F. Lanternier, C. Lebbe, N. Schartz, D. Farhi, A. Marcelin et al., Kaposi??s sarcoma in HIV-negative men having sex with men, AIDS, vol.22, issue.10, pp.1163-1168, 2008.
DOI : 10.1097/QAD.0b013e3283031a8a

S. Lodi, M. Guiguet, D. Costagliola, M. Fisher, A. De-luca et al., Kaposi Sarcoma Incidence and Survival Among HIV-Infected Homosexual Men After HIV Seroconversion, JNCI Journal of the National Cancer Institute, vol.102, issue.11, pp.784-792, 2010.
DOI : 10.1093/jnci/djq134

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879418

E. Mesri, E. Cesarman, and C. Boshoff, Kaposi's sarcoma and its associated herpesvirus, Nature Reviews Cancer, vol.311, issue.10, pp.707-719, 2010.
DOI : 10.1038/nrc2888

Y. Chang, E. Cesarman, M. Pessin, F. Lee, J. Culpepper et al., Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma, Science, vol.266, issue.5192, pp.1865-1869, 1994.
DOI : 10.1126/science.7997879

C. Boshoff, D. Whitby, T. Hatziioannou, C. Fisher, J. Van-der-walt et al., Kaposi's-sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma, The Lancet, vol.345, issue.8956, pp.1043-1044, 1995.
DOI : 10.1016/S0140-6736(95)90780-7

D. Whitby, M. Howard, M. Tenant-flowers, N. Brink, A. Copas et al., Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma, The Lancet, vol.346, issue.8978, pp.799-802, 1995.
DOI : 10.1016/S0140-6736(95)91619-9

E. Cesarman, R. Nador, K. Aozasa, G. Delsol, J. Said et al., Kaposi's sarcoma-associated herpesvirus in non-AIDS related lymphomas occurring in body cavities, Am J Pathol, vol.149, pp.53-57, 1996.

E. Mesri, E. Cesarman, L. Arvanitakis, S. Rafii, M. Moore et al., Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells, Journal of Experimental Medicine, vol.183, issue.5, pp.2385-2390, 1996.
DOI : 10.1084/jem.183.5.2385

Y. Chen, A. Rahemtullah, and E. Hochberg, Primary Effusion Lymphoma, The Oncologist, vol.12, issue.5, pp.569-576, 2007.
DOI : 10.1634/theoncologist.12-5-569

J. , S. Y. Fisher, M. Rettig, and M. , Antitumor effects of bortezomib (PS-341) on primary effusion lymphomas, Leukemia, vol.18, pp.1699-1704, 2004.

H. Matta and P. Chaudhary, Activation of alternative NF-??B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1??-converting enzyme inhibitory protein (vFLIP), Proceedings of the National Academy of Sciences, vol.101, issue.25, pp.9399-9404, 2004.
DOI : 10.1073/pnas.0308016101

S. Keller, D. Hernandez-hopkins, J. Vider, V. Ponomarev, E. Hyjek et al., NF-??B is essential for the progression of KSHV- and EBV-infected lymphomas in vivo, Blood, vol.107, issue.8, pp.3295-3302, 2006.
DOI : 10.1182/blood-2005-07-2730

S. Montaner, A. Sodhi, J. Servitja, A. Ramsdell, A. Barac et al., The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia, Blood, vol.104, issue.9, pp.2903-2911, 2004.
DOI : 10.1182/blood-2003-12-4436

C. Grossmann, S. Podgrabinska, M. Skobe, and D. Ganem, Activation of NF-??B by the Latent vFLIP Gene of Kaposi's Sarcoma-Associated Herpesvirus Is Required for the Spindle Shape of Virus-Infected Endothelial Cells and Contributes to Their Proinflammatory Phenotype, Journal of Virology, vol.80, issue.14, pp.7179-7185, 2006.
DOI : 10.1128/JVI.01603-05

E. Caselli, S. Fiorentini, C. Amici, D. Luca, D. Caruso et al., Human herpesvirus 8 acute infection of endothelial cells induces monocyte chemoattractant protein 1-dependent capillary-like structure formation: role of the IKK/NF-??B pathway, Blood, vol.109, pp.2718-2726, 2007.
DOI : 10.1182/blood-2006-03-012500

D. Martin, R. Galisteo, Y. Ji, S. Montaner, and J. Gutkind, An NF-??B gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia, Oncogene, vol.191, issue.13, pp.1844-1852, 2008.
DOI : 10.1038/sj.onc.1210817

