Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study.

Abstract : Inflammatory processes are putative mechanisms underlying the cardioprotective effects of physical activity. An inverse association between physical activity and inflammation has been demonstrated, but no long-term prospective data are available. We therefore examined the association between physical activity and inflammatory markers over a 10-year follow-up period. Participants were 4289 men and women (mean age, 49.2 years) from the Whitehall II cohort study. Self-reported physical activity and inflammatory markers (serum high-sensitivity C-reactive protein and interleukin-6) were measured at baseline (1991) and follow-up (2002). Forty-nine percent of the participants adhered to standard physical activity recommendations for cardiovascular health (2.5 h/wk moderate to vigorous physical activity) across all assessments. Physically active participants at baseline had lower C-reactive protein and interleukin-6 levels, and this difference remained stable over time. Compared with participants who rarely adhered to physical activity guidelines over the 10-year follow-up, the high-adherence group displayed lower log(e) C-reactive protein (β=-0.07; 95% confidence interval, -0.12 to -0.02) and log(e) interleukin-6 (β=-0.07; 95% confidence interval, -0.10 to -0.03) at follow-up after adjustment for a range of covariates. Compared with participants who remained stable, those who reported an increase in physical activity of at least 2.5 h/wk displayed lower log(e) C-reactive protein (β coefficient=-0.05; 95% confidence interval, -0.10 to -0.001) and log(e) interleukin-6 (β coefficient=-0.06; 95% confidence interval, -0.09 to -0.03) at follow-up. Regular physical activity is associated with lower markers of inflammation over 10 years of follow-up and thus may be important in preventing the proinflammatory state seen with aging.
Type de document :
Article dans une revue
Circulation, American Heart Association, 2012, 126 (8), pp.928-33. 〈10.1161/CIRCULATIONAHA.112.103879〉
Liste complète des métadonnées

Littérature citée [27 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01147305
Contributeur : Pascale Sztajnbok <>
Soumis le : jeudi 30 avril 2015 - 10:12:07
Dernière modification le : vendredi 17 février 2017 - 14:30:34
Document(s) archivé(s) le : lundi 14 septembre 2015 - 16:12:01

Fichier

 Accès restreint
Fichier visible le : jamais

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

Citation

Mark Hamer, Severine Sabia, G David Batty, Martin Shipley, Adam Tabák, et al.. Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study.. Circulation, American Heart Association, 2012, 126 (8), pp.928-33. 〈10.1161/CIRCULATIONAHA.112.103879〉. 〈inserm-01147305〉

Partager

Métriques

Consultations de la notice

177