Structure and function of the blood???brain barrier, Neurobiology of Disease, vol.37, issue.1, pp.13-25, 2010. ,
DOI : 10.1016/j.nbd.2009.07.030
Effect of intravenous injection speed on responses to cocaine and hydromorphone in humans, Psychopharmacology, vol.154, issue.1, pp.76-84, 2001. ,
DOI : 10.1007/s002130000624
Quantitative Proteomics of Transporter Expression in Brain Capillary Endothelial Cells Isolated from P-Glycoprotein (P-gp), Breast Cancer Resistance Protein (Bcrp), and P-gp/Bcrp Knockout Mice, Drug Metabolism and Disposition, vol.40, issue.6, pp.1164-1169, 2012. ,
DOI : 10.1124/dmd.112.044719
Antiporter that Interacts with Addictive Drugs, Journal of Cerebral Blood Flow & Metabolism, vol.292, issue.7, pp.1293-1304, 2009. ,
DOI : 10.1038/nature03720
Transport of Biogenic Amine Neurotransmitters at the Mouse Blood???Retina and Blood???Brain Barriers by Uptake1 and Uptake2, Journal of Cerebral Blood Flow & Metabolism, vol.36, issue.11, pp.1989-2001, 2012. ,
DOI : 10.1111/j.1471-4159.2010.06801.x
PAMPA???a drug absorption in vitro model*111. Matching the in vivo unstirred water layer thickness by individual-well stirring in microtitre plates, European Journal of Pharmaceutical Sciences, vol.22, issue.5, pp.365-374, 2004. ,
DOI : 10.1016/S0928-0987(04)00121-6
Pharmacokinetics of systemically administered cocaine and locomotor stimulation in mice, J Pharmacol Exp Ther, vol.243, pp.144-149, 1987. ,
Dose-response cocaine pharmacokinetics and metabolite profile following intravenous administration and arterial sampling in unanesthetized, freely moving male rats, Neurotoxicology and Teratology, vol.19, issue.1, pp.7-15, 1997. ,
DOI : 10.1016/S0892-0362(96)00180-8
Mouse Carotid Perfusion Model: Glucose and Cholesterol Transport in the Eye and Brain, Journal of Cerebral Blood Flow & Metabolism, vol.79, issue.8, pp.1449-1459, 2008. ,
DOI : 10.1038/jcbfm.2008.34
Direct Nose???Brain Transport of Benzoylecgonine Following Intranasal Administration in Rats, Journal of Pharmaceutical Sciences, vol.90, issue.11, pp.1729-1735, 2001. ,
DOI : 10.1002/jps.1122
Coexistence of Passive and Proton Antiporter-Mediated Processes in Nicotine Transport at the Mouse Blood???Brain Barrier, The AAPS Journal, vol.15, issue.2, pp.299-307, 2013. ,
DOI : 10.1208/s12248-012-9434-6
Development of an In Situ Mouse Brain Perfusion Model and Its Application to mdr1a P-Glycoprotein-Deficient Mice, Journal of Cerebral Blood Flow & Metabolism, vol.46, pp.381-386, 2000. ,
DOI : 10.1097/00004647-200002000-00020
Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells, Biochemical Pharmacology, vol.77, issue.5, pp.897-909, 2009. ,
DOI : 10.1016/j.bcp.2008.11.001
URL : https://hal.archives-ouvertes.fr/hal-00531837
Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice, Behavioral and Brain Functions, vol.7, issue.1, p.29, 2011. ,
DOI : 10.1016/0006-8993(89)90411-3
Uptake of codeine into intestinal epithelial (Caco-2) and brain endothelial (RBE4) cells, European Journal of Pharmaceutical Sciences, vol.41, issue.1, pp.31-42, 2010. ,
DOI : 10.1016/j.ejps.2010.05.010
Rapid Stereoselective Hydrolysis of (+)-Cocaine in Baboon Plasma Prevents Its Uptake in the Brain: Implications for Behavioral Studies, Journal of Neurochemistry, vol.225, issue.2, pp.720-723, 1990. ,
DOI : 10.1016/0009-8981(82)90410-7
Studies with Differentially Labeled [11C]Cocaine, [11C]Norcocaine, [11C]Benzoylecgonine, and [11C]-and 4???-[18F]Fluorococaine to Probe the Extent to Which [11C]Cocaine Metabolites Contribute to PET Images of the Baboon Brain, Journal of Neurochemistry, vol.35, issue.3, pp.1154-1162, 1994. ,
DOI : 10.1046/j.1471-4159.1994.62031154.x
Membrane transporters in drug development, Nature Reviews Drug Discovery, vol.20, issue.3, pp.215-236, 2010. ,
DOI : 10.1038/nrd3028
Severity of dependence and route of administration of heroin, cocaine and amphetamines, Addiction, vol.246, issue.11, pp.1527-1536, 1992. ,
DOI : 10.1037//0021-843X.91.3.199
