E. R. Moxon and C. A. Siegrist, The next decade of vaccines: societal and scientific challenges, The Lancet, vol.378, issue.9788, pp.378-348, 2011.
DOI : 10.1016/S0140-6736(11)60407-8

N. Agmon-levin, Z. Paz, E. Israeli, and Y. Shoenfeld, Vaccines and autoimmunity, Nature Reviews Rheumatology, vol.23, issue.11, pp.5-648, 2009.
DOI : 10.1038/nrrheum.2009.196

V. Molina and Y. Shoenfeld, Infection, vaccines and other environmental triggers of autoimmunity, Autoimmunity, vol.18, issue.3, pp.235-280, 2005.
DOI : 10.1080/08916930500050277

J. Stübgen, Neuromuscular disorders associated with Hepatitis B vaccination, Journal of the Neurological Sciences, vol.292, issue.1-2, pp.1-4, 2010.
DOI : 10.1016/j.jns.2010.02.016

R. K. Gherardi, M. Coquet, P. Cherin, L. Belec, P. Moretto et al., Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle, Brain, vol.124, issue.9, pp.1821-1831, 2001.
DOI : 10.1093/brain/124.9.1821

M. S. Petrik, M. C. Wong, R. C. Tabata, R. F. Garry, and C. A. Shaw, Aluminum Adjuvant Linked to Gulf War Illness Induces Motor Neuron Death in Mice, NeuroMolecular Medicine, vol.9, issue.1, pp.83-100, 2007.
DOI : 10.1385/NMM:9:1:83

P. B. Asa, Y. Cao, and R. F. Garry, Antibodies to Squalene in Gulf War Syndrome, Experimental and Molecular Pathology, vol.68, issue.1, pp.55-64, 2000.
DOI : 10.1006/exmp.1999.2295

H. Nohynek, J. Jokinen, M. Partinen, O. Vaarala, T. Kirjavainen et al., AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland, PLoS ONE, vol.21, issue.3, p.33536, 2012.
DOI : 10.1371/journal.pone.0033536.t004

C. Exley, P. Siesjö, and H. Eriksson, The immunobiology of aluminium adjuvants: how do they really work?, Trends in Immunology, vol.31, issue.3, pp.31-103, 2010.
DOI : 10.1016/j.it.2009.12.009

P. Marrack, A. Mckee, and M. Munks, Towards an understanding of the adjuvant action of aluminium, Nature Reviews Immunology, vol.49, issue.4, pp.287-293, 2009.
DOI : 10.1038/nri2510

V. Hornung, F. Bauernfeind, A. Halle, E. O. Samstad, H. Kono et al., Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization, Nature Immunology, vol.109, issue.8, pp.847-56, 2008.
DOI : 10.1016/0008-8749(88)90236-5

H. Rosenblum, Y. Shoenfeld, and H. Amital, The Common Immunogenic Etiology of Chronic Fatigue Syndrome: From Infections to Vaccines via Adjuvants to the ASIA Syndrome, Infectious Disease Clinics of North America, vol.25, issue.4, pp.25-851, 2011.
DOI : 10.1016/j.idc.2011.07.012

Y. Shoenfeld, ???ASIA??? ??? Autoimmune/inflammatory syndrome induced by adjuvants, Journal of Autoimmunity, vol.36, issue.1, pp.4-8, 2011.
DOI : 10.1016/j.jaut.2010.07.003

R. K. Gherardi, Lessons from Macrophagic Myofasciitis: Towards Definition of a Vaccine Adjuvant-Related Syndrome, Rev Neurol, vol.159, issue.2, pp.162-164, 2003.
DOI : 10.1007/978-94-010-0167-0_16

R. K. Gherardi and F. J. Authier, Aluminum inclusion macrophagic myofasciitis: a recently identified condition, Immunology and Allergy Clinics of North America, vol.23, issue.4, pp.699-712, 2003.
DOI : 10.1016/S0889-8561(03)00095-X

