J. Armitage, The safety of statins in clinical practice, The Lancet, vol.370, issue.9601, pp.1781-1790, 2007.
DOI : 10.1016/S0140-6736(07)60716-8

S. Lewington, G. Whitlock, R. Clarke, P. Sherliker, J. Emberson et al., Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths, Lancet, issue.9602, pp.3701829-1839, 2007.

C. Baigent, L. Blackwell, J. Emberson, L. Holland, C. Reith et al., Cholesterol Treatment Trialists' (CTT) Collaboration: Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials, Lancet, issue.9753, pp.3761670-1681, 2010.

S. Ward, L. Jones, M. Pandor, A. Holmes, M. et al., A systematic review and economic evaluation of statins for the prevention of coronary events, Health Technology Assessment, vol.11, issue.14, pp.1-160, 2007.
DOI : 10.3310/hta11140

A. Gotto, . Jr, and J. Moon, Recent clinical studies of the effects of lipidmodifying therapies, Am J Cardiol, vol.2012, issue.1101, pp.15-26

K. Solomon and M. Freeman, Do the cholesterol-lowering properties of statins affect cancer risk?, Trends in Endocrinology & Metabolism, vol.19, issue.4, pp.113-121, 2008.
DOI : 10.1016/j.tem.2007.12.004

A. Gvozdjakova, J. Kucharska, L. Sykora, and R. Singh, Balneotherapy and coenzyme Q10 in clinical and experimental medicine, Front Biosci, vol.6, pp.29-38, 2013.

M. Brault, J. Ray, Y. Gomez, C. Mantzoros, and S. Daskalopoulou, Statin treatment and new-onset diabetes: A review of proposed mechanisms, Metabolism, vol.63, issue.6, pp.735-745
DOI : 10.1016/j.metabol.2014.02.014

G. Littarru and P. Langsjoen, Coenzyme Q10 and statins: Biochemical and clinical implications, Mitochondrion, vol.7, pp.168-174, 2007.
DOI : 10.1016/j.mito.2007.03.002

A. Travis and G. Kopf, The role of cholesterol efflux in regulating the fertilization potential of mammalian spermatozoa, Journal of Clinical Investigation, vol.110, issue.6, pp.731-736, 2002.
DOI : 10.1172/JCI0216392

N. Cross, Role of Cholesterol in Sperm Capacitation1, Biology of Reproduction, vol.59, issue.1, pp.7-11, 1998.
DOI : 10.1095/biolreprod59.1.7

I. Brewis, H. Moore, L. Fraser, W. Holt, E. Baldi et al., Molecular mechanisms during sperm capacitation, Human Fertility, vol.403, issue.4, pp.253-261, 2005.
DOI : 10.1080/01652176.1999.9695009

R. Jones, Plasma membrane structure and remodelling during sperm maturation in the epididymis, J Reprod Fertil, vol.53, pp.73-84, 1998.

L. Fraser, The ???switching on??? of mammalian spermatozoa: Molecular events involved in promotion and regulation of capacitation, Molecular Reproduction and Development, vol.17, issue.3, pp.197-208, 2010.
DOI : 10.1002/mrd.21124

B. Gadella, P. Tsai, A. Boerke, and I. Brewis, Sperm head membrane reorganisation during capacitation, The International Journal of Developmental Biology, vol.52, issue.5-6, pp.5-6473, 2008.
DOI : 10.1387/ijdb.082583bg

P. Visconti, H. Galantino-homer, G. Moore, J. Bailey, X. Ning et al., The molecular basis of sperm capacitation, pp.242-248, 1998.

