B. Rini, S. Campbell, and B. Escudier, Renal cell carcinoma, The Lancet, vol.373, issue.9669, pp.1119-1132, 2009.
DOI : 10.1016/S0140-6736(09)60229-4

R. Motzer, N. Bander, and D. Nanus, Renal cell carcinoma, Medical Prog, vol.335, pp.865-875, 1996.

M. Itsumi and K. Tatsugami, Immunotherapy for Renal Cell Carcinoma, Clinical and Developmental Immunology, vol.59, issue.13, p.284581, 2010.
DOI : 10.1172/JCI25947

C. Hollenbeak, L. Nikkel, E. Schaefer, E. Alemao, N. Ghahramani et al., Determinants of Medicare All-Cause Costs Among Elderly Patients with Renal Cell Carcinoma, Journal of Managed Care Pharmacy, vol.17, issue.8, pp.610-620, 2011.
DOI : 10.18553/jmcp.2011.17.8.610

C. Thoma, A. Toso, P. Meraldi, and W. Krek, Double-trouble in mitosis caused by von Hippel-Lindau tumor-suppressor protein inactivation, Cell Cycle, vol.8, issue.22, pp.3619-3620, 2009.
DOI : 10.4161/cc.8.22.9907

Y. Nadler, R. Camp, C. Schwartz, D. Rimm, H. Kluger et al., Expression of Aurora A (but Not Aurora B) Is Predictive of Survival in Breast Cancer, Clinical Cancer Research, vol.14, issue.14, pp.4455-4462, 2008.
DOI : 10.1158/1078-0432.CCR-07-5268

P. Cammareri, A. Scopelliti, M. Todaro, V. Eterno, F. Francescangeli et al., Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells, Cancer Research, vol.70, issue.11, pp.4655-4665, 2010.
DOI : 10.1158/0008-5472.CAN-09-3953

M. Rugge, M. Fassan, G. Zaninotto, M. Pizzi, L. Giacomelli et al., Aurora kinase A in Barrett???s carcinogenesis, Human Pathology, vol.41, issue.10, pp.1380-1386, 2010.
DOI : 10.1016/j.humpath.2010.02.016

H. Lassus, S. Staff, A. Leminen, J. Isola, and R. Butzow, Aurora-A overexpression and aneuploidy predict poor outcome in serous ovarian carcinoma, Gynecologic Oncology, vol.120, issue.1, pp.11-17, 2011.
DOI : 10.1016/j.ygyno.2010.09.003

H. Ehara, S. Yokoi, M. Tamaki, Y. Nishino, Y. Takahashi et al., Expression of mitotic Aurora/Ipl1p-related kinases in renal cell carcinomas: an immunohistochemical study, Urological Research, vol.31, issue.6, pp.31-382, 2003.
DOI : 10.1007/s00240-003-0354-x

T. Kurahashi, H. Miyake, I. Hara, and M. Fujisawa, Significance of Aurora-A expression in renal cell carcinoma, Urologic Oncology: Seminars and Original Investigations, vol.25, issue.2, pp.128-133, 2007.
DOI : 10.1016/j.urolonc.2006.06.001

R. Mathieu, J. Patard, N. Stock, N. Rioux-leclercq, . Guilléf et al., ??tude de l???expression des kinases Aurora dans le carcinome ?? cellules r??nales, Progr??s en Urologie, vol.20, issue.13, pp.1200-1205, 2010.
DOI : 10.1016/j.purol.2010.05.005

P. Meraldi, R. Honda, and E. Nigg, Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells, The EMBO Journal, vol.21, issue.4, pp.483-492, 2002.
DOI : 10.1093/emboj/21.4.483

J. Fu, M. Bian, Q. Jiang, and C. Zhang, Roles of Aurora Kinases in Mitosis and Tumorigenesis, Molecular Cancer Research, vol.5, issue.1, pp.1-10, 2007.
DOI : 10.1158/1541-7786.MCR-06-0208

H. Katayama, K. Sasai, H. Kawai, Z. Yuan, J. Bondaruk et al., Phosphorylation by aurora kinase A induces Mdm2-mediated destabilizationand inhibition of p53, Nat Genet, pp.36-55, 2004.

