P. Wolf, The Nature and Significance of Platelet Products in Human Plasma, British Journal of Haematology, vol.8, issue.3, pp.269-288, 1967.
DOI : 10.1136/jcp.6.1.34

O. Morel, F. Toti, N. Morel, and J. Freyssinet, Microparticles in endothelial cell and vascular homeostasis: are they really noxious?, Haematologica, vol.94, issue.3, pp.313-317, 2009.
DOI : 10.3324/haematol.2008.003657

N. Ogata, S. Nomura, A. Shouzu, M. Imaizumi, and M. Arichi, Elevation of monocyte-derived microparticles in patients with diabetic retinopathy, Diabetes Research and Clinical Practice, vol.73, issue.3, pp.241-248, 2006.
DOI : 10.1016/j.diabres.2006.01.014

M. Trappenburg, M. Van-schilfgaarde, F. Frerichs, H. Spronk, and H. Ten-cate, Chronic renal failure is accompanied by endothelial activation and a large increase in microparticle numbers with reduced procoagulant capacity, Nephrology Dialysis Transplantation, vol.27, issue.4, 2011.
DOI : 10.1093/ndt/gfr474

N. Amabile, C. Heiss, W. Real, P. Minasi, and D. Mcglothlin, Circulating Endothelial Microparticle Levels Predict Hemodynamic Severity of Pulmonary Hypertension, American Journal of Respiratory and Critical Care Medicine, vol.177, issue.11, pp.1268-1275, 2008.
DOI : 10.1164/rccm.200710-1458OC

P. Mfonkeu, J. Gouado, I. , F. Kuaté, H. Zambou et al., Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria, PLoS ONE, vol.52, issue.10, p.13415, 2010.
DOI : 10.1371/journal.pone.0013415.t001

M. Vanwijk, E. Vanbavel, A. Sturk, and R. Nieuwland, Microparticles in cardiovascular diseases, Cardiovascular Research, vol.59, issue.2, pp.277-287, 2003.
DOI : 10.1016/S0008-6363(03)00367-5

R. Zwaal and A. Schroit, Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells, Blood, vol.89, pp.1121-1132, 1997.

N. Satta, F. Toti, O. Feugeas, A. Bohbot, and J. Dachary-prigent, Monocyte vesiculation is a possible mechanism for dissemination of membraneassociated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide, The Journal of Immunology, vol.153, pp.3245-3255, 1994.

D. Connor, T. Exner, D. Ma, and J. Joseph, Detection of the procoagulant activity of microparticle-associated phosphatidylserine using XACT, Blood Coagulation & Fibrinolysis, vol.20, issue.7, pp.558-564, 2009.
DOI : 10.1097/MBC.0b013e32832ee915

T. Warkentin, C. Hayward, L. Boshkov, A. Santos, and J. Sheppard, Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia, Blood, vol.84, pp.3691-3699, 1994.

S. Oehmcke, M. Mörgelin, J. Malmström, A. Linder, and M. Chew, Stimulation of blood mononuclear cells with bacterial virulence factors leads to the release of pro-coagulant and pro-inflammatory microparticles, Cellular Microbiology, vol.156, issue.1, p.no?no, 2011.
DOI : 10.1111/j.1462-5822.2011.01705.x

S. Kanazawa, S. Nomura, M. Kuwana, M. Muramatsu, and K. Yamaguchi, Monocyte-derived microparticles may be a sign of vascular complication in patients with lung cancer, Lung Cancer, vol.39, issue.2, pp.145-149, 2003.
DOI : 10.1016/S0169-5002(02)00441-5

A. Mackenzie, H. Wilson, E. Kiss-toth, S. Dower, and R. North, Rapid Secretion of Interleukin-1?? by Microvesicle Shedding, Immunity, vol.15, issue.5, pp.825-835, 2001.
DOI : 10.1016/S1074-7613(01)00229-1

A. Sarkar, S. Mitra, S. Mehta, R. Raices, and M. Wewers, Monocyte Derived Microvesicles Deliver a Cell Death Message via Encapsulated Caspase-1, PLoS ONE, vol.159, issue.8, p.7140, 2009.
DOI : 10.1371/journal.pone.0007140.s001

