Mitochondrial complex I deficiency in Parkinson's disease, Lancet, vol.1, p.1269, 1989. ,
BRAIN, SKELETAL MUSCLE AND PLATELET HOMOGENATE MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE, Brain, vol.115, issue.2, 1992. ,
DOI : 10.1093/brain/115.2.333
Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism, Neurobiology of Disease, vol.51, pp.35-42, 2013. ,
DOI : 10.1016/j.nbd.2012.10.011
What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease, Physiological Reviews, vol.91, issue.4, pp.1161-1218, 2011. ,
DOI : 10.1152/physrev.00022.2010
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death, Human Molecular Genetics, vol.12, issue.5, pp.517-526, 2003. ,
DOI : 10.1093/hmg/ddg044
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization, Proceedings of the National Academy of Sciences, vol.101, issue.24, pp.9103-9108, 2004. ,
DOI : 10.1073/pnas.0402959101
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1, Science, vol.304, issue.5674, pp.1158-1160, 2004. ,
DOI : 10.1126/science.1096284
Mitochondrial quality control turns out to be the principal suspect in parkin and PINK1-related autosomal recessive Parkinson's disease, Current Opinion in Neurobiology, vol.23, issue.1, pp.100-108, 2013. ,
DOI : 10.1016/j.conb.2012.11.002
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, The Journal of Cell Biology, vol.84, issue.5, pp.795-803, 2008. ,
DOI : 10.1073/pnas.0711845105
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin, PLoS Biology, vol.126, issue.1, p.1000298, 2010. ,
DOI : 10.1371/journal.pbio.1000298.s013
Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism, Cold Spring Harbor Perspectives in Biology, vol.4, issue.11, 2012. ,
DOI : 10.1101/cshperspect.a011338
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy, Proceedings of the National Academy of Sciences, vol.107, issue.1, pp.378-383, 2010. ,
DOI : 10.1073/pnas.0911187107
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations, Autophagy, vol.6, issue.7, pp.871-878, 2010. ,
DOI : 10.4161/auto.6.7.13286
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy, The Journal of Cell Biology, vol.19, issue.2, pp.211-221, 2010. ,
DOI : 10.1073/pnas.0802814105
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proceedings of the National Academy of Sciences, vol.103, issue.28, pp.10793-10798, 2006. ,
DOI : 10.1073/pnas.0602493103
The PINK1/Parkin pathway regulates mitochondrial morphology, Proceedings of the National Academy of Sciences, vol.105, issue.5, pp.1638-1643, 2008. ,
DOI : 10.1073/pnas.0709336105
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila, Proceedings of the National Academy of Sciences, vol.105, issue.38, pp.14503-14508, 2008. ,
DOI : 10.1073/pnas.0803998105
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility, Cell, vol.147, issue.4, pp.893-906, 2011. ,
DOI : 10.1016/j.cell.2011.10.018
Parkinson's Disease???Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria, PLoS Genetics, vol.5, issue.3, p.1002537, 2012. ,
DOI : 10.1371/journal.pgen.1002537.s008
PARIS (ZNF746) Repression of PGC-1?? Contributes to Neurodegeneration in Parkinson's Disease, Cell, vol.144, issue.5, pp.689-702, 2011. ,
DOI : 10.1016/j.cell.2011.02.010
Mitochondrial defect and PGC-1?? dysfunction in parkin-associated familial Parkinson's disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1812, issue.8, pp.1041-1053, 2011. ,
DOI : 10.1016/j.bbadis.2010.12.022
Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin, Journal of Neuroscience, vol.27, issue.45, pp.12413-12418, 2007. ,
DOI : 10.1523/JNEUROSCI.0719-07.2007
PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death, Molecular Cell, vol.33, issue.5, pp.627-638, 2009. ,
DOI : 10.1016/j.molcel.2009.02.013
7. Mitochondrial function and morphology are impaired in parkin mutant fibroblasts, Mitochondrion, vol.9, issue.1, pp.555-565, 2008. ,
DOI : 10.1016/j.mito.2008.12.009
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function, EMBO Molecular Medicine, vol.14, issue.2, pp.99-111, 2009. ,
DOI : 10.1002/emmm.200900006
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect, Proceedings of the National Academy of Sciences, vol.108, issue.39, pp.16259-16264, 2011. ,
DOI : 10.1073/pnas.1113884108
Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology, Experimental Neurology, vol.219, issue.1, pp.266-273, 2009. ,
DOI : 10.1016/j.expneurol.2009.05.027
Mutant Parkin Impairs Mitochondrial Function and Morphology in Human Fibroblasts, PLoS ONE, vol.5, issue.9, p.12962, 2010. ,
DOI : 10.1371/journal.pone.0012962.t001
Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations, Movement Disorders, vol.254, issue.Suppl., pp.544-548, 2004. ,
DOI : 10.1002/mds.10695
Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo, Proceedings of the National Academy of Sciences, vol.108, issue.31, pp.12937-12942, 2011. ,
DOI : 10.1073/pnas.1103295108
Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization, Human Molecular Genetics, vol.20, issue.5, pp.927-940, 2011. ,
DOI : 10.1093/hmg/ddq531
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress, Proceedings of the National Academy of Sciences, vol.105, issue.32, pp.11364-11369, 2008. ,
DOI : 10.1073/pnas.0802076105
Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration, PLoS ONE, vol.18, issue.6, p.5777, 2009. ,