M. Hotopf, A. David, L. Hull, I. Khalida, C. Unwin et al., Role of vaccinations as risk factors for ill health in veterans of the Gulf war: cross sectional study, BMJ, vol.320, issue.7246, pp.1363-1367, 2000.
DOI : 10.1136/bmj.320.7246.1363

C. A. Shaw and M. S. Petrik, Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration, Journal of Inorganic Biochemistry, vol.103, issue.11, pp.1555-1562, 2009.
DOI : 10.1016/j.jinorgbio.2009.05.019

K. Miyoshi, T. Miyamura, Y. Kobayashi, T. Itakura, and K. Nishijo, Hypergammaglobulinemia by prolonged adjuvanticity in man disorders developed after augmentation mammoplasty, Jpn. Med. J, vol.2122, pp.9-14, 1964.

B. O. Shoaib and B. M. Patten, HUMAN ADJUVANT DISEASE, Southern Medical Journal, vol.88, pp.179-88, 1996.
DOI : 10.1097/00007611-199510001-00115

P. L. Meroni, Autoimmune or auto-inflammatory syndrome induced by adjuvants (ASIA): Old truths and a new syndrome?, Journal of Autoimmunity, vol.36, issue.1, pp.1-3, 2011.
DOI : 10.1016/j.jaut.2010.10.004

R. Cervera, ???ASIA???: a new systemic autoimmune syndrome?, Lupus, vol.50, issue.7, pp.665-671, 2011.
DOI : 10.1177/0961203309345724

G. R. Hughes, Foreword, Lupus, vol.21, issue.2, p.117, 2012.
DOI : 10.1177/0961203311431250

F. B. Vasey, S. A. Zarabadi, M. Seleznick, and L. Ricca, Where there!s smoke there!s fire: the silicone breast implant controversy continues to flicker: a new disease that needs to be defined, J. Rheumatol, issue.10, pp.30-2092, 2003.

R. K. Gherardi, M. Coquet, P. Chérin, F. J. Authier, P. Laforêt et al., Macrophagic myofasciitis: an emerging entity, The Lancet, vol.352, issue.9125, pp.352-347, 1998.
DOI : 10.1016/S0140-6736(98)02326-5

M. Couette, M. F. Boisse, P. Maison, P. Brugieres, P. Cesaro et al., Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction, Journal of Inorganic Biochemistry, vol.103, issue.11, pp.1571-1578, 2009.
DOI : 10.1016/j.jinorgbio.2009.08.005

E. Passeri, C. Villa, M. Couette, E. Itti, P. Brugieres et al., Long-term follow-up of cognitive dysfunction in patients with aluminum hydroxide-induced macrophagic myofasciitis (MMF), Journal of Inorganic Biochemistry, vol.105, issue.11, pp.1457-1463, 2011.
DOI : 10.1016/j.jinorgbio.2011.08.006

F. J. Authier, S. Sauvat, J. Champey, I. Drogou, M. Coquet et al., Chronic fatigue syndrome in patients with macrophagic myofasciitis, Arthritis & Rheumatism, vol.56, issue.2, pp.569-570, 2003.
DOI : 10.1002/art.10740

R. K. Gherardi, Central nervous system disease in patients with macrophagic myofasciitis, Brain, vol.124, pp.974-83, 2001.

F. J. Authier, S. Sauvat, C. Christov, P. Chariot, G. Raisbeck et al., Al(OH)3-adjuvanted vaccine-induced macrophagic myofasciitis in rats is influenced by the genetic background, Neuromuscular Disorders, vol.16, issue.5, pp.347-352, 2006.
DOI : 10.1016/j.nmd.2006.02.004

URL : https://hal.archives-ouvertes.fr/in2p3-00068499

A. Seubert, E. Monaci, M. Pizza, D. T. O-'hagan, and A. Wack, The adjuvants aluminium hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells, J Immunol. J. Immunol, vol.180182, issue.81, pp.5402-5414, 2008.

