Y. Tung and G. Yeo, From GWAS to biology: lessons from FTO, Annals of the New York Academy of Sciences, vol.102, issue.1, pp.162-171, 2011.
DOI : 10.1111/j.1749-6632.2010.05903.x

T. Berulava and B. Horsthemke, The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels, European Journal of Human Genetics, vol.294, issue.9, pp.1054-1056, 2010.
DOI : 10.1016/j.bbrc.2008.01.087

URL : https://hal.archives-ouvertes.fr/hal-00540037

A. Bravard, E. Lefai, E. Meugnier, S. Pesenti, E. Disse et al., FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction, Diabetes, vol.60, issue.1, pp.258-268, 2011.
DOI : 10.2337/db10-0281

URL : https://hal.archives-ouvertes.fr/inserm-00809741

A. Bravard, A. Veilleux, E. Disse, M. Laville, H. Vidal et al., The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity, Obesity, vol.582, issue.6, pp.1165-1173, 2013.
DOI : 10.1002/oby.20110

C. Church, S. Lee, E. Bagg, J. Mctaggart, R. Deacon et al., A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene, PLoS Genetics, vol.13, issue.4, p.1000599, 2009.
DOI : 10.1371/journal.pgen.1000599.s016

J. Fischer, L. Koch, C. Emmerling, J. Vierkotten, T. Peters et al., Inactivation of the Fto gene protects from obesity, Nature, vol.134, issue.7240, pp.894-898, 2009.
DOI : 10.1038/nature07848

J. Friedman and J. Halaas, Leptin and the regulation of body weight in mammals, Nature, vol.395, issue.6704, pp.763-770, 1998.
DOI : 10.1038/27376

D. Muoio, Peripheral metabolic actions of leptin, Best Practice & Research Clinical Endocrinology & Metabolism, vol.16, issue.4, pp.653-666, 2002.
DOI : 10.1053/beem.2002.0223

G. Paz-filho, C. Mastronardi, M. Wong, and J. Licinio, Leptin therapy, insulin sensitivity, and glucose homeostasis, Indian Journal of Endocrinology and Metabolism, vol.16, issue.9, pp.549-555, 2012.
DOI : 10.4103/2230-8210.105571

URL : http://doi.org/10.4103/2230-8210.105571

J. Wegrzyn, R. Potla, Y. Chwae, N. Sepuri, Q. Zhang et al., Function of Mitochondrial Stat3 in Cellular Respiration, Science, vol.323, issue.5915, pp.793-797, 2009.
DOI : 10.1126/science.1164551

R. Wakahara, H. Kunimoto, K. Tanino, H. Kojima, A. Inoue et al., Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45, Genes to Cells, vol.325, issue.2, pp.132-145, 2012.
DOI : 10.1111/j.1365-2443.2011.01575.x

P. Wang, F. Yang, H. Du, Y. Guan, T. Xu et al., Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass-and obesity-associated (FTO) downregulation during energy restriction, Mol Med, vol.17, pp.523-532, 2011.

R. Fredriksson, M. Hagglund, P. Olszewski, O. Stephansson, J. Jacobsson et al., The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain, Endocrinology, vol.149, issue.5, pp.2062-2071, 2008.
DOI : 10.1210/en.2007-1457

T. Gerken, C. Girard, Y. Tung, C. Webby, V. Saudek et al., The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase, Science, vol.318, issue.5855, pp.1469-1472, 2007.
DOI : 10.1126/science.1151710

P. Olszewski, K. Radomska, K. Ghimire, A. Klockars, C. Ingman et al., Fto immunoreactivity is widespread in the rodent brain and abundant in feeding-related sites, but the number of Fto-positive cells is not affected by changes in energy balance, Physiology & Behavior, vol.103, issue.2, pp.248-253, 2011.
DOI : 10.1016/j.physbeh.2011.01.022

X. Gao, Y. Shin, M. Li, F. Wang, Q. Tong et al., The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice, PLoS ONE, vol.50, issue.11, p.14005, 2010.
DOI : 10.1371/journal.pone.0014005.s007

Y. Tung, E. Ayuso, X. Shan, F. Bosch, O. Rahilly et al., Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats, PLoS ONE, vol.5, issue.1, p.8771, 2010.
DOI : 10.1371/journal.pone.0008771.g005

H. Inoue, W. Ogawa, M. Ozaki, S. Haga, M. Matsumoto et al., Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo, Nature Medicine, vol.10, issue.2, pp.168-174, 2004.
DOI : 10.1038/nm980

N. Poritsanos, P. Lew, and T. Mizuno, Relationship between blood glucose levels and hepatic Fto mRNA expression in mice, Biochemical and Biophysical Research Communications, vol.400, issue.4, pp.713-717, 2010.
DOI : 10.1016/j.bbrc.2010.08.133

A. Tiwari, S. Krzysik-walker, and R. Ramachandran, Cloning and characterization of chicken fat mass and obesity associated (Fto) gene: fasting affects Fto expression, Domestic Animal Endocrinology, vol.42, issue.1, pp.1-10, 2012.
DOI : 10.1016/j.domaniend.2011.08.001

J. Leu, M. Crissey, J. Leu, G. Ciliberto, and R. Taub, Interleukin-6-Induced STAT3 and AP-1 Amplify Hepatocyte Nuclear Factor 1-Mediated Transactivation of Hepatic Genes, an Adaptive Response to Liver Injury, Molecular and Cellular Biology, vol.21, issue.2, pp.414-424, 2001.
DOI : 10.1128/MCB.21.2.414-424.2001