P. Visconti and G. Kopf, Regulation of Protein Phosphorylation during Sperm Capacitation1, Biology of Reproduction, vol.59, issue.1, pp.1-6, 1998.
DOI : 10.1095/biolreprod59.1.1

A. Carrera, J. Moos, X. Ning, G. Gerton, J. Tesarik et al., Regulation of Protein Tyrosine Phosphorylation in Human Sperm by a Calcium/Calmodulin-Dependent Mechanism: Identification of A Kinase Anchor Proteins as Major Substrates for Tyrosine Phosphorylation, Developmental Biology, vol.180, issue.1
DOI : 10.1006/dbio.1996.0301

P. Leclerc, E. De-lamirande, and C. Gagnon, Cyclic Adenosine 3???,5???monophosphate-Dependent Regulation of Protein Tyrosine Phosphorylation in Relation to Human Sperm Capacitation and Motility1, Biology of Reproduction, vol.55, issue.3, pp.684-692, 1996.
DOI : 10.1095/biolreprod55.3.684

R. Yanagimachi, Fertilization in mammals, Tokai J Exp Clin Med, vol.9, issue.2, pp.81-85, 1984.

M. Ramirez-torres, A. Carrera, and M. Zambrana, [High incidence of hyperestrogenemia and dyslipidemia in a group of infertile men

R. Padron, J. Mas, R. Zamora, F. Riverol, M. Licea et al., Lipids and testicular function, International Urology and Nephrology, vol.25, issue.5, pp.515-519, 1989.
DOI : 10.1007/BF02549590

C. Schooling, A. Yeung, S. Freeman, G. Cowling, and B. , The effect of statins on testosterone in men and women, a systematic review and meta-analysis of randomized controlled trials, BMC Medicine, vol.76, issue.1, p.57, 2013.
DOI : 10.1016/j.urology.2010.03.044

E. Stein, M. Davidson, A. Dobs, H. Schrott, C. Dujovne et al., Efficacy and safety of Simvastatin 80 mg/day in hypercholesterolemic patients, The American Journal of Cardiology, vol.82, issue.3, pp.311-316, 1998.
DOI : 10.1016/S0002-9149(98)00421-4

A. Dobs, H. Schrott, M. Davidson, H. Bays, E. Stein et al., Effects of high-dose simvastatin on adrenal and gonadal steroidogenesis in men with hypercholesterolemia, Metabolism, vol.49, issue.9, pp.491234-1238, 2000.
DOI : 10.1053/meta.2000.7716a

M. Davidson, E. Stein, D. Hunninghake, L. Ose, C. Dujovne et al., Worldwide Expanded Dose Simvastatin Study Group: Lipid-altering efficacy and safety of simvastatin 80 mg/day: worldwide long-term experience in patients with hypercholesterolemia, Nutr Metab Cardiovasc Dis, vol.10, issue.5, pp.253-262, 2000.

C. Azzarito, L. Boiardi, W. Vergoni, M. Zini, and I. Portioli, Testicular Function in Hypercholesterolemic Male Patients During Prolonged Simvastatin Treatment, Hormone and Metabolic Research, vol.28, issue.04, pp.193-198, 1996.
DOI : 10.1055/s-2007-979159

G. Bernini, G. Brogi, G. Argenio, A. Moretti, and A. Salvetti, Effects of long-term pravastatin treatment on spermatogenesis and on adrenal and testicular steroidogenesis in male hypercholesterolemic patients, Journal of Endocrinological Investigation, vol.38, issue.suppl. 4A, pp.310-317, 1998.
DOI : 10.1007/BF03350334

C. Azzarito, L. Boiardi, M. Zini, A. Agosti, C. Dotti et al., Long-term therapy with high-dose simvastatin does not affect adrenocortical and gonadal hormones in hypercholesterolemic patients, Metabolism, vol.41, issue.2, pp.41148-153, 1992.
DOI : 10.1016/0026-0495(92)90143-X

S. Santini, C. Carrozza, P. Lulli, C. Zuppi, G. Carlotonolo et al., Atorvastatin Treatment Does Not Affect Gonadal and Adrenal Hormones in Type 2 Diabetes Patients with Mild to Moderate Hypercholesterolemia, Journal of Atherosclerosis and Thrombosis, vol.10, issue.3, pp.160-164, 2003.
DOI : 10.5551/jat.10.160

A. Mondul, E. Selvin, S. Rohrmann, A. Menke, M. Feinleib et al., Association of serum cholesterol and cholesterol-lowering drug use with serum sex steroid hormones in men in NHANES III, Cancer Causes & Control, vol.4, issue.1, pp.1575-1583, 2010.
DOI : 10.1007/s10552-010-9586-6

D. Travia, F. Tosi, C. Negri, G. Faccini, P. Moghetti et al., Sustained therapy with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors does not impair steroidogenesis by adrenals and gonads, JClinEndocrinolMetab, vol.80, issue.3, pp.836-840, 1995.

