K. Allers, G. Hütter, and J. Hofmann, Evidence for the cure of HIV infection by CCR5??32/??32 stem cell transplantation, Blood, vol.117, issue.10, pp.2791-2799, 2011.
DOI : 10.1182/blood-2010-09-309591

J. Anderson, M. Li, and B. Palmer, Safety and Efficacy of a Lentiviral Vector Containing Three Anti-HIV Genes???CCR5 Ribozyme, Tat-rev siRNA, and TAR Decoy???in SCID-hu Mouse???Derived T Cells, Molecular Therapy, vol.15, issue.6, pp.1182-1188, 2007.
DOI : 10.1038/sj.mt.6300157

H. Deng, R. Liu, and W. Ellmeier, Identification of a major co-receptor for primary isolates of HIV-1, Nature, vol.381, issue.6584, pp.661-666, 1996.
DOI : 10.1038/381661a0

J. De-rijck, L. Vandekerckhove, and R. Gijsbers, Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication, Journal of Virology, vol.80, issue.23, pp.11498-11509, 2006.
DOI : 10.1128/JVI.00801-06

C. A. Didigu, C. B. Wilen, and J. Wang, Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection, Blood, vol.123, issue.1, pp.61-69, 2014.
DOI : 10.1182/blood-2013-08-521229

D. L. Digiusto, A. Krishnan, and L. Li, RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma, Science Translational Medicine, vol.2, issue.36, pp.36-43, 2010.
DOI : 10.1126/scitranslmed.3000931

G. Doitsh, N. L. Galloway, and X. Geng, Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection, Nature, vol.11, issue.7484, pp.509-514, 2014.
DOI : 10.1186/1742-4690-9-87

F. P. Dupuy, E. Mouly, and M. Mesel-lemoine, Lentiviral transduction of human hematopoietic cells by HIV-1- and SIV-based vectors containing a bicistronic cassette driven by various internal promoters, The Journal of Gene Medicine, vol.304, issue.9, pp.1158-1171, 2005.
DOI : 10.1002/jgm.769

M. Egelhofer, G. Brandenburg, and H. Martinius, Inhibition of Human Immunodeficiency Virus Type 1 Entry in Cells Expressing gp41-Derived Peptides, Journal of Virology, vol.78, issue.2, pp.568-575, 2004.
DOI : 10.1128/JVI.78.2.568-575.2004

M. L. Greenberg, C. , and N. , Resistance to enfuvirtide, the first HIV fusion inhibitor, Journal of Antimicrobial Chemotherapy, vol.54, issue.2, pp.333-340, 2004.
DOI : 10.1093/jac/dkh330

O. Hartley, K. Dorgham, and D. Perez-bercoff, Human Immunodeficiency Virus Type 1 Entry Inhibitors Selected on Living Cells from a Library of Phage Chemokines, Journal of Virology, vol.77, issue.12, pp.6637-6644, 2003.
DOI : 10.1128/JVI.77.12.6637-6644.2003

A. Heredia, B. Gilliam, and A. Devico, CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1, AIDS, vol.21, issue.10, pp.1317-1322, 2007.
DOI : 10.1097/QAD.0b013e32815278ea

M. Hildinger, M. T. Dittmar, and P. Schult-dietrich, Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry, Journal of Virology, vol.75, issue.6, pp.3038-3042, 2001.
DOI : 10.1128/JVI.75.6.3038-3042.2001
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC115933

N. Holt, J. Wang, and K. Kim, Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo, Nature Biotechnology, vol.11, issue.8, pp.839-847, 2010.
DOI : 10.1038/nbt.1663

G. Hutter, D. Nowak, and M. Mossner, Delta32/Delta32 Stem-Cell Transplantation, New England Journal of Medicine, vol.360, issue.7, pp.692-698, 2009.
DOI : 10.1056/NEJMoa0802905

H. Jin, I. Kagiampakis, and P. Li, Structural and functional studies of the potent anti-HIV chemokine variant P2-RANTES, Proteins: Structure, Function, and Bioinformatics, vol.36, issue.2, pp.295-308, 2010.
DOI : 10.1002/prot.22542