S. Essayagh, J. Xuereb, A. Terrisse, L. Tellier-cirioni, and B. Pipy, Microparticles from apoptotic monocytes induce transient platelet recruitment and tissue factor expression by cultured human vascular endothelial cells via a redox sensitive mechanism, Thrombosis and Haemostasis, vol.98, pp.831-837, 2007.
DOI : 10.1160/TH07-02-0082
URL : https://hal.archives-ouvertes.fr/inserm-00409864

M. Mastronardi, H. Mostefai, R. Soleti, A. Agouni, and M. Martínez, Microparticles from apoptotic monocytes enhance nitrosative stress in human endothelial cells, Fundamental & Clinical Pharmacology, vol.85, issue.6, p.no?no, 2010.
DOI : 10.1111/j.1472-8206.2010.00898.x

H. Mostefai, F. Meziani, M. Mastronardi, A. Agouni, and C. Heymes, Circulating Microparticles from Patients with Septic Shock Exert Protective Role in Vascular Function, American Journal of Respiratory and Critical Care Medicine, vol.178, issue.11, pp.1148-1155, 2008.
DOI : 10.1164/rccm.200712-1835OC
URL : https://hal.archives-ouvertes.fr/hal-01389216

R. Nieuwland, R. Berckmans, S. Mcgregor, A. Boing, and F. Romijn, Cellular origin and procoagulant properties of microparticles in meningococcal sepsis, Blood, vol.95, pp.930-935, 2000.

D. Annane, P. Aegerter, M. Jars-guincestre, and B. Guidet, Current Epidemiology of Septic Shock, American Journal of Respiratory and Critical Care Medicine, vol.168, issue.2, pp.165-172, 2003.
DOI : 10.1164/rccm.2201087

V. Sundararajan, C. Macisaac, J. Presneill, J. Cade, and K. Visvanathan, Epidemiology of sepsis in Victoria, Australia, Critical Care Medicine, vol.33, issue.1, pp.71-80, 2005.
DOI : 10.1097/01.CCM.0000150027.98160.80

R. Pine, M. Wertz, E. Lennard, E. Dellinger, and C. Carrico, Determinants of Organ Malfunction or Death in Patients With Intra-abdominal Sepsis, Archives of Surgery, vol.118, issue.2, pp.242-249, 1983.
DOI : 10.1001/archsurg.1983.01390020084014

C. Sprung, P. Peduzzi, C. Shatney, R. Schein, and M. Wilson, Impact of encephalopathy on mortality in the sepsis syndrome, Critical Care Medicine, vol.18, issue.8, pp.801-806, 1990.
DOI : 10.1097/00003246-199008000-00001

G. Young, C. Bolton, T. Austin, Y. Archibald, and J. Gonder, The encephalopathy associated with septic illness, Clin Invest Med, vol.13, pp.297-304, 1990.

N. Riedemann, R. Guo, and P. Ward, Novel strategies for the treatment of sepsis, Nature Medicine, vol.9, issue.5, pp.517-524, 2003.
DOI : 10.1038/nm0503-517

N. Goldenberg, B. Steinberg, A. Slutsky, and W. Lee, Broken Barriers: A New Take on Sepsis Pathogenesis, Science Translational Medicine, vol.3, issue.88, pp.88-113, 2011.
DOI : 10.1126/scitranslmed.3002011

F. Marceau, D. Deblois, E. Petitclerc, L. Levesque, and G. Drapeau, Vascular smooth muscle contractility assays for inflammatory and immunological mediators, International Immunopharmacology, vol.10, issue.11, pp.1344-1353, 2010.
DOI : 10.1016/j.intimp.2010.08.016

S. Hollenberg, M. Guglielmi, and J. Parrillo, Discordance between microvascular permeability and leukocyte dynamics in septic inducible nitric oxide synthase deficient mice, Critical Care, vol.11, issue.6, p.125, 2007.
DOI : 10.1186/cc6190

F. Bozza, P. Garteiser, M. Oliveira, S. Doblas, and R. Cranford, Sepsis-Associated Encephalopathy: A Magnetic Resonance Imaging and Spectroscopy Study, Journal of Cerebral Blood Flow & Metabolism, vol.220, issue.2, pp.440-448, 2010.
DOI : 10.1016/j.pneurobio.2006.12.003

G. Fingerle, A. Pforte, B. Passlick, M. Blumenstein, and M. Strobel, The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients, Blood, vol.82, pp.3170-3176, 1993.

