P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment.

Abstract : To investigate whether P2rx7 inhibition prevented photoreceptor toxicity of C57BL/6J-Mononucelar phagocytes (MPs), we submitted C57BL/6J and P2rx7-/- mice to experimental retinal detachment, where subretinal C57BL/6J-MPs have been shown to participate in photoreceptor degeneration (Nakazawa et al., 2007). C57BL/6J and P2rx7-/- mice exhibit similar subretinal MP accumulation but showed no difference in the number of TUNEL positive photoreceptor cells under these conditions.
Type de document :
Pré-publication, Document de travail
Referenced in J Neurosci as URL. 2015
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-01113110
Contributeur : Xavier Guillonneau <>
Soumis le : mercredi 4 février 2015 - 14:16:37
Dernière modification le : mercredi 21 mars 2018 - 18:57:36

Annexe

  •  supp-02.tif    Visible le : jamais  Figure, Image

Licence


Distributed under a Creative Commons Paternité - Pas d'utilisation commerciale - Pas de modification 4.0 International License

Identifiants

  • HAL Id : inserm-01113110, version 1

Collections

UPMC | U968 | ICM

Citation

Shulong J Hu, Bertrand Calippe, Sophie Lavalette, Christophe Roubeix, Fadoua Montassar, et al.. P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment.. Referenced in J Neurosci as URL. 2015. 〈inserm-01113110〉

Partager

Métriques

Consultations de la notice

146

Téléchargements de fichiers

5