Targeting the microenvironment in chronic lymphocytic leukemia is changing the therapeutic landscape, Current Opinion in Oncology, vol.24, issue.6, pp.643-649, 2012. ,
DOI : 10.1097/CCO.0b013e3283589950
: Lessons Learned from Studies of the B Cell Antigen Receptor, Annual Review of Immunology, vol.21, issue.1, pp.841-894, 2003. ,
DOI : 10.1146/annurev.immunol.21.120601.141018
Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia, Blood, vol.115, issue.22, pp.4497-4506, 2010. ,
DOI : 10.1182/blood-2009-07-233692
The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways, Blood, vol.111, issue.2, pp.517-524, 2008. ,
DOI : 10.1182/blood-2007-04-087882
CLL, but not normal, B cells are dependent on autocrine VEGF and ??4??1 integrin for chemokine-induced motility on and through endothelium, Blood, vol.105, issue.12, pp.4813-4819, 2005. ,
DOI : 10.1182/blood-2004-10-4054
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia, Nature Cell Biology, vol.17, issue.3, pp.276-286, 2012. ,
DOI : 10.1038/ncb2432
Signalling: STATs: transcriptional control and biological impact, Nature Reviews Molecular Cell Biology, vol.93, issue.9, pp.651-662, 2002. ,
DOI : 10.1038/nrm909
Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival, Blood, vol.99, issue.1, pp.252-257, 2002. ,
DOI : 10.1182/blood.V99.1.252
STAT proteins: novel molecular targets for cancer drug discovery, Oncogene, vol.19, issue.56, pp.6613-6626, 2000. ,
DOI : 10.1038/sj.onc.1204086
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF??B, Genes & Development, vol.21, issue.11, pp.1396-1408, 2007. ,
DOI : 10.1101/gad.1553707
Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation, Science, vol.324, issue.5935, pp.1713-1716, 2009. ,
DOI : 10.1126/science.1171721
Function of Mitochondrial Stat3 in Cellular Respiration, Science, vol.323, issue.5915, pp.793-797, 2009. ,
DOI : 10.1126/science.1164551
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues., Journal of Clinical Investigation, vol.100, issue.12, pp.3140-3148, 1997. ,
DOI : 10.1172/JCI119869
STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells, Blood, vol.115, issue.14, pp.2852-2863, 2010. ,
DOI : 10.1182/blood-2009-10-230060
Roles of unphosphorylated STATs in signaling, Cell Research, vol.12, issue.4, pp.443-451, 2008. ,
DOI : 10.1016/S1534-5807(02)00126-0
Nuclear DNA origin of mitochondrial complex I deficiency in fatal infantile lactic acidosis evidenced by transnuclear complementation of cultured fibroblasts, Journal of Clinical Investigation, vol.104, issue.1, pp.83-92, 1999. ,
DOI : 10.1172/JCI6184
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance, Blood, vol.114, issue.20, pp.4441-4450, 2009. ,
DOI : 10.1182/blood-2009-07-233718
Increased mitochondrial biogenesis in primary leukemia cells: the role of endogenous nitric oxide and impact on sensitivity to fludarabine, Leukemia, vol.18, issue.12, pp.1934-1940, 2004. ,
DOI : 10.1038/sj.leu.2403545
Quantification of Basal and Stimulated ROS Levels as Predictors of Islet Potency and Function, American Journal of Transplantation, vol.53, issue.2, pp.38-47, 2007. ,
DOI : 10.1016/S0014-5793(03)00235-7
Proteins as binding targets of isothiocyanates in cancer prevention, Carcinogenesis, vol.32, issue.10, pp.1405-1413, 2011. ,
DOI : 10.1093/carcin/bgr111
The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation, PLoS ONE, vol.7, issue.11, p.83395, 2013. ,
DOI : 10.1371/journal.pone.0083395.g004
