I. U987 and I. Laboratoire-d-'excellence, Simone Veil, Versailles Saint Quentin en Yvelines Université, Montigny-Le-Bretonneux 78180, France. 3 Rheumatology Division, Ambroise Paré Hospital (AP-HP). 5 Antigen Presentation by Dendritic Cell Team

I. Cochin, I. U1016, and . Cnrs, Université Paris-Descartes, Sorbonne Paris-Cité 75014, France. 6 Duke-NUS Graduate Medical School, Program in Emerging Infectious Disease

F. Costantino, A. Talpin, R. Said-nahal, M. Goldberg, J. Henny et al., Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort, Annals of the Rheumatic Diseases, vol.81, issue.4, pp.10-1136, 2013.
DOI : 10.1136/annrheumdis-2013-204436

J. Smith, M. Barnes, D. Hong, M. Delay, R. Inman et al., Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-?? dysregulation, Arthritis & Rheumatism, vol.29, issue.6, pp.1640-1649, 2008.
DOI : 10.1002/art.23512

J. Gu, Y. Wei, J. Wei, F. Huang, M. Jan et al., Identification of RGS1 as a candidate biomarker for undifferentiated spondylarthritis by genome-wide expression profiling and real-time polymerase chain reaction, Arthritis & Rheumatism, vol.27, issue.11, pp.3269-3279, 2009.
DOI : 10.1002/art.24968

R. Duan, P. Leo, L. Bradbury, M. Brown, and G. Thomas, Gene expression profiling reveals a downregulation in immune-associated genes in patients with AS, Annals of the Rheumatic Diseases, vol.69, issue.9, pp.1724-1729, 2010.
DOI : 10.1136/ard.2009.111690

S. Assassi, J. Reveille, F. Arnett, M. Weisman, M. Ward et al., Whole-blood Gene Expression Profiling in Ankylosing Spondylitis Shows Upregulation of Toll-like Receptor 4 and 5, The Journal of Rheumatology, vol.38, issue.1, pp.87-98, 2011.
DOI : 10.3899/jrheum.100469

F. Pimentel-santos, D. Ligeiro, M. Matos, A. Mourão, J. Costa et al., Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects, Arthritis Research & Therapy, vol.13, issue.2, p.57, 2011.
DOI : 10.4049/jimmunol.0903938

S. Sharma, D. Choi, S. Planck, C. Harrington, C. Austin et al., Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles, Arthritis Research & Therapy, vol.11, issue.6, p.168, 2009.
DOI : 10.1186/ar2855

M. Breban, C. Hacquard-bouder, and G. Falgarone, Animal Models of HLA-B27-Associated Diseases, Current Molecular Medicine, vol.4, issue.1, pp.31-40, 2004.
DOI : 10.2174/1566524043479347

C. Hacquard-bouder, G. Falgarone, A. Bosquet, F. Smaoui, D. Monnet et al., Defective costimulatory function is a striking feature of antigen-presenting cells in an HLA-B27-transgenic rat model of spondylarthropathy, Arthritis & Rheumatism, vol.30, issue.5, pp.1624-1635, 2004.
DOI : 10.1002/art.20211

C. Hacquard-bouder, M. Chimenti, B. Giquel, E. Donnadieu, I. Fert et al., Alteration of antigen-independent immunologic synapse formation between dendritic cells from HLA???B27???transgenic rats and CD4+ T cells: Selective impairment of costimulatory molecule engagement by mature HLA???B27, Arthritis & Rheumatism, vol.41, issue.5, pp.1478-1489, 2007.
DOI : 10.1002/art.22572

S. Glatigny, I. Fert, M. Blaton, R. Lories, L. Araujo et al., Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats, Arthritis & Rheumatism, vol.60, issue.Suppl, pp.110-120, 2012.
DOI : 10.1002/art.33321

L. Utriainen, D. Firmin, P. Wright, V. Cerovic, M. Breban et al., Expression of HLA-B27 causes loss of migratory dendritic cells in a rat model of spondylarthritis, Arthritis & Rheumatism, vol.107, issue.Suppl 1, pp.3199-3209, 2012.
DOI : 10.1002/art.34561

L. Araujo, I. Fert, Q. Jouhault, K. Labroquère, M. Andrieu et al., Increased production of interleukin-17 over interleukin-10 by regulatory T cells implicates ICOS molecule in experimental spondyloarthritis, Arthritis Rheum, 2014.