DOI : 10.1371/journal.pone.0005777.s010
Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice, Journal of Biological Chemistry, vol.279, issue.18, pp.18614-18622, 2004. ,
DOI : 10.1074/jbc.M401135200
Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function, Journal of Neurochemistry, vol.44, issue.5, pp.1259-1276, 2005. ,
DOI : 10.1111/j.1471-4159.2005.03442.x
Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage, Human Molecular Genetics, vol.16, issue.20, pp.2377-2393, 2007. ,
DOI : 10.1093/hmg/ddm083
Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons, Journal of Biological Chemistry, vol.278, issue.44, pp.43628-43635, 2003. ,
DOI : 10.1074/jbc.M308947200
Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse, Human Molecular Genetics, vol.12, issue.18, pp.2277-2291, 2003. ,
DOI : 10.1093/hmg/ddg239
Loss of locus coeruleus neurons and reduced startle in parkin null mice, Proceedings of the National Academy of Sciences, vol.101, issue.29, pp.10744-10749, 2004. ,
DOI : 10.1073/pnas.0401297101
Parkin-deficient mice are not a robust model of parkinsonism, Proceedings of the National Academy of Sciences, vol.102, issue.6, pp.2174-2179, 2005. ,
DOI : 10.1073/pnas.0409598102
Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy, PLoS ONE, vol.23, issue.8, p.6629, 2009. ,
DOI : 10.1371/journal.pone.0006629.s006
URL : https://hal.archives-ouvertes.fr/hal-00541956
Isolation and Functional Assessment of Mitochondria from Small Amounts of Mouse Brain Tissue, Methods Mol Biol, vol.793, pp.311-324, 2011. ,
DOI : 10.1007/978-1-61779-328-8_20
Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain, Experimental Neurology, vol.119, issue.1, pp.72-78, 1993. ,
DOI : 10.1006/exnr.1993.1007
Oligodendrocyte-derived J1-160/180 extracellular matrix glycoproteins are adhesive or repulsive depending on the partner cell type and time of interaction, Experimental Neurology, vol.109, issue.1, pp.98-110, 1990. ,
DOI : 10.1016/S0014-4886(05)80012-3
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells, AJP: Cell Physiology, vol.292, issue.1, pp.125-136, 2007. ,
DOI : 10.1152/ajpcell.00247.2006
Development and implementation of standardized respiratory chain spectrophotometric assays for clinical diagnosis, Mitochondrion, vol.9, issue.5, pp.331-339, 2009. ,
DOI : 10.1016/j.mito.2009.05.001
URL : https://hal.archives-ouvertes.fr/inserm-00516056
The ratio of oxidative phosphorylation complexes I?V in bovine heart mitochondria and the composition of respiratory chain supercomplexes, J Biol Chem, vol.276, pp.37861-37867, 2001. ,
High Level of Uncoupling Protein 1 Expression in Muscle of Transgenic Mice Selectively Affects Muscles at Rest and Decreases Their IIb Fiber Content, Journal of Biological Chemistry, vol.277, issue.45, pp.43079-43088, 2002. ,
DOI : 10.1074/jbc.M206726200
Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown adipocytes, Antivir Ther, vol.12, pp.919-929, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00148353
Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia, Human Molecular Genetics, vol.17, issue.18, pp.2790-2802, 2008. ,
DOI : 10.1093/hmg/ddn178
Oxidative stress and protease dysfunction in the yeast model of Friedreich ataxia, Free Radical Biology and Medicine, vol.42, issue.10, pp.1561-1570, 2007. ,
DOI : 10.1016/j.freeradbiomed.2007.02.014
Cellular Mechanisms of Brain Energy Metabolism. Relevance to Functional Brain Imaging and to Neurodegenerative Disordersa, Annals of the New York Academy of Sciences, vol.90, issue.1, pp.380-387, 1996. ,
DOI : 10.1111/j.1749-6632.1996.tb34449.x
DJ-1 knock-down impairs astrocyte mitochondrial function, Neuroscience, vol.196, pp.251-264, 2011. ,
DOI : 10.1016/j.neuroscience.2011.08.016
BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures, Neuron, vol.74, issue.4, pp.719-730, 2012. ,
DOI : 10.1016/j.neuron.2012.03.032
Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases, Human Molecular Genetics, vol.18, issue.R2, pp.169-176, 2009. ,
DOI : 10.1093/hmg/ddp326
Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio), Brain, vol.132, issue.6, pp.1613-1623, 2009. ,
DOI : 10.1093/brain/awp108
Biochemical Assays of Respiratory Chain Complex Activity, Methods Cell Biol, vol.80, pp.93-119, 2007. ,
DOI : 10.1016/S0091-679X(06)80004-X
Manganese superoxide dismutase in disease, Free Radical Research, vol.96, issue.8, pp.325-336, 2001. ,
DOI : 10.1002/(SICI)1097-0045(19980515)35:3<221::AID-PROS8>3.0.CO;2-J
Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease, Cell Death and Differentiation, vol.254, issue.12, pp.1914-1923, 2011. ,
DOI : 10.1038/cdd.2011.74
Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction, Journal of Biological Chemistry, vol.288, issue.2, pp.915-926, 2013. ,
DOI : 10.1074/jbc.M112.411363
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543040
Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes, Communicative & Integrative Biology, vol.1, issue.4, p.24511, 2013. ,
DOI : 10.1002/mds.10695
The Biologic Clock: The Mitochondria?, Journal of the American Geriatrics Society, vol.12, issue.II, pp.145-147, 1972. ,
DOI : 10.1111/j.1532-5415.1972.tb00787.x
Loss of PINK1 enhances neurodegeneration in a mouse model of??Parkinson's disease triggered by mitochondrial stress, Neuropharmacology, vol.77, pp.350-357, 2014. ,
DOI : 10.1016/j.neuropharm.2013.10.009