Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.

Abstract : During the past five years, a growing number of serine-threonine kinases highly homologous to the Saccharomyces cerevisiae Ipl1p kinase have been isolated in various organisms. A Drosophila melanogaster homologue, aurora, was the first to be isolated from a multicellular organism. Since then, several related kinases have been found in mammalian cells. They localise to the mitotic apparatus: in the centrosome, at the poles of the bipolar spindle or in the midbody. The kinases are necessary for completion of mitotic events such as centrosome separation, bipolar spindle assembly and chromosome segregation. Extensive research is now focusing on these proteins because the three human homologues are overexpressed in various primary cancers. Furthermore, overexpression of one of these kinases transforms cells. Because of the myriad of kinases identified, we suggest a generic name: Aurora/Ipl1p-related kinase (AIRK). We denote AIRKs with a species prefix and a number, e.g. HsAIRK1.
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Article dans une revue
Journal of Cell Science, Company of Biologists, 1999, 112 ( Pt 21), pp.3591-601
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Contributeur : Claude Prigent <>
Soumis le : mercredi 26 mars 2014 - 11:35:18
Dernière modification le : lundi 26 mars 2018 - 15:22:31

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  • HAL Id : inserm-00966175, version 1
  • PUBMED : 10523496

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Régis Giet, Claude Prigent. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.. Journal of Cell Science, Company of Biologists, 1999, 112 ( Pt 21), pp.3591-601. 〈inserm-00966175〉

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