Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response

Abstract : Bipolar disorder (BD) is a common, severe mental disorder with a high recurrence rate. Lithium (Li) is the cornerstone of BD treatments to reduce recurrence, suicide, and mortality risks. However, only 30% of patients treated with Li achieve complete remission, and few markers of the response to treatment have yet been identified for application in routine practice. Circadian biomarkers may be relevant predictors of individual responses to Li because (1) Li has been shown to affect circadian rhythms, (2) disrupted circadian rhythms are a core expression of susceptibility to BD, and (3) circadian abnormalities during euthymia are associated with relapses.
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International Journal of Bipolar Disorders, Springer Open, 2014, 2 (1), pp.5
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http://www.hal.inserm.fr/inserm-00979772
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Pierre Geoffroy, Bruno Etain, Sarah Sportiche, Frank Bellivier. Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response. International Journal of Bipolar Disorders, Springer Open, 2014, 2 (1), pp.5. 〈inserm-00979772〉

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