L. Ossowski and J. Aguirre-ghiso, Dormancy of metastatic melanoma, Pigment Cell & Melanoma Research, vol.157, issue.Suppl 2, pp.41-56, 2010.
DOI : 10.1111/j.1755-148X.2009.00647.x

D. Strauss and J. Thomas, Transmission of donor melanoma by organ transplantation, The Lancet Oncology, vol.11, issue.8, pp.790-796, 2010.
DOI : 10.1016/S1470-2045(10)70024-3

J. Aguirre-ghiso, Models, mechanisms and clinical evidence for cancer dormancy, Nature Reviews Cancer, vol.20, issue.11, pp.834-846, 2007.
DOI : 10.1038/nrc2256

J. Chomel and A. Turhan, Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy, Oncotarget, vol.2, issue.9, pp.713-727, 2011.
DOI : 10.18632/oncotarget.333

M. Alison, W. Lin, S. Lim, and L. Nicholson, Cancer stem cells: In the line of fire, Cancer Treatment Reviews, vol.38, issue.6, pp.589-598, 2012.
DOI : 10.1016/j.ctrv.2012.03.003

P. Borst, Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?, Open Biology, vol.483, issue.7391, pp.120066-120066, 2012.
DOI : 10.1038/483546a

Y. Touil, W. Igoudjil, M. Corvaisier, A. Dessein, J. Vandomme et al., Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis, Clinical Cancer Research, vol.20, issue.4, pp.837-846, 2014.
DOI : 10.1158/1078-0432.CCR-13-1854

M. Essers and A. Trumpp, Targeting leukemic stem cells by breaking their dormancy, Molecular Oncology, vol.8, issue.5, pp.443-450, 2010.
DOI : 10.1016/j.molonc.2010.06.001

T. Tanno and W. Matsui, Development and Maintenance of Cancer Stem Cells under Chronic Inflammation, Journal of Nippon Medical School, vol.78, issue.3, pp.138-145, 2011.
DOI : 10.1272/jnms.78.138

J. Kundu and Y. Surh, Emerging avenues linking inflammation and cancer, Free Radical Biology and Medicine, vol.52, issue.9, pp.2013-2037, 2012.
DOI : 10.1016/j.freeradbiomed.2012.02.035

E. Carswell, L. Old, R. Kassel, S. Green, N. Fiore et al., An endotoxin-induced serum factor that causes necrosis of tumors., Proceedings of the National Academy of Sciences, vol.72, issue.9, pp.3666-3670, 1975.
DOI : 10.1073/pnas.72.9.3666

A. Mantovani, P. Allavena, A. Sica, and F. Balkwill, Cancer-related inflammation, Nature, vol.342, issue.7203, pp.436-444, 2008.
DOI : 10.1038/nature07205

L. Hruza and A. Pentland, Mechanisms of UV-Induced Inflammation, Journal of Investigative Dermatology, vol.100, issue.1, pp.35-41, 1993.
DOI : 10.1038/jid.1993.21

S. Pece, D. Tosoni, S. Confalonieri, G. Mazzarol, M. Vecchi et al., Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content, Cell, vol.140, issue.1, pp.62-73, 2010.
DOI : 10.1016/j.cell.2009.12.007

T. Tumbar, Defining the Epithelial Stem Cell Niche in Skin, Science, vol.303, issue.5656, pp.359-363, 2004.
DOI : 10.1126/science.1092436

T. Kanda, K. Sullivan, and G. Wahl, Histone???GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells, Current Biology, vol.8, issue.7, pp.377-385, 1998.
DOI : 10.1016/S0960-9822(98)70156-3

M. Tesio and A. Trumpp, Breaking the Cell Cycle of HSCs by p57 and Friends, Cell Stem Cell, vol.9, issue.3, pp.187-192, 2011.
DOI : 10.1016/j.stem.2011.08.005

T. Schatton, N. Frank, and M. Frank, Identification and targeting of cancer stem cells, BioEssays, vol.11, issue.10, pp.1038-1049, 2009.
DOI : 10.1002/bies.200900058

A. Boiko, O. Razorenova, M. Van-de-rijn, S. Swetter, D. Johnson et al., Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271, Nature, vol.453, issue.7302, pp.133-137, 2010.
DOI : 10.1038/nature09161

N. Frank, T. Schatton, S. Kim, Q. Zhan, B. Wilson et al., VEGFR-1 Expressed by Malignant Melanoma-Initiating Cells Is Required for Tumor Growth, Cancer Research, vol.71, issue.4, pp.1474-1485, 2011.
DOI : 10.1158/0008-5472.CAN-10-1660