R. Stanworth, D. Kapoor, K. Channer, and T. Jones, Statin Therapy Is Associated With Lower Total but Not Bioavailable or Free Testosterone in Men With Type 2 Diabetes, Diabetes Care, vol.32, issue.4, pp.541-546, 2009.
DOI : 10.2337/dc08-1183

M. Hyyppa, E. Kronholm, A. Virtanen, A. Leino, and A. Jula, Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial, Psychoneuroendocrinology, vol.28, issue.2, pp.181-194, 2003.
DOI : 10.1016/S0306-4530(02)00014-8

C. Niederberger, Atorvastatin and male infertility: is there a link?, J Androl, vol.26, issue.1, p.12, 2005.

P. Jouannet, B. Ducot, D. Feneux, and A. Spira, Male factors and the likelihood of pregnancy in infertile couples. I. Study of sperm characteristics, International Journal of Andrology, vol.28, issue.5, pp.379-394, 1988.
DOI : 10.1097/00000441-193809000-00009

M. Ratain and D. Sargent, Optimising the design of phase II oncology trials: The importance of randomisation, European Journal of Cancer, vol.45, issue.2, pp.275-280, 2009.
DOI : 10.1016/j.ejca.2008.10.029

G. Grizard, L. Ouchchane, H. Roddier, C. Artonne, B. Sion et al., In vitro alachlor effects on reactive oxygen species generation, motility patterns and apoptosis markers in human spermatozoa, Reproductive Toxicology, vol.23, issue.1, pp.55-62, 2007.
DOI : 10.1016/j.reprotox.2006.08.007

G. Grizard, B. Sion, P. Jouanel, P. Benoit, and D. Boucher, Cholesterol, phospholipids and markers of the function of the accessory sex glands in the semen of men with hypercholesterolaemia, International Journal of Andrology, vol.882, issue.3, pp.151-156, 1995.
DOI : 10.3109/01485018908986750

A. Force, G. Grizard, M. Giraud, C. Motta, B. Sion et al., Membrane fluidity and lipid content of human spermatozoa selected by swim-up method, Int J Androl, vol.24, issue.6, pp.327-334, 2001.

H. Rejraji, B. Sion, G. Prensier, M. Carreras, C. Motta et al., Lipid remodeling of murine epididymosomes and spermatozoa during epididymal maturation, Biol Reprod, issue.6, pp.741104-1113, 2006.

F. Flesch, J. Brouwers, P. Nievelstein, A. Verkleij, L. Van-golde et al., Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane, pp.3543-3555, 2001.

B. Gadella and R. Harrison, Capacitation Induces Cyclic Adenosine 3???,5???-Monophosphate-Dependent, but Apoptosis-Unrelated, Exposure of Aminophospholipids at the Apical Head Plasma Membrane of Boar Sperm Cells1, Biology of Reproduction, vol.67, issue.1, pp.340-350, 2002.
DOI : 10.1095/biolreprod67.1.340

H. Pons-rejraji, J. Bailey, and P. Leclerc, Modulation of bovine sperm signalling pathways: correlation between intracellular parameters and sperm capacitation and acrosome exocytosis, Reproduction, Fertility and Development, vol.21, issue.4, pp.511-524, 2009.
DOI : 10.1071/RD07169

H. Pons-rejraji, C. Artonne, B. Sion, F. Brugnon, M. Canis et al., Prostasomes: inhibitors of capacitation and modulators of cellular signalling in human sperm, International Journal of Andrology, vol.55, issue.83, pp.568-580, 2010.
DOI : 10.1111/j.1365-2605.2010.01116.x

M. Diaz-fontdevila, W. Pena, and E. Bustos-obregon, Experimental hypercholesterolaemia in rabbits. Effect on lipid domains in homologous spermatozoa, Andrologia, vol.143, issue.1, pp.15-22, 1998.
DOI : 10.1111/j.1439-0272.1998.tb01377.x

