1016/S0006-3223(97)00165-0

O. T. Wolf, A. Convit, E. Thorn, and M. J. De-leon, Salivary cortisol day profiles in elderly with mild cognitive impairment, Psychoneuroendocrinology, vol.27, issue.7, pp.777-789, 2002.
DOI : 10.1016/S0306-4530(01)00079-8