R. Barter and A. G. Pearse, Mammalian enterochromaffin cells as the source of serotonin (5-hydroxytryptamine), The Journal of Pathology and Bacteriology, vol.li, issue.1, pp.25-31, 1955.
DOI : 10.1002/path.1700690106

G. Rudnick and P. J. Nelson, Reconstitution of 5-hydroxytryptamine transport from cholate-disrupted platelet plasma membrane vesicles, Biochemistry, vol.17, issue.24, pp.5300-5303, 1978.
DOI : 10.1021/bi00617a033

K. Vikenes, M. Farstad, and J. Nordrehaug, Serotonin Is Associated with Coronary Artery Disease and Cardiac Events, Circulation, vol.100, issue.5, pp.483-489, 1999.
DOI : 10.1161/01.CIR.100.5.483

E. K. Van-den-berg, Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphology, Circulation, vol.79, issue.1, pp.116-124, 1989.
DOI : 10.1161/01.CIR.79.1.116

W. Ni and S. W. Watts, 5-HYDROXYTRYPTAMINE IN THE CARDIOVASCULAR SYSTEM: FOCUS ON THE SEROTONIN TRANSPORTER (SERT), Clinical and Experimental Pharmacology and Physiology, vol.285, issue.7, pp.575-583, 2006.
DOI : 10.2174/1389200033489433

Y. Ban, Impact of increased plasma serotonin levels and carotid atherosclerosis on vascular dementia, Atherosclerosis, vol.195, issue.1, pp.153-159, 2007.
DOI : 10.1016/j.atherosclerosis.2006.09.005

W. A. Freyburger, The pharmacology of 5-hydroxytryptamine (serotonin)

P. M. Vanhoutte, Platelet-Derived Serotonin, the Endothelium, and Cardiovascular Disease, Journal of Cardiovascular Pharmacology, vol.17, issue.Supplement 5, pp.6-12, 1991.
DOI : 10.1097/00005344-199100175-00003

G. L. Reed, Platelet Secretion, pp.309-319, 2006.
DOI : 10.1016/B978-012369367-9/50777-1

F. Miller, R. Friedman, J. Tanenbaum, and A. Griffin, Disseminated intravescular coagulation and acute myoglobinuric renal failure: A consequence of the serotonergic syndrome, J Clin Psychopharm, vol.11, pp.277-279, 1991.

B. L. Roth, Drugs and Valvular Heart Disease, New England Journal of Medicine, vol.356, issue.1, pp.6-9, 2007.
DOI : 10.1056/NEJMp068265

A. Mcnicol and S. J. Israel, Platelets and Anti-platelet Therapy, Journal of Pharmacological Sciences, vol.93, issue.4, pp.381-396, 2003.
DOI : 10.1254/jphs.93.381

D. Clerck, F. F. Herman, and A. G. , 5-Hydroxytryptamine and platelet aggregation, Fed Proc, vol.42, pp.228-232, 1983.

D. Clerck, F. F. Janssen, and P. A. , Amplification mechanisms in platelet activation and arterial thrombosis, J Hypertens, vol.8, pp.87-93, 1990.

K. Nakamura, H. Kariyazono, H. Masuda, R. Sakata, and K. Yamada, Effects of sarpogrelate hydrochloride on platelet aggregation, and its relation to the release of serotonin and P-selectin, Blood Coagulation & Fibrinolysis, vol.10, issue.8, pp.513-519, 1999.
DOI : 10.1097/00001721-199912000-00009

C. N. Berry, Antiplatelet and antithrombotic activity of SL65.0472, a mixed 5-HT1B/5-HT2A receptor antagonist, Thromb Haemost, vol.85, pp.521-528, 2001.

K. Nishihira, Inhibition of 5-hydroxytryptamine2A receptor prevents occlusive thrombus formation on neointima of the rabbit femoral artery, Journal of Thrombosis and Haemostasis, vol.37, issue.1, pp.247-255, 2006.
DOI : 10.1016/S0024-3205(00)00879-1

K. Przyklenk, receptor improves coronary patency in an in??vivo model of recurrent thrombosis, Journal of Thrombosis and Haemostasis, vol.115, issue.2, pp.331-340, 2010.
DOI : 10.1111/j.1538-7836.2009.03693.x

R. Shirakawa, Small GTPase Rab4 Regulates Ca2+-induced ??-Granule Secretion in Platelets, Journal of Biological Chemistry, vol.275, issue.43, pp.33844-33849, 2000.
DOI : 10.1074/jbc.M002834200

D. J. Walther, Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet ??-Granule Release, Cell, vol.115, issue.7, pp.851-862, 2003.
DOI : 10.1016/S0092-8674(03)01014-6

E. Ziu, Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin, Journal of Molecular and Cellular Cardiology, vol.52, issue.5, pp.1112-1121, 2012.
DOI : 10.1016/j.yjmcc.2012.02.004

G. L. Dale, Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface, Nature, vol.415, issue.6868, pp.175-179, 2002.
DOI : 10.1038/415175a

G. L. Dale, Coated-platelets: an emerging component of the procoagulant response, Journal of Thrombosis and Haemostasis, vol.84, issue.Suppl. 1, pp.2185-2192, 2005.
DOI : 10.1111/j.1538-7836.2005.01274.x

J. P. Ottervanger, B. H. Stricker, J. Huls, and J. N. Weeda, Bleeding attributed to the intake of paroxetine, Am J Psychiatry, vol.151, pp.781-782, 1992.