M. Diaz-fontdevila and E. Bustos-obregon, Cholesterol and polyunsaturated acid enriched diet: Effect on kinetics of the acrosome reaction in rabbit spermatozoa, Molecular Reproduction and Development, vol.882, issue.2, pp.176-180, 1993.
DOI : 10.1002/mrd.1080350211

S. Lancellotti, T. Boarelli, P. Monclus, M. Cabrillana, M. Clementi et al., Hypercholesterolemia Impaired Sperm Functionality in Rabbits, PLoS ONE, vol.285, issue.1???4, p.13457, 2010.
DOI : 10.1371/journal.pone.0013457.t001

R. Sullivan, C. Legare, M. Thabet, and V. Thimon, Gene Expression in the Epididymis of Normal and Vasectomized Men: What Can We Learn About Human Sperm Maturation?, Journal of Andrology, vol.32, issue.6, pp.686-697
DOI : 10.2164/jandrol.110.012575

B. Robaire and M. Hamzeh, Androgen Action in the Epididymis, Journal of Andrology, vol.32, issue.6, pp.592-599, 2011.
DOI : 10.2164/jandrol.111.014266

S. Green, E. Mostaghel, and P. Nelson, Androgen action and metabolism in prostate cancer, Molecular and Cellular Endocrinology, vol.360, issue.1-2, pp.3-13
DOI : 10.1016/j.mce.2011.09.046

E. Castellon and C. Huidobro, Androgen regulation of glycosidase secretion in epithelial cell cultures from human epididymis, Human Reproduction, vol.14, issue.6, pp.1522-1527, 1999.
DOI : 10.1093/humrep/14.6.1522

A. Mahmoud, J. Geslevich, J. Kint, C. Depuydt, L. Huysse et al., Seminal plasma alpha-glucosidase activity and male infertility, Human Reproduction, vol.13, issue.3, pp.591-595, 1998.
DOI : 10.1093/humrep/13.3.591

URL : http://humrep.oxfordjournals.org/cgi/content/short/13/3/591

S. Muniyan, N. Chaturvedi, J. Dwyer, C. Lagrange, W. Chaney et al., Human Prostatic Acid Phosphatase: Structure, Function and Regulation, International Journal of Molecular Sciences, vol.14, issue.5
DOI : 10.3390/ijms140510438

G. Balercia, A. Mancini, F. Paggi, L. Tiano, A. Pontecorvi et al., Coenzyme Q10 in Male Infertility, J Endocrinol Invest, vol.14, issue.2, pp.626-632, 2009.
DOI : 10.1002/14651858.CD007411.pub2

G. Littarru and L. Tiano, Clinical aspects of coenzyme Q10: an update, Nutrition, vol.2010, issue.263, pp.250-254

K. Purvis, A. Tollefsrud, H. Rui, E. Haug, J. Norseth et al., Short-term effects of treatment with simvastatin on testicular function in patients with heterozygous familial hypercholesterolaemia, European Journal of Clinical Pharmacology, vol.4, issue.3, pp.61-64, 1992.
DOI : 10.1007/BF00314921

B. Akduman, D. Tandberg, O. Donnell, C. Hughes, A. Moyad et al., Effect of Statins on Serum Prostate-specific Antigen Levels, Urology, vol.76, issue.5, pp.1048-1051, 2010.
DOI : 10.1016/j.urology.2010.03.044

M. Cyrus-david, A. Weinberg, T. Thompson, and D. Kadmon, THE EFFECT OF STATINS ON SERUM PROSTATE SPECIFIC ANTIGEN LEVELS IN A COHORT OF AIRLINE PILOTS: A PRELIMINARY REPORT, The Journal of Urology, vol.173, issue.6, pp.1923-1925, 2005.
DOI : 10.1097/01.ju.0000158044.94188.88

L. Zhuang, J. Kim, R. Adam, K. Solomon, and M. Freeman, Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts, Journal of Clinical Investigation, vol.115, issue.4, pp.959-968, 2005.
DOI : 10.1172/JCI200519935

A. Llorente, B. Van-deurs, and K. Sandvig, Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells, European Journal of Cell Biology, vol.86, issue.7
DOI : 10.1016/j.ejcb.2007.05.001

M. Aberg, M. Johnell, M. Wickstrom, A. Widunder, and A. Siegbahn, Simvastatin reduces the production of prothrombotic prostasomes in human prostate cancer cells, Thromb Haemost, vol.100, issue.4, pp.655-662, 2008.

