Forging a field: the golden age of iron biology, Blood, vol.112, issue.2, pp.219-230, 2008. ,
DOI : 10.1182/blood-2007-12-077388
Regulation of systemic iron homeostasis: how the body responds to changes in iron demand, BioMetals, vol.34, issue.3-4, pp.3-4665, 2007. ,
DOI : 10.1007/s10534-006-9030-2
Hepcidin and iron homeostasis, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1823, issue.9, pp.1434-1443, 2012. ,
DOI : 10.1016/j.bbamcr.2012.01.014
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization, Science, vol.306, issue.5704, pp.2090-2093, 2004. ,
DOI : 10.1126/science.1104742
Intestinal Iron Absorption: Regulation by Dietary & Systemic Factors, International Journal for Vitamin and Nutrition Research, vol.80, issue.45, pp.4-5231, 2010. ,
DOI : 10.1024/0300-9831/a000029
An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron, Science, vol.291, issue.5509, pp.1755-1759, 2001. ,
DOI : 10.1126/science.1057206
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice, Blood, vol.106, issue.8, pp.2879-2883, 2005. ,
DOI : 10.1182/blood-2005-02-0716
Duodenal Reductase Activity and Spleen Iron Stores Are Reduced and Erythropoiesis Is Abnormal in Dcytb Knockout Mice Exposed to Hypoxic Conditions, Journal of Nutrition, vol.142, issue.11, pp.1929-1934, 2012. ,
DOI : 10.3945/jn.112.160358
Steap Proteins: Implications for Iron and Copper Metabolism, Nutrition Reviews, vol.65, issue.7, pp.335-340, 2007. ,
DOI : 10.1111/j.1753-4887.2007.tb00311.x
Cloning and characterization of a mammalian proton-coupled metal-ion transporter, Nature, vol.388, issue.6641, pp.482-488, 1997. ,
DOI : 10.1038/41343
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver, Journal of Clinical Investigation, vol.115, issue.5, pp.1258-1266, 2005. ,
DOI : 10.1172/JCI24356
Not all DMT1 mutations lead to iron overload, Blood Cells, Molecules, and Diseases, vol.43, issue.2, pp.199-201, 2009. ,
DOI : 10.1016/j.bcmd.2009.05.003
A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation, Molecular Cell, vol.5, issue.2, pp.299-309, 2000. ,
DOI : 10.1016/S1097-2765(00)80425-6
Intestinal Ferritin H Is Required for an Accurate Control of Iron Absorption, Cell Metabolism, vol.12, issue.3, pp.273-282, 2010. ,
DOI : 10.1016/j.cmet.2010.08.003
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis, Cell Metabolism, vol.1, issue.3, pp.191-200, 2005. ,
DOI : 10.1016/j.cmet.2005.01.003
Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium, AJP: Gastrointestinal and Liver Physiology, vol.296, issue.1, pp.55-65, 2009. ,
DOI : 10.1152/ajpgi.90298.2008
Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency Pathways of iron absorption, J Nutr. Blood Cells Mol Dis, vol.13629, issue.203, pp.1236-1241, 2002. ,
Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption, Cell, vol.127, issue.5, pp.917-928, 2006. ,
DOI : 10.1016/j.cell.2006.09.041
Heme and non-heme iron transporters in non-polarized and polarized cells, BMC Cell Biology, vol.11, issue.1, p.39, 2010. ,
DOI : 10.1186/1471-2121-11-39
HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis, Cell Metabolism, vol.17, issue.2, pp.261-270, 2013. ,
DOI : 10.1016/j.cmet.2013.01.005
Identification of a Human Heme Exporter that Is Essential for Erythropoiesis, Cell, vol.118, issue.6, pp.757-766, 2004. ,
DOI : 10.1016/j.cell.2004.08.014
Effect of altitude on erythropoiesis, Blood, vol.33, issue.5, pp.668-676, 1969. ,
Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1690, issue.2, pp.169-176, 2004. ,