Q. Liu, S. Kaneko, L. Yang, R. Feldman, S. Nicosia et al., Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215, Journal of Biological Chemistry, vol.279, issue.50, pp.52175-52182, 2004.
DOI : 10.1074/jbc.M406802200

J. Xu, H. Li, B. Wang, Y. Xu, Y. J. Zhang et al., VHL Inactivation Induces HEF1 and Aurora Kinase A, Journal of the American Society of Nephrology, vol.21, issue.12, pp.2041-2046, 2010.
DOI : 10.1681/ASN.2010040345

F. Latif, K. Tory, J. Gnarra, M. Yao, F. Duh et al., Identification of the von Hippel-Lindau disease tumor suppressor gene, of the von Hippel?Lindau disease tumor suppressor gene, pp.1317-1320, 1993.
DOI : 10.1126/science.8493574

W. Kaelin and . Jr, The von Hippel-Lindau Tumor Suppressor Protein and Clear Cell Renal Carcinoma, Clinical Cancer Research, vol.13, issue.2, pp.680-684, 2007.
DOI : 10.1158/1078-0432.CCR-06-1865

R. Banks, P. Tirukonda, C. Taylor, N. Hornigold, D. Astuti et al., Genetic and Epigenetic Analysis of von Hippel-Lindau (VHL) Gene Alterations and Relationship with Clinical Variables in Sporadic Renal Cancer, Cancer Research, vol.66, issue.4, pp.66-2000, 2006.
DOI : 10.1158/0008-5472.CAN-05-3074

J. Gnarra, K. Tory, Y. Weng, L. Schmidt, M. Wei et al., Mutations of the VHL tumour suppressor gene in renal carcinoma, Nature Genetics, vol.88, issue.1, pp.85-90, 1994.
DOI : 10.1038/ng0594-85

H. Brauch, G. Weirich, J. Brieger, D. Glavac, H. Rödl et al., Stö r k e lS ,R o t t e rM ,M a s e r a A, Gugeler N, Decker HJ. VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation, Cancer Res, pp.60-1942, 2000.

M. Nickerson, E. Jaeger, Y. Shi, J. Durocher, S. Mahurkar et al., Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors, Improved identification of von Hippel?Lindau gene alterations in clear cell renal tumors, pp.4726-4734, 2008.
DOI : 10.1158/1078-0432.CCR-07-4921

A. Young, R. Craven, D. Cohen, C. Taylor, C. Booth et al., Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma, Clinical Cancer Research, vol.15, issue.24, pp.7582-7592, 2009.
DOI : 10.1158/1078-0432.CCR-09-2131

M. Ohh, R. Yauch, K. Lonergan, J. Whaley, A. Stemmer-rachamimov et al., The von Hippel-Lindau Tumor Suppressor Protein Is Required for Proper Assembly of an Extracellular Fibronectin Matrix, Molecular Cell, vol.1, issue.7, pp.959-968, 1998.
DOI : 10.1016/S1097-2765(00)80096-9

J. Roe and H. Youn, The Positive Regulation of p53 by the Tumor Suppressor VHL, Cell Cycle, vol.5, issue.18, pp.2054-2056, 2006.
DOI : 10.4161/cc.5.18.3247

A. Pause, S. Lee, K. Lonergan, and R. Klausner, The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal, Proceedings of the National Academy of Sciences, vol.95, issue.3, pp.993-998, 1998.
DOI : 10.1073/pnas.95.3.993

M. Lolkema, N. Mehra, A. Jorna, M. Van-beest, R. Giles et al., The von Hippel???Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery, Experimental Cell Research, vol.301, issue.2, pp.139-146, 2004.
DOI : 10.1016/j.yexcr.2004.07.016

A. Hergovich, J. Lisztwan, R. Barry, P. Ballschmieter, and W. Krek, Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL, Nature Cell Biology, vol.10, issue.1, pp.64-70, 2003.
DOI : 10.1093/emboj/17.2.368

E. Kuehn, G. Walz, and T. Benzing, von Hippel-Lindau: A Tumor Suppressor Links Microtubules to Ciliogenesis and Cancer Development, Cancer Research, vol.67, issue.10, pp.4537-4540, 2007.
DOI : 10.1158/0008-5472.CAN-07-0391

S. Sinha, G. Mondal, E. Hwang, W. Han-da, S. Dutta et al., Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function, Journal of Cell Science, vol.124, issue.13, pp.2132-2142, 2011.
DOI : 10.1242/jcs.087122

C. Thoma, A. Toso, K. Gutbrodt, S. Reggi, I. Frew et al., VHL loss causes spindle misorientation and chromosome instability, Nature Cell Biology, vol.10, issue.8, pp.994-1001, 2009.
DOI : 10.1007/s004280050085

