Change in fast walking speed preceding death: results from a prospective longitudinal cohort study.

Abstract : Walking speed (WS) predicts mortality. However, it is unclear if decline in WS increases prior to death. We examined whether (a) WS declined faster in persons who died during the follow-up compared with those who remained alive and (b) adding change in WS to a model including age, sex, and baseline WS improved prediction of mortality. Data are from 4,016 participants of the Dijon center of the Three-City study (France), aged 65-85 years. Fast WS (FWS) was measured up to five times over a 12-year period. Mortality was ascertained until 2012. Linear mixed models using a backward time scale showed that FWS declined faster in 908 participants who died during the follow-up (annual change = -0.031 m/s) than in those who survived (-0.021 m/s), corresponding to a difference of -0.009 (95% confidence interval = -0.013 to -0.005) m/s. Compared with "normal" change in FWS (annual change ≥-0.04 m/s), "substantial" decline (<-0.08 m/s) was associated with a 1.4-fold greater risk of mortality (hazards ratio = 1.40, confidence interval = 1.02-1.92) and small decline (-0.08 to -0.04 m/s) with a 1.2-fold greater risk (hazards ratio = 1.18, confidence interval = 0.89-1.57). The net reclassification index when adding these categories of change in FWS to the model adjusted for age, sex, and baseline FWS was 19.0% (0.6, 36.8%). Participants who died during the follow-up had a steeper decline in FWS than the others. Both baseline FWS and FWS decline predict mortality.
Type de document :
Article dans une revue
Journals of Gerontology, Series A, Oxford University Press (OUP): Policy B - Oxford Open Option D, 2014, 69 (3), pp.354-62. 〈10.1093/gerona/glt114〉
Liste complète des métadonnées

Littérature citée [40 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01148001
Contributeur : Pascale Sztajnbok <>
Soumis le : lundi 4 mai 2015 - 09:18:06
Dernière modification le : mercredi 8 février 2017 - 01:07:20
Document(s) archivé(s) le : lundi 14 septembre 2015 - 17:56:32

Fichier

Sabia_JGerontolA_Biol_Sci_Med_...
Publication financée par une institution

Identifiants

Collections

Citation

Séverine Sabia, Julien Dumurgier, Béatrice Tavernier, Jenny Head, Christophe Tzourio, et al.. Change in fast walking speed preceding death: results from a prospective longitudinal cohort study.. Journals of Gerontology, Series A, Oxford University Press (OUP): Policy B - Oxford Open Option D, 2014, 69 (3), pp.354-62. 〈10.1093/gerona/glt114〉. 〈inserm-01148001〉

Partager

Métriques

Consultations de la notice

130

Téléchargements de fichiers

105