C-reactive protein levels in patients at cardiovascular risk: EURIKA study

Abstract : Background
Elevated C-reactive protein (CRP) levels are associated with high cardiovascular risk, and might identify patients who could benefit from more carefully adapted risk factor management. We have assessed the prevalence of elevated CRP levels in patients with one or more traditional cardiovascular risk factors.
Methods
Data were analysed from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA, ClinicalTrials.gov Identifier: NCT00882336), which included patients (aged ≥50 years) from 12 European countries with at least one traditional cardiovascular risk factor but no history of cardiovascular disease. Analysis was also carried out on the subset of patients without diabetes mellitus who were not receiving statin therapy.
Results
In the overall population, CRP levels were positively correlated with body mass index and glycated haemoglobin levels, and were negatively correlated with high-density lipoprotein cholesterol levels. CRP levels were also higher in women, those at higher traditionally estimated cardiovascular risk and those with greater numbers of metabolic syndrome markers. Among patients without diabetes mellitus who were not receiving statin therapy, approximately 30% had CRP levels ≥3 mg/L, and approximately 50% had CRP levels ≥2 mg/L, including those at intermediate levels of traditionally estimated cardiovascular risk.
Conclusions
CRP levels are elevated in a large proportion of patients with at least one cardiovascular risk factor, without diabetes mellitus who are not receiving statin therapy, suggesting a higher level of cardiovascular risk than predicted according to conventional risk estimation systems.
Trial registration
ClinicalTrials.gov Identifier: NCT00882336
Type de document :
Article dans une revue
BMC Cardiovascular Disorders, BioMed Central, 2014, 14 (1), pp.25. 〈10.1186/1471-2261-14-25〉
Liste complète des métadonnées

Littérature citée [40 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00956193
Contributeur : Ed. Bmc <>
Soumis le : jeudi 6 mars 2014 - 01:07:29
Dernière modification le : mercredi 24 janvier 2018 - 01:05:41
Document(s) archivé(s) le : vendredi 6 juin 2014 - 10:47:36

Fichiers

Identifiants

Collections

Citation

Julian Halcox, Carine Roy, Florence Tubach, José Banegas, Jean Dallongeville, et al.. C-reactive protein levels in patients at cardiovascular risk: EURIKA study. BMC Cardiovascular Disorders, BioMed Central, 2014, 14 (1), pp.25. 〈10.1186/1471-2261-14-25〉. 〈inserm-00956193〉

Partager

Métriques

Consultations de la notice

251

Téléchargements de fichiers

210