]. O. Farokhzad and R. Langer, Impact of Nanotechnology on Drug Delivery, ACS Nano, vol.3, issue.1, pp.16-20, 2009.
DOI : 10.1021/nn900002m

]. S. Hirsjärvi, C. Passirani, and J. Benoit, Passive and Active Tumour Targeting with Nanocarriers, Current Drug Discovery Technologies, vol.8, issue.3, pp.188-196, 2011.
DOI : 10.2174/157016311796798991

]. M. Gottesman, T. Fojo, and S. E. Bates, MULTIDRUG RESISTANCE IN CANCER: ROLE OF ATP-DEPENDENT TRANSPORTERS, Nature Reviews Cancer, vol.2, issue.1, pp.48-58, 2002.
DOI : 10.1038/nrc706

S. Bao, Q. Wu, R. E. Mclendon, Y. Hao, Q. Shi et al., Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, vol.8, issue.7120, pp.756-760, 2006.
DOI : 10.1038/nature05236

]. V. Torchilin, Recent advances with liposomes as pharmaceutical carriers, Nature Reviews Drug Discovery, vol.103, issue.2, pp.145-160, 2005.
DOI : 10.1081/LPR-120017488

]. A. Kumari, S. K. Yadav, and S. C. Yadav, Biodegradable polymeric nanoparticles based drug delivery systems, Colloids and Surfaces B: Biointerfaces, vol.75, issue.1, pp.1-18, 2010.
DOI : 10.1016/j.colsurfb.2009.09.001

B. Heurtault, P. Saulnier, B. Pech, J. Proust, and J. Benoit, A novel phase inversionbased process for the preparation of lipid nanocarriers, Pharmaceutical Research, vol.19, issue.6, pp.875-880, 2002.
DOI : 10.1023/A:1016121319668

J. Luu and . Benoit, The influence of lipid nanocapsule composition on their size distribution, Eur J Pharm Sci, vol.18, pp.55-61, 2003.

S. Peltier, J. Oger, F. Lagarce, W. Couet, and J. Benoit, Enhanced Oral Paclitaxel Bioavailability After Administration of Paclitaxel-Loaded Lipid Nanocapsules, Pharmaceutical Research, vol.47, issue.6, pp.1243-1250, 2006.
DOI : 10.1007/s11095-006-0022-2

F. Lacoeuille, F. Hindré, F. Moal, J. Roux, C. Passirani et al., In vivo evaluation of lipid nanocapsules as a promising colloidal carrier for paclitaxel, International Journal of Pharmaceutics, vol.344, issue.1-2, pp.143-149, 2007.
DOI : 10.1016/j.ijpharm.2007.06.014

URL : https://hal.archives-ouvertes.fr/inserm-00258366

E. Garcion, A. Lamprecht, B. Heurtault, A. Paillard, A. Aubert-pouessel et al., A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats, Molecular Cancer Therapeutics, vol.5, issue.7, pp.1710-1722, 2006.
DOI : 10.1158/1535-7163.MCT-06-0289

URL : https://hal.archives-ouvertes.fr/hal-00358958

M. Weyland, F. Manero, A. Paillard, D. Grée, G. Viault et al., Mitochondrial targeting by use of lipid nanocapsules loaded with SV30, an analogue of the small-molecule Bcl-2 inhibitor HA14-1, Journal of Controlled Release, vol.151, issue.1, pp.74-82, 2011.
DOI : 10.1016/j.jconrel.2010.11.032

URL : https://hal.archives-ouvertes.fr/hal-00842655

A. Lamprecht, J. Saumet, J. Roux, and J. Benoit, Lipid nanocarriers as drug delivery system for ibuprofen in pain treatment, International Journal of Pharmaceutics, vol.278, issue.2, pp.407-414, 2004.
DOI : 10.1016/j.ijpharm.2004.03.018

