. Dr and . Bry, Private practice), Dr Cadart (Private practice

D. Gassmann, Private practice, Strasbourg)

D. Guillet, CSST Le trait d'union; Boulogne)

D. Marre, Private practice, Le Havre), Dr. Mauraycaplanne; Dr Michel (Private practice, Lillebonne)

D. Wajsbrot, J. Bachellier, P. Beauverie, R. Jp-couteron, H. Baker et al., Centre of Methodology and Management, INSERM U912: Protocol, guidelines, training: MP Phone interviews, training Data collection, management and statistical analyses, French agency for the safety of health products (ANSM): N. Richard. French Ministry of Health: A.Herszkowicz, N. Prisse. ASUD association: F. Olivet; AIDES association. Center of evaluation and information on drug dependence (CEIP): J.Arditti. Author details 1

R. Mattick, C. Breen, J. Kimber, and M. Davoli, Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence, Cochrane Database Syst Rev, vol.2, p.2207, 2014.

R. Mattick, C. Breen, J. Kimber, and M. Davoli, Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence, Cochrane Database Syst Rev, vol.2, p.2209, 2009.

B. Smyth, J. Barry, A. Lane, M. Cotter, O. Neill et al., In-patient treatment of opiate dependence: medium-term follow-up outcomes, The British Journal of Psychiatry, vol.187, issue.4, pp.360-365, 2005.
DOI : 10.1192/bjp.187.4.360

A. Gibson, D. Randall, and L. Degenhardt, The increasing mortality burden of liver disease among opioid-dependent people: cohort study, Addiction, vol.341, issue.12, pp.2186-2192, 2011.
DOI : 10.1111/j.1360-0443.2011.03575.x

P. Vickerman, N. Martin, K. Turner, and M. Hickman, Can needle and syringe programmes and opiate substitution therapy achieve substantial reductions in hepatitis C virus prevalence? Model projections for different epidemic settings, Addiction, vol.367, issue.3, pp.1984-1995, 2012.
DOI : 10.1111/j.1360-0443.2012.03932.x

J. Van-den-hoek, H. Van-haastrecht, J. Goudsmit, F. De-wolf, and R. Coutinho, Prevalence, Incidence, and Risk Factors of Hepatitis C Virus Infection among Drug Users in Amsterdam, Journal of Infectious Diseases, vol.162, issue.4, pp.823-826, 1990.
DOI : 10.1093/infdis/162.4.823

N. Palmateer, S. Hutchinson, G. Mcallister, A. Munro, S. Cameron et al., Risk of transmission associated with sharing drug injecting paraphernalia: analysis of recent hepatitis C virus (HCV) infection using cross-sectional survey data, Journal of Viral Hepatitis, vol.204, issue.12, pp.25-32, 2014.
DOI : 10.1111/jvh.12117

S. Aaron, J. Mcmahon, D. Milano, L. Torres, M. Clatts et al., Intranasal Transmission of Hepatitis C Virus: Virological and Clinical Evidence, Clinical Infectious Diseases, vol.47, issue.7, pp.931-934, 2008.
DOI : 10.1086/591699

R. Tohme and S. Holmberg, Transmission of Hepatitis C Virus Infection Through Tattooing and Piercing: A Critical Review, Clinical Infectious Diseases, vol.54, issue.8, pp.1167-1178, 2012.
DOI : 10.1093/cid/cir991

Z. Ackerman, E. Ackerman, and O. Paltiel, Intrafamilial transmission of hepatitis C virus: a systematic review, Journal of Viral Hepatitis, vol.316, issue.2, pp.93-103, 2000.
DOI : 10.1016/S1386-6346(98)00004-7

A. Tiftikci, O. Atug, and N. Tozun, Awareness of hepatitis C virus transmission routes among patients, their household contacts and health care staff: does perception match the reality, Turk J Gastroenterol, vol.20, pp.104-107, 2009.