A. Hillenbrand, U. Knippschild, M. Weiss, H. Schrezenmeier, and D. Henne-bruns, Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients, BMC Surgery, vol.18, issue.Suppl 5, p.26, 2010.
DOI : 10.1016/S0749-0704(02)00007-6

E. Borrelli, P. Roux-lombard, G. Grau, E. Girardin, and B. Ricou, Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk, Critical Care Medicine, vol.24, issue.3, pp.392-397, 1996.
DOI : 10.1097/00003246-199603000-00006

H. Ziegler-heitbrock, E. Thiel, A. Futterer, V. Herzog, and A. Wirtz, Establishment of a human cell line (mono mac 6) with characteristics of mature monocytes, International Journal of Cancer, vol.46, issue.3, pp.456-461, 1988.
DOI : 10.1002/ijc.2910410324

S. Walters, J. Kieckbusch, G. Nagalingam, A. Swain, and S. Latham, Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration, The Journal of Immunology, vol.190, issue.2, pp.669-677, 2013.
DOI : 10.4049/jimmunol.1201856

B. Weksler, E. Subileau, N. Perrière, P. Charneau, and K. Holloway, Blood-brain barrier-specific properties of a human adult brain endothelial cell line, The FASEB Journal, 2005.
DOI : 10.1096/fj.04-3458fje

P. Mfonkeu, J. Gouado, I. , F. Kuate, H. Zambou et al., Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria, PLoS ONE, vol.52, issue.10, p.13415, 2010.
DOI : 10.1371/journal.pone.0013415.t001

J. Lou, J. Dayer, G. Grau, and D. Burger, Direct cell/cell contact with stimulated T lymphocytes induces the expression of cell adhesion molecules and cytokines by human brain microvascular endothelial cells, European Journal of Immunology, vol.83, issue.12, pp.3107-3113, 1996.
DOI : 10.1002/eji.1830261242

S. Wassmer, C. Moxon, T. Taylor, G. Grau, and M. Molyneux, Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF, Cellular Microbiology, vol.89, issue.2, pp.198-209, 2011.
DOI : 10.1111/j.1462-5822.2010.01528.x

V. Combes, A. Simon, G. Grau, D. Arnoux, and L. Camoin, In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant, Journal of Clinical Investigation, vol.104, issue.1, pp.93-102, 1999.
DOI : 10.1172/JCI4985

G. Brown and T. Mcintyre, Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding of Proinflammatory IL-1??-Rich Microparticles, The Journal of Immunology, vol.186, issue.9, 2011.
DOI : 10.4049/jimmunol.1001623

M. Bernimoulin, E. Waters, M. Foy, B. Steele, and M. Sullivan, Differential stimulation of monocytic cells results in distinct populations of microparticles, Journal of Thrombosis and Haemostasis, vol.581, issue.6, pp.1019-1028, 2009.
DOI : 10.1111/j.1538-7836.2009.03434.x

R. Jaiswal, J. Gong, S. Sambasivam, V. Combes, and J. Mathys, Microparticle-associated nucleic acids mediate trait dominance in cancer, The FASEB Journal, vol.26, issue.1, 2011.
DOI : 10.1096/fj.11-186817

R. Jaiswal, F. Luk, P. Dalla, G. Grau, and M. Bebawy, Breast Cancer-Derived Microparticles Display Tissue Selectivity in the Transfer of Resistance Proteins to Cells, PLoS ONE, vol.104, issue.4, p.61515, 2013.
DOI : 10.1371/journal.pone.0061515.g006

J. Habersberger, F. Strang, A. Scheichl, N. Htun, and N. Bassler, Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction, Cardiovascular Research, vol.96, issue.1, pp.64-72, 2012.
DOI : 10.1093/cvr/cvs237

P. Diehl, A. Fricke, L. Sander, J. Stamm, and N. Bassler, Microparticles: major transport vehicles for distinct microRNAs in circulation, Cardiovascular Research, vol.93, issue.4, pp.633-644, 2012.
DOI : 10.1093/cvr/cvs007

I. Del-conde, C. Shrimpton, P. Thiagarajan, and J. López, Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation, Blood, vol.106, issue.5, pp.1604-1611, 2005.
DOI : 10.1182/blood-2004-03-1095

O. Morel, F. Toti, B. Hugel, B. Bakouboula, and L. Camoin-jau, Procoagulant Microparticles: Disrupting the Vascular Homeostasis Equation?, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.26, issue.12, pp.2594-2604, 2006.
DOI : 10.1161/01.ATV.0000246775.14471.26