K. M. Hoffmeister, Glycosylation Restores Survival of Chilled Blood Platelets, Science, vol.301, issue.5639, pp.1531-1534, 2003.
DOI : 10.1126/science.1085322

H. H. Wandall, The origin and function of platelet glycosyltransferases, Blood, vol.120, issue.3, pp.626-635, 2012.
DOI : 10.1182/blood-2012-02-409235

S. Kelm and R. Schauer, Sialic Acids in Molecular and Cellular Interactions, Int Rev Cytol, vol.175, pp.137-240, 1997.
DOI : 10.1016/S0074-7696(08)62127-0

A. Varki, Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins, Nature, vol.204, issue.7139, pp.1023-1029, 2007.
DOI : 10.1038/nature05816

H. H. Chou, A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence, Proceedings of the National Academy of Sciences, vol.95, issue.20, pp.11751-11756, 1998.
DOI : 10.1073/pnas.95.20.11751

A. Irie, S. Koyama, Y. Kozutsumi, T. Kawasaki, and A. Suzuki, The Molecular Basis for the Absence of N-Glycolylneuraminic Acid in Humans, Journal of Biological Chemistry, vol.273, issue.25, pp.15866-15871, 1998.
DOI : 10.1074/jbc.273.25.15866

C. P. Mercado, Impact of Elevated Plasma Serotonin on Global Gene Expression of Murine Megakaryocytes, PLoS ONE, vol.4, issue.1, p.72580, 2013.
DOI : 10.1371/journal.pone.0072580.t002

D. Bengel, Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter deficient mice, Mol Pharmacol, vol.53, pp.649-655, 1998.

J. L. Daniel, Molecular Basis for ADP-induced Platelet Activation: I. EVIDENCE FOR THREE DISTINCT ADP RECEPTORS ON HUMAN PLATELETS, Journal of Biological Chemistry, vol.273, issue.4, pp.2024-2029, 1998.
DOI : 10.1074/jbc.273.4.2024

K. Iizuka, N. Hamaue, T. Machida, M. Hirafuji, and M. Tsuji, Receptor Antagonist, Supplemented with Pioglitazone on Diabetic Model Mice, Endocrine Research, vol.13, issue.1-2, pp.18-30, 2009.
DOI : 10.1016/S0168-8227(02)00105-5

S. C. Bir, New Therapeutic Approach for Impaired Arteriogenesis in Diabetic Mouse Hindlimb Ischemia, Circulation Journal, vol.72, issue.4, pp.633-640, 2008.
DOI : 10.1253/circj.72.633

F. Kilic and G. Rudnick, Oligomerization of serotonin transporter and its functional consequences, Proceedings of the National Academy of Sciences, vol.97, issue.7, pp.3106-3111, 2000.
DOI : 10.1073/pnas.97.7.3106

K. R. Anumula and P. B. Taylor, A comprehensive procedure for preparation of partially methylated alditol acetates from glycoprotein carbohydrates, Analytical Biochemistry, vol.203, issue.1, pp.101-108, 1992.
DOI : 10.1016/0003-2697(92)90048-C

B. Domon and C. Costello, Structure elucidation of glycosphingolipids and gangliosides using high-performance tandem mass spectrometry, Biochemistry, vol.27, issue.5, pp.1534-1543, 1988.
DOI : 10.1021/bi00405a021

Y. Kozutsumi, Reconstitution of CMP-N-Acetylneuraminic Acid Hydroxylation Activity Using a Mouse Liver Cytosol Fraction and Soluble Cytochrome b5 Purified from Horse Erythrocytes1, The Journal of Biochemistry, vol.110, issue.3, pp.429-435, 1991.
DOI : 10.1093/oxfordjournals.jbchem.a123598

L. Shaw, CMP-N-acetylneuraminic acid hydroxylase from mouse liver and pig submandibular glands. Interaction with membrane-bound and soluble cytochrome b5-dependent electron transport chains, European Journal of Biochemistry, vol.253, issue.3, pp.1001-1011, 1994.
DOI : 10.1007/BF00731194

S. Chenu, Reduction of CMP-N-acetylneuraminic acid hydroxylase activity in engineered Chinese hamster ovary cells using an antisense-RNA strategy, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1622, issue.2, pp.133-144, 2003.
DOI : 10.1016/S0304-4165(03)00137-5

T. J. Budd, Comparison of theN-glycoloylneuraminic andN-acetylneuraminic acid content of platelets and their precursors using high performance anion exchange chromatography, Glycoconjugate Journal, vol.263, issue.5, pp.274-278, 1992.
DOI : 10.1007/BF00731139

A. Ahmed, Serotonin Transamidates Rab4 and Facilitates Its Binding to the C Terminus of Serotonin Transporter, Journal of Biological Chemistry, vol.283, issue.14, pp.9388-9398, 2008.
DOI : 10.1074/jbc.M706367200

T. Kawano, Molecular Cloning of Cytidine Monophospho-N-acetylneuraminic Acid Hydroxylase. REGULATION OF SPECIES- AND TISSUE-SPECIFIC EXPRESSION OF N-GLYCOLYLNEURAMINIC ACID, Journal of Biological Chemistry, vol.270, issue.27, pp.16458-16463, 1995.
DOI : 10.1074/jbc.270.27.16458

S. Inoue, C. Sato, and K. Kitajima, Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells, Glycobiology, vol.20, issue.6, pp.752-762, 2010.
DOI : 10.1093/glycob/cwq030

T. Pham, Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium, Blood, vol.114, issue.25, pp.5225-5235, 2009.
DOI : 10.1182/blood-2009-05-220400