M. Vogt, T. Domoszlai, D. Kleshchanok, S. Lehmann, A. Schmitt et al., The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3, Journal of Cell Science, vol.124, issue.6, pp.900-909, 2011.
DOI : 10.1242/jcs.072520

M. Nemecz, K. Preininger, R. Englisch, C. Furnsinn, B. Schneider et al., Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver, Hepatology, vol.53, issue.5, pp.166-172, 1999.
DOI : 10.1002/hep.510290110

C. Liang and A. Tall, Transcriptional Profiling Reveals Global Defects in Energy Metabolism, Lipoprotein, and Bile Acid Synthesis and Transport with Reversal by Leptin Treatment in Ob/ob Mouse Liver, Journal of Biological Chemistry, vol.276, issue.52, pp.49066-49076, 2001.
DOI : 10.1074/jbc.M107250200

K. Ikejima, T. Lang, Y. Zhang, S. Yamashina, H. Honda et al., Expression of leptin receptors in hepatic sinusoidal cells, Comparative Hepatology, vol.3, issue.Suppl 1, p.12, 2004.
DOI : 10.1186/1476-5926-2-S1-S12

P. Raman, S. Donkin, and M. Spurlock, Regulation of hepatic glucose metabolism by leptin in pig and rat primary hepatocyte cultures, AJP: Regulatory, Integrative and Comparative Physiology, vol.286, issue.1
DOI : 10.1152/ajpregu.00340.2003

H. Fukuda, N. Iritani, T. Sugimoto, and H. Ikeda, Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats, European Journal of Biochemistry, vol.274, issue.2, pp.505-511, 1999.
DOI : 10.1046/j.1432-1327.1999.00183.x

J. Park, C. Kusminski, S. Chua, and P. Scherer, Leptin Receptor Signaling Supports Cancer Cell Metabolism through Suppression of Mitochondrial Respiration in Vivo, The American Journal of Pathology, vol.177, issue.6, pp.3133-3144, 2010.
DOI : 10.2353/ajpath.2010.100595

M. Bernier, R. Paul, A. Martin-montalvo, M. Scheibye-knudsen, S. Song et al., Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein, Journal of Biological Chemistry, vol.286, issue.22
DOI : 10.1074/jbc.M110.200311

M. Holmstrom, R. Tom, M. Bjornholm, P. Garcia-roves, and J. Zierath, Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice, Metabolism, vol.62, issue.9, pp.1258-1267, 2013.
DOI : 10.1016/j.metabol.2013.04.001

A. Singh, M. Wirtz, N. Parker, M. Hogan, J. Strahler et al., Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels, Proceedings of the National Academy of Sciences, vol.106, issue.31, pp.13100-13105, 2009.
DOI : 10.1073/pnas.0903723106

G. Jia, Y. Fu, X. Zhao, Q. Dai, G. Zheng et al., N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO, Nature Chemical Biology, vol.6, issue.12, pp.885-887, 2011.
DOI : 10.1038/nchembio.687

E. Karra, O. Daly, O. Choudhury, A. Yousseif, A. Millership et al., A link between FTO, ghrelin, and impaired brain food-cue responsivity, Journal of Clinical Investigation, vol.123, issue.8, pp.3539-3551, 2013.
DOI : 10.1172/JCI44403DS1

J. Guo, W. Ren, A. Li, Y. Ding, W. Guo et al., Fat Mass and Obesity-Associated Gene Enhances Oxidative Stress and Lipogenesis in Nonalcoholic Fatty Liver Disease, Digestive Diseases and Sciences, vol.318, issue.5855, pp.1004-1009, 2013.
DOI : 10.1007/s10620-012-2516-6

K. Imajo, K. Fujita, M. Yoneda, Y. Nozaki, Y. Ogawa et al., Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling, Cell Metabolism, vol.16, issue.1, pp.44-54, 2012.
DOI : 10.1016/j.cmet.2012.05.012

M. Aziz, B. Hafeez, J. Sand, D. Pierce, S. Aziz et al., Protein kinase C?? mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2), Oncogene, vol.26, issue.21, pp.3100-3109, 2010.
DOI : 10.1038/onc.2010.63

I. Hazan-halevy, D. Harris, Z. Liu, J. Liu, P. Li et al., STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells, Blood, vol.115, issue.14, pp.2852-2863, 2010.
DOI : 10.1182/blood-2009-10-230060

K. Stevens, C. Vachon, and F. Couch, Genetic Susceptibility to Triple-Negative Breast Cancer, Cancer Research, vol.73, issue.7, pp.2025-2030, 2013.
DOI : 10.1158/0008-5472.CAN-12-1699

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654815

M. Berry and D. Friend, HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS: A Biochemical and Fine Structural Study, The Journal of Cell Biology, vol.43, issue.3, pp.506-520, 1969.
DOI : 10.1083/jcb.43.3.506

A. Groen, R. Vervoorn, R. Van-der-meer, and J. Tager, Control of gluconeogenesis in rat liver cells. I. Kinetics of the individual enzymes and the effect of glucagon, J Biol Chem, vol.258, pp.14346-14353, 1983.

S. Belouzard, D. Delcroix, and Y. Rouille, Low Levels of Expression of Leptin Receptor at the Cell Surface Result from Constitutive Endocytosis and Intracellular Retention in the Biosynthetic Pathway, Journal of Biological Chemistry, vol.279, issue.27, pp.28499-28508, 2004.
DOI : 10.1074/jbc.M400508200

C. Bonnard, A. Durand, S. Peyrol, E. Chanseaume, M. Chauvin et al., Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice, Journal of Clinical Investigation
DOI : 10.1172/JCI32601

URL : https://hal.archives-ouvertes.fr/inserm-00808486