E. Dupin and J. Coelho-aguiar, Isolation and differentiation properties of neural crest stem cells, Cytometry Part A, vol.2, issue.1, pp.38-47, 2013.
DOI : 10.1002/cyto.a.22098

J. Liu, C. Sato, M. Cerletti, and A. Wagers, Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation, Curr Top Dev Biol, vol.92, pp.367-409, 2010.
DOI : 10.1016/S0070-2153(10)92012-7

M. Croft, C. Benedict, and C. Ware, Clinical targeting of the TNF and TNFR superfamilies, Nature Reviews Drug Discovery, vol.66, issue.2, pp.147-168, 2013.
DOI : 10.1038/nrd3930

B. Reynolds and S. Weiss, Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system, Science, vol.255, issue.5052, pp.1707-1710, 1992.
DOI : 10.1126/science.1553558

M. Perego, M. Alison, L. Mariani, L. Rivoltini, and C. Castelli, Spheres of Influence in Cancer Stem Cell Biology, Journal of Investigative Dermatology, vol.131, issue.2, pp.546-547, 2010.
DOI : 10.1038/jid.2010.305

F. Hirschhaeuser, H. Menne, C. Dittfeld, J. West, W. Mueller-klieser et al., Multicellular tumor spheroids: An underestimated tool is catching up again, Journal of Biotechnology, vol.148, issue.1, pp.3-15, 2010.
DOI : 10.1016/j.jbiotec.2010.01.012

M. Davies and Y. Samuels, Analysis of the genome to personalize therapy for melanoma, Oncogene, vol.157, issue.41, pp.5545-5555, 2010.
DOI : 10.1038/onc.2008.244

M. Chartrain, J. Riond, A. Stennevin, I. Vandenberghe, B. Gomes et al., Melanoma Chemotherapy Leads to the Selection of ABCB5-Expressing Cells, PLoS ONE, vol.70, issue.12, p.36762, 2012.
DOI : 10.1371/journal.pone.0036762.s002

D. Fang, T. Nguyen, K. Leishear, R. Finko, A. Kulp et al., A Tumorigenic Subpopulation with Stem Cell Properties in Melanomas, Cancer Research, vol.65, issue.20, pp.9328-9337, 2005.
DOI : 10.1158/0008-5472.CAN-05-1343

P. Eves, C. Layton, S. Hedley, R. Dawson, M. Wagner et al., Characterization of an in vitro model of human melanoma invasion based on reconstructed human skin, British Journal of Dermatology, vol.91, issue.Suppl., pp.210-222, 2000.
DOI : 10.1046/j.1365-2133.2000.03287.x

L. Li, M. Fukunaga-kalabis, and M. Herlyn, The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression, Journal of Visualized Experiments, vol.54, issue.54, p.2937, 2011.
DOI : 10.3791/2937

J. Landsberg, J. Kohlmeyer, M. Renn, T. Bald, M. Rogava et al., Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation, Nature, vol.6, issue.7420, pp.412-416, 2012.
DOI : 10.1038/nature11538

H. Takizawa, R. Regoes, C. Boddupalli, S. Bonhoeffer, and M. Manz, Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation, The Journal of Experimental Medicine, vol.156, issue.2, pp.273-284, 2011.
DOI : 10.1016/j.stem.2007.10.020

B. Jiang and L. Liu, Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis, In Adv Cancer Res, vol.102, pp.19-65, 2009.
DOI : 10.1016/S0065-230X(09)02002-8

T. Kimura and T. Nakano, Regulation of Stem Cell Systems by PI3K/Akt Signaling, Regul Netw Stem Cells, pp.309-318, 2009.
DOI : 10.1007/978-1-60327-227-8_26

K. Ito and T. Suda, Metabolic requirements for the maintenance of self-renewing stem cells, Nature Reviews Molecular Cell Biology, vol.21, issue.4, pp.243-256, 2014.
DOI : 10.1038/nrm3772

S. Sykes, S. Lane, L. Bullinger, D. Kalaitzidis, R. Yusuf et al., AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias, Cell, vol.146, issue.5, pp.697-708, 2011.
DOI : 10.1016/j.cell.2011.07.032

J. Wray, T. Kalkan, S. Gomez-lopez, D. Eckardt, A. Cook et al., Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation, Nature Cell Biology, vol.128, issue.7, pp.838-845, 2011.
DOI : 10.1016/j.stem.2008.09.013

M. Davies, The Role of the PI3K-AKT Pathway in Melanoma, The Cancer Journal, vol.18, issue.2, pp.142-147, 2012.
DOI : 10.1097/PPO.0b013e31824d448c

A. Russo, B. Ficili, S. Candido, F. Pezzino, C. Guarneri et al., Emerging targeted therapies for melanoma treatment (Review), International Journal of Oncology, vol.45, pp.516-524, 2014.
DOI : 10.3892/ijo.2014.2481

