, Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis, Lancet Circulation Circulation Feb Bmj, vol.362112115336, issue.2077655, pp.428-323495, 2003.
, Biological effects of estradiol-17 beta in postmenopausal women: oral versus percutaneous administration Differential effects of oral and transdermal estrogen/progesterone regimens on sensitivity to activated protein C among postmenopausal women: a randomized trial, J Clin Endocrinol Metab Arterioscler Thromb Vasc Biol, vol.62238, issue.39, pp.536-411671, 1986.
, Coagulation activation following estrogen administration to postmenopausal women Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women, Thromb Haemost, vol.68, issue.4, pp.392-397, 1992.
, Synergism between Oral Estrogen Therapy and Cytochrome P450 3A5*1 Allele on the Risk of Venous Thromboembolism among Postmenopausal Women, The Journal of Clinical Endocrinology & Metabolism, vol.93, issue.8, pp.3082-3089, 2008.
DOI : 10.1210/jc.2008-0450
URL : https://hal.archives-ouvertes.fr/inserm-01148136
, Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray, Cancer Res, vol.62, issue.18, pp.5196-203, 2002.
, Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury, The FASEB Journal, vol.21, issue.9, pp.2237-2283, 2007.
DOI : 10.1096/fj.06-7759com
, Genetic Variations and Haplotype Structures of Transcriptional Pactor Nrf2 and Its Cytosolic Reservoir Protein Keap1 in Japanese, Drug Metabolism and Pharmacokinetics, vol.22, issue.3, pp.212-221, 2007.
DOI : 10.2133/dmpk.22.212
, Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1, Molecular and Cellular Biology, vol.26, issue.1, pp.221-230, 2006.
DOI : 10.1128/MCB.26.1.221-229.2006
, Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene, Proceedings of the National Academy of Sciences of the United States of America, pp.14960-14965, 1996.
DOI : 10.1073/pnas.93.25.14960
, Gene expression profiling of NRF2-mediated protection against oxidative injury. Free radical biology & medicine, Feb, vol.138, issue.3, pp.325-368, 2005.
, Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice, Proceedings of the National Academy of Sciences, vol.98, issue.6, pp.3410-3415, 2001.
DOI : 10.1073/pnas.051618798
, An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen, Proceedings of the National Academy of Sciences, vol.98, issue.8, pp.4611-4617, 2001.
DOI : 10.1073/pnas.081082098
, Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. The Journal of experimental medicine, pp.47-59, 2005.
, Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2. The American journal of pathology, 2006.
, Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circulation research, pp.723-756, 2007.
, The antioxidant responsive element Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity, J Biol Chem, vol.266, issue.18, pp.11632-11641, 1991.
, Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence, Biochemical Journal, vol.374, issue.2, pp.337-385, 2003.
DOI : 10.1042/bj20030754
, Estrogen metabolism by conjugation, Journal of the National Cancer Institute, issue.27, pp.113-137, 2000.
DOI : 10.1093/oxfordjournals.jncimonographs.a024234
URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.2848
, Effects of the route of oestrogen administration on IGF-1 and IGFBP-3 in healthy postmenopausal women: results from a randomized placebo-controlled study, Clinical Endocrinology, vol.45, issue.5, pp.626-657, 2007.
DOI : 10.1016/S0015-0282(00)01691-5
URL : https://hal.archives-ouvertes.fr/hal-00688275
, 4-Hydroxyestradiol Induces Anchorage-Independent Growth of Human Mammary Epithelial Cells via Activation of I??B Kinase: Potential Role of Reactive Oxygen Species, Cancer Research, vol.69, issue.6, pp.2416-2440, 2009.
DOI : 10.1158/0008-5472.CAN-08-2177
, Repression of cancer protective genes by 17??-estradiol: Ligand-dependent interaction between human Nrf2 and estrogen receptor ??, Molecular and Cellular Endocrinology, vol.243, issue.1-2, pp.27-34, 2005.
DOI : 10.1016/j.mce.2005.08.002
, Cardiovascular Risk Factors and Venous Thromboembolism: A Meta-Analysis, Circulation, vol.117, issue.1, pp.93-102, 2008.
DOI : 10.1161/CIRCULATIONAHA.107.709204
, Oxidative stress and metabolic syndrome. Life sciences, 2009.
, admission date b Further adjusted for obesity, family history of Vte and varicose veins Test for interaction between oral estrogen use and genetic mutation of NRF2 was significant (p=0.01) Test for interaction between transdermal estrogen use and genetic mutation of NRF2 was not significant, p=0.13) Variables Cases (n=161) Controls (n=474) OR (95% CI