EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue European Journal of Epidemiology Année : 2006

EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries.

1 Department of Public Health & Primary Care
2 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
3 Department of Clinical Sciences
4 Division of Human Nutrition
5 Department of Clinical Epidemiology
6 Department of Clinical and Experimental Medicine
7 Plasmon Nano-optics
8 E3N - Nutrition, hormones et cancer: épidémiologie et prévention
9 INSERM UNIT 780: Epidemiology and biostatistics
10 Division of Cancer Epidemiology
11 Department of Epidemiology
12 Institute of Cancer Epidemiology, Danish Cancer Society
13 Centre for Ice and Climate [Copenhagen]
14 Public Health and Health Planning Directorate
15 ICO - Catalan Institute of Oncology = Instituto Catalán de Oncología
16 MATEIS - Matériaux, ingénierie et science [Villeurbanne]
17 Public Health Department of Gipuzkoa
18 LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris
19 Public Health Institute of Navarra
20 MRC Centrer for Nutritional Epidemiology and Cancer Prevention and Survival
21 Clinical Gerontology Unit
22 MRC epidemiology Unit
23 Cancer Epidemiology Unit
24 Cancer Research UK Epidemiology Unit
25 Department of Hygiene, Epidemiology and Medical Statistics
26 WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene
27 ISPO - Molecular and Nutritional Epidemiology Unit
28 Nutritional Epidemiology Unit
29 Cancer Registry and Histopathology Unit
30 CPO Piemonte - Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica in Piemonte = Center for Cancer Prevention-Piemonte
31 Department of Clinical and Experimental Medicine
32 RIVM - National Institute for Public Health and the Environment [Bilthoven]
33 Julius Center for Health Sciences and Primary Care
34 University Medical Center [Utrecht]
35 Department of Medecine, Skellefteå Hospital
36 Institute of Community Medicine University of Tromsø
37 CRPA - Centro Ricerche Produzioni Animali
38 Dietary Exposure Assessment Grp
39 School of Public Health
40 Department of Epidemiology and Biostatistics
Edith Feskens
Tobias Pischon
Sabina Sieri
Rosario Tumino
Göran Hallmans
  • Fonction : Auteur
Eiliv Lund
  • Fonction : Auteur
Guri Skeie
Elio Riboli

Résumé

EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition (EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle (especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants (366,521 women and 153,457 men, mostly aged 35-70 years) in 23 centres in 10 European countries commenced follow-up for cause- specific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors.
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Dates et versions

inserm-01149104 , version 1 (06-05-2015)

Identifiants

  • HAL Id : inserm-01149104 , version 1
  • PUBMED : 17295097

Citer

John Danesh, Rodolfo Saracci, Göran Berglund, Edith Feskens, Kim Overvad, et al.. EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries.. European Journal of Epidemiology, 2006, 22 (2), pp.129-41. ⟨inserm-01149104⟩
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