A. Richmond, NF-??B, chemokine gene transcription and tumour growth, Nature Reviews Immunology, vol.70, issue.9, pp.664-674, 2002.
DOI : 10.1038/nri887

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668257

S. Smale, Hierarchies of NF-??B target-gene regulation, Nature Immunology, vol.12, issue.8, pp.689-694, 2011.
DOI : 10.1093/emboj/cdg370

Y. Ben-neriah and K. M. , Inflammation meets cancer, with NF-??B as the matchmaker, Nature Immunology, vol.104, issue.8, pp.715-723, 2011.
DOI : 10.1038/nature09673

M. Baldridge, K. King, and M. Goodell, Inflammatory signals regulate hematopoietic stem cells, Trends in Immunology, vol.32, issue.2, pp.57-65, 2011.
DOI : 10.1016/j.it.2010.12.003

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042730

F. Meng, L. Liu, P. Chin, D. Mello, and S. , Akt Is a Downstream Target of NF-kappa B, Journal of Biological Chemistry, vol.277, issue.33, pp.29674-29680, 2002.
DOI : 10.1074/jbc.M112464200

A. Oeckinghaus, M. Hayden, and S. Ghosh, Crosstalk in NF-??B signaling pathways, Nature Immunology, vol.13, issue.8, pp.695-708, 2011.
DOI : 10.1016/j.cell.2007.07.009

S. Sundaramoorthy, M. Ryu, and I. Lim, B-cell translocation gene 2 mediates crosstalk between PI3K/Akt1 and NF??B pathways which enhances transcription of MnSOD by accelerating I??B?? degradation in normal and cancer cells, Cell Communication and Signaling, vol.11, issue.1, pp.69-83, 2013.
DOI : 10.1016/j.bbrc.2013.03.114

N. Moore and S. Lyle, Quiescent, Slow-Cycling Stem Cell Populations in Cancer: A Review of the Evidence and Discussion of Significance, Journal of Oncology, vol.9, issue.6, p.11, 2011.
DOI : 10.1038/sj.onc.1202840

T. Cheung and T. Rando, Molecular regulation of stem cell quiescence, Nature Reviews Molecular Cell Biology, vol.302, issue.6, pp.329-340, 2013.
DOI : 10.1038/nrm3591

D. Paez, M. Labonte, P. Bohanes, W. Zhang, L. Benhanim et al., Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence, Clinical Cancer Research, vol.18, issue.3, pp.645-653, 2011.
DOI : 10.1158/1078-0432.CCR-11-2186

S. Shigdar, Y. Li, S. Bhattacharya, O. Connor, M. Pu et al., Inflammation and cancer stem cells, Cancer Letters, vol.345, issue.2, pp.271-278, 2014.
DOI : 10.1016/j.canlet.2013.07.031

L. Schuettpelz and D. Link, Regulation of Hematopoietic Stem Cell Activity by Inflammation, Frontiers in Immunology, vol.4, pp.204-213, 2013.
DOI : 10.3389/fimmu.2013.00204

A. Cicalese, G. Bonizzi, C. Pasi, M. Faretta, S. Ronzoni et al., The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells, Cell, vol.138, issue.6, pp.1083-1095, 2009.
DOI : 10.1016/j.cell.2009.06.048

K. Nicholson and N. Anderson, The protein kinase B/Akt signalling pathway in human malignancy, Cellular Signalling, vol.14, issue.5, pp.381-395, 2002.
DOI : 10.1016/S0898-6568(01)00271-6

M. Martini, D. Santis, M. Braccini, L. Gulluni, F. Hirsch et al., PI3K/AKT signaling pathway and cancer: an updated review, Annals of Medicine, vol.15, issue.3, pp.372-383, 2014.
DOI : 10.1158/1535-7163.MCT-11-1021

B. Wilson, K. Saab, M. J. Schatton, T. Putz, P. Zhan et al., ABCB5 Maintains Melanoma-Initiating Cells through a Proinflammatory Cytokine Signaling Circuit, Cancer Research, vol.74, issue.15, pp.4196-4207, 2014.
DOI : 10.1158/0008-5472.CAN-14-0582

S. Mani, W. Guo, M. Liao, E. Eaton, A. Ayyanan et al., The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells, Cell, vol.133, issue.4, pp.704-715, 2008.
DOI : 10.1016/j.cell.2008.03.027

C. Chaffer, I. Brueckmann, C. Scheel, A. Kaestli, P. Wiggins et al., Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state, Proceedings of the National Academy of Sciences, vol.108, issue.19, pp.7950-7955, 2011.
DOI : 10.1073/pnas.1102454108