M. Morille, C. Passirani, S. Dufort, G. Bastiat, B. Pitard et al., Tumor transfection after systemic injection of DNA lipid nanocapsules, Biomaterials, vol.32, issue.9, pp.2327-2333, 2011.
DOI : 10.1016/j.biomaterials.2010.11.063

F. Oberti, N. Bouchet, E. Noiret, J. Garin, O. Benoit et al., Lipid nanocapsules loaded with rhenium-188 reduce tumor progression in a rat hepatocellular carcinoma model, PLoS ONE, vol.6, p.16926, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00741696

. Benoit, Re-188-loaded lipid nanocapsules as a promising radiopharmaceutical carrier for internal radiotherapy of malignant gliomas, European Journal of Nuclear Medicine and Molecular Imaging, vol.35, pp.1838-1846, 2008.
URL : https://hal.archives-ouvertes.fr/inserm-00343438

J. Lejeune, P. Benoit, O. F. Menei, E. Couturier, F. Garcion et al., Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with 188Re-lipid nanocapsules, Biomaterials, vol.32, pp.6781-6790, 2011.

S. Ballot, N. Noiret, F. Hindré, B. Denizot, E. Garin et al., Tc/ 188 Re-labelled lipid nanocapsules as promising radiotracers for imaging and therapy: Formulation and biodistribution, European Journal of Nuclear Medicine and Molecular Imaging, vol.33, pp.99-602, 2006.

M. Morille, T. Montier, P. Legras, N. Carmoy, P. Brodin et al., Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting, Biomaterials, vol.31, issue.2, pp.31-321, 2010.
DOI : 10.1016/j.biomaterials.2009.09.044

URL : https://hal.archives-ouvertes.fr/inserm-00491402

A. Béduneau, F. Hindré, A. Clavreul, J. Leroux, P. Saulnier et al., Brain targeting using novel lipid nanovectors, Journal of Controlled Release, vol.126, issue.1, pp.44-49, 2008.
DOI : 10.1016/j.jconrel.2007.11.001

E. Bourseau-guilmain, J. Béjaud, A. Griveau, N. Lautram, F. Hindré et al., Development and characterization of immuno-nanocarriers targeting the cancer stem cell marker AC133, International Journal of Pharmaceutics, vol.423, issue.1, pp.93-101, 2012.
DOI : 10.1016/j.ijpharm.2011.06.001

R. Misra, S. Acharya, and S. K. Sahoo, Cancer nanotechnology: application of nanotechnology in cancer therapy, Drug Discovery Today, vol.15, issue.19-20, pp.842-850, 2010.
DOI : 10.1016/j.drudis.2010.08.006

J. D. Byrne, T. Betancourt, and L. Brannon-peppas, Active targeting schemes for nanoparticle systems in cancer therapeutics, Advanced Drug Delivery Reviews, vol.60, issue.15, pp.1615-1626, 2008.
DOI : 10.1016/j.addr.2008.08.005

J. S. Desgrosellier and D. A. Cheresh, Integrins in cancer: biological implications and therapeutic opportunities, Nature Reviews Cancer, vol.13, issue.1, pp.9-22, 2010.
DOI : 10.1038/nrc2748

E. Koivunen, B. C. Wang, and E. Ruoslahti, Phage Libraries Displaying Cyclic Peptides with Different Ring Sizes: Ligand Specificities of the RGD-Directed Integrins, Bio/Technology, vol.268, issue.3, pp.265-270, 1995.
DOI : 10.1016/0076-6879(82)82103-4

W. Arap, R. Pasqualini, and E. Ruoslahti, Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model, Science, vol.279, issue.5349, pp.377-380, 1998.
DOI : 10.1126/science.279.5349.377

J. D. Hood, M. Bednarski, R. Frausto, S. Guccione, R. A. Reisfeld et al., Tumor Regression by Targeted Gene Delivery to the Neovasculature, Science, vol.296, issue.5577, pp.2404-2407, 2002.
DOI : 10.1126/science.1070200

D. A. Wrasidlo and . Cheresh, Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis, PNAS, vol.105, pp.9343-9348, 2008.

R. F. Hanahan, E. Mattrey, and . Ruoslahti, Tissue-penetrating delivery of compounds and nanoparticles into tumors, pp.16-510, 2009.

