Crypt architecture is one of the most significant histological features used for the examination of colorectal biopsy specimens enabling clinical decisions in the investigation of Inflammatory Bowel Diseases. However , the architecture modelling remains a challenging problem leading to variability in reporting and subjectiv-ity in pathological examination. In this context, intestinal gland detection represent a necessary step before a clinical study of their architecture. This work presents a graph-based technique describing spatial relationships over sparse structures for crypt detection using morphological mesh filtering operators.