A. Poole, N. Knowland, E. Cooper, R. Cole, H. Wang et al., Transitory FGF Treatment Results in the Long-Lasting Suppression of the Proliferative Response to Repeated FGF Stimulation, Journal of Cellular Biochemistry, vol.268, issue.5, pp.874-888, 2014.
DOI : 10.1002/jcb.24731

D. Tang, Understanding cancer stem cell heterogeneity and plasticity, Cell Research, vol.5, issue.3, pp.457-472, 2012.
DOI : 10.1038/nm.2415

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292302

P. Bhat-nakshatri, H. Appaiah, C. Ballas, P. Pick-franke, R. Goulet et al., SLUG/SNAI2 and Tumor Necrosis Factor Generate Breast Cells With CD44+/CD24- Phenotype, BMC Cancer, vol.297, issue.6, pp.411-427, 2010.
DOI : 10.1152/ajpgi.00292.2009

M. Amoyel and E. Bach, Cell competition: how to eliminate your neighbours, Development, vol.141, issue.5, pp.988-1000, 2014.
DOI : 10.1242/dev.079129

R. Levayer and E. Moreno, Mechanisms of cell competition: Themes and variations, The Journal of Cell Biology, vol.200, issue.6, pp.689-698, 2013.
DOI : 10.1242/dev.032383

C. Klein, Selection and adaptation during metastatic cancer progression, Nature, vol.2013, issue.501, pp.365-372

C. Wang, Y. Akalu, M. Suarez-farinas, J. Gonzalez, H. Mitsui et al., IL-17 and TNF Synergistically Modulate Cytokine Expression while Suppressing Melanogenesis: Potential Relevance to Psoriasis, Journal of Investigative Dermatology, vol.133, issue.12, pp.2741-2752, 2013.
DOI : 10.1038/jid.2013.237

D. Widera, I. Mikenberg, M. Elvers, C. Kaltschmidt, and B. Kaltschmidt, Tumor necrosis factor ? triggers proliferation of adult neural stem cells via IKK/NF-?B signaling, BMC Neuroscience, vol.7, issue.1, pp.64-82, 2006.
DOI : 10.1186/1471-2202-7-64

T. Mori, Y. Sato, K. Miyamoto, T. Kobayashi, T. Shimizu et al., TNF?? promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state, Oncogene, vol.80, issue.33, pp.4236-4241, 2013.
DOI : 10.1038/onc.2013.545

L. Rusten, F. Jacobsen, W. Lesslauer, H. Loetscher, E. Smeland et al., Bifunctional effects of tumor necrosis factor alpha (TNF alpha) on the growth of mature and primitive human hematopoietic progenitor cells: involvement of p55 and p75 TNF receptors, Blood, vol.83, pp.3152-3159, 1994.

C. Pronk, O. Veiby, D. Bryder, and S. Jacobsen, Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors, The Journal of Experimental Medicine, vol.86, issue.8, pp.1563-1570, 2011.
DOI : 10.1073/pnas.93.9.4040

I. Dybedal, Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells, Blood, vol.98, issue.6, pp.1782-1791, 2001.
DOI : 10.1182/blood.V98.6.1782

A. Roesch, M. Fukunaga-kalabis, E. Schmidt, S. Zabierowski, P. Brafford et al., A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth, Cell, vol.141, issue.4, pp.583-594, 2010.
DOI : 10.1016/j.cell.2010.04.020

I. Dey-guha, A. Wolfer, A. Yeh, J. Albeck, R. Darp et al., Asymmetric cancer cell division regulated by AKT, Proceedings of the National Academy of Sciences, vol.108, issue.31, pp.12845-12850, 2011.
DOI : 10.1073/pnas.1109632108

G. Ghanem, G. Comunale, A. Libert, A. Vercammen-grandjean, and F. Lejeune, Evidence for alpha-melanocyte-stimulating hormone (??-MSH) receptors on human malignant melanoma cells, International Journal of Cancer, vol.73, issue.2, pp.248-255, 1988.
DOI : 10.1002/ijc.2910410216

L. Roy, H. Zuliani, T. Wolowczuk, I. Faivre, N. Jouy et al., Asymmetric Distribution of Epidermal Growth Factor Receptor Directs the Fate of Normal and Cancer Keratinocytes In Vitro, Stem Cells and Development, vol.19, issue.2, pp.209-220, 2010.
DOI : 10.1089/scd.2009.0150

A. Haake and R. Polakowska, UV-induced apoptosis in skin equivalents: inhibition by phorbol ester and Bcl-2 overexpression, Cell Death Differ, vol.2, pp.183-193, 1995.