Synaptic and cellular profile of neurons in the lateral habenula.

Abstract : The lateral habenula (LHb) is emerging as a crucial structure capable of conveying rewarding and aversive information. Recent evidence indicates that a rapid increase in the activity of LHb neurons drives negative states and avoidance. Furthermore, the hyperexcitability of neurons in the LHb, especially those projecting to the midbrain, may represent an important cellular correlate for neuropsychiatric disorders like depression and drug addiction. Despite the recent insights regarding the implications of the LHb in the context of reward and aversion, the exact nature of the synaptic and cellular players regulating LHb neuronal functions remains largely unknown. Here we focus on the synaptic and cellular physiology of LHb neurons. First, we discuss the properties of excitatory transmission and the implications of glutamate receptors for long-term synaptic plasticity; second, we review the features of GABAergic transmission onto LHb neurons; and finally, we describe the contribution that neuromodulators such as dopamine (DA) and serotonin may have for LHb neuronal physiology. We relate these findings to the role that the LHb can play in processing aversive and rewarding stimuli, both in health and disease states.
Type de document :
Article dans une revue
Frontiers in Human Neuroscience, Frontiers, 2013, 7, pp.860. 〈10.3389/fnhum.2013.00860〉
Liste complète des métadonnées

Littérature citée [62 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01011506
Contributeur : Nathalie Duchange <>
Soumis le : mardi 24 juin 2014 - 09:50:16
Dernière modification le : mercredi 21 mars 2018 - 18:57:30
Document(s) archivé(s) le : mardi 11 avril 2017 - 08:20:13

Fichier

fnhum-07-00860.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

IFM | UPMC

Citation

Frank Meye, Salvatore Lecca, Kristina Valentinova, Manuel Mameli. Synaptic and cellular profile of neurons in the lateral habenula.. Frontiers in Human Neuroscience, Frontiers, 2013, 7, pp.860. 〈10.3389/fnhum.2013.00860〉. 〈inserm-01011506〉

Partager

Métriques

Consultations de la notice

472

Téléchargements de fichiers

285