S. Wassmer, V. Combes, F. Candal, I. Juhan-vague, and G. Grau, Platelets Potentiate Brain Endothelial Alterations Induced by Plasmodium falciparum, Infection and Immunity, vol.74, issue.1, pp.645-653, 2006.
DOI : 10.1128/IAI.74.1.645-653.2006

J. Jimenez, W. Jy, L. Mauro, L. Horstman, and E. Ahn, Elevated endothelial microparticle???monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-<I>??</I>lb on release of endothelial microparticles, formation and transendothelial migration of monocyte???endothelial microparticle complexes, Multiple Sclerosis, vol.11, issue.3, pp.310-315, 2005.
DOI : 10.1191/1352458505ms1184oa

J. Densmore, P. Signorino, J. Ou, O. Hatoum, and J. Rowe, ENDOTHELIUM-DERIVED MICROPARTICLES INDUCE ENDOTHELIAL DYSFUNCTION AND ACUTE LUNG INJURY, Shock, vol.26, issue.5, pp.464-471, 2006.
DOI : 10.1097/01.shk.0000228791.10550.36

J. Wang, J. Williams, B. Davis, K. Jacobson, and C. Doerschuk, Monocytic microparticles activate endothelial cells in an IL-1??-dependent manner, Blood, vol.118, issue.8, pp.2366-2374, 2011.
DOI : 10.1182/blood-2011-01-330878

A. Aharon, T. Tamari, and B. Brenner, Monocyte-derived microparticles and exosomes induce procoagulant and apoptotic effects on endothelial cells, Thrombosis and Haemostasis, vol.100, pp.878-885, 2008.
DOI : 10.1160/TH07-11-0691

W. Dean, M. Lee, T. Cummins, D. Schultz, and D. Powell, Proteomic and functional characterisation of platelet microparticle size classes, Thrombosis and Haemostasis, vol.102, pp.711-718, 2009.
DOI : 10.1160/TH09-04-0243

G. Hu and R. Minshall, Regulation of transendothelial permeability by Src Kinase, Microvascular Research, vol.77, issue.1, pp.21-25, 2009.
DOI : 10.1016/j.mvr.2008.10.002

L. Scheppke, E. Aguilar, R. Gariano, R. Jacobson, and J. Hood, Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits, Journal of Clinical Investigation, vol.118, pp.2337-2346, 2008.
DOI : 10.1172/JCI33361DS1

E. Gorbunova, I. Gavrilovskaya, T. Pepini, and E. Mackow, VEGFR2 and Src Kinase Inhibitors Suppress Andes Virus-Induced Endothelial Cell Permeability, Journal of Virology, vol.85, issue.5, pp.2296-2303, 2011.
DOI : 10.1128/JVI.02319-10
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067787

F. Orsenigo, C. Giampietro, A. Ferrari, M. Corada, and A. Galaup, Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo, Nature Communications, vol.86, p.1208, 2012.
DOI : 10.1038/ncomms2199

S. Weis, S. Shintani, A. Weber, R. Kirchmair, and M. Wood, Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction, Journal of Clinical Investigation, vol.113, issue.6, pp.885-894, 2004.
DOI : 10.1172/JCI200420702

D. Angelini, S. Hyun, D. Grigoryev, P. Garg, and P. Gong, TNF-?? increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia, AJP: Lung Cellular and Molecular Physiology, vol.291, issue.6, pp.1232-1245, 2006.
DOI : 10.1152/ajplung.00109.2006

J. Gilleron, C. Fiorini, D. Carette, C. Avondet, and M. Falk, Molecular reorganization of Cx43, Zo-1 and Src complexes during the endocytosis of gap junction plaques in response to a non-genomic carcinogen, Journal of Cell Science, vol.121, issue.24, pp.4069-4078, 2008.
DOI : 10.1242/jcs.033373

Y. Wallez, F. Cand, F. Cruzalegui, C. Wernstedt, and S. Souchelnytskyi, Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site, Oncogene, vol.174, issue.7, pp.1067-1077, 2007.
DOI : 10.1038/sj.onc.1209855

J. Dwyer, L. Guelte, A. , G. Moya, E. Sumbal et al., Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor, Oncogene, vol.9, issue.2, pp.190-200, 2011.
DOI : 10.1038/nature03987