The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so, Drug Discovery Today, vol.18, issue.5-6, pp.218-239, 2013. ,
DOI : 10.1016/j.drudis.2012.11.008
Uptake of 3,4-methylenedioxymethamphetamine and its related compounds by a proton-coupled transport system in Caco-2 cells, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1778, issue.1, pp.42-50, 2008. ,
DOI : 10.1016/j.bbamem.2007.08.023
for Cocaine, Nicotine, Neurotransmitters, and Anilines in Aqueous Solution, The Journal of Physical Chemistry B, vol.111, issue.35, pp.10599-10605, 2007. ,
DOI : 10.1021/jp072917r
The Speed of Cocaine Delivery Determines the Subsequent Motivation to Self-Administer the Drug, Neuropsychopharmacology, vol.486, issue.13, pp.2644-2656, 2013. ,
DOI : 10.1038/npp.2013.173
Age-specific behavioral responses to psychostimulants in mice, Pharmacology Biochemistry and Behavior, vol.82, issue.2, pp.280-288, 2005. ,
DOI : 10.1016/j.pbb.2005.08.014
Involvement of the Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone, Drug Metabolism and Disposition, vol.36, issue.10, pp.2005-2013, 2008. ,
DOI : 10.1124/dmd.108.022087
Evaluation of the Blood-Brain Barrier Transport, Population Pharmacokinetics, and Brain Distribution of Benztropine Analogs and Cocaine Using in Vitro and in Vivo Techniques, Journal of Pharmacology and Experimental Therapeutics, vol.307, issue.2, pp.801-808, 2003. ,
DOI : 10.1124/jpet.103.053504
Diphenhydramine Active Uptake at the Blood???Brain Barrier and Its Interaction with Oxycodone in vitro and in Vivo, Journal of Pharmaceutical Sciences, vol.100, issue.9, pp.3912-3923, 2011. ,
DOI : 10.1002/jps.22567
The Rate of Cocaine Administration Alters Gene Regulation and Behavioral Plasticity: Implications for Addiction, Journal of Neuroscience, vol.24, issue.28, pp.6362-6370, 2004. ,
DOI : 10.1523/JNEUROSCI.1205-04.2004
Why does the rapid delivery of drugs to the brain promote addiction?, Trends in Pharmacological Sciences, vol.26, issue.2, pp.82-87, 2005. ,
DOI : 10.1016/j.tips.2004.12.007
Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties, Psychopharmacology, vol.17, issue.Suppl 2, pp.3139-3149, 2014. ,
DOI : 10.1007/s00213-014-3490-9
An in situ brain perfusion technique to study cerebrovascular transport in the rat, Am J Physiol, vol.247, pp.484-493, 1984. ,
Transporters involved in regulation of intracellular pH in primary cultured rat brain endothelial cells, The Journal of Physiology, vol.258, issue.Suppl, pp.769-785, 2006. ,
DOI : 10.1113/jphysiol.2006.117374
Distribution of tracer levels of cocaine in the human brain as assessed with averaged [11C]cocaine images, Synapse, vol.57, issue.4, pp.290-296, 1999. ,
DOI : 10.1002/(SICI)1098-2396(19990315)31:4<290::AID-SYN7>3.0.CO;2-G
Opioid Transport by ATP-Binding Cassette Transporters at the Blood-Brain Barrier: Implications for Neuropsychopharmacology, Current Pharmaceutical Design, vol.17, issue.26, pp.2829-2842, 2011. ,
DOI : 10.2174/138161211797440203
Cocaine Uptake Is Decreased in the Brain of Detoxified Cocaine Abusers, Neuropsychopharmacology, vol.14, issue.3, pp.159-168, 1996. ,
DOI : 10.1016/0893-133X(95)00073-M
Imaging Studies of Cocaine in the Human Brain and Studies of the Cocaine Addict, Annals of the New York Academy of Sciences, vol.151, issue.7, pp.41-54, 1997. ,
DOI : 10.1016/0893-133X(95)00073-M
Relationship between subjective effects of cocaine and dopamine transporter occupancy, Nature, vol.386, issue.6627, pp.827-830, 1997. ,
DOI : 10.1038/386827a0
Effects of route of administration on cocaine induced dopamine transporter blockade in the human brain, Life Sciences, vol.67, issue.12, pp.1507-1515, 2000. ,
DOI : 10.1016/S0024-3205(00)00731-1
Addiction Circuitry in the Human Brain, Annual Review of Pharmacology and Toxicology, vol.52, issue.1, pp.321-336, 2012. ,
DOI : 10.1146/annurev-pharmtox-010611-134625
The hCMEC/D3 cell line as a model of the human blood brain barrier, Fluids and Barriers of the CNS, vol.10, issue.1, p.16, 2013. ,
DOI : 10.1038/nbt.2247
URL : https://hal.archives-ouvertes.fr/inserm-00812147