S. Alavian, A. Mirahmadizadeh, M. Javanbakht, A. Keshtkaran, A. Heidari et al., Effectiveness of Methadone Maintenance Treatment in Prevention of Hepatitis C Virus Transmission among Injecting Drug Users, Hepatitis Monthly, vol.13, issue.8, pp.13-12411
DOI : 10.5812/hepatmon.12411

C. Van-den-berg, C. Smit, V. Brussel, G. Coutinho, R. Prins et al., Full participation in harm reduction programmes is associated with decreased risk for human immunodeficiency virus and hepatitis C virus: evidence from the Amsterdam Cohort Studies among drug users, Addiction, vol.361, issue.9, pp.1454-1462, 2007.
DOI : 10.1111/j.1360-0443.2007.01912.x

P. Roux, L. Michel, J. Cohen, M. Mora, A. Morel et al., Methadone induction in primary care (ANRS-Methaville): a phase III randomized intervention trial, BMC Public Health, vol.35, issue.12 Pt 1, p.488, 2012.
DOI : 10.1016/S0755-4982(06)74906-5
URL : https://hal.archives-ouvertes.fr/inserm-00768513

J. Johnson, A. Lee, D. Vinson, and J. Seale, Use of AUDIT-Based Measures to Identify Unhealthy Alcohol Use and Alcohol Dependence in Primary Care: A Validation Study, Alcoholism: Clinical and Experimental Research, vol.50, issue.Suppl 20, pp.253-259
DOI : 10.1111/j.1530-0277.2012.01898.x

S. Darke, W. Hall, A. Wodak, N. Heather, and J. Ward, Development and validation of a multidimensional instrument for assessing outcome of treatment among opiate users: the Opiate Treatment Index, Addiction, vol.83, issue.5, pp.733-742, 1992.
DOI : 10.1016/0376-8716(90)90049-K

C. Fry and N. Lintzeris, Psychometric properties of the Blood-borne Virus Transmission Risk Assessment Questionnaire (BBV-TRAQ) Addiction, pp.171-178, 2003.

D. Lucidarme, A. Bruandet, D. Ilef, J. Harbonnier, C. Jacob et al., Incidence and risk factors of HCV and HIV infections in a cohort of intravenous drug users in the North and East of France, Epidemiology and Infection, vol.132, issue.4, pp.699-708, 2004.
DOI : 10.1017/S095026880400247X

A. Beck and M. Weishaar, Suicide risk assessment and prediction, Crisis, vol.11, pp.22-30, 1990.

D. Huo, S. Bailey, R. Garfein, and L. Ouellet, Changes in the Sharing of Drug Injection Equipment among Street-Recruited Injection Drug Users in Chicago, Illinois, 1994???1996, Substance Use & Misuse, vol.12, issue.6, pp.63-76, 1994.
DOI : 10.1080/02791072.1991.10472569

L. Thorpe, S. Bailey, D. Huo, E. Monterroso, and L. Ouellet, Injection-Related Risk Behaviors in Young Urban and Suburban Injection Drug Users in Chicago (1997???1999), JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.27, issue.1, pp.71-78, 2001.
DOI : 10.1097/00126334-200105010-00012

M. Mackesy-amiti, L. Finnegan, L. Ouellet, E. Golub, H. Hagan et al., Peer-Education Intervention to Reduce Injection Risk Behaviors Benefits High-Risk Young Injection Drug Users: A Latent Transition Analysis of the CIDUS 3/DUIT Study, AIDS and Behavior, vol.84, issue.6, pp.2075-2083, 2013.
DOI : 10.1007/s10461-012-0373-0

D. Jarlais, D. Mcknight, C. Arasteh, K. Feelemyer, J. Perlman et al., Transitions from injecting to non-injecting drug use: Potential protection against HCV infection, Journal of Substance Abuse Treatment, vol.46, issue.3, pp.325-331, 2014.
DOI : 10.1016/j.jsat.2013.09.004

J. Macias, R. Palacios, E. Claro, J. Vargas, S. Vergara et al., High prevalence of hepatitis C virus infection among noninjecting drug users: association with sharing the inhalation implements of crack, Liver International, vol.13, issue.6, pp.781-786, 2008.
DOI : 10.1111/j.1478-3231.2008.01688.x

D. Buchanan, J. Tooze, S. Shaw, M. Kinzly, R. Heimer et al., Demographic, HIV risk behavior, and health status characteristics of ???crack??? cocaine injectors compared to other injection drug users in three New England cities, Drug and Alcohol Dependence, vol.81, issue.3, pp.221-229, 2006.
DOI : 10.1016/j.drugalcdep.2005.07.011