S. L. Deshmane, S. Kremlev, S. Amini, and B. Sawaya, Monocyte Chemoattractant Protein-1 (MCP-1): An Overview, Journal of Interferon & Cytokine Research, vol.29, issue.6, pp.29-313, 2009.
DOI : 10.1089/jir.2008.0027

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755091

M. Brigitte, C. Schilte, A. Plonquet, Y. Baba-amer, A. Henri et al., Muscle resident macrophages control the immune cell reaction in a mouse model of notexin-induced myoinjury, Arthritis & Rheumatism, vol.100, issue.1, pp.62-268, 2010.
DOI : 10.1002/art.27183

URL : https://hal.archives-ouvertes.fr/pasteur-01402283

L. Izikson, R. S. Klein, I. F. Charo, H. L. Weiner, and A. D. Luster, Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2, J. Exp. Med, issue.7, pp.192-1075, 2000.

A. Mildner, H. Schmidt, M. Nitsche, D. Merkler, U. K. Hanisch et al., Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions, Nature Neuroscience, vol.72, issue.12, pp.1544-53, 2007.
DOI : 10.1038/nn2015

P. Amarenco, Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients, Stroke, issue.7, pp.371691-371697, 2006.

P. O. Flores-villanueva, J. A. Ruiz-morales, C. H. Song, L. M. Flores, E. K. Jo et al., A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis, J. Exp. Med, vol.19, issue.12, pp.2021649-58, 2005.

Z. Navratilova, F. Mrazek, E. Kriegova, B. Hutyrova, V. Kolek et al., The MCP-1-2518 (A to G) single nucleotide polymorphism in Czech patients with pulmonary sarcoidosis: association with Löfgren's syndrome, Sarcoidosis Vasc. Diffuse Lung Dis, issue.1, pp.24-33, 2007.

R. Nadif, M. Mintz, S. Rivas-fuentes, A. Jedlicka, E. Lavergne et al., Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis, Cytokine, vol.33, issue.3, pp.33-171, 2006.
DOI : 10.1016/j.cyto.2006.01.001

URL : https://hal.archives-ouvertes.fr/inserm-00127760

M. Tucci, E. V. Barnes, E. S. Sobel, B. P. Croker, M. S. Segal et al., Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis, Arthritis & Rheumatism, vol.73, issue.6, pp.50-1842, 2004.
DOI : 10.1002/art.20266

P. Malafronte, J. M. Vieira, . Jr, A. C. Pereira, J. E. Krieger et al., Association of the MCP-1 -2518 A/G Polymorphism and No Association of Its Receptor CCR2 -64 V/I Polymorphism with Lupus Nephritis, The Journal of Rheumatology, vol.37, issue.4, pp.776-82, 2010.
DOI : 10.3899/jrheum.090681

A. Mangano, R. Bologna, S. S. Ahuja, M. J. Dolan, and S. K. Ahuja, HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels, Proc. Natl. Acad. Sci. U S A, issue.21, pp.99-13795, 2002.

L. Gu, S. Tseng, R. M. Horner, C. Tam, M. Loda et al., Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1, Nature, vol.404, issue.6776, pp.404-407, 2000.
DOI : 10.1038/35006097

A. S. Mansfield, W. K. Nevala, R. S. Dronca, A. A. Leontovich, L. Shuster et al., Normal ageing is associated with an increase in Th2 cells, MCP-1 (CCL1) and RANTES (CCL5), with differences in sCD40L and PDGF-AA between sexes, Clinical & Experimental Immunology, vol.81, issue.2, pp.186-93, 2012.
DOI : 10.1111/j.1365-2249.2012.04644.x

J. Harris, S. A. De-haro, S. S. Master, J. Keane, E. A. Roberts et al., Deretic, V. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis, Immunity, issue.3, pp.27-505, 2007.

H. Eidi, O. Joubert, C. Némos, S. Grandemange, B. Mograbi et al., Aboukhamis, I.; Rihn, B.; Drug delivery by polymeric nanoparticles induces autophagy in macrophages International, J. Pharmaceutics, pp.422-495, 2012.

