Implementation of an adaptive group sequential design in a bioequivalence study, Pharmaceutical Statistics, vol.96, issue.2, pp.115-137, 2007. ,
DOI : 10.1002/pst.252
Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0, Computer Methods and Programs in Biomedicine, vol.98, issue.1, pp.55-65, 2010. ,
DOI : 10.1016/j.cmpb.2009.09.012
URL : https://hal.archives-ouvertes.fr/inserm-00431457
Fisher information matrix for nonlinear mixed effects multiple response models: Evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model, Statistics in Medicine, vol.60, issue.14, pp.1940-56, 2009. ,
DOI : 10.1111/j.0006-341X.2004.00148.x
URL : https://hal.archives-ouvertes.fr/inserm-00371363
Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials, Journal of Biopharmaceutical Statistics, vol.40, issue.6, pp.965-95, 2007. ,
DOI : 10.2307/2530666
Evaluation of a sparse sampling strategy for determining vancomycin pharmacokinetics in preterm neonates: application of optimal sampling theory. The Annals of Pharmacotherapy, pp.980-983, 1997. ,
Optimal three-stage designs for phase II cancer clinical trials, Statistics in Medicine, vol.16, issue.23, pp.2701-2712, 1997. ,
DOI : 10.1002/(SICI)1097-0258(19971215)16:23<2701::AID-SIM704>3.0.CO;2-1
Adaptive design methods in clinical trials. Chapman and Hall/CRC ; Boca Raton, 2007. ,
Model selection and model averaging, Cambridge Series in Statistical and Probabilistic Mathematics, 2008. ,
SAEMIX, an R version of the SAEM algorithm, Population Approach Group in Europe, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00717539
Robust Population Pharmacokinetic Experiment Design, Journal of Pharmacokinetics and Pharmacodynamics, vol.99, issue.1, pp.33-64, 2005. ,
DOI : 10.1007/s10928-005-2102-z
Adaptive designs: terminology and classification, Drug Information Journal, vol.40, pp.425-460, 2006. ,
A Simulation Study to Compare New Adaptive Dose???Ranging Designs, Statistics in Biopharmaceutical Research, vol.2, issue.4, pp.487-512, 2010. ,
DOI : 10.1198/sbr.2010.09045
Model, Journal of Biopharmaceutical Statistics, vol.35, issue.6, pp.1051-70, 2007. ,
DOI : 10.1080/10543400600860469
Guideline on the role of pharmacokinetics in the development of medicinal products in the paediatric population, 2006. ,
Reflection paper on methodological issues in confirmatory clinical trials planned with an adaptive design, 2009. ,
Optimal design for nonlinear response models. Chapman & Hall, CRC Biostatistics Series, p.2014 ,
Optimal dose-finding designs with correlated continuous and discrete responses, Statistics in Medicine, vol.72, issue.3, pp.217-251, 2012. ,
DOI : 10.1002/sim.4388
Critical Path Opportunities List, 2006. ,
Guidance for Industry: adaptive design clinical trials for drugs and biologics, 2010. ,
Adaptive Optimal Design for Bridging Studies with an Application to Population Pharmacokinetic Studies, Pharmaceutical Research, vol.34, issue.6, pp.1530-1573, 2012. ,
DOI : 10.1007/s11095-011-0659-3
Comparison of Robust Criteria for D-Optimal Designs, Journal of Biopharmaceutical Statistics, vol.253, issue.1, pp.1193-1205, 2012. ,
DOI : 10.1023/A:1025701327672
A program for individual and population optimal design for univariate and multivariate response pharmacokinetic???pharmacodynamic models, Computer Methods and Programs in Biomedicine, vol.86, issue.1, pp.51-61, 2007. ,
DOI : 10.1016/j.cmpb.2007.01.004
A Unified Theory of Two-Stage Adaptive Designs, Journal of the American Statistical Association, vol.97, issue.460, pp.1034-1075, 2002. ,
DOI : 10.1198/016214502388618852
Current Use and Developments Needed for Optimal Design in Pharmacometrics: A Study Performed Among DDMoRe???s European Federation of Pharmaceutical Industries and Associations Members, CPT: Pharmacometrics & Systems Pharmacology, vol.2, issue.6, p.46, 2013. ,
DOI : 10.1007/s11095-011-0659-3
Population pharmacokinetic analysis and optimization of the experimental design for Mizolastine solution in children, Journal of Pharmacokinetics and Pharmacodynamics, vol.28, issue.3, pp.299-319, 2001. ,
DOI : 10.1023/A:1011583210549
Optimal design in random-effects regression models, Biometrika, vol.84, issue.2, pp.429-442, 1997. ,
DOI : 10.1093/biomet/84.2.429
Approximations of the Fisher information for the construction of efficient experimental designs in nonlinear mixed effects models, 2012. ,
Some Considerations on the Fisher Information in Nonlinear Mixed Effects Models, Proceedings of the 9th international workshop in model-oriented design and analysis, 2010. ,
DOI : 10.1007/978-3-7908-2410-0_17
Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models, Statistics in Medicine, vol.30, issue.11-12, pp.1043-1058, 2012. ,
DOI : 10.1002/sim.4191
URL : https://hal.archives-ouvertes.fr/inserm-00629594
Methods and software tools for design evaluation in population pharmacokinetics-pharmacodynamics ,
URL : https://hal.archives-ouvertes.fr/hal-00951896
Design of experiments in nonlinear models, p.2013 ,
DOI : 10.1007/978-1-4614-6363-4
URL : https://hal.archives-ouvertes.fr/hal-00879984
Robust experiment design via maximin optimization, Mathematical Biosciences, vol.89, issue.2, pp.161-76, 1988. ,
DOI : 10.1016/0025-5564(88)90097-1
Design in nonlinear mixed effects models: Optimization using the Fedorov???Wynn algorithm and power of the Wald test for binary covariates, Statistics in Medicine, vol.39, issue.28, pp.5162-5179, 2007. ,
DOI : 10.1002/sim.2910
URL : https://hal.archives-ouvertes.fr/hal-00263513
Development and implementation of the population Fisher information matrix for the evaluation of population pharmacokinetic designs, Computer Methods and Programs in Biomedicine, vol.65, issue.2, pp.141-51, 2001. ,
DOI : 10.1016/S0169-2607(00)00117-6
Fisher information matrix for non-linear mixed-effects models: evaluation and application for optimal design of enoxaparin population pharmacokinetics, Statistics in Medicine, vol.26, issue.6, pp.2623-2662, 2002. ,
DOI : 10.1002/sim.1041
Modelling of individual pharmacokinetics for computeraided drug dosage, Computers and Biomedical Research, vol.5, pp.411-459, 1972. ,
Pharmacokinetic/Pharmacodynamic Modeling in Drug Development, Annual Review of Pharmacology and Toxicology, vol.40, issue.1, pp.67-95, 2000. ,
DOI : 10.1146/annurev.pharmtox.40.1.67
Facilitation of Drug Evaluation in Children by??Population Methods and Modelling???, Clinical Pharmacokinetics, vol.116, issue.4, pp.231-274, 2008. ,
DOI : 10.2165/00003088-200847040-00002
Adaptive-Optimal Design in PET Occupancy Studies, Clinical Pharmacology & Therapeutics, vol.87, issue.5, pp.563-71, 2010. ,
DOI : 10.1111/j.2005.0906-7590.04112.x