Antioxidant properties of phenolic Schiff bases: structure-activity relationship and mechanism of action.

El Hassane Anouar 1 Salwa Raweh 1 Imene Bayach 2 Muhammad Taha 1 Mohd Syukri Baharudin 1 Florent Di Meo 3 Mizaton Hazizul Hasan 1 Aishah Adam 4 Nor Hadiani Ismail 1 Jean-Frédéric F Weber 1 Patrick Trouillas 3
1 Pharmacie
2 UNILIM - Université de Limoges
3 PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation
4 Laboratoire de Chimie des Matériaux Nouveaux
Abstract : Phenolic Schiff bases are known for their diverse biological activities and ability to scavenge free radicals. To elucidate (1) the structure-antioxidant activity relationship of a series of thirty synthetic derivatives of 2-methoxybezohydrazide phenolic Schiff bases and (2) to determine the major mechanism involved in free radical scavenging, we used density functional theory calculations (B3P86/6-31+(d,p)) within polarizable continuum model. The results showed the importance of the bond dissociation enthalpies (BDEs) related to the first and second (BDEd) hydrogen atom transfer (intrinsic parameters) for rationalizing the antioxidant activity. In addition to the number of OH groups, the presence of a bromine substituent plays an interesting role in modulating the antioxidant activity. Theoretical thermodynamic and kinetic studies demonstrated that the free radical scavenging by these Schiff bases mainly proceeds through proton-coupled electron transfer rather than sequential proton loss electron transfer, the latter mechanism being only feasible at relatively high pH.
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Journal of Computer-Aided Molecular Design, Springer Verlag, 2013, 27 (11), pp.951-64. 〈10.1007/s10822-013-9692-0〉
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Contributeur : Pierre Marquet <>
Soumis le : jeudi 9 janvier 2014 - 11:30:57
Dernière modification le : jeudi 21 juin 2018 - 16:58:02

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El Hassane Anouar, Salwa Raweh, Imene Bayach, Muhammad Taha, Mohd Syukri Baharudin, et al.. Antioxidant properties of phenolic Schiff bases: structure-activity relationship and mechanism of action.. Journal of Computer-Aided Molecular Design, Springer Verlag, 2013, 27 (11), pp.951-64. 〈10.1007/s10822-013-9692-0〉. 〈inserm-00926218〉

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