I. Guasparri, S. Keller, and E. Cesarman, KSHV vFLIP Is Essential for the Survival of Infected Lymphoma Cells, The Journal of Experimental Medicine, vol.4, issue.7, pp.993-1003, 2004.
DOI : 10.1038/sj.onc.1204895

L. Liu, M. Eby, N. Rathore, S. Sinha, A. Kumar et al., The Human Herpes Virus 8-encoded Viral FLICE Inhibitory Protein Physically Associates with and Persistently Activates the I??B Kinase Complex, Journal of Biological Chemistry, vol.277, issue.16, pp.13745-13751, 2002.
DOI : 10.1074/jbc.M110480200

N. Field, W. Low, M. Daniels, S. Howell, L. Daviet et al., KSHV vFLIP binds to IKK-?? to activate IKK, Journal of Cell Science, vol.116, issue.18, pp.3721-3728, 2003.
DOI : 10.1242/jcs.00691

S. Montaner, A. Sodhi, A. Molinolo, T. Bugge, E. Sawai et al., Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes, Cancer Cell, vol.3, issue.1, pp.23-36, 2003.
DOI : 10.1016/S1535-6108(02)00237-4

P. Chugh, H. Matta, S. Schamus, S. Zachariah, A. Kumar et al., Constitutive NF-??B activation, normal Fas-induced apoptosis, and increased incidence of lymphoma in human herpes virus 8 K13 transgenic mice, Proceedings of the National Academy of Sciences, vol.102, issue.36, pp.12885-12890, 2005.
DOI : 10.1073/pnas.0408577102

G. Ballon, K. Chen, R. Perez, W. Tam, and E. Cesarman, Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice, Journal of Clinical Investigation, vol.121, issue.3, pp.1141-1153, 2011.
DOI : 10.1172/JCI44417DS1

C. Boshoff, Unraveling virus-induced lymphomagenesis, Journal of Clinical Investigation, vol.121, issue.3, pp.838-841, 2011.
DOI : 10.1172/JCI46499

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046640

S. Dittmer and D. , Viral latency locus augments B cell response in vivo to induce chronic marginal zone enlargement, plasma cell hyperplasia and lymphoma, Blood, vol.121, pp.2952-2963, 2013.

L. Arvanitakis, E. Geras-raaka, A. Varma, M. Gershengorn, and E. Cesarman, Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation, Nature, vol.385, issue.6614, pp.347-350, 1997.
DOI : 10.1038/385347a0

C. Santomasso, B. Coso, O. Arvanitakis, L. Raaka, E. Gutkind et al., G-proteincoupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator, Nature, vol.391, pp.86-89, 1998.

M. 27-rosenkilde, T. Kledal, P. Holst, and T. Schwartz, Selective Elimination of High Constitutive Activity or Chemokine Binding in the Human Herpesvirus 8 Encoded Seven Transmembrane Oncogene ORF74, Journal of Biological Chemistry, vol.275, issue.34, pp.26309-26315, 2000.
DOI : 10.1074/jbc.M003800200

C. , V. Geelen, A. Eroles, P. Mutlu, A. Chiozzini et al., Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2, Cancer Cell, vol.3, pp.131-143, 2003.

D. Martin, R. Galisteo, A. Molinolo, R. Wetzker, E. Hirsch et al., PI3K?? Mediates Kaposi's Sarcoma-Associated Herpesvirus vGPCR-Induced Sarcomagenesis, Cancer Cell, vol.19, issue.6, pp.805-813, 2011.
DOI : 10.1016/j.ccr.2011.05.005

URL : http://doi.org/10.1016/j.ccr.2011.05.005

J. Couty, E. Geras-raaka, B. Weksler, and M. Gershengorn, Kaposi's Sarcoma-associated Herpesvirus G Protein-coupled Receptor Signals through Multiple Pathways in Endothelial Cells, Journal of Biological Chemistry, vol.276, issue.36, pp.33805-33811, 2001.
DOI : 10.1074/jbc.M104631200

M. Smit, D. Verzijl, P. Casarosa, M. Navis, H. Timmerman et al., Kaposi's Sarcoma-Associated Herpesvirus-Encoded G Protein-Coupled Receptor ORF74 Constitutively Activates p44/p42 MAPK and Akt via Gi and Phospholipase C-Dependent Signaling Pathways, Journal of Virology, vol.76, issue.4, pp.1744-1752, 2002.
DOI : 10.1128/JVI.76.4.1744-1752.2002

