Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study.

Abstract : Background:APOEis the biomarker with the greatest known influence on cognitive function; however, the effectof complex haplotypes involving polymorphisms rs449647, rs405509, rs440446, rs429358 and rs7412 has never beenstudied in older populations.Methods:We evaluatedAPOEpolymorphisms using multiplex PCR for genotyping and Mini-Mental State Examination(MMSE) to evaluate cognitive function in 819 individuals from VA Normative Aging Study.Results:Combinatorial analysis of all polymorphisms and individual analysis of polymorphisms rs449647, rs405509,rs440446 and rs7412 did not show any association with cognitive performance. Polymorphism rs429358 was associatedwith better cognitive performance (odds of MMSE≤25 = 0.63, 95% CI 0.42-0.95;p= 0.03) in the oldest subsample(5thquintile of age) (odds of MMSE≤25 = 0.34; 95% CI 0.13-0.86;p=0.02).APOEalleleε4 was also associated withbetter cognitive performance (odds of MMSE≤25 = 0.61, 95% CI 0.40-0.94;p= 0.02), also in the oldest subsample(odds of MMSE≤25 = 0.35, 95% CI 0.14-0.90;p=0.03).Conclusions:These results suggest a beneficial effect of polymorphism rs429358 in the oldest men.
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BMC Psychiatry, BioMed Central, 2013, pp.223
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Diddier Prada, Elena Colicino, Melinda Power, David Cox, Marc Weisskopf, et al.. Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study.. BMC Psychiatry, BioMed Central, 2013, pp.223. 〈inserm-01088750〉

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