Identification of a functional destruction box in the Xenopus laevis aurora-A kinase pEg2. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue FEBS Letters Année : 2001

Identification of a functional destruction box in the Xenopus laevis aurora-A kinase pEg2.

Résumé

Like for all aurora-A kinases, the Xenopus pEg2 kinase level peaks in G(2)/M and is hardly detectable in G(1) cells, suggesting that the protein is degraded upon exit from mitosis as reported for the human aurora-A kinase. We identified for the first time a sequence RxxL in the C-terminal end of the kinase catalytic domain. Mutation of this sequence RxxL to RxxI suppresses the ubiquitination of the protein as well as its degradation. The sequence RxxL corresponding to the pEg2 functional destruction box has been conserved throughout evolution in all aurora kinases including aurora-A, -B and -C.

Dates et versions

inserm-00966222 , version 1 (26-03-2014)

Identifiants

Citer

Yannick Arlot-Bonnemains, Andrea Klotzbucher, Régis Giet, Rustem Uzbekov, Réjane Bihan, et al.. Identification of a functional destruction box in the Xenopus laevis aurora-A kinase pEg2.. FEBS Letters, 2001, 508 (1), pp.149-52. ⟨10.1016/S0014-5793(01)03048-4⟩. ⟨inserm-00966222⟩
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