Efficient and stable transduction of resting B lymphocytes and primary chronic lymphocyte leukemia cells using measles virus gp displaying lentiviral vectors, Blood, vol.114, issue.15, pp.3173-3180, 2009. ,
DOI : 10.1182/blood-2009-05-220798
VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance, Leukemia, vol.19, pp.513-523, 2005. ,
Notch signalling regulates stem cell numbers in vitro and in vivo, Nature, vol.12, issue.7104, pp.823-826, 2006. ,
DOI : 10.1016/j.devcel.2005.09.010
STAT3 as a Downstream Mediator of Trk Signaling and Functions, Journal of Biological Chemistry, vol.281, issue.23, pp.15636-15644, 2006. ,
DOI : 10.1074/jbc.M601863200
Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells, Journal of Cell Science, vol.125, issue.13, pp.3210-3220, 2012. ,
DOI : 10.1242/jcs.102210
The cdk5 Kinase Regulates the STAT3 Transcription Factor to Prevent DNA Damage upon Topoisomerase I Inhibition, Journal of Biological Chemistry, vol.285, issue.35, pp.26765-26778, 2010. ,
DOI : 10.1074/jbc.M109.092304
Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species, Journal of Biological Chemistry, vol.286, issue.34, pp.29610-29620, 2011. ,
DOI : 10.1074/jbc.M111.226209
Mitochondrial Localized STAT3 Is Involved in NGF Induced Neurite Outgrowth, PLoS ONE, vol.10, issue.3, p.21680, 2011. ,
DOI : 10.1371/journal.pone.0021680.g009
Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727, Journal of Biological Chemistry, vol.288, issue.43, pp.31280-31288, 2013. ,
DOI : 10.1074/jbc.M113.505057
Antioxidant enzyme activities and the production of MDA and 8-oxo-dG in chronic lymphocytic lerkenia, Free Radical Biology and Medicine, vol.30, issue.11, pp.1286-1292, 2001. ,
DOI : 10.1016/S0891-5849(01)00521-4
Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents, Blood, vol.101, issue.10, pp.4098-4104, 2003. ,
DOI : 10.1182/blood-2002-08-2512
Mitochondrial glutathione: Features, regulation and role in disease, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1830, issue.5, pp.3317-3328, 2013. ,
DOI : 10.1016/j.bbagen.2012.10.018
Could STAT3 provide a link between respiration and cell cycle progression?, Cell Cycle, vol.277, issue.21, pp.4294-4296, 2010. ,
DOI : 10.1074/jbc.M606940200
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055182
-Glutathionylation Impairs Signal Transducer and Activator of Transcription 3 Activation and Signaling, Endocrinology, vol.150, issue.3, pp.1122-1131, 2009. ,
DOI : 10.1210/en.2008-1241
URL : https://hal.archives-ouvertes.fr/hal-01258438
Stoichiometry of STAT3 and Mitochondrial Proteins: IMPLICATIONS FOR THE REGULATION OF OXIDATIVE PHOSPHORYLATION BY PROTEIN-PROTEIN INTERACTIONS, Journal of Biological Chemistry, vol.285, issue.31, pp.23532-23536, 2010. ,
DOI : 10.1074/jbc.C110.152652
Cytometric assessment of mitochondria using fluorescent probes, Cytometry Part A, vol.122, issue.Suppl A, pp.405-425, 2011. ,
DOI : 10.1002/cyto.a.21061
URL : https://hal.archives-ouvertes.fr/inserm-00628558
Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells, Cell, vol.118, issue.2, pp.217-228, 2004. ,
DOI : 10.1016/j.cell.2004.06.028
A guided tour into subcellular colocalization analysis in light microscopy, Journal of Microscopy, vol.56, issue.3, pp.213-232, 2006. ,
DOI : 10.1016/S0014-5793(03)00521-0
URL : https://hal.archives-ouvertes.fr/hal-00132481
Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V, Blood, vol.87, pp.1385-1395, 1996. ,
STAT5 and Oct-1 Form a Stable Complex That Modulates Cyclin D1 Expression, Molecular and Cellular Biology, vol.23, issue.24, pp.8934-8945, 2003. ,
DOI : 10.1128/MCB.23.24.8934-8945.2003