M. Rudwaleit, D. Van-der-heijde, R. Landewé, J. Listing, N. Akkoc et al., The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection, Annals of the Rheumatic Diseases, vol.68, issue.6, pp.777-783, 2009.
DOI : 10.1136/ard.2009.108233

C. Dutertre, S. Amraoui, A. Derosa, J. Jourdain, L. Vimeux et al., Pivotal role of M-DC8+ monocytes from viremic HIV-infected patients in TNF?? overproduction in response to microbial products, Blood, vol.120, issue.11, pp.2259-2268, 2012.
DOI : 10.1182/blood-2012-03-418681

L. Gautier, L. Cope, B. Bolstad, and R. Irizarry, affy--analysis of Affymetrix GeneChip data at the probe level, Bioinformatics, vol.20, issue.3, pp.307-315, 2004.
DOI : 10.1093/bioinformatics/btg405

M. Dai, P. Wang, A. Boyd, G. Kostov, B. Athey et al., Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data, Nucleic Acids Research, vol.33, issue.20, pp.175-175, 2005.
DOI : 10.1093/nar/gni179

G. Smyth, Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments, Statistical Applications in Genetics and Molecular Biology, vol.3, issue.1, 2004.
DOI : 10.2202/1544-6115.1027

C. Plessy, L. Desbois, T. Fujii, and P. Carninci, Population transcriptomics with single-cell resolution: A new field made possible by microfluidics, BioEssays, vol.9, issue.2, pp.131-140, 2013.
DOI : 10.1002/bies.201200093
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583089

I. Fert, N. Cagnard, S. Glatigny, F. Letourneur, S. Jacques et al., Reverse Interferon Signature Is Characteristic of Antigen-Presenting Cells in Human and Rat Spondyloarthritis, Arthritis & Rheumatology, vol.13, issue.Suppl, pp.841-851, 2014.
DOI : 10.1002/art.38318

J. Zhu and D. Yu, Matrix metalloproteinase expression in the spondyloarthropathies, Current Opinion in Rheumatology, vol.18, issue.4, pp.364-368, 2006.
DOI : 10.1097/01.bor.0000231904.04548.09

W. Maksymowych, R. Landewé, B. Conner-spady, M. Dougados, H. Mielants et al., Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis, Arthritis & Rheumatism, vol.38, issue.6, pp.1846-1853, 2007.
DOI : 10.1002/art.22589

D. Mattey, J. Packham, N. Nixon, L. Coates, P. Creamer et al., Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis, Arthritis Research & Therapy, vol.14, issue.3, p.127, 2012.
DOI : 10.1093/rheumatology/keh317

L. Kevorkian, D. Young, C. Darrah, S. Donell, L. Shepstone et al., Expression profiling of metalloproteinases and their inhibitors in cartilage, Arthritis & Rheumatism, vol.102, issue.1, pp.131-141, 2004.
DOI : 10.1002/art.11433

J. Bragança, T. Swingler, F. Marques, T. Jones, J. Eloranta et al., Human CREB-binding Protein/p300-interacting Transactivator with ED-rich Tail (CITED) 4, a New Member of the CITED Family, Functions as a Co-activator for Transcription Factor AP-2, Journal of Biological Chemistry, vol.277, issue.10, pp.8559-8565, 2002.
DOI : 10.1074/jbc.M110850200

X. Lou, S. Sun, W. Chen, Y. Zhou, Y. Huang et al., Negative Feedback Regulation of NF-??B Action by CITED2 in the Nucleus, The Journal of Immunology, vol.186, issue.1, pp.539-548, 2011.
DOI : 10.4049/jimmunol.1001650

R. Goodman and S. Smolik, CBP/p300 in cell growth, transformation, and development, Genes Dev, vol.14, pp.1553-1577, 2000.