L. Oliveira, P. Jde, C. Nappo, and S. , Crack Cocaine Use in Barcelona: A Reason of Worry, Substance Use & Misuse, vol.92, issue.6, pp.2291-2300, 2010.
DOI : 10.1093/alcalc/agh260

L. Wilkins, P. Bissell, and P. Meier, Risky injecting practices associated with snowballing: A qualitative study, Drug and Alcohol Review, vol.97, issue.3, pp.256-262, 2010.
DOI : 10.1111/j.1465-3362.2009.00142.x

A. Chaudhry, M. Botsko, L. Weiss, J. Egan, J. Mitty et al., Participant Characteristics and HIV Risk Behaviors Among Individuals Entering Integrated Buprenorphine/Naloxone and HIV Care, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.56, issue.1, pp.56-70, 2011.
DOI : 10.1097/QAI.0b013e318209d3b9

L. Marchand, C. Evans, J. Page, K. Davidson, P. Hahn et al., Hazardous alcohol consumption among young adult IDU and its association with high risk behaviors, Drug and Alcohol Dependence, vol.127, issue.1-3, pp.143-149, 2013.
DOI : 10.1016/j.drugalcdep.2012.06.024

C. Field, G. Cochran, and R. Caetano, Treatment Utilization and Unmet Treatment Need Among Hispanics Following Brief Intervention, Alcoholism: Clinical and Experimental Research, vol.36, issue.2, pp.300-307, 2012.
DOI : 10.1111/j.1530-0277.2012.01878.x

W. Zule, E. Costenbader, C. Coomes, and W. Wechsberg, Effects of a Hepatitis C Virus Educational Intervention or a Motivational Intervention on Alcohol Use, Injection Drug Use, and Sexual Risk Behaviors Among Injection Drug Users, American Journal of Public Health, vol.99, issue.S1, pp.99-180, 2009.
DOI : 10.2105/AJPH.2007.126854

K. Dolan, S. Salimi, B. Nassirimanesh, S. Mohsenifar, D. Allsop et al., Sixmonth follow-up of Iranian women in methadone treatment: drug use, social functioning, crime, and HIV and HCV seroincidence, pp.37-43

D. Otiashvili, G. Piralishvili, Z. Sikharulidze, G. Kamkamidze, S. Poole et al., Methadone and buprenorphine-naloxone are effective in reducing illicit buprenorphine and other opioid use, and reducing HIV risk behavior???Outcomes of a randomized trial, Drug and Alcohol Dependence, vol.133, issue.2, pp.376-382, 2013.
DOI : 10.1016/j.drugalcdep.2013.06.024

K. Turner, S. Hutchinson, P. Vickerman, V. Hope, N. Craine et al., The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence, Addiction, vol.122, issue.11, pp.1978-1988, 2011.
DOI : 10.1111/j.1360-0443.2011.03515.x

M. Ng, J. Chou, T. Chang, P. Lee, W. Shao et al., High prevalence but low awareness of hepatitis C virus infection among heroin users who received methadone maintenance therapy in Taiwan, Addictive Behaviors, vol.38, issue.4, pp.2089-2093, 2013.
DOI : 10.1016/j.addbeh.2013.01.010

J. Emmanuelli and J. Desenclos, Harm reduction interventions, behaviours and associated health outcomes in France, 1996-2003, Addiction, vol.91, issue.11, pp.1690-1700, 1996.
DOI : 10.1111/j.1360-0443.2005.01271.x

X. Zhuang, Y. Liang, E. Chow, Y. Wang, D. Wilson et al., HIV and HCV prevalence among entrants to methadone maintenance treatment clinics in China: a systematic review and meta-analysis, BMC Infectious Diseases, vol.31, issue.2, p.130, 2012.
DOI : 10.1186/1477-7517-7-30

C. Fuller, D. Ompad, S. Galea, Y. Wu, B. Koblin et al., Hepatitis C Incidence--a Comparison Between Injection and Noninjection Drug Users in New York City, Journal of Urban Health: Bulletin of the New York Academy of Medicine, vol.81, issue.1, pp.20-24, 2004.
DOI : 10.1093/jurban/jth084

S. Darke, A. Williamson, J. Ross, and M. Teesson, Attempted suicide among heroin users: 12-month outcomes from the Australian Treatment Outcome Study (ATOS) Drug Alcohol Depend, pp.177-186, 2005.