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135879

J. Dwyer, L. Guelte, A. , G. Moya, E. Sumbal et al., Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor, Oncogene, vol.9, issue.2, pp.190-200, 2011.
DOI : 10.1038/nature03987

M. Schwarz and P. Murphy, Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Constitutively Activates NF-??B and Induces Proinflammatory Cytokine and Chemokine Production Via a C-Terminal Signaling Determinant, The Journal of Immunology, vol.167, issue.1, pp.505-513, 2001.
DOI : 10.4049/jimmunol.167.1.505

M. 35-cannon, N. Philpott, and E. Cesarman, The Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Has Broad Signaling Effects in Primary Effusion Lymphoma Cells, Journal of Virology, vol.77, issue.1, pp.57-67, 2003.
DOI : 10.1128/JVI.77.1.57-67.2003

D. Lagos, R. Vart, F. Gratrix, S. Westrop, V. Emuss et al., Toll-like Receptor 4 Mediates Innate Immunity to Kaposi Sarcoma Herpesvirus, Cell Host & Microbe, vol.4, issue.5, pp.470-483, 2008.
DOI : 10.1016/j.chom.2008.09.012

S. Montaner, I. Kufareva, R. Abagyan, and J. Gutkind, Molecular Mechanisms Deployed by Virally Encoded G Protein???Coupled Receptors in Human Diseases, Annual Review of Pharmacology and Toxicology, vol.53, issue.1, pp.331-354, 2013.
DOI : 10.1146/annurev-pharmtox-010510-100608

D. Oliveira, G. Ballon, and E. Cesarman, NF-??B signaling modulation by EBV and KSHV, Trends in Microbiology, vol.18, issue.6, pp.248-257, 2010.
DOI : 10.1016/j.tim.2010.04.001

H. Chang and D. Ganem, A Unique Herpesviral Transcriptional Program in KSHV-Infected Lymphatic Endothelial Cells Leads to mTORC1 Activation and Rapamycin Sensitivity, Cell Host & Microbe, vol.13, issue.4, pp.429-440, 2013.
DOI : 10.1016/j.chom.2013.03.009

F. Liu, Y. Xia, A. Parker, and I. Verma, IKK biology, Immunological Reviews, vol.246, issue.1, pp.239-253, 2012.
DOI : 10.1111/j.1600-065X.2012.01107.x

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311052

A. Marchese, C. Chen, Y. Kim, and J. Benovic, The ins and outs of G protein-coupled receptor trafficking, Trends in Biochemical Sciences, vol.28, issue.7, pp.369-376, 2003.
DOI : 10.1016/S0968-0004(03)00134-8

D. Waugh and C. Wilson, The Interleukin-8 Pathway in Cancer, Clinical Cancer Research, vol.14, issue.21, pp.6735-6741, 2008.
DOI : 10.1158/1078-0432.CCR-07-4843

L. Hassman, T. Ellison, and D. Kedes, KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation, Journal of Clinical Investigation, vol.121, issue.2, pp.752-768, 2011.
DOI : 10.1172/JCI44185

J. Myoung and D. Ganem, Active lytic infection of human primary tonsillar B cells by KSHV and its noncytolytic control by activated CD4+ T cells, Journal of Clinical Investigation, vol.121, issue.3, pp.1130-1140, 2011.
DOI : 10.1172/JCI43755DS1

M. Cannon and E. Cesarman, The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells, Oncogene, vol.23, issue.2, pp.514-523, 2004.
DOI : 10.1038/sj.onc.1207021

A. Sodhi, S. Montaner, V. Patel, J. Gomez-roman, Y. Li et al., Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor, Proceedings of the National Academy of Sciences, vol.101, issue.14, pp.4821-4826, 2004.
DOI : 10.1073/pnas.0400835101

A. Benmerah, M. Bayrou, N. Cerf-bensussan, and A. Dautry-varsat, Inhibition of clathrincoated pit assembly by an Eps15 mutant, J Cell Sci, vol.112, pp.1303-1311, 1999.

J. Dwyer, J. Hebda, L. Guelte, A. Galan-moya, E. Smith et al., Glioblastoma Cell-Secreted Interleukin-8 Induces Brain Endothelial Cell Permeability via CXCR2, PLoS ONE, vol.7, issue.9, p.45562, 2012.
DOI : 10.1371/journal.pone.0045562.t001

W. , M. D. Gutkind, and J. , The Galpha13-Rho signaling axis is required for SDF- 1-induced migration through CXCR4, J Biol Chem, vol.281, pp.39542-39549, 2006.