L. Bai and J. Merchant, A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion, FEBS Letters, vol.260, issue.30, pp.5904-5910, 2007.
DOI : 10.1016/j.febslet.2007.11.072

J. Lee, P. Taub, L. Wang, A. Clark, L. Zhu et al., Identification of CITED2 as a negative regulator of fracture healing, Biochemical and Biophysical Research Communications, vol.387, issue.4, pp.641-645, 2009.
DOI : 10.1016/j.bbrc.2009.07.029

D. Leong, Y. Li, X. Gu, L. Sun, Z. Zhou et al., Physiological loading of joints prevents cartilage degradation through CITED2, The FASEB Journal, vol.25, issue.1, pp.182-191, 2011.
DOI : 10.1096/fj.10-164277
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005439

S. Goldring and M. Goldring, Eating bone or adding it: the Wnt pathway decides, Nature Medicine, vol.280, issue.2, pp.133-134, 2007.
DOI : 10.1038/nm0207-133

C. Laine, K. Joeng, P. Campeau, R. Kiviranta, K. Tarkkonen et al., mutations in early-onset osteoporosis and osteogenesis imperfecta, N Engl J Med, vol.368, pp.11809-1816, 2013.

C. Bennett, K. Longo, W. Wright, L. Suva, T. Lane et al., Regulation of osteoblastogenesis and bone mass by Wnt10b, Proceedings of the National Academy of Sciences, vol.102, issue.9, pp.3324-3329, 2005.
DOI : 10.1073/pnas.0408742102

H. Franck, T. Meurer, and L. Hofbauer, Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis, J Rheumatol, vol.31, pp.2236-2241, 2004.

S. Manicassamy, B. Reizis, R. Ravindran, H. Nakaya, R. Salazar-gonzalez et al., Activation of ??-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine, Science, vol.329, issue.5993, pp.849-853, 2010.
DOI : 10.1126/science.1188510

M. Nishita, S. Yoo, A. Nomachi, S. Kani, N. Sougawa et al., Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration, The Journal of Cell Biology, vol.119, issue.4, pp.555-562, 2006.
DOI : 10.1081/RRS-120018757

A. Nomachi, M. Nishita, D. Inaba, M. Enomoto, M. Hamasaki et al., Receptor Tyrosine Kinase Ror2 Mediates Wnt5a-induced Polarized Cell Migration by Activating c-Jun N-terminal Kinase via Actin-binding Protein Filamin A, Journal of Biological Chemistry, vol.283, issue.41, pp.27973-27981, 2008.
DOI : 10.1074/jbc.M802325200

M. Dhaenens, I. Fert, S. Glatigny, S. Haerinck, C. Poulain et al., Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability, Arthritis & Rheumatism, vol.174, issue.9, pp.2622-2632, 2009.
DOI : 10.1002/art.24780

K. Johnson, S. Hashimoto, M. Lotz, K. Pritzker, and R. Terkeltaub, Interleukin-1 Induces Pro-Mineralizing Activity of Cartilage Tissue Transglutaminase and Factor XIIIa, The American Journal of Pathology, vol.159, issue.1, pp.149-163, 2001.
DOI : 10.1016/S0002-9440(10)61682-3
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850418

B. Hoppe, T. Häupl, A. Skapenko, S. Ziemer, R. Tauber et al., Fibrinogen and factor XIII A-subunit genotypes interactively influence C-reactive protein levels during inflammation, Annals of the Rheumatic Diseases, vol.71, issue.7
DOI : 10.1136/annrheumdis-2011-200738
URL : http://ard.bmj.com/cgi/content/short/71/7/1163

B. Sarraj, K. Ludányi, T. Glant, A. Finnegan, and K. Mikecz, Expression of CD44 and L-Selectin in the Innate Immune System Is Required for Severe Joint Inflammation in the Proteoglycan-Induced Murine Model of Rheumatoid Arthritis, The Journal of Immunology, vol.177, issue.3, pp.1932-1940, 2006.
DOI : 10.4049/jimmunol.177.3.1932