A. D. Judge, V. Sood, and J. R. Shaw, Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA, Nature Biotechnology, vol.165, issue.4, pp.457-462, 2005.
DOI : 10.1007/s11095-004-1873-z

J. Kimpel, S. E. Braun, and G. Qiu, Survival of the Fittest: Positive Selection of CD4+ T Cells Expressing a Membrane-Bound Fusion Inhibitor Following HIV-1 Infection, PLoS ONE, vol.79, issue.8, 2010.
DOI : 10.1371/journal.pone.0012357.g006

S. Lohrengel, F. Hermann, and I. Hagmann, Determinants of Human Immunodeficiency Virus Type 1 Resistance to Membrane-Anchored gp41-Derived Peptides, Journal of Virology, vol.79, issue.16, pp.10237-10246, 2005.
DOI : 10.1128/JVI.79.16.10237-10246.2005

G. Marodon, D. Warren, and M. C. Filomio, Productive infection of double-negative T cells with HIV in vivo, Proceedings of the National Academy of Sciences, vol.96, issue.21, pp.11958-11963, 1999.
DOI : 10.1073/pnas.96.21.11958

G. Marodon, E. Mouly, and E. J. Blair, Specific transgene expression in human and mouse CD4+ cells using lentiviral vectors with regulatory sequences from the CD4 gene, Blood, vol.101, issue.9, pp.3416-3423, 2003.
DOI : 10.1182/blood-2002-02-0578

V. Pattanayak, C. L. Ramirez, and J. K. Joung, Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection, Nature Methods, vol.132, issue.9, pp.765-770, 2011.
DOI : 10.1038/nbt1409

E. E. Perez, J. L. Riley, and R. G. Carroll, Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed gp41-derived fusion inhibitor, Clinical Immunology, vol.115, issue.1, pp.26-32, 2005.
DOI : 10.1016/j.clim.2005.02.019

E. E. Perez, J. Wang, and J. C. Miller, Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases, Nature Biotechnology, vol.73, issue.7, pp.808-816, 2008.
DOI : 10.1038/nbt1410

C. W. Peterson, P. Younan, and K. R. Jerome, Combinatorial anti-HIV gene therapy: using a multipronged approach to reach beyond HAART, Gene Therapy, vol.52, issue.7, pp.695-702, 2013.
DOI : 10.1038/mt.2008.200

X. F. Qin, D. S. An, and I. S. Chen, Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5, Proceedings of the National Academy of Sciences, vol.100, issue.1, pp.183-188, 2003.
DOI : 10.1073/pnas.232688199

M. Robbins, A. Judge, and E. Ambegia, Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation, Human Gene Therapy, vol.19, issue.10, pp.991-999, 2008.
DOI : 10.1089/hum.2008.131

C. H. Swan, B. Buhler, and M. P. Tschan, T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery, Gene Therapy, vol.29, issue.20, pp.1480-1492, 2006.
DOI : 10.1038/sj.gt.3302801

P. Tebas, D. Stein, and W. W. Tang, in Autologous CD4 T Cells of Persons Infected with HIV, New England Journal of Medicine, vol.370, issue.10, pp.901-910, 2014.
DOI : 10.1056/NEJMoa1300662

J. E. Walker, R. X. Chen, and J. Mcgee, Generation of an HIV-1-Resistant Immune System with CD34+ Hematopoietic Stem Cells Transduced with a Triple-Combination Anti-HIV Lentiviral Vector, Journal of Virology, vol.86, issue.10, pp.5719-5729, 2012.
DOI : 10.1128/JVI.06300-11

A. G. Yang, X. Bai, and X. F. Huang, Phenotypic knockout of HIV type 1 chemokine coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infection, Address correspondence to: Dr. G. Marodon CIMI INSERM U1135 CNRS ERL 8255 CERVI 83 Bd de l'Hôpital F-75013, pp.11567-11572, 1997.
DOI : 10.1073/pnas.94.21.11567