A. F. Ippoliti, E. J. Bernard, L. Mei, D. L. Nicolae, M. Regueiro et al., Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis, Nat. Genet, issue.5, pp.39-596, 2007.

A. Lerner, Aluminum as an adjuvant in Crohn???s disease induction, Lupus, vol.16, issue.2, pp.231-239
DOI : 10.1016/j.jaut.2010.07.003

Z. Khan, F. Authier, V. Itier, O. Tillement, J. Cadusseau et al., Nanosized particles injected into muscle slowly disseminate within phagocytes and accumulate in brain through MCP1-driven mechanism, Communication at the 63rd American Academy of Neurology Annual Meeting, pp.76-186, 2011.

S. Mélik-parsadaniantz and W. Rostène, Chemokines and neuromodulation, Journal of Neuroimmunology, vol.198, issue.1-2, pp.62-70, 2008.
DOI : 10.1016/j.jneuroim.2008.04.022

D. J. Mahad and R. M. Ransohoff, The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), Seminars in Immunology, vol.15, issue.1, pp.23-32, 2003.
DOI : 10.1016/S1044-5323(02)00125-2

A. Sokolova, M. D. Hill, F. Rahimi, L. A. Warden, G. M. Halliday et al., Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease, Brain Pathology, vol.28, issue.3, pp.19-392, 2009.
DOI : 10.1111/j.1750-3639.2008.00188.x

N. K. Dhillon, R. Williams, S. Callen, C. Zien, O. Narayan et al., Roles of MCP-1 in development of HIV-dementia, Frontiers in Bioscience, vol.Volume, issue.13, pp.3913-3921, 2008.
DOI : 10.2741/2979

D. Godefroy, R. D. Gosselin, A. Yasutake, M. Fujimura, C. Combadière et al., The Chemokine CCL2 Protects Against Methylmercury Neurotoxicity, Toxicological Sciences, vol.125, issue.1, pp.209-227
DOI : 10.1093/toxsci/kfr252

URL : https://hal.archives-ouvertes.fr/inserm-00630697

M. Tani, I. F. Charo, A. E. Proudfoot, B. J. Rollins, T. Handel et al., Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice, FASEB J, issue.7, pp.19-761, 2005.

J. Menetski, S. Mistry, M. Lu, J. S. Mudgett, R. M. Ransohoff et al., Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses, Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses, pp.706-714, 2007.
DOI : 10.1016/j.neuroscience.2007.08.014

H. Jung, P. T. Toth, F. A. White, and R. J. Miller, Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons, Journal of Neurochemistry, vol.142, issue.0, pp.254-263, 2008.
DOI : 10.1038/sj.emboj.7600893

M. A. Thacker, A. K. Clark, T. Bishop, J. Grist, P. K. Yip et al., CCL2 is a key mediator of microglia activation in neuropathic pain states, European Journal of Pain, vol.27, issue.14, pp.263-272, 2009.
DOI : 10.1016/j.ejpain.2008.04.017

Y. J. Gao and R. R. Ji, Chemokines, neuronal???glial interactions, and central processing of neuropathic pain, Pharmacology & Therapeutics, vol.126, issue.1, pp.56-68, 2010.
DOI : 10.1016/j.pharmthera.2010.01.002

D. C. Ang, M. N. Moore, and J. Hilligoss, MCP-1 and IL-8 as Pain Biomarkers in Fibromyalgia: A Pilot Study, Pain Medicine, vol.12, issue.8, pp.1154-61, 2011.
DOI : 10.1111/j.1526-4637.2011.01179.x

D. Galimberti, C. Fenoglio, C. Lovati, E. Venturelli, I. Guidi et al., Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease, Neurobiology of Aging, vol.27, issue.12, pp.271763-271771, 2006.
DOI : 10.1016/j.neurobiolaging.2005.10.007