W. Kim and W. Kaelin, Gene Mutation in Human Cancer, Journal of Clinical Oncology, vol.22, issue.24, pp.4991-5004, 2004.
DOI : 10.1200/JCO.2004.05.061

J. Yuen, Molecular targeted therapy in advanced renal cell carcinoma: A review of its recent past and a glimpse into the near future, Indian Journal of Urology, vol.25, issue.4, p.427, 2009.
DOI : 10.4103/0970-1591.57899

R. Rajaganeshan, P. Prasad, N. Guillou, G. Scott, and D. Poston, Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases, European Journal of Surgical Oncology (EJSO), vol.35, issue.12, pp.1286-1294, 2009.
DOI : 10.1016/j.ejso.2009.05.008
URL : https://hal.archives-ouvertes.fr/hal-00556309

L. Chen, X. Ao, Q. Ren, Z. Wang, C. Lu et al., Linkage disequilibrium and haplotype analysis of two single nucleotide polymorphisms in STK15 in Chinese, Yi Chuan Xue Bao, vol.32, issue.4, pp.331-336, 2005.

L. Gossage and T. Eisen, Alterations in VHL as potential biomarkers in renal-cell carcinoma, Nature Reviews Clinical Oncology, vol.8, issue.5, pp.277-288, 2010.
DOI : 10.1038/nrclinonc.2010.42

P. Schraml, A. Hergovich, F. Hatz, M. Amin, S. Lim et al., Relevance of Nuclear and Cytoplasmic von Hippel Lindau Protein Expression for Renal Carcinoma Progression, The American Journal of Pathology, vol.163, issue.3, pp.1013-1020, 2003.
DOI : 10.1016/S0002-9440(10)63461-X

H. Shiao, A. Forsti, L. Egevad, L. Anderson, P. Lindblad et al., VHL down-regulation and differential localization as mechanisms in tumorigenesis, Kidney International, vol.64, issue.5, pp.1671-1674, 2003.
DOI : 10.1046/j.1523-1755.2003.00257.x

C. Corless, A. Kibel, O. Iliopoulos, W. Kaelin, and . Jr, Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues, Human Pathology, vol.28, issue.4, pp.459-464, 1997.
DOI : 10.1016/S0046-8177(97)90035-6

J. Y. Cremet, S. Descamps, F. Vérité, A. Martin, and C. Prigent, Preparation and characterization of a human aurora-A kinase monoclonal antibody, pp.243-123, 2003.
URL : https://hal.archives-ouvertes.fr/inserm-00966484

V. Ficarra, M. Brunelli, and L. Cheng, Prognostic and Therapeutic Impact of the Histopathologic Definition of Parenchymal Epithelial Renal Tumors, European Urology, vol.58, issue.5, pp.655-668, 2010.
DOI : 10.1016/j.eururo.2010.08.001

A. Dar, A. Zaika, A. Piazuelo, M. Correa, P. Koyama et al., Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions, Cancer, vol.279, issue.8, pp.1688-1698, 2008.
DOI : 10.1002/cncr.23371

F. Lin, J. Shi, H. Liu, J. Zhang, P. Zhang et al., Immunohistochemical Detection of the von Hippel-Lindau Gene Product (pVHL) in Human Tissues and Tumors, American Journal of Clinical Pathology, vol.129, issue.4, pp.592-605, 2008.
DOI : 10.1309/Q0FLUXFJ4FTTW1XR

O. Iliopoulos, M. Ohh, W. Kaelin, and . Jr, pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation, Proceedings of the National Academy of Sciences, vol.95, issue.20, pp.11661-11666, 1998.
DOI : 10.1073/pnas.95.20.11661

I. Ferchichi, N. Stambouli, R. Marrackchi, Y. Arlot, C. Prigent et al., Experimental and Computational Studies Indicate Specific Binding of pVHL Protein to Aurora-A Kinase, The Journal of Physical Chemistry B, vol.114, issue.3, pp.1486-1497, 2010.
DOI : 10.1021/jp909869g
URL : https://hal.archives-ouvertes.fr/inserm-00451872

I. Ferchichi, Y. Arlot, C. Prigent, B. Elgaaied, and A. , Aurora- A kinase interact with and phosphorylate pVHL, Biologia, vol.67, issue.5, pp.1026-1030, 2012.