A. Dobs, S. Miller, G. Neri, S. Weiss, A. Tate et al., Effects of simvastatin and prevastatin on gonadal function in male hypercholesterolemic patients, Metabolism, vol.49, issue.1, pp.115-121, 2000.
DOI : 10.1016/S0026-0495(00)90938-7

A. Dobs, P. Sarma, and D. Schteingart, Long-term endocrine function in hypercholesterolemic patients treated with pravastatin, a new 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, Metabolism, vol.42, issue.9, pp.1146-1152, 1993.
DOI : 10.1016/0026-0495(93)90272-P

W. Farnsworth, J. Hoeg, M. Maher, E. Brittain, R. Sherins et al., Testicular Function in Type II Hyperlipoproteinemic Patients Treated with Lovastatin (Mevinolin) or Neomycin, The Journal of Clinical Endocrinology & Metabolism, vol.65, issue.3, pp.546-550, 1987.
DOI : 10.1210/jcem-65-3-546

S. Hall, S. Page, T. Travison, R. Montgomery, C. Link et al., Do Statins Affect Androgen Levels in Men? Results from the Boston Area Community Health Survey, Cancer Epidemiology Biomarkers & Prevention, vol.16, issue.8, pp.161587-1594, 2007.
DOI : 10.1158/1055-9965.EPI-07-0306

M. Bohm, W. Herrmann, S. Wassmann, U. Laufs, and G. Nickenig, Beeinflusst die Statin-Therapie die Steroid-Hormon-Synthese?, Zeitschrift f???r Kardiologie, vol.93, issue.1, pp.43-48, 2004.
DOI : 10.1007/s00392-004-1003-2

R. Jay, R. Sturley, C. Stirling, H. Mcgarrigle, M. Katz et al., Effects of pravastatin and cholestyramine on gonadal and adrenal steroid production in familial hypercholesterolaemia., British Journal of Clinical Pharmacology, vol.19, issue.4, pp.417-422, 1991.
DOI : 10.1111/j.1365-2125.1991.tb03924.x

T. Kocum, T. Ozcan, R. Gen, A. Tekin, T. Erol et al., Does atorvastatin affect androgen levels in men in the era of very-low LDL targeting therapy?, Exp Clin Endocrinol Diabetes, vol.117, issue.2, pp.60-63, 2009.

D. Preiss and N. Sattar, Statins and the risk of new-onset diabetes, Current Opinion in Lipidology, vol.22, issue.6, pp.460-466, 2011.
DOI : 10.1097/MOL.0b013e32834b4994

G. Corona, V. Boddi, G. Balercia, G. Rastrelli, D. Vita et al., The Effect of Statin Therapy on Testosterone Levels in Subjects Consulting for Erectile Dysfunction, The Journal of Sexual Medicine, vol.7, issue.4, pp.1547-1556, 2010.
DOI : 10.1111/j.1743-6109.2009.01698.x

C. Do, E. Huyghe, M. Lapeyre-mestre, J. Montastruc, and H. Bagheri, Statins and Erectile Dysfunction, Drug Safety, vol.60, issue.7, pp.32591-597, 2009.
DOI : 10.2165/00002018-200932070-00005

E. Ding, Y. Song, V. Malik, and S. Liu, Sex Differences of Endogenous Sex Hormones and Risk of Type 2 Diabetes, JAMA, vol.295, issue.11, pp.2951288-1299, 2006.
DOI : 10.1001/jama.295.11.1288

L. Vignera, S. Condorelli, R. Vicari, E. Calogero, and A. , Statins and Erectile Dysfunction: A Critical Summary of Current Evidence, Journal of Andrology, vol.33, issue.4, pp.552-558
DOI : 10.2164/jandrol.111.015230

J. Tobert, G. Bell, J. Birtwell, I. James, W. Kukovetz et al., Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers., Journal of Clinical Investigation, vol.69, issue.4, pp.913-919, 1982.
DOI : 10.1172/JCI110530