BIOACTIVE COMPOUNDS IN HUMAN MILK AND INTESTINAL HEALTH AND MATURITY IN PRETERM NEWBORN: AN OVERVIEW

Abstract : Premature births are increasing worldwide (about 15 millions per year) due to several reasons (an advanced maternal age, fertility treatments, stress, smoking, nutritional deficiencies) and lead to a high societal overall cost. Among neonatal care procedures, the clinical nutrition practices are essential to promote the development and to minimize the sequelae. Prema-ture newborns are at major risk of death by infections due to the immaturity of their intestine. Human milk provides not only nutrients but also a plethora of biologically active components that are tailored to contribute to the development of the intes-tinal tract early in postnatal life. Among them, some bioactive molecules exhibit trophic effects (LC-PUFA, sphingomyelin, IGF-I and IGF-II, EGF, insulin, leptin, adiponectin, lactoferrin, lactadherin, probiotics, prebiotics, miRNA) or are part of the intestinal cell membranes (PUFA, LC-PUFA, phospholipids, sphingolipids, cholesterol), others educate the intestine for innate microbial recognition (sCD14, sTLR-2, miRNA), many of them display direct fighting against pathogens (some fatty acids and monoglycerides, some phospholipids and sphingolipids, BSSL, insulin, lactoferrin, sIgAs, MUC-1, lactadherin, probiotics, prebiotics), or contribute to establish the gut microbiota (LC-PUFA, lactoferrin, probiotics, prebiotics). A syn-ergetic action exists between several bioactive molecules. All together these precious agents regulate the maturation of the intestinal mucosal barrier, and might program early in postnatal life the future adult intestinal health. This review lists the main bioactive compounds and addresses their plausible roles and mechanisms of action.
Type de document :
Article dans une revue
Cellular and Molecular Biology, 2013, 59, pp.108 - 131. 〈10.1170/T952〉
Liste complète des métadonnées

Littérature citée [215 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01098435
Contributeur : Martine Armand <>
Soumis le : mercredi 24 décembre 2014 - 17:06:27
Dernière modification le : jeudi 17 mai 2018 - 10:10:02
Document(s) archivé(s) le : samedi 15 avril 2017 - 11:59:21

Fichier

GARCIA C. et al. CMB2013.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Cyrielle Garcia, Rui-Dong Duan, Véronique Brévaut-Malaty, Catherine Gire, Véronique Millet, et al.. BIOACTIVE COMPOUNDS IN HUMAN MILK AND INTESTINAL HEALTH AND MATURITY IN PRETERM NEWBORN: AN OVERVIEW. Cellular and Molecular Biology, 2013, 59, pp.108 - 131. 〈10.1170/T952〉. 〈inserm-01098435〉

Partager

Métriques

Consultations de la notice

444

Téléchargements de fichiers

795