X. Xiong, Y. Huang, W. Lu, X. Zhang, H. Zhang et al., Intracellular delivery of doxorubicin with RGD-modified sterically stabilized liposomes for an improved antitumor efficacy: In vitro and in vivo, Journal of Pharmaceutical Sciences, vol.94, issue.8, pp.1782-1793, 2005.
DOI : 10.1002/jps.20397

R. M. Schiffelers, G. A. Koning, T. L. Ten-hagen, M. H. Fens, A. J. Schraa et al., Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin, Journal of Controlled Release, vol.91, issue.1-2, pp.115-122, 2003.
DOI : 10.1016/S0168-3659(03)00240-2

J. Jérôme, O. Marchand-brynaert, V. Feron, and . Préat, Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel, J Control Release, vol.140, pp.166-173, 2009.

M. Goutayer, S. Dufort, V. Josserand, A. Royère, E. Heinrich et al., Tumor targeting of functionalized lipid nanoparticles: Assessment by in vivo fluorescence imaging, European Journal of Pharmaceutics and Biopharmaceutics, vol.75, issue.2, pp.137-147, 2010.
DOI : 10.1016/j.ejpb.2010.02.007

L. Bello, M. Francolini, P. Marthyn, J. Zhang, R. S. Carroll et al., Black, ? v ? 3 and ? v ? 5 integrin expression in glioma periphery, Neurosurgery, vol.49, pp.380-390, 2001.

F. Mévellec, F. Tisato, F. Refosco, A. Roucoux, N. Noiret et al., Synthesis and Characterization of the ???Sulfur-Rich??? Bis(perthiobenzoato)(dithiobenzoato)technetium(III) Heterocomplex, Inorganic Chemistry, vol.41, issue.3, pp.41-598, 2002.
DOI : 10.1021/ic0107577

M. Brinkley, A brief survey of methods for preparing protein conjugates with dyes, haptens and crosslinking reagents, Bioconjugate Chemistry, vol.3, issue.1, pp.2-13, 1992.
DOI : 10.1021/bc00013a001

T. Perrier, P. Saulnier, F. Fouchet, N. Lautram, and J. Benoit, Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms, International Journal of Pharmaceutics, vol.396, issue.1-2, pp.204-209, 2010.
DOI : 10.1016/j.ijpharm.2010.06.019

A. Vonarbourg, C. Passirani, P. Saulnier, P. Simard, J. Leroux et al., Evaluation of pegylated lipid nanocapsules versus complement system activation and macrophage uptake, Journal of Biomedical Materials Research Part A, vol.21, issue.3, pp.78-620, 2006.
DOI : 10.1002/jbm.a.30711

A. H. Cory, T. C. Owen, J. A. Barltrop, and J. G. Cory, Use of an aqueous soluble tetrazolium formazan assay for cell-growth assays in culture, Cancer Comm, vol.3, pp.207-212, 1991.

G. Meijer and . Molema, Preparation and functional evaluation of RGD-modified proteins as ? v ? 3 integrin directed therapeutics, Bioconjugate Chem, vol.13, pp.128-135, 2001.