L. Bradvik, A. Frank, P. Hulenvik, A. Medvedeo, and M. Berglund, Heroin Addicts Reporting Previous Heroin Overdoses Also Report Suicide Attempts, Suicide and Life-Threatening Behavior, vol.4, issue.4, pp.475-481, 2007.
DOI : 10.1016/j.drugalcdep.2004.08.004

R. Lowry, A. Crosby, N. Brener, and L. Kann, Suicidal Thoughts and Attempts Among U.S. High School Students: Trends and Associated Health-Risk Behaviors, 1991???2011, Journal of Adolescent Health, vol.54, issue.1, pp.100-108, 1991.
DOI : 10.1016/j.jadohealth.2013.07.024

A. Bohnert, K. Roeder, and M. Ilgen, Unintentional overdose and suicide among substance users: A review of overlap and risk factors, Drug and Alcohol Dependence, vol.110, issue.3, pp.183-192, 2010.
DOI : 10.1016/j.drugalcdep.2010.03.010

E. Sarin, B. Singh, L. Samson, and M. Sweat, Suicidal ideation and HIV risk behaviors among a cohort of injecting drug users in, Subst Abuse Treat Prev Policy, vol.8, issue.2, 2013.

I. De-carvalho-mello, J. Filho, M. Gomes-gouvea, M. De-mello, A. De-queiroz et al., Molecular evidence of horizontal transmission of hepatitis C virus within couples, Journal of General Virology, vol.91, issue.3, pp.691-696, 2010.
DOI : 10.1099/vir.0.015594-0

N. El-bassel, L. Gilbert, A. Terlikbayeva, E. Wu, C. Beyrer et al., HIV Among Injection Drug Users and Their Intimate Partners in Almaty, Kazakhstan, AIDS and Behavior, vol.376, issue.9738, pp.2490-2500, 2013.
DOI : 10.1007/s10461-013-0484-2

E. Pouget, H. Hagan, D. Jarlais, and D. , Meta-analysis of hepatitis C seroconversion in relation to shared syringes and drug preparation equipment, Addiction, vol.317, issue.6, pp.1057-1065, 2011.
DOI : 10.1111/j.1360-0443.2011.03765.x

J. Bryant, L. Brener, P. Hull, and C. Treloar, Needle sharing in regular sexual relationships: An examination of serodiscordance, drug using practices, and the gendered character of injecting, Drug and Alcohol Dependence, vol.107, issue.2-3, pp.182-187, 2010.
DOI : 10.1016/j.drugalcdep.2009.10.007

R. Dwyer, S. Fraser, and C. Treloar, Doing things together? Analysis of health education materials to inform hepatitis C prevention among couples, Addiction Research & Theory, vol.19, issue.3, pp.352-361, 2011.
DOI : 10.1016/j.drugalcdep.2007.03.001

J. Simmons, S. Rajan, and J. Mcmahon, Retrospective accounts of injection initiation in intimate partnerships, International Journal of Drug Policy, vol.23, issue.4, pp.303-311, 2012.
DOI : 10.1016/j.drugpo.2012.01.009

M. Harris and T. Rhodes, Injecting practices in sexual partnerships: Hepatitis C transmission potentials in a ???risk equivalence??? framework, Drug and Alcohol Dependence, vol.132, issue.3, pp.617-623, 2013.
DOI : 10.1016/j.drugalcdep.2013.04.012

L. Wang, X. Wei, X. Wang, J. Li, H. Li et al., Long-Term Effects of Methadone Maintenance Treatment with Different Psychosocial Intervention Models, PLoS ONE, vol.58, issue.2, p.87931, 2014.
DOI : 10.1371/journal.pone.0087931.t004

S. Darke, Self-report among injecting drug users: A review, Drug and Alcohol Dependence, vol.51, issue.3, pp.253-263, 1998.
DOI : 10.1016/S0376-8716(98)00028-3