DOI : 10.1016/j.bbadis.2004.06.011
Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression, Gut, vol.54, issue.10, pp.1391-1395, 2005. ,
DOI : 10.1136/gut.2004.062083
Mechanisms of Iron Mediated Regulation of the Duodenal Iron Transporters Divalent Metal Transporter 1 and Ferroportin 1, Blood Cells, Molecules, and Diseases, vol.29, issue.3, pp.488-497, 2002. ,
DOI : 10.1006/bcmd.2002.0587
Hypoxia-Inducible Factor-2?? Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice, Gastroenterology, vol.140, issue.7, pp.2044-2055, 2011. ,
DOI : 10.1053/j.gastro.2011.03.007
Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis, Blood, vol.108, issue.4, pp.1402-1405, 2006. ,
DOI : 10.1182/blood-2006-02-003376
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats, Gastroenterology, vol.123, issue.3, pp.835-844, 2002. ,
DOI : 10.1053/gast.2002.35353
Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice, Blood, vol.105, issue.12, pp.4861-4864, 2005. ,
DOI : 10.1182/blood-2004-12-4608
Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells, Gut, vol.57, issue.3, pp.374-382, 2008. ,
DOI : 10.1136/gut.2007.131722
Hepcidin inhibits apical iron uptake in intestinal cells, AJP: Gastrointestinal and Liver Physiology, vol.294, issue.1, pp.192-198, 2008. ,
DOI : 10.1152/ajpgi.00122.2007
Intestinal DMT1 Cotransporter Is Down-regulated by Hepcidin via Proteasome Internalization and Degradation, Gastroenterology, vol.140, issue.4, pp.1261-1271, 2011. ,
DOI : 10.1053/j.gastro.2010.12.037
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2, Blood, vol.112, issue.10, pp.4268-4275, 2008. ,
DOI : 10.1182/blood-2008-04-150953
The influence of hypoxia on iron absorption in the rat, Gastroenterology, vol.60, issue.1, pp.76-81, 1971. ,
) absorption, hypoxia and erythropoiesis in the mouse, British Journal of Haematology, vol.11, issue.3, pp.373-378, 1988. ,
DOI : 10.1002/cbf.290050109
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation, Journal of Clinical Investigation, vol.110, issue.7 ,
DOI : 10.1172/JCI0215686
Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project, Blood, vol.117, issue.10, pp.2953-2959, 2011. ,
DOI : 10.1182/blood-2010-08-299859
Regulation of hepcidin expression at high altitude, Blood, vol.119, issue.3, pp.857-860, 2012. ,
DOI : 10.1182/blood-2011-03-341776
Dietary iron levels and hypoxia independently affect iron absorption in mice ,
Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure, Kidney International, vol.78, issue.7, pp.660-667, 2010. ,
DOI : 10.1038/ki.2010.217
A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption, Gut, vol.52, issue.3, pp.340-346, 2003. ,
DOI : 10.1136/gut.52.3.340
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway, Molecular Cell, vol.30, issue.4, pp.393-402, 2008. ,
DOI : 10.1016/j.molcel.2008.04.009
The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1?? and HIF-2??, Molecular Biology of the Cell, vol.18, issue.11, pp.4528-4542, 2007. ,
DOI : 10.1091/mbc.E06-05-0419
Lack of iron-related phenotype in Sp6 intestinal knockout mice, Blood Cells, Molecules, and Diseases, vol.47, issue.1, pp.46-49, 2011. ,
DOI : 10.1016/j.bcmd.2011.03.009
pH control mechanisms of tumor survival and growth, Journal of Cellular Physiology, vol.11, issue.2, pp.299-308, 2011. ,
DOI : 10.1002/jcp.22400
URL : https://hal.archives-ouvertes.fr/hal-00533764
Intestinal Hypoxia-inducible Factor-2?? (HIF-2??) Is Critical for Efficient Erythropoiesis, Journal of Biological Chemistry, vol.286, issue.22, pp.19533-19540, 2011. ,
DOI : 10.1074/jbc.M111.238667
Widespread, hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs, The FASEB Journal, vol.17, issue.2, pp.271-273, 2003. ,
DOI : 10.1096/fj.02-0445fje
Two to Tango: Regulation of Mammalian Iron Metabolism, Cell, vol.142, issue.1, pp.24-38, 2010. ,
DOI : 10.1016/j.cell.2010.06.028
Mammalian iron metabolism and its control by iron regulatory proteins, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1823, issue.9, pp.1468-1483, 2012. ,
DOI : 10.1016/j.bbamcr.2012.05.010
Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase, Science, vol.326, issue.5953, pp.718-721, 2009. ,
DOI : 10.1126/science.1176333
A Ferroportin Transcript that Lacks an Iron-Responsive Element Enables Duodenal and Erythroid Precursor Cells to Evade Translational Repression, Cell Metabolism, vol.9, issue.5, pp.461-473, 2009. ,
DOI : 10.1016/j.cmet.2009.03.006
Iron Regulatory Proteins Are Essential for Intestinal Function and Control Key Iron Absorption Molecules in the Duodenum, Cell Metabolism, vol.7, issue.1, pp.79-85, 2008. ,
DOI : 10.1016/j.cmet.2007.10.006
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2), Blood, vol.106, issue.7 ,
DOI : 10.1182/blood-2005-04-1365
Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism, Blood, vol.113, issue.3, pp.679-687, 2009. ,
DOI : 10.1182/blood-2008-05-155093
Iron-regulatory proteins limit hypoxia-inducible factor-2?? expression in iron deficiency, Nature Structural & Molecular Biology, vol.12, issue.5, pp.420-426, 2007. ,
DOI : 10.1007/s11010-006-9393-2
Hypoxia Inducible Factor-2?? Is Translationally Repressed in Response to Dietary Iron Deficiency in Sprague-Dawley Rats, Journal of Nutrition, vol.141, issue.9, pp.1590-1596, 2011. ,
DOI : 10.3945/jn.111.144105
The IRP1-HIF-2?? Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption, Cell Metabolism, vol.17, issue.2, pp.282-290, 2013. ,
DOI : 10.1016/j.cmet.2013.01.007
Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2??, Cell Metabolism, vol.17, issue.2, pp.271-281, 2013. ,
DOI : 10.1016/j.cmet.2012.12.016
Iron Regulatory Proteins Control a Mucosal Block to Intestinal Iron Absorption, Cell Reports, vol.3, issue.3, pp.844-857, 2013. ,
DOI : 10.1016/j.celrep.2013.02.026
Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency, Haematologica, vol.91, issue.3, pp.303-310, 2006. ,
Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved, IUBMB Life, vol.36, issue.2, pp.120-128, 2011. ,
DOI : 10.1002/iub.419
Copper Deficiency Leads to Anemia, Duodenal Hypoxia, Upregulation of HIF-2?? and Altered Expression of Iron Absorption Genes in Mice, PLoS ONE, vol.63, issue.3, p.59538, 2013. ,
DOI : 10.1371/journal.pone.0059538.s004
Iron metabolism in the anemia of chronic disease, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1790, issue.7, pp.682-693, 2009. ,
DOI : 10.1016/j.bbagen.2008.08.006
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin, Journal of Clinical Investigation, vol.113, issue.9, pp.1271-1276, 2004. ,
DOI : 10.1172/JCI200420945
Animal Models of Anemia of Inflammation, Seminars in Hematology, vol.46, issue.4, pp.351-357, 2009. ,
DOI : 10.1053/j.seminhematol.2009.06.003
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia, Blood, vol.105, issue.4, pp.1797-1802, 2005. ,
DOI : 10.1182/blood-2004-08-3375
Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation, Blood, vol.109, issue.9, pp.4038-4044, 2007. ,
DOI : 10.1182/blood-2006-10-051755
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs, Blood, vol.106, issue.6, pp.2196-2199, 2005. ,
DOI : 10.1182/blood-2005-04-1766
Tumour necrosis factor alpha regulates iron transport and transporter expression in human intestinal epithelial cells, FEBS Letters, vol.275, issue.1-3, pp.1-3195, 2004. ,
DOI : 10.1016/j.febslet.2004.07.081
Tumour necrosis factor alpha causes hypoferraemia and reduced intestinal iron absorption in mice ,
URL : https://hal.archives-ouvertes.fr/hal-00478530
Hypoferraemia during the early inflammatory response is dependent on tumour necrosis factor activity in a murine model of protracted peritonitis, Molecular Medicine Reports, vol.6, issue.4, pp.838-842, 2012. ,
DOI : 10.3892/mmr.2012.1004
Hypoxia and gastrointestinal disease, Journal of Molecular Medicine, vol.201, issue.12, pp.1295-1300, 2007. ,
DOI : 10.1007/s00109-007-0277-z
Iron Regulatory Protein 1 Outcompetes Iron Regulatory Protein 2 in Regulating Cellular Iron Homeostasis in Response to Nitric Oxide, Journal of Biological Chemistry, vol.286, issue.26, pp.22846-22854, 2011. ,
DOI : 10.1074/jbc.M111.231902
The polycythemia of high altitudes: iron metabolism and related aspects, Blood, vol.14, issue.4, pp.433-455, 1959. ,
Natural selection on EPAS1 (HIF2??) associated with low hemoglobin concentration in Tibetan highlanders, Proceedings of the National Academy of Sciences, vol.107, issue.25, pp.11459-11464, 2010. ,
DOI : 10.1073/pnas.1002443107
Genetic Evidence for High-Altitude Adaptation in Tibet, Science, vol.329, issue.5987, pp.72-75, 2010. ,
DOI : 10.1126/science.1189406
??-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism, Blood, vol.118, issue.16, pp.4321-4330, 2011. ,
DOI : 10.1182/blood-2011-03-283614
Ineffective erythropoiesis in -thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin, Blood, vol.109, issue.11, pp.5027-5035, 2007. ,
DOI : 10.1182/blood-2006-09-048868
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin, Nature Medicine, vol.33, issue.9, pp.1096-1101, 2007. ,
DOI : 10.1038/nm1629
The Molecular Pathogenesis of Hereditary Hemochromatosis, Seminars in Liver Disease, vol.31, issue.03, pp.280-292, 2011. ,
DOI : 10.1055/s-0031-1286059
The molecular basis of ferroportin-linked hemochromatosis, Proceedings of the National Academy of Sciences, vol.102, issue.25, pp.8955-8960, 2005. ,
DOI : 10.1073/pnas.0503804102
Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism, Molecular and Cellular Biology, vol.29, issue.16, pp.4527-4538, 2009. ,
DOI : 10.1128/MCB.00200-09
Genes that modify the hemochromatosis phenotype in mice, Journal of Clinical Investigation, vol.105, issue.9 ,
DOI : 10.1172/JCI9635
hereditary haemochromatosis, British Journal of Haematology, vol.37, issue.1, pp.140-149, 2009. ,
DOI : 10.1111/j.1365-2141.2009.07843.x
Small-Molecule Inhibitors of HIF-2a Translation Link Its 5???UTR Iron-Responsive Element to Oxygen Sensing, Molecular Cell, vol.32, issue.6, pp.838-848, 2008. ,
DOI : 10.1016/j.molcel.2008.12.004
1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1???3 (HIF PHD1???3) for the Treatment of Anemia, Journal of Medicinal Chemistry, vol.55, issue.7, pp.2945-2959, 2012. ,
DOI : 10.1021/jm201542d
Giving Anemia a Boost with Inhibitors of Prolyl Hydroxylase, Journal of Medicinal Chemistry, vol.55, issue.7, pp.2943-2944, 2012. ,
DOI : 10.1021/jm300314a
Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia, Blood, vol.116, issue.16, pp.3039-3048, 2010. ,
DOI : 10.1182/blood-2010-02-270322