X. Montet, M. Funovics, K. Montet-abou, R. Weissleder, and L. Josephson, Multivalent Effects of RGD Peptides Obtained by Nanoparticle Display, Journal of Medicinal Chemistry, vol.49, issue.20, pp.6087-6093, 2006.
DOI : 10.1021/jm060515m

T. Taga, A. Suzuki, I. Gonzalez-gomez, F. H. Gilles, M. Stins et al., ?v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin, International Journal of Cancer, vol.46, issue.87, pp.690-697, 2002.
DOI : 10.1002/ijc.10265

A. Béduneau, P. Saulnier, F. Hindré, A. Clavreul, J. Leroux et al., Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab??? fragments, Biomaterials, vol.28, issue.33, pp.4978-4990, 2007.
DOI : 10.1016/j.biomaterials.2007.05.014

A. Vonarbourg, P. Saulnier, C. Passirani, and J. Benoit, Electrokinetic properties of noncharged lipid nanocapsules: Influence of the dipolar distribution at the interface, ELECTROPHORESIS, vol.15, issue.11, pp.2066-2075, 2005.
DOI : 10.1002/elps.200410145

J. Lu, M. Shi, and M. S. Shoichet, Click Chemistry Functionalized Polymeric Nanoparticles Target Corneal Epithelial Cells through RGD-Cell Surface Receptors, Bioconjugate Chemistry, vol.20, issue.1, pp.87-94, 2009.
DOI : 10.1021/bc8003167

K. Temming, R. M. Schiffelers, G. Molema, and R. J. Kok, RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature, Drug Resistance Updates, vol.8, issue.6, pp.381-402, 2005.
DOI : 10.1016/j.drup.2005.10.002

A. Paillard, F. Hindré, C. Vignes-colombeix, J. Benoit, and E. Garcion, The importance of endo-lysosomal escape with lipid nanocapsules for drug subcellular bioavailability, Biomaterials, vol.31, issue.29, pp.31-7542, 2010.
DOI : 10.1016/j.biomaterials.2010.06.024

. Speiser, Pharmacokinetics and distribution of a biodegradable drug-carrier, Int J Pharm, vol.15, pp.335-345, 1983.

S. Li and L. Huang, Stealth nanoparticles: High density but sheddable PEG is a key for tumor targeting, Journal of Controlled Release, vol.145, issue.3, pp.178-181, 2010.
DOI : 10.1016/j.jconrel.2010.03.016

C. H. Choi, J. E. Zuckerman, P. Webster, and M. E. Davis, Targeting kidney mesangium by nanoparticles of defined size, Proceedings of the National Academy of Sciences, vol.108, issue.16, pp.6656-6661, 2011.
DOI : 10.1073/pnas.1103573108

F. Coll, J. Hindré, and . Benoît, Effect of particle size on the biodistribution of lipid nanocapsules: Comparison between nuclear and fluorescence imaging and counting, Int J Pharm, vol.453, pp.594-600, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00855672

H. Maeda, T. Sawa, and T. Konno, Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS, Journal of Controlled Release, vol.74, issue.1-3, pp.47-61, 2001.
DOI : 10.1016/S0168-3659(01)00309-1

Z. Hu, F. Luo, Y. Pan, C. Hou, L. Ren et al., Arg-Gly-Asp (RGD) peptide conjugated poly(lactic acid)-poly(ethylene oxide) micelle for targeted drug delivery, Journal of Biomedical Materials Research Part A, vol.114, issue.1, Part 1, pp.85-797, 2008.
DOI : 10.1002/jbm.a.31615

M. Yoshimoto, K. Ogawa, K. Washiyama, N. Shikano, H. Mori et al., ??v??3 Integrin-targeting radionuclide therapy and imaging with monomeric RGD peptide, International Journal of Cancer, vol.59, issue.3, pp.709-715, 2008.
DOI : 10.1002/ijc.23575

?. Toulas, ? 3 and ? v ? ? integrins control glioma cell response to ionising radiation through ILK and RhoB, Int J Cancer, vol.123, pp.357-364, 2008.

A. Abdollahi, D. W. Griggs, H. Zieher, A. Roth, K. E. Lipson et al., Inhibition of ??v??3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy, Clinical Cancer Research, vol.11, issue.17, pp.6270-6279, 2005.
DOI : 10